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1. Full Text Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine
by Heikkinen, Aki T and Heikkinen, Aki T and Friedlein, Arno and Friedlein, Arno and Matondo, Mariette and Matondo, Mariette and Hatley, Oliver J. D and Hatley, Oliver J. D and Petsalo, Aleksanteri and Petsalo, Aleksanteri and Juvonen, Risto and Juvonen, Risto and Galetin, Aleksandra and Galetin, Aleksandra and Rostami-Hodjegan, Amin and Rostami-Hodjegan, Amin and Aebersold, Ruedi and Aebersold, Ruedi and Lamerz, Jens and Lamerz, Jens and Dunkley, Tom and Dunkley, Tom and Cutler, Paul and Cutler, Paul and Parrott, Neil and Parrott, Neil
Pharmaceutical research, ISSN 0724-8741, 1/2015, Volume 32, Issue 1, pp. 74 - 90
Biochemistry, general | Biomedical Engineering | Protein quantitation | Biomedicine | Pharmacy | Interspecies differences | Drug metabolism | Medical Law | Pharmacology/Toxicology | In vitro - in vivo extrapolation | Canine | In vitro-in vivo extrapolation | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Colon - enzymology | Cytochrome P-450 Enzyme System - analysis | Liver - enzymology | Species Specificity | Humans | Cytochrome P-450 Enzyme System - metabolism | Male | Microsomes - enzymology | Glucuronosyltransferase - analysis | Intestine, Small - enzymology | Animals | Glucuronosyltransferase - metabolism | Models, Biological | Mass Spectrometry | Dogs | Female | Proteomics - methods | Physiological aspects | Liver | Cytochrome P-450 | Enzymes | Small intestine | Pharmaceutical sciences | Proteomics | Index Medicus | Glucuronosyltransferase/metabolism | Glucuronosyltransferase/analysis | Liver/enzymology | Life Sciences | Intestine, Small/enzymology | Proteomics/methods | Cytochrome P-450 Enzyme System/metabolism | Microsomes/enzymology | Cytochrome P-450 Enzyme System/analysis | Colon/enzymology
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2. Full Text Role of inflammatory and oxidative stress, cytochrome P450 2E1, and bile acid disturbance in rat liver injury induced by isoniazid and lipopolysaccharide cotreatment
by Hassan, Hozeifa Mohamed and Guo, Hongli and Yousef, Bashir Alsiddig and Guerram, Mounia and Hamdi, Aida Mejda and Zhang, Luyong and Jiang, Zhenzhou
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 09/2016, Volume 60, Issue 9, pp. 5285 - 5293
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Up-Regulation | Antitubercular Agents - adverse effects | Liver - pathology | Bile Acids and Salts - blood | Liver - enzymology | Reactive Oxygen Species - metabolism | Fatty Liver - pathology | Isoniazid - adverse effects | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Fatty Liver - chemically induced | Reactive Oxygen Species - agonists | Liver - drug effects | Microsomes, Liver - drug effects | Fatty Liver - enzymology | Microsomes, Liver - enzymology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - enzymology | Fatty Liver - genetics | Gene Expression | Lipopolysaccharides - toxicity | Rats | Inflammation | Chemical and Drug Induced Liver Injury - genetics | Rats, Sprague-Dawley | Animals | Oxidative Stress - drug effects | Drug Combinations | Microsomes, Liver - pathology | Index Medicus
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3. Full Text Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate
by Hong Lu and Xiaofeng Meng and Chung S. Yang
Drug metabolism and disposition, ISSN 0090-9556, 05/2003, Volume 31, Issue 5, pp. 572 - 579
