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1. Full Text The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort
by Morita, Akio and Kirino, Takaaki and Hashi, Kazuo and Aoki, Noriaki and Fukuhara, Shunichi and Hashimoto, Nobuo and Nakayama, Takeo and Sakai, Michi and Teramoto, Akira and Tominari, Shinjiro and Yoshimoto, Takashi and The UCAS Japan Investigators and UCAS Japan Investigators
The New England Journal of Medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 26, pp. 2474 - 2482
In this observational study involving 5720 Japanese adults who had saccular aneurysms that were 3 mm or larger, the annual risk of rupture was 0.95%. The risk... 
MEDICINE, GENERAL & INTERNAL | SHAPE | METAANALYSIS | MANAGEMENT | INTRACRANIAL ANEURYSMS | PERIOD | RUPTURE | RISK | HISTORY | Prospective Studies | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Male | Middle Cerebral Artery - pathology | Disease Progression | Aneurysm, Ruptured | Cerebral Arteries - pathology | Sex Factors | Observation | Female | Aged | Intracranial Aneurysm - pathology | Carotid Artery, Internal - pathology | Rupture, Spontaneous | Women | Intracranial aneurysms | Causes of | Statistics | Japanese | Health aspects | Risk factors | Diseases | Medical imaging | Enrollments | Aneurysm | Rupture | Aneurysms | Neurosurgery | Patients | Hemorrhage | Saccule | Hypotheses | Entrance examinations | Data collection | Carotid artery | Public health | Health informatics
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2. Full Text Decompressive surgery for the treatment of malignant infarction of the middle cerebral artery (DESTINY): A randomized, controlled trial
by Jüttler, Eric and Schwab, Stefan and Schmiedek, Peter and Unterberg, Andreas and Hennerici, Michael and Woitzik, Johannes and Witte, Steffen and Jenetzky, Ekkehart and Hacke, Werner and DESTINY Study Group
Stroke, ISSN 0039-2499, 09/2007, Volume 38, Issue 9, pp. 2518 - 2525
Decompressive surgery (hemicraniectomy) for life-threatening massive cerebral infarction represents a controversial issue in neurocritical care medicine. We... 
Decompressive surgery | Malignant middle cerebral artery infarction | Randomized trials | Prospective Studies | Humans | Middle Aged | Male | Treatment Outcome | Infarction, Middle Cerebral Artery - pathology | Recovery of Function | Infarction, Middle Cerebral Artery - mortality | Stroke - pathology | Stroke - surgery | Survival Analysis | Infarction, Middle Cerebral Artery - surgery | Adult | Craniotomy | Female | Decompression, Surgical - utilization
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3. Full Text The importance of size: Successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length
by Riedel, Christian H and Zimmermann, Philip and Jensen-Kondering, Ulf and Stingele, Robert and Deuschl, Günther and Jansen, Olav
Stroke, ISSN 0039-2499, 06/2011, Volume 42, Issue 6, pp. 1775 - 1777
Background and Purpose-We hypothesize that in acute middle cerebral artery stroke, thrombus lengths measured in thin-slice nonenhanced CT images define a limit... 
computed tomography | cerebral ischemia | ischemic stroke | MIDDLE CEREBRAL-ARTERY | PERIPHERAL VASCULAR DISEASE | SIGN | ISCHEMIC-STROKE | BURDEN | CLINICAL NEUROLOGY | Humans | Middle Aged | Tomography, X-Ray Computed | Infarction, Middle Cerebral Artery - pathology | Infarction, Middle Cerebral Artery - therapy | Stroke - pathology | Thrombosis - pathology | Fibrinolytic Agents - therapeutic use | Thrombolytic Therapy - methods | Female | Aged | Retrospective Studies | Infusions, Intravenous | Stroke - therapy | Cerebral Revascularization
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4. Full Text Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
by Yemisci, Muge and Gursoy-Ozdemir, Yasemin and Vural, Atay and Can, Alp and Topalkara, Kamil and Dalkara, Turgay
Nature Medicine, ISSN 1078-8956, 09/2009, Volume 15, Issue 9, pp. 1031 - 1037
Here we show that ischemia induces sustained contraction of pericytes on microvessels in the intact mouse brain. Pericytes remain contracted despite successful... 
MEDICINE, RESEARCH & EXPERIMENTAL | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EARLY REPERFUSION | FOCAL ISCHEMIA | BLOOD-BRAIN-BARRIER | CELL BIOLOGY | STROKE | MICROCIRCULATORY OBSTRUCTION | THERAPY | LEUKOCYTE ACCUMULATION | IN-VIVO | HYDROGEN-PEROXIDE | Capillaries - physiopathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Reperfusion Injury - pathology | Reactive Nitrogen Species - metabolism | Enzyme Inhibitors - pharmacology | Ornithine - pharmacology | Ornithine - analogs & derivatives | Cell Size | Middle Cerebral Artery - pathology | Brain Ischemia - physiopathology | Microscopy, Interference | Pericytes - physiology | Mice, Knockout | Nitric Oxide Synthase Type I - deficiency | Nitric Oxide Synthase Type III - antagonists & inhibitors | Animals | Pericytes - pathology | Brain Ischemia - pathology | Middle Cerebral Artery - physiopathology | Reperfusion Injury - physiopathology | Mice | Nitric Oxide Synthase Type I - genetics | Microscopy, Fluorescence | Drugs | Oxidative stress | Care and treatment | Drug delivery systems | Usage | Ischemia | Patient outcomes | Physiological aspects | Research | Cerebral arteries | Vehicles | Blood flow | Brain | Stroke | Cellular biology | Rodents | Blood vessels | Oxidation | Circulatory system
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5. Full Text Middle cerebral artery intraplaque hemorrhage: Prevalence and Clinical Relevance
by Xu, Wei‐Hai and Li, Ming‐Li and Gao, Shan and Ni, Jun and Yao, Ming and Zhou, Li‐Xin and Peng, Bin and Feng, Feng and Jin, Zheng‐Yu and Cui, Li‐Ying
Annals of Neurology, ISSN 0364-5134, 02/2012, Volume 71, Issue 2, pp. 195 - 198
Objective: Little is known about the composition of middle cerebral artery (MCA) plaques and how they relate to clinical status. Using high‐resolution magnetic... 
HIGH-RESOLUTION MRI | STENOSIS | SIZE | ATHEROSCLEROTIC CAROTID PLAQUE | NEUROSCIENCES | LESIONS | CLINICAL NEUROLOGY | Severity of Illness Index | Constriction, Pathologic - pathology | Prevalence | Hemorrhage - epidemiology | Constriction, Pathologic - epidemiology | Humans | Middle Aged | Middle Cerebral Artery - pathology | Plaque, Atherosclerotic - epidemiology | Magnetic Resonance Imaging | Retrospective Studies | Plaque, Atherosclerotic - pathology | Hemorrhage - pathology | Brain | Hemorrhage | Nuclear magnetic resonance--NMR
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6. Full Text Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
by Gelderblom, Mathias and Leypoldt, Frank and Steinbach, Karin and Behrens, Doerthe and Choe, Chi-Un and Siler, Dominic A and Arumugam, Thiruma V and Orthey, Ellen and Gerloff, Christian and Tolosa, Eva and Magnus, Tim
Stroke, ISSN 0039-2499, 05/2009, Volume 40, Issue 5, pp. 1849 - 1857
Background and Purpose-Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of... 
MICROGLIAL RESPONSE | NKT CELLS | ARTERY OCCLUSION | DENDRITIC CELLS | FOCAL ISCHEMIA | RAT MODEL | CLINICAL NEUROLOGY | ischemia-reperfusion injury | BRAIN ISCHEMIA | INFLAMMATORY CELLS | REGULATORY T-CELLS | PERIPHERAL VASCULAR DISEASE | flow cytometry | microglia | ISCHEMIC-STROKE | dendritic cell | middle cerebral artery occlusion | Immunohistochemistry | Forkhead Transcription Factors - biosynthesis | Inflammation - pathology | Dendritic Cells - immunology | Mice, Inbred C57BL | Neutrophils - immunology | Infarction, Middle Cerebral Artery - immunology | Infarction, Middle Cerebral Artery - pathology | Forkhead Transcription Factors - genetics | Antigen-Presenting Cells - immunology | Stroke - pathology | Immunity, Cellular - immunology | Animals | Flow Cytometry | Lymphocytes - immunology | Microglia - immunology | Reperfusion Injury - immunology | Killer Cells, Natural - immunology | Mice | Kinetics | Macrophages - immunology | Stroke - immunology
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7. Full Text Risk factors and stroke mechanisms in atherosclerotic stroke: Intracranial compared with extracranial and anterior compared with posterior circulation disease
by Kim, Jong S and Nah, Hyun-Wook and Park, Sea Mi and Kim, Su-Kyung and Cho, Ki Hyun and Lee, Jun and Lee, Yong-Seok and Kim, Jei and Ha, Sang-Won and Kim, Eung-Gyu and Kim, Dong-Eog and Kang, Dong-Wha and Kwon, Sun U and Yu, Kyung-Ho and Lee, Byung-Chul
Stroke, ISSN 0039-2499, 12/2012, Volume 43, Issue 12, pp. 3313 - 3318
Background and Purpose-The aim of this study was to investigate differences in risk factors and stroke mechanisms between intracranial atherosclerosis (ICAS)... 
Angiogram | Diagnosis | Registry | Cerebrovascular disease | LOCATION | registry | METABOLIC SYNDROME | cerebrovascular disease | RACE | SEX | diagnosis | PERIPHERAL VASCULAR DISEASE | angiogram | ISCHEMIC-STROKE | CLINICAL NEUROLOGY | Prevalence | Prospective Studies | Cerebrovascular Circulation - physiology | Humans | Middle Aged | Male | Intracranial Embolism - epidemiology | Posterior Cerebral Artery - pathology | Stroke - physiopathology | Stroke - pathology | Young Adult | Posterior Cerebral Artery - metabolism | Anterior Cerebral Artery - physiopathology | Registries - statistics & numerical data | Aged, 80 and over | Adult | Female | Stroke - epidemiology | Republic of Korea - epidemiology | Intracranial Embolism - physiopathology | Intracranial Arteriosclerosis - pathology | Anterior Cerebral Artery - pathology | Risk Factors | Intracranial Embolism - pathology | Magnetic Resonance Angiography | Anterior Cerebral Artery - metabolism | Magnetic Resonance Imaging | Intracranial Arteriosclerosis - epidemiology | Posterior Cerebral Artery - physiopathology | Aged | Intracranial Arteriosclerosis - physiopathology
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8. Full Text In vivo high-resolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis
by Xu, Wei-Hai and Li, Ming-Li and Gao, Shan and Ni, Jun and Zhou, Li-Xin and Yao, Ming and Peng, Bin and Feng, Feng and Jin, Zheng-Yu and Cui, Li-Ying
Atherosclerosis, ISSN 0021-9150, 2010, Volume 212, Issue 2, pp. 507 - 511
Abstract Objective Recently, the technique of high-resolution magnetic resonance imaging (HR-MRI) has been developed to depict intracranial artery wall. We... 
Cardiovascular | Cerebral ischemia | Magnetic resonance imaging | Middle cerebral artery | Atherosclerosis | Plaque | OCCLUSIVE DISEASE | PROGNOSIS | COMPONENTS | LESIONS | CORONARY PLAQUE | ANGIOGRAPHY | FIBROUS CAP | CAROTID PLAQUE | PERIPHERAL VASCULAR DISEASE | INTRAVASCULAR ULTRASOUND | ASSOCIATION | Atherosclerosis - pathology | Brain Ischemia | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Middle Cerebral Artery - pathology | Risk | Carotid Stenosis - pathology | Disease Progression | Diagnostic Imaging - methods | Female | Aged
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9. Full Text Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial)
by Vahedi, Katayoun and Vicaut, Eric and Mateo, Joaquim and Kurtz, Annie and Orabi, Mikael and Guichard, Jean-Pierre and Boutron, Carole and Couvreur, Gregory and Rouanet, François and Touzé, Emmanuel and Guillon, Benoît and Carpentier, Alexandre and Yelnik, Alain and George, Bernard and Payen, Didier and Bousser, Marie-Germaine and DECIMAL Investigators
Stroke, ISSN 0039-2499, 09/2007, Volume 38, Issue 9, pp. 2506 - 2517
Background and Purpose - There is no effective medical treatment of malignant middle cerebral artery (MCA) infarction. The purpose of this clinical trial was... 
Clinical trials | Craniectomy | Middle cerebral artery | STATEMENT | SURGERY | MANAGEMENT | COUNCIL | GUIDELINES | middle cerebral artery | CLINICAL NEUROLOGY | HEMICRANIECTOMY | RECOVERY | craniectomy | PERIPHERAL VASCULAR DISEASE | clinical trials | QUALITY-OF-LIFE | ISCHEMIC-STROKE | ASSOCIATION | Follow-Up Studies | Humans | Middle Aged | Male | Survival Rate | Treatment Outcome | Statistics as Topic | Infarction, Middle Cerebral Artery - pathology | Recovery of Function | Adolescent | Infarction, Middle Cerebral Artery - surgery | Quality of Life | Adult | