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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2014, Volume 96, Issue 3, pp. 349 - 359
The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and... 
P4502B6 ACTIVITY | VORICONAZOLE | LC-MS/MS | SINGLE-POINT | ORAL MIDAZOLAM | VOLUNTEERS | IN-VIVO | PHARMACOLOGY & PHARMACY | DRUG-METABOLIZING-ENZYMES | KAROLINSKA COCKTAIL | BUPROPION HYDROXYLATION | Predictive Value of Tests | Pharmaceutical Preparations - blood | Caffeine - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Dried Blood Spot Testing | Humans | Omeprazole - blood | Bupropion - blood | Midazolam - administration & dosage | Substrate Specificity | Male | Chromatography, High Pressure Liquid | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Coffee | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Feasibility Studies | Enzyme Inhibitors - administration & dosage | Young Adult | Chromatography, Reverse-Phase | Tandem Mass Spectrometry | Capsules | Spectrometry, Mass, Electrospray Ionization | Flurbiprofen - administration & dosage | Adult | Dextromethorphan - pharmacokinetics | Terfenadine - blood | ATP-Binding Cassette, Sub-Family B, Member 1 - blood | Pharmaceutical Preparations - administration & dosage | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 Enzyme System - blood | Administration, Oral | Isoenzymes | Caffeine - blood | Omeprazole - administration & dosage | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Carbonated Beverages | Midazolam - pharmacokinetics | Bupropion - administration & dosage | Dextromethorphan - blood | Flurbiprofen - blood | Phenotype | Pilot Projects | Midazolam - blood | Dextromethorphan - administration & dosage | Usage | Glycoproteins | Liquid chromatography | Research | Pharmacokinetics | Cytochrome P-450 | Index Medicus | Abridged Index Medicus
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2013, Volume 76, Issue 3, pp. 455 - 466
AimsThe anticoagulant rivaroxaban is an oral, direct Factor Xa inhibitor for the management of thromboembolic disorders. Metabolism and excretion involve... 
cytochrome | glycoprotein | rivaroxaban | drug interactions | healthy subjects | 450 | P-glycoprotein | Rivaroxaban | Healthy subjects | Cytochrome P450 | Drug interactions | BAY-59-7939 | SAFETY | PREVENTION | PHARMACODYNAMICS | cytochrome P450 | PROTEASE INHIBITORS | IN-VITRO | FACTOR-XA INHIBITOR | ERYTHROMYCIN | PHARMACOLOGY & PHARMACY | LIVER-MICROSOMES | Anticoagulants - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Erythromycin - pharmacology | Ketoconazole - administration & dosage | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Midazolam - administration & dosage | Substrate Specificity | Metabolic Clearance Rate | Thiophenes - administration & dosage | Ketoconazole - pharmacology | Enzyme Inhibitors - administration & dosage | Young Adult | Drug Interactions | Enzyme Inhibitors - pharmacokinetics | Clarithromycin - pharmacokinetics | Clarithromycin - administration & dosage | Adult | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Ketoconazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP3A - administration & dosage | Erythromycin - administration & dosage | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Thiophenes - pharmacokinetics | Erythromycin - pharmacokinetics | Cytochrome P-450 CYP3A - metabolism | Adolescent | Anticoagulants - pharmacokinetics | Morpholines - pharmacokinetics | Clarithromycin - pharmacology | Midazolam - pharmacology | Ketoconazole | Protease inhibitors | Fluconazole | Proteases | Cytochrome P-450 | Dosage and administration | Anticoagulants (Medicine) | Erythromycin | Thromboembolism | Index Medicus
Journal Article
Annals of Surgery, ISSN 0003-4932, 08/2013, Volume 258, Issue 2, pp. 262 - 269
OBJECTIVE:We conducted a pharmacokinetic (PK) study and a pharmacodynamic (PD) study to assess whether Roux-en-Y gastric bypass (RYGB) surgery is associated... 
furosemide | oral cocktail | CYP3A | gastric bypass | drug metabolism | SURGERY | FATTY LIVER-DISEASE | WEIGHT-LOSS | TRENDS | P-GLYCOPROTEIN | OBESITY | INTESTINAL ADAPTATION | BARIATRIC SURGERY | ABSORPTION | HEPATIC STEATOSIS | Gastric Bypass | Diuretics - pharmacokinetics | Excitatory Amino Acid Antagonists - pharmacokinetics | Humans | Middle Aged | Tolbutamide - urine | Male | Caffeine - pharmacokinetics | Midazolam - urine | Anti-Ulcer Agents - pharmacokinetics | Young Adult | Hypoglycemic Agents - administration & dosage | Aged, 80 and over | Diuretics - urine | Diuretics - administration & dosage | Hypoglycemic Agents - pharmacokinetics | Administration, Oral | Furosemide - pharmacokinetics | Omeprazole - administration & dosage | Excitatory Amino Acid Antagonists - administration & dosage | Hypoglycemic Agents - urine | Omeprazole - urine | Central Nervous System Stimulants - pharmacokinetics | Midazolam - blood | Dextromethorphan - urine | Adolescent | GABA Modulators - urine | Central Nervous System Stimulants - urine | Dextromethorphan - administration & dosage | Furosemide - administration & dosage | Tolbutamide - administration & dosage | Tolbutamide - pharmacokinetics | Caffeine - administration & dosage | Omeprazole - blood | GABA Modulators - pharmacokinetics | Midazolam - administration & dosage | Anti-Ulcer Agents - blood | Chromatography, High Pressure Liquid | Case-Control Studies | Excitatory Amino Acid Antagonists - urine | Hypoglycemic Agents - blood | Tandem Mass Spectrometry | Biotransformation | Adult | Female | Dextromethorphan - pharmacokinetics | Furosemide - urine | Caffeine - urine | Caffeine - blood | GABA Modulators - administration & dosage | GABA Modulators - blood | Omeprazole - pharmacokinetics | Anti-Ulcer Agents - urine | Midazolam - pharmacokinetics | Anti-Ulcer Agents - administration & dosage | Dextromethorphan - blood | Excitatory Amino Acid Antagonists - blood | Tolbutamide - blood | Aged | Central Nervous System Stimulants - blood | Pharmacokinetics | Central Nervous System Stimulants - administration & dosage | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 12/2009, Volume 68, Issue 6, pp. 928 - 935
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Numerous cocktails using concurrent administration of several cytochrome P450 (CYP) isoform-selective probe drugs... 
in vivo drug-drug interaction | cocktail | CYP | Cocktail | In vivo drug-drug interaction | DRUG | CAFFEINE | COMBINED PHENOTYPIC ASSESSMENT | METOPROLOL | OMEPRAZOLE TREATMENT | XANTHINE-OXIDASE | METABOLISM | ENZYMES | IN-VIVO | N-ACETYLTRANSFERASE-2 | PHARMACOLOGY & PHARMACY | Anti-Anxiety Agents - administration & dosage | Caffeine - administration & dosage | Anticoagulants - administration & dosage | Area Under Curve | Humans | Midazolam - administration & dosage | Cytochrome P-450 CYP1A2 - administration & dosage | Male | Metabolic Clearance Rate | Warfarin - administration & dosage | Caffeine - pharmacokinetics | Anti-Ulcer Agents - pharmacokinetics | Young Adult | Anti-Anxiety Agents - pharmacokinetics | Drug Interactions | Adult | Drug Therapy, Combination | Administration, Oral | Omeprazole - administration & dosage | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Anti-Ulcer Agents - administration & dosage | Central Nervous System Stimulants - pharmacokinetics | Anticoagulants - pharmacokinetics | Central Nervous System Stimulants - administration & dosage | Drug Combinations | Cytochrome P-450 CYP1A2 - pharmacokinetics | Omeprazole | Warfarin | Analysis | Drug interactions | Cytochrome P-450 | Physiological aspects | Liquid chromatography | Mass spectrometry | Caffeine | Index Medicus | Drug Metabolism | in vivo drug–drug interaction
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2006, Volume 80, Issue 3, pp. 203 - 215
Objectives: A volunteer trial was performed to compare the pharmacokinetics of 5 drugs-warfarin, ZK253 (Schering), diazepam, midazolam, and erythromycin-when... 
METABOLISM | WARFARIN | ERYTHROMYCIN | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | MACROLIDE ANTIBIOTICS | ABSORPTION | PATHOPHYSIOLOGICAL STATES | ACCELERATOR MASS-SPECTROMETRY | BIOAVAILABILITY | DISPOSITION | Estradiol - blood | Estradiol - analogs & derivatives | Injections, Intravenous | Anticoagulants - administration & dosage | Area Under Curve | Humans | Middle Aged | GABA Modulators - pharmacokinetics | Midazolam - administration & dosage | Male | Drug Monitoring - methods | Warfarin - administration & dosage | Diazepam - pharmacokinetics | Dose-Response Relationship, Drug | Aged, 80 and over | Adult | Female | Administration, Oral | Diazepam - administration & dosage | Estradiol - administration & dosage | GABA Modulators - administration & dosage | GABA Modulators - blood | Midazolam - pharmacokinetics | Anticoagulants - blood | Erythromycin - administration & dosage | Warfarin - pharmacokinetics | Cross-Over Studies | Erythromycin - blood | Estradiol - pharmacokinetics | Erythromycin - pharmacokinetics | Midazolam - blood | Warfarin - blood | Adolescent | Diazepam - blood | Aged | Anticoagulants - pharmacokinetics | Chromatography, Liquid - methods | Mass Spectrometry - methods | Carbon Radioisotopes | Warfarin | Dosage and administration | Erythromycin | Health aspects | Diazepam | Index Medicus | Abridged Index Medicus
Journal Article
Clinical pharmacokinetics, ISSN 0312-5963, 2017, Volume 56, Issue 10, pp. 1231 - 1244
Journal Article
Journal Article