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | Intestinal Mucosa - metabolism | Gas Chromatography-Mass Spectrometry | Liver - enzymology | Species Specificity | Microsomes, Liver - metabolism | Cytosol - drug effects | Male | Catechol O-Methyltransferase - metabolism | Glucuronides - pharmacology | Microsomes, Liver - drug effects | Swine | Female | Microsomes, Liver - enzymology | Glucuronides - biosynthesis | Catechin - metabolism | Catechin - pharmacology | Liver - ultrastructure | Liver - metabolism | Enzyme Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Enzyme Inhibitors - isolation & purification | Intestines - ultrastructure | Animals | Catechin - isolation & purification | Cytosol - metabolism | Catechin - analogs & derivatives | Catechol O-Methyltransferase Inhibitors | Mice | Methylation | Tea - chemistry | Intestines - enzymology | Index Medicus
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4. Full Text In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol
by Negreira, Noelia and Erratico, Claudio and Kosjek, Tina and van Nuijs, Alexander L. N and Heath, Ester and Neels, Hugo and Covaci, Adrian
Analytical and bioanalytical chemistry, ISSN 1618-2642, 7/2015, Volume 407, Issue 19, pp. 5803 - 5816
Biochemistry, general | Cathinones | In vitro metabolism | Food Science | Methedrone | Laboratory Medicine | Chemistry | Analytical Chemistry | α-PVP | Quadrupole time-of-flight mass spectrometry | Characterization and Evaluation of Materials | MDPV | New psychoactive substances | Environmental Monitoring/Analysis | Biochemistry & Molecular Biology | Physical Sciences | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Cytosol - enzymology | Tandem Mass Spectrometry | Liver - enzymology | Humans | Liver - metabolism | Microsomes, Liver - metabolism | Cytochromes - metabolism | Pyrrolidines - metabolism | Benzodioxoles - metabolism | Cytosol - metabolism | Microsomes, Liver - enzymology | Propiophenones - metabolism | Index Medicus | Human | Enzymes | Reduction | Phase transformations | Metabolites | Hydroxylation | Liver | In vitro testing
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5. Full Text Raloxifene glucuronidation in human intestine, kidney, and liver microsomes and in human liver microsomes genotyped for the UGT1A128 polymorphism
by Lušin, Tina Trdan and Trontelj, Jurij and Mrhar, Aleš
Drug metabolism and disposition, ISSN 0090-9556, 12/2011, Volume 39, Issue 12, pp. 2347 - 2354
Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Glucuronosyltransferase - genetics | Raloxifene Hydrochloride - metabolism | Glucuronides - metabolism | Humans | Kidney - enzymology | Genotype | Microsomes, Liver - enzymology | Intestines - enzymology | Polymorphism, Genetic | Index Medicus
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6. Full Text Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury
by Amano, Takayuki and Fukami, Tatsuki and Ogiso, Takuo and Hirose, Daisuke and Jones, Jeffrey P and Taniguchi, Tsuyoshi and Nakajima, Miki
Biochemical pharmacology, ISSN 0006-2952, 05/2018, Volume 151, pp. 69 - 78
Aldehyde oxidase | Drug reductase | Glutathione trap | Dantrolene | Liver injury | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neuromuscular Agents - metabolism | Arylamine N-Acetyltransferase - metabolism | Liver - enzymology | Dantrolene - metabolism | Humans | Cytosol - drug effects | Male | Dantrolene - adverse effects | Cytosol - enzymology | Liver - drug effects | Microsomes, Liver - drug effects | Aldehyde Oxidase - metabolism | Neuromuscular Agents - adverse effects | Female | Microsomes, Liver - enzymology | Chemical and Drug Induced Liver Injury - enzymology | Chemical and Drug Induced Liver Injury - etiology | Oxidases | Phosphates | Niacinamide | Hydroxides | Liver | Cytochrome P-450 | Aldehydes | Ethylenediamines | Cytokinins | Physiological aspects | Single nucleotide polymorphisms | Mass spectrometry | High performance liquid chromatography | Index Medicus
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7. Full Text Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring
by Fallon, John K and Neubert, Hendrik and Hyland, Ruth and Goosen, Theunis C and Smith, Philip C
Journal of proteome research, ISSN 1535-3893, 10/2013, Volume 12, Issue 10, pp. 4402 - 4413
targeted quantitative proteomics | nanoUPLC-MS/MS | SIL | UGT1As | UGT2Bs | S9s | microsomes | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Amino Acid Sequence | Limit of Detection | Reproducibility of Results | Liver - enzymology | Humans | Molecular Sequence Data | Male | Isoenzymes - chemistry | Chromatography, High Pressure Liquid | Peptide Fragments - chemistry | Glucuronosyltransferase - chemistry | Glucuronosyltransferase - metabolism | Isoenzymes - metabolism | Proteomics | Female | Microsomes, Liver - enzymology | Indicator Dilution Techniques | Tandem Mass Spectrometry - methods | Trypsin - chemistry | Index Medicus
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8. Full Text Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: Comparison with liver and intestinal glucuronidation and impact of albumin
by Gill, Katherine L and Houston, J. Brian and Galetin, Aleksandra
Drug metabolism and disposition, ISSN 0090-9556, 04/2012, Volume 40, Issue 4, pp. 825 - 835
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Intestines - drug effects | Microsomes - metabolism | Predictive Value of Tests | Liver - enzymology | Humans | Kidney - enzymology | Middle Aged | Substrate Specificity | Male | Metabolic Clearance Rate | Intestines - metabolism | Microsomes - drug effects | Young Adult | Kidney - metabolism | Glucuronides - metabolism | Liver - drug effects | Adult | Female | Serum Albumin, Bovine - pharmacology | Kidney - drug effects | Liver - metabolism | Microsomes - enzymology | Organ Specificity | Pharmaceutical Preparations - metabolism | Glucuronosyltransferase - metabolism | Pharmaceutical Preparations - chemistry | Protein Binding | Aged | In Vitro Techniques | Intestines - enzymology | Index Medicus
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9. Full Text Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions
by Wang, Xinwen and He, Bing and Shi, Jian and Li, Qian and Zhu, Hao-Jie
Drug metabolism and disposition, ISSN 0090-9556, 01/2020, Volume 48, Issue 1, pp. 31 - 40
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Liver - enzymology | Humans | Liver - metabolism | Microsomes, Liver - metabolism | Proteomics - instrumentation | Male | Metabolic Clearance Rate | Cytosol - enzymology | Pharmaceutical Preparations - metabolism | Cytosol - metabolism | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Proteomics - methods | In Vitro Techniques | Proteome - metabolism | Proteins | Liver | Proteomics | Drug metabolism | Metabolism | Organelles | Cytosol | Microsomes | Data interpretation | Index Medicus
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10. Full Text Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine
by Hu, Nan and Huang, Yanjuan and Gao, Xuejiao and Li, Sai and Yan, Zhixiang and Wei, Bin and Yan, Ru
Chemico-biological interactions, ISSN 0009-2797, 06/2017, Volume 271, pp. 48 - 58
Experimental colitis | Rat intestinal microsomes | CYPs | Rat liver microsomes | Dextran sulfate sodium | Rat renal microsomes | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Colitis, Ulcerative - enzymology | Liver - enzymology | Humans | Kidney - enzymology | Cytochrome P-450 Enzyme System - metabolism | Rats | Male | Enzyme Activation - drug effects | Liver - physiopathology | Rats, Sprague-Dawley | Dextran Sulfate - toxicity | Animals | Colitis, Ulcerative - chemically induced | Microsomes, Liver - enzymology | Intestines - physiopathology | Kidney - physiopathology | Colitis, Ulcerative - physiopathology | Disease Models, Animal | Intestines - enzymology | Microsomes, Liver - pathology | Dextran | Medical research | Liver | Cytochrome P-450 | Physiological aspects | Medicine, Experimental | Sulfates | Ulcerative colitis | Nifedipine | Index Medicus
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