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Chemical Research in Toxicology, ISSN 0893-228X, 06/2007, Volume 20, Issue 6, pp. 954 - 964
Time-dependent inactivation of cytochrome P450s is typically a result of substrate bioactivation to form reactive species that subsequently alkylate the heme... 
PATHWAYS | CHEMISTRY, MEDICINAL | MECHANISM | ACTIVE-SITE | ESCHERICHIA-COLI | BIOACTIVATION | HUMAN CYTOCHROME-P450 3A4 | CHEMISTRY, MULTIDISCIPLINARY | INHIBITION | ACID ADDUCTS | PURIFICATION | TOXICOLOGY | EXPRESSION | Apoproteins - chemistry | Endopeptidase K - chemistry | Raloxifene Hydrochloride - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Glutathione - metabolism | Alkylating Agents - pharmacology | Cytochrome P-450 Enzyme System - metabolism | Estrogen Antagonists - pharmacology | Sequence Analysis, Protein | Midazolam - chemistry | Spectrometry, Mass, Electrospray Ionization | Time Factors | Enzyme Inhibitors - chemistry | Estrogen Antagonists - chemistry | Cysteine - metabolism | Molecular Structure | Binding Sites | Apoproteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Quinolines - chemistry | Enzyme Inhibitors - pharmacology | Iodoacetamide - pharmacology | Cysteine - chemistry | Spectrophotometry, Ultraviolet | Alkylating Agents - chemistry | Quinolines - metabolism | Iodoacetamide - analogs & derivatives | Endopeptidase K - metabolism | Cytochrome P-450 Enzyme System - genetics | Alkylation - drug effects | Glutathione - chemistry | Kinetics | Raloxifene Hydrochloride - chemistry | Midazolam - pharmacology | Iodoacetamide - chemistry | Index Medicus
Journal Article
Monatshefte für Chemie - Chemical Monthly, ISSN 0026-9247, 1/2016, Volume 147, Issue 1, pp. 127 - 134
Journal Article
Journal of the Iranian Chemical Society, ISSN 1735-207X, 4/2019, Volume 16, Issue 4, pp. 785 - 794
Journal Article
Biochemistry, ISSN 0006-2960, 12/2011, Volume 50, Issue 50, pp. 10804 - 10818
Journal Article
Journal Article
Drugs & Aging, ISSN 1170-229X, 2005, Volume 22, Issue 6, pp. 525 - 539
Journal Article
Molecules, ISSN 1420-3049, 11/2017, Volume 22, Issue 11, p. 1879
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 3, pp. 486 - 491
Human cytochrome P450 3A4 (CYP3A4) is a major hepatic and intestinal enzyme that oxidizes more than 60% of administered therapeutics. Knowledge of how CYP3A4... 
Drug metabolism | Midazolam | CYP3A4 | Crystal structure | Substrate binding | ALPHA-NAPHTHOFLAVONE | STIMULATION | TESTOSTERONE |