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Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 10/2015, Volume 288, Issue 1, pp. 12 - 18
The risk of drug-induced liver injury (DILI) is of great concern to the pharmaceutical industry... 
Mitochondria | Membrane permeability transition | Benzbromarone | Drug-induced liver toxicity | Reactive metabolite | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Activation, Metabolic | Liver - pathology | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Mitochondrial Swelling - drug effects | Mitochondria, Liver - metabolism | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | Membrane Potential, Mitochondrial - drug effects | Cytochrome P-450 CYP2C9 Inhibitors - pharmacology | Liver - drug effects | Microsomes, Liver - drug effects | Benzbromarone - toxicity | NADP - metabolism | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Mitochondria, Liver - pathology | Benzbromarone - metabolism | Liver - metabolism | Rats, Sprague-Dawley | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Cytochrome P-450 CYP3A - metabolism | Kinetics | Drugs | Metabolites | Analysis | Liver | Cytochrome P-450 | Mitochondrial DNA | Permeability | Pharmaceutical industry | Index Medicus | DEXAMETHASONE | METABOLITES | INJURIES | PERMEABILITY | IMINES | MITOCHONDRIA | RATS | METABOLIC ACTIVATION | TOXICITY | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | DNA | GLUCOSE | MICROSOMES | DRUGS | LIVER | PHOSPHATES | OXIDOREDUCTASES
Journal Article
PloS one, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e54522 - e54522
.... The pharmacokinetics of belinostat in liver cancer patients were characterized by rapid plasma clearance of belinostat with extensive metabolism with more than 4-fold greater relative systemic... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Microsomes, Liver - metabolism | Substrate Specificity | Antineoplastic Agents - toxicity | Antineoplastic Agents - metabolism | Glucuronosyltransferase - genetics | Histone Deacetylase Inhibitors - pharmacokinetics | Carcinoma, Hepatocellular - genetics | Antineoplastic Agents - pharmacokinetics | Liver Neoplasms - enzymology | Hydroxamic Acids - toxicity | Gene Expression | Liver Neoplasms - genetics | Drug Stability | Metabolome | Genotype | Carcinoma, Hepatocellular - enzymology | Sulfonamides - pharmacokinetics | Hydroxamic Acids - pharmacokinetics | Hydroxamic Acids - metabolism | Glucuronosyltransferase - metabolism | Metabolic Networks and Pathways | Histone Deacetylase Inhibitors - toxicity | Liver Neoplasms - metabolism | Sulfonamides - metabolism | Sulfonamides - toxicity | Kinetics | Histone Deacetylase Inhibitors - metabolism | Carcinoma, Hepatocellular - metabolism | Hydrogen-Ion Concentration | Antimitotic agents | Medical research | Liver cancer | Enzymes | Cancer patients | Care and treatment | Metabolites | Physiological aspects | Medicine, Experimental | Non-Hodgkin's lymphomas | Antineoplastic agents | T cells | Histone deacetylase | Liver | Genomics | Clinical trials | Science | Oncology | Hepatocellular carcinoma | Lymphocytes T | Cancer therapies | Genotype & phenotype | Drug dosages | Neutropenia | Hematology | Pharmacology | FDA approval | Metabolism | Patients | Lymphoma | Substrates | Microsomes | Chromatography | Acids | Pharmacy | Epigenetics | Lymphomas | Pharmacokinetics | T-cell lymphoma | Cancer | Index Medicus
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2007, Volume 221, Issue 1, pp. 1 - 12
.... In this study the distribution and activities of esterases that catalyze pyrethroid metabolism have been investigated in vitro using several human and rat tissues, including small intestine, liver and serum... 
Pyrethroids | Xenobiotic metabolism | Carboxylesterases | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Liver - enzymology | Humans | Microsomes, Liver - metabolism | Chlorpyrifos - metabolism | Carboxylic Ester Hydrolases - blood | Valerates - chemistry | Umbelliferones - metabolism | Chlorpyrifos - chemistry | Microsomes, Liver - enzymology | Molecular Structure | Pyrethrins - metabolism | Pancreas - enzymology | Benzyl Alcohols - chemistry | Carboxylesterase - blood | Chlorpyrifos - analogs & derivatives | Electrophoresis, Polyacrylamide Gel | Rats | Umbelliferones - chemistry | Valerates - metabolism | Lipase - metabolism | Carboxylesterase - metabolism | Blotting, Western | Pyrethrins - chemistry | Hydrolysis | Nitrobenzoates - metabolism | Animals | Benzyl Alcohols - metabolism | Thiolester Hydrolases - metabolism | Kinetics | Carboxylic Ester Hydrolases - metabolism | Intestines - enzymology | Physiological aspects | Liver | Adenosine triphosphatase | Index Medicus | SMALL INTESTINE | CLEARANCE | LIPASES | SUBSTRATES | HYDROLYSIS | RATS | 60 APPLIED LIFE SCIENCES | ALCOHOLS | METABOLISM | IN VITRO | MICROSOMES | LIVER | ACETATES | STEARATES | MAN | INSECTICIDES | pyrethroids | carboxylesterases | xenobiotic metabolism
Journal Article