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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2017, Volume 25, Issue 2, pp. 545 - 556
The utility of cytostatic antiangiogenic agents (AA) in cancer chemotherapy lies in their combination with cytotoxic chemotherapeutic agents. Clinical... 
Receptor tyrosine kinase inhibitors | Microtubule targeting agents | Combination chemotherapy | Antiangiogenic | Multitargeted agents | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DRUG-RESISTANCE | TUMOR HETEROGENEITY | CELL LUNG-CANCER | BREAST-CANCER | COLCHICINE SITE | BIOLOGICAL EVALUATION | ANGIOGENESIS INHIBITOR | ANTIANGIOGENIC AGENTS | RECEPTOR TYROSINE KINASE | ENDOTHELIAL GROWTH-FACTOR | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Microtubules - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Angiogenesis Inhibitors - chemical synthesis | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Angiogenesis Inhibitors - pharmacology | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Neovascularization, Pathologic - drug therapy | Pyrroles - chemistry | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Antimitotic agents | Amines | Antineoplastic agents | Analysis | Index Medicus | receptor tyrosine kinase inhibitors | multitargeted agents | microtubule targeting agents | antiangiogenic | combination chemotherapy
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2014, Volume 22, Issue 14, pp. 3753 - 3772
The design, synthesis and biological evaluations of fourteen 4-substituted 2,6-dimethylfuro[2,3- ]pyrimidines are reported. Four compounds ( – , ) inhibit... 
Single agent combination chemotherapy | Anticancer agents | Microtubule targeting agents | Tyrosine kinase inhibitors | BETA-TUBULIN | SITE | CHEMISTRY, MEDICINAL | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | COMBINATION | CHEMOTHERAPY | TRIAL | IN-VITRO | STABILIZING AGENTS | CHLORIDE | Apoptosis - drug effects | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Protein Kinase Inhibitors - chemistry | Microtubules - drug effects | Water - chemistry | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - chemical synthesis | Aniline Compounds - pharmacology | Solubility | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Animals | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Aniline Compounds - chemistry | HeLa Cells | Neoplasms, Experimental - drug therapy | Aniline Compounds - chemical synthesis | Drug Screening Assays, Antitumor | Antimitotic agents | Tyrosine | Pyrimidines | Antineoplastic agents | Index Medicus
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 181, pp. 111584 - 111584
Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we identified ethyl... 
Microtubule-targeting agents | p-glycoprotein | Acquired resistance | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Mutagenesis | Medical treatment | Cancer | Index Medicus | Biological Sciences
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 10/2014, Volume 18, Issue 19, pp. 2462 - 2512
Journal Article
Biologics: Targets and Therapy, ISSN 1177-5475, 2008, Volume 2, Issue 4, pp. 789 - 811
Covers epothilones, a new class of antimicrotubule agents currently in clinical trials. Discusses their history, chemistry, structure/function activity,... 
Microtubule-targeting agents | Ixabepilone | Taxanes | Epothilones | Antineoplastic agents | Microtubules | Research | Clinical trials | Breast cancer | Drug dosages | Regulatory approval
Journal Article