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Brain, ISSN 0006-8950, 11/2015, Volume 138, Issue 11, pp. 3206 - 3220
X-linked adrenoleukodystrophy is caused by mutations in the ABCD1 gene leading to accumulation of very long chain fatty acids. Its most severe neurological... 
blood-brain barrier | neurodegeneration | leukodystrophy | genetics | neuroinflammation | demyelination | LESION PROGRESSION | C-MYC | X-LINKED ADRENOLEUKODYSTROPHY | NEUROSCIENCES | CLINICAL NEUROLOGY | BARRIER DISRUPTION | TIGHT JUNCTIONS | IN-VITRO | APPEARING WHITE-MATTER | MULTIPLE-SCLEROSIS | CNS MYELOID CELLS | CENTRAL-NERVOUS-SYSTEM | Up-Regulation | Humans | Middle Aged | Microvessels - metabolism | Microvessels - pathology | Male | RNA, Messenger - metabolism | Gene Knockdown Techniques | Brain - metabolism | Young Adult | ATP-Binding Cassette Transporters - genetics | Aged, 80 and over | Zonula Occludens-1 Protein - metabolism | Child | Multiple Sclerosis, Relapsing-Remitting - metabolism | Zonula Occludens-1 Protein - genetics | Endothelial Cells - metabolism | ATP Binding Cassette Transporter, Sub-Family D, Member 1 | Reverse Transcriptase Polymerase Chain Reaction | Blood-Brain Barrier - metabolism | Microscopy, Confocal | Intercellular Adhesion Molecule-1 - metabolism | Endothelium, Vascular - metabolism | Intercellular Adhesion Molecule-1 - genetics | Adolescent | Brain - pathology | Endothelium, Vascular - pathology | Proto-Oncogene Proteins c-myc - genetics | Endothelial Cells - pathology | Vascular Cell Adhesion Molecule-1 - metabolism | Human Umbilical Vein Endothelial Cells | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Claudin-5 - metabolism | Adrenoleukodystrophy - pathology | Demyelinating Diseases - metabolism | Case-Control Studies | DNA-Binding Proteins - metabolism | Brain - blood supply | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Adult | Female | Vascular Cell Adhesion Molecule-1 - genetics | Demyelinating Diseases - pathology | Fatty Acids - metabolism | Microvessels - cytology | Multiple Sclerosis, Relapsing-Remitting - pathology | Cells, Cultured | Claudin-5 - genetics | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Adrenoleukodystrophy - metabolism | Homozygote | Heterozygote | Aged | Adrenoleukodystrophy - genetics | blood–brain barrier | Original | 1050
Journal Article
Circulation Research, ISSN 0009-7330, 02/2013, Volume 112, Issue 3, pp. 510 - 522
RATIONALE:The impact of diabetes mellitus on bone marrow (BM) structure is incompletely understood. OBJECTIVE:Investigate the effect of type-2 diabetes... 
microangiopathy | stem cells | macroangiopathy | diabetes mellitus type 2 | bone marrow | CARDIAC & CARDIOVASCULAR SYSTEMS | TRANSCRIPTION | MICRORNAS | TRANSPLANTATION | HEART | ENDOTHELIAL PROGENITOR CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | NEOVASCULARIZATION | DIFFERENTIATION | HEMATOLOGY | EXPRESSION | Immunohistochemistry | Humans | Middle Aged | Microvessels - metabolism | Hematopoietic Stem Cells - pathology | Microvessels - pathology | Male | MicroRNAs - metabolism | Ischemia - genetics | Adipose Tissue - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Forkhead Transcription Factors - metabolism | Bone Marrow Cells - immunology | Aged, 80 and over | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Ischemia - pathology | Biomarkers - metabolism | Peripheral Arterial Disease - metabolism | Stem Cell Niche | Signal Transduction | Endothelial Cells - metabolism | Adipose Tissue - pathology | Bone Marrow Cells - pathology | Bone Marrow Examination | Cell Lineage | MicroRNAs - genetics | Diabetes Mellitus, Type 2 - pathology | Endothelial Cells - pathology | Forkhead Box Protein O3 | Antigens, CD34 - metabolism | Peripheral Arterial Disease - pathology | Diabetes Mellitus, Type 2 - genetics | Diabetes Mellitus, Type 2 - metabolism | Microvessels - immunology | Case-Control Studies | Hematopoietic Stem Cells - immunology | Diabetic Angiopathies - pathology | Flow Cytometry | Transfection | Peripheral Arterial Disease - genetics | Adult | Female | Diabetic Angiopathies - genetics | Diabetic Angiopathies - metabolism | Cells, Cultured | Gene Expression Regulation | Ischemia - metabolism | Hematopoietic Stem Cells - metabolism | Forkhead Transcription Factors - genetics | Aged | Bone Marrow Cells - metabolism | Apoptosis
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 5/2016, Volume 53, Issue 4, pp. 2451 - 2467
Elevated plasma total homocysteine (Hcy) level is associated with an increased risk of Alzheimer’s disease (AD). During transsulfuration pathways, Hcy is... 
Cerebrovascular pathology | Neurology | Neurosciences | Biomedicine | Blood–brain barrier dysfunction | Alzheimer’s disease | Neurobiology | Homocysteine | Cell Biology | Dementia | COGNITIVE PERFORMANCE | NEUROSCIENCES | MATRIX METALLOPROTEINASES | INDUCED MEMORY IMPAIRMENT | RISK-FACTOR | Blood-brain barrier dysfunction | RECEPTOR TRAFFICKING | MATRIX-METALLOPROTEINASE-9 | RAT-BRAIN | Alzheimer's disease | PLASMA HOMOCYSTEINE | EXPRESSION | Memory - drug effects | Glial Fibrillary Acidic Protein - genetics | Cadherins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Blood-Brain Barrier - physiopathology | Claudin-5 - metabolism | Microvessels - pathology | Male | Synapses - pathology | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Matrix Metalloproteinase 9 - metabolism | Cadherins - genetics | Synapses - drug effects | Alzheimer Disease - physiopathology | Hydrogen Sulfide - pharmacology | Cerebrovascular Circulation - drug effects | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Alzheimer Disease - drug therapy | Microvessels - drug effects | Claudin-5 - genetics | Cystathionine beta-Synthase - metabolism | Permeability | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Blood-Brain Barrier - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Hydrogen Sulfide - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Intercellular Adhesion Molecule-1 - genetics | Avoidance Learning - drug effects | Alzheimer Disease - genetics | Dizocilpine Maleate - pharmacology | Hydrogen sulfide | Methyl aspartate | Brain | RNA | Neurons | Intermediate filament proteins | cerebrovascular pathology | dementia | blood brain barrier dysfunction
Journal Article
The American journal of pathology, ISSN 0002-9440, 2013, Volume 183, Issue 5, pp. 1548 - 1558
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 330, Issue 6002, pp. 362 - 366
Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage. By using... 
Liver | REPORTS | Neutrophils | Antibodies | Mice | Physical trauma | Inflammation | Sine waves | Neutrophil infiltration | Chemotaxis | Necrosis | DYING CELLS | IMMUNE-SYSTEM | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | INJURY | NLRP3 INFLAMMASOME | HEPATOTOXICITY | RELEASE | HMGB1 | IDENTIFICATION | NALP3 INFLAMMASOME | Chemotaxis, Leukocyte | Microscopy - methods | Inflammation - pathology | Liver - pathology | NLR Family, Pyrin Domain-Containing 3 Protein | Liver Diseases - pathology | Neutrophil Infiltration | Endothelium, Vascular - physiology | Inflammation - metabolism | Liver - immunology | Peptides - metabolism | Adenosine Triphosphate - metabolism | Receptors, Formyl Peptide - metabolism | Macrophage-1 Antigen - physiology | Chemokine CXCL2 - metabolism | Cues | Liver Diseases - immunology | Signal Transduction | Liver - metabolism | Neutrophils - physiology | Inflammation - immunology | Cell Adhesion | Receptors, Purinergic P2X7 | Microscopy, Confocal | Microvessels - physiology | Liver - blood supply | Animals | Carrier Proteins - metabolism | Receptors, Interleukin-8B - metabolism | Receptors, Purinergic P2 - metabolism | Chemokines - metabolism | Kinetics | Liver Diseases - metabolism | Physiological aspects | Properties | Gangrene | Molecular biology | Immune system | Cell adhesion & migration
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 8/2015, Volume 112, Issue 32, pp. 9914 - 9919
Intracerebral hemorrhagic stroke and vascular dementia are ageand hypertension-associated manifestations of human cerebral small vessel disease (SVD). Cerebral... 
Cerebral microbleeds | Blood-brain barrier | Transcription | Stroke mouse model | Conditional gene knockout | blood-brain barrier | CEREBRAL AMYLOID ANGIOPATHY | MICROBLEEDS | transcription | ANGIOGENESIS | ACTIN | MULTIDISCIPLINARY SCIENCES | cerebral microbleeds | BLOOD-BRAIN-BARRIER | conditional gene knockout | SMALL-VESSEL DISEASE | CLINICAL-APPLICATIONS | MOUSE MODEL | SERUM RESPONSE FACTOR | MICE | stroke mouse model | Serum Response Factor - genetics | Cerebral Hemorrhage - metabolism | Cadherins - metabolism | Astrocytes - pathology | Microvessels - metabolism | Microvessels - pathology | Cerebral Hemorrhage - physiopathology | Motor Activity | Basement Membrane - pathology | Stroke - physiopathology | Brain - metabolism | Stroke - pathology | Brain - blood supply | Time Factors | Gene Deletion | Evans Blue - metabolism | Animals, Newborn | Collagen Type IV - metabolism | Exploratory Behavior | Tight Junctions - metabolism | Endothelial Cells - metabolism | Serum Response Factor - metabolism | Brain - physiopathology | Down-Regulation | Permeability | Basement Membrane - metabolism | Blood-Brain Barrier - metabolism | Mice, Knockout | Transcription Factors - metabolism | Magnetic Resonance Imaging | Stroke - etiology | Stroke - metabolism | Animals | Brain - pathology | Trans-Activators - metabolism | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | Extravasation of Diagnostic and Therapeutic Materials | Astrocytes - metabolism | Stroke (Disease) | Genetic aspects | Genetic transcription | Observations | Biological Sciences | blood–brain barrier
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 5, pp. 1298 - 1311
Idiopathic pulmonary fibrosis (IPF) can lead to the development of secondary pulmonary hypertension (PH) and ultimately death. Despite this known association,... 
MEDICINE, RESEARCH & EXPERIMENTAL | EPITHELIUM-DERIVED FACTOR | GROWTH-FACTOR-BETA | RECEPTOR | PROLIFERATION | GENE-TRANSFER | CELL APOPTOSIS | EXPRESSION | BINDING | PIGMENT-EPITHELIUM | Genetic Therapy | Idiopathic Pulmonary Fibrosis - therapy | Apoptosis - drug effects | Gene Expression - genetics | Humans | Transforming Growth Factor beta1 - metabolism | Caspase 3 - metabolism | Hypertension, Pulmonary - physiopathology | Microvessels - pathology | Idiopathic Pulmonary Fibrosis - chemically induced | Nerve Growth Factors - metabolism | Vascular Endothelial Growth Factor A - metabolism | Hypertension, Pulmonary - therapy | Idiopathic Pulmonary Fibrosis - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Pulmonary Artery - metabolism | Idiopathic Pulmonary Fibrosis - complications | Vascular Endothelial Growth Factor A - pharmacology | Transforming Growth Factor beta1 - pharmacology | Disease Models, Animal | Fibroblasts - metabolism | Serpins - genetics | Endothelial Cells - metabolism | Smad2 Protein - metabolism | Rats | Lung - physiopathology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Eye Proteins - metabolism | Models, Biological | Nerve Growth Factors - genetics | Fibroblasts - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Bronchoalveolar Lavage Fluid - chemistry | Hypertension, Pulmonary - etiology | Serum Albumin - metabolism | Phosphorylation | Female | Lung - metabolism | Eye Proteins - genetics | Lung - pathology | Serpins - metabolism | Vascular Endothelial Growth Factor A - therapeutic use | Microvessels - drug effects | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Transforming Growth Factor beta1 - genetics | Animals | Endothelial Cells - cytology | Pulmonary Artery - pathology | Endothelial Cells - drug effects | Immunohistochemistry | Usage | Care and treatment | Genetic aspects | Research | Health aspects | Vascular endothelial growth factor | Pulmonary hypertension | Risk factors | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e82823
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 3, pp. e1099 - e1099
Methamphetamine (METH) is a psychostimulant with high abuse potential and severe neurotoxicity. Recent studies in animal models have indicated that METH can... 
Cell death | Autophagy | Kappa opioid receptor | Methamphetamine | TRANSPORT | autophagy | PROTEIN-1 LAMP-1 | cell death | MELATONIN | methamphetamine | PATHWAY | CROSS | EXPRESSION | MODULATION | CELL BIOLOGY | Phosphorylation | Human Umbilical Vein Endothelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Methamphetamine - toxicity | Microtubule-Associated Proteins - metabolism | Humans | Microvessels - metabolism | Microvessels - pathology | Autophagy - drug effects | Dose-Response Relationship, Drug | Transfection | RNA Interference | Time Factors | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptors, Opioid, kappa - genetics | Beclin-1 | Cell Survival - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Lysosome-Associated Membrane Glycoproteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Cells, Cultured | Receptors, Opioid, kappa - metabolism | Microvessels - drug effects | Blood-Brain Barrier - drug effects | Central Nervous System Stimulants - toxicity | Apoptosis Regulatory Proteins - metabolism | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Receptors, Opioid, kappa - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Human Umbilical Vein Endothelial Cells - pathology | Enzyme Activation | Endothelial Cells - pathology | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Original
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2015, Volume 73, Issue 1, pp. 57 - 77
As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB) exists between the blood microcirculation system and the brain... 
Life Sciences | Biochemistry, general</