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Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62082
Some potent chemotherapy drugs including tubulin-binding agents had been developed from nature plants, such as podophyllotoxin and paclitaxel. However, poor... 
MITOSIS | ANTIMITOTIC ACTIVITY | MICROTUBULES | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | RESISTANCE | TUBULIN | BINDING AGENTS | EXPRESSION | KINASES | Lung Neoplasms - drug therapy | Podophyllotoxin - pharmacology | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | Endoplasmic Reticulum Stress - genetics | Microtubules - metabolism | Podophyllotoxin - toxicity | Drug Evaluation, Preclinical | Disease Models, Animal | DNA Damage - drug effects | Lung Neoplasms - genetics | M Phase Cell Cycle Checkpoints - drug effects | Endoplasmic Reticulum Stress - drug effects | Antineoplastic Agents, Phytogenic - toxicity | Xenograft Model Antitumor Assays | Animals | Mitosis - drug effects | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Protein Multimerization - drug effects | Podophyllotoxin - analogs & derivatives | Chemotherapy | Podophyllotoxin | Analysis | Lung cancer | Polymerization | Stress (Physiology) | Tubulins | Health aspects | Apoptosis | Cancer | Drugs | Flow cytometry | Toxicity | Mitosis | Leukemia | DNA damage | Cytotoxicity | Selectivity | Drug development | Kinases | Cancer therapies | Anticancer properties | Metastases | Proteins | Signal transduction | Tubulin | Paclitaxel | Xenografts | Cell cycle | Inhibition | Stains | Deoxyribonucleic acid--DNA | Stresses | Plants (botany) | Hematology | Injection | Survivin | Tumor cell lines | Gene expression | Stress | Aurora B protein | Signaling | Side effects | Cell lines | Colonization | Deoxyribonucleic acid | DNA
Journal Article
Neuron, ISSN 0896-6273, 2009, Volume 62, Issue 4, pp. 479 - 493
Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of... 
STEMCELL | HUMDISEASE | MOLNEURO | SEROTONIN-1A RECEPTOR FUNCTION | MESSENGER-RNA | BETA-ARRESTINS | PROTEIN-COUPLED RECEPTORS | ANTIDEPRESSANT TREATMENT | CELL-PROLIFERATION | ADULT MICE | MAJOR DEPRESSION | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | NEUROSCIENCES | Depression - pathology | Microtubule-Associated Proteins - metabolism | Radiation | Arrestins - genetics | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | Male | Hippocampus - drug effects | Antidepressive Agents, Second-Generation - therapeutic use | RNA, Messenger - metabolism | Arrestins - metabolism | Hypothalamus - radiation effects | Corticosterone - toxicity | Depression - drug therapy | GTP-Binding Protein alpha Subunit, Gi2 - genetics | Anxiety - diet therapy | Depression - chemically induced | Reaction Time - drug effects | Exploratory Behavior - drug effects | Neurogenesis - radiation effects | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Fluoxetine - therapeutic use | Hypothalamus - drug effects | Disease Models, Animal | Cell Survival - drug effects | Drug Administration Schedule | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Neuropeptides - metabolism | Hippocampus - pathology | Cell Survival - radiation effects | Anxiety - pathology | Feeding Behavior - drug effects | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Hypothalamus - metabolism | Analysis of Variance | beta-Arrestin 2 | beta-Arrestins | Hippocampus - radiation effects | Gene Expression Regulation - radiation effects | Anxiety - chemically induced | Cell Proliferation - drug effects | Mice | Arrestins - deficiency | Cell Proliferation - radiation effects | Neurosciences | Corticosterone | Neurons | Fluoxetine | Analysis | Depression, Mental | Models | Survival analysis | Genotype & phenotype | Brain research | Antidepressants | Anxieties | Rodents | Behavior | Feeds | Neurogenesis | Index Medicus
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 12/2008, Volume 20, Issue 3, pp. 870 - 881
Journal Article
Cell, ISSN 0092-8674, 2002, Volume 110, Issue 4, pp. 429 - 441
The adult brain is extremely vulnerable to various insults. The recent discovery of neural progenitors in adult mammals, however, raises the possibility of... 
RAT SPINAL-CORD | GERBIL HIPPOCAMPUS | STEM-CELLS | TRANSIENT FOREBRAIN ISCHEMIA | NEUROTROPHIC FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBROBLAST-GROWTH-FACTOR | CENTRAL-NERVOUS-SYSTEM | ADULT MAMMALIAN BRAIN | SUBVENTRICULAR ZONE | SYNAPTIC PLASTICITY | CELL BIOLOGY | Neural Pathways - drug effects | Recovery of Function - drug effects | Nerve Regeneration - physiology | Neuronal Plasticity - drug effects | Male | Dendrites - ultrastructure | Nerve Degeneration - metabolism | Neuronal Plasticity - physiology | Recovery of Function - physiology | Hippocampus - ultrastructure | Pyramidal Cells - drug effects | Organ Culture Techniques | Dendrites - drug effects | Synapses - drug effects | Neural Pathways - growth & development | Rats | Synapses - ultrastructure | Brain Ischemia - physiopathology | Cell Division - drug effects | Stem Cells - ultrastructure | Cell Division - physiology | Cell Movement - drug effects | Brain Ischemia - drug therapy | Nerve Regeneration - drug effects | Growth Substances - pharmacology | Pyramidal Cells - metabolism | Rats, Wistar | Microtubule-Associated Proteins - metabolism | Nerve Degeneration - physiopathology | Brain Ischemia - metabolism | Hippocampus - drug effects | Stem Cells - metabolism | Excitatory Postsynaptic Potentials - drug effects | Cell Movement - physiology | Excitatory Postsynaptic Potentials - physiology | Synapses - metabolism | Up-Regulation - physiology | Hippocampus - growth & development | Pyramidal Cells - ultrastructure | Dendrites - metabolism | Transcription Factors - genetics | Microscopy, Electron | Transcription Factors - metabolism | Up-Regulation - drug effects | Animals | Growth Substances - therapeutic use | Stem Cells - drug effects | Neural Pathways - ultrastructure | Nerve Degeneration - drug therapy | Neural circuitry | Neurons | Growth | Physiological aspects | Hippocampus (Brain) | Developmental neurology | Research
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2011, Volume 31, Issue 42, pp. 15113 - 15127
New neurons are continuously generated in the subgranular zone of the adult hippocampus and, once sufficiently mature, are thought to integrate into... 
PATTERN SEPARATION | STEM-CELLS | ANTERIOR CINGULATE CORTEX | REMOTE SPATIAL MEMORY | RETROGRADE-AMNESIA | DORSAL HIPPOCAMPUS | DENTATE GYRUS | GRANULE CELLS | HIPPOCAMPAL NEUROGENESIS | DIPHTHERIA-TOXIN | NEUROSCIENCES | Memory - drug effects | Diphtheria Toxin - pharmacology | Nestin | Microtubule-Associated Proteins - metabolism | Fear - drug effects | Bromodeoxyuridine | Neurogenesis - genetics | Space Perception - physiology | Membrane Transport Proteins - genetics | Space Perception - drug effects | Intermediate Filament Proteins - genetics | Neurons - physiology | Discrimination (Psychology) - drug effects | Behavior, Animal - drug effects | Estrogen Receptor alpha - metabolism | Microfilament Proteins - metabolism | Neurogenesis - drug effects | Taste - genetics | Neurons - drug effects | Calcium-Binding Proteins - metabolism | Cell Survival - drug effects | Antineoplastic Agents, Hormonal - pharmacology | Maze Learning - physiology | Conditioning (Psychology) - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Neuropeptides - metabolism | Avoidance Learning - physiology | Maze Learning - drug effects | Nerve Tissue Proteins - genetics | Haplorhini | Naphthalenes | Oxepins | Nerve Tissue Proteins - metabolism | Heparin-binding EGF-like Growth Factor | Dentate Gyrus - cytology | Animals | Taste - drug effects | Neurogenesis - physiology | Discrimination (Psychology) - physiology | Tamoxifen - pharmacology | Avoidance Learning - drug effects | Cell Proliferation - drug effects | Mice | Cell Line, Transformed | Memory - physiology
Journal Article
Small, ISSN 1613-6810, 04/2010, Volume 6, Issue 7, pp. 832 - 842
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. 315 - 326
Secondary damage following primary spinal cord injury extends pathology beyond the site of initial trauma, and effective management is imperative for... 
SURVIVAL | PROTEIN-KINASE-B | TYROSINE-PHOSPHATASE INHIBITION | MULTIDISCIPLINARY SCIENCES | CONTUSION INJURY | PTEN | AKT | UP-REGULATION | EXPRESSION | BRAIN | CELL-DEATH | Neuroprotective Agents - therapeutic use | Spinal Cord Injuries - drug therapy | Recovery of Function - drug effects | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Cervical Vertebrae - blood supply | Protein Transport - drug effects | Autophagy - drug effects | Motor Neurons - pathology | Spinal Cord Injuries - pathology | Forelimb - physiopathology | Neuroprotective Agents - pharmacology | Spinal Cord Injuries - enzymology | Vanadium Compounds - pharmacology | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Forelimb - drug effects | Motor Neurons - drug effects | Contusions - complications | Phagosomes - drug effects | Cervical Vertebrae - drug effects | Phagosomes - metabolism | Contusions - physiopathology | PTEN Phosphohydrolase - metabolism | Rats | Vanadium Compounds - therapeutic use | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Contusions - drug therapy | Animals | Signal Transduction - drug effects | Models, Biological | Cervical Vertebrae - pathology | Spinal Cord Injuries - physiopathology | Spinal cord injuries | Phosphatases | TOR protein | Neuroprotection | Neurosciences | Spinal cord | Vanadium compounds | Traumatic brain injury | Central nervous system | Vanadium | Recovery of function | Homology | AKT protein | Spinal cord injury | Kinases | Phosphatase | Autophagy | Western blotting | Proteins | Rodents | Cell cycle | Bisperoxovanadium | Tumorigenesis | Research centers | Tensin | Hematology | Neurons | Rapamycin | Pharmacology | Functional analysis | Trauma | Medicine | Signaling | Injury prevention | Brain research | Insects | Immunofluorescence | Potassium | Histochemistry | Phagocytosis | Apoptosis
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2011, Volume 99, Issue 3, pp. 287 - 292
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2016, Volume 215, Issue 6, pp. 801 - 821
The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA... 
CHROMOSOME | MEIOTIC PROPHASE | ANEMIA-ASSOCIATED NUCLEASE | MEMBRANE PROTEIN | DOUBLE-STRAND BREAKS | STALLED REPLICATION FORKS | C-ELEGANS | DNA-REPAIR | FANCONI-ANEMIA | SUN PROTEIN UNC-84 | CELL BIOLOGY | Hydroxyurea - pharmacology | Homologous Recombination - drug effects | DNA End-Joining Repair - radiation effects | Microtubule-Associated Proteins - metabolism | Germ Cells - drug effects | Humans | Caenorhabditis elegans Proteins - metabolism | Protein Transport - drug effects | Multiprotein Complexes - metabolism | Polymerization - drug effects | Meiosis - drug effects | Microtubules - metabolism | Cell Nucleus - metabolism | Cell Nucleus - radiation effects | Microtubules - drug effects | Protein Binding - drug effects | Protein Binding - radiation effects | Microtubules - radiation effects | Germ Cells - cytology | Membrane Proteins - metabolism | Germ Cells - metabolism | Germ Cells - radiation effects | Radiation, Ionizing | DNA End-Joining Repair - drug effects | Homologous Recombination - radiation effects | Nuclear Proteins - metabolism | Cisplatin - pharmacology | Cross-Linking Reagents - metabolism | Meiosis - radiation effects | Cell Cycle Checkpoints - radiation effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Protein Transport - radiation effects | Cell Proliferation - drug effects | DNA Damage | Cell Nucleus - drug effects | Cell Proliferation - radiation effects | Caenorhabditis elegans | Cellular proteins | Cell research | DNA damage | Microtubules | Physiological aspects | Genetic aspects | Research
Journal Article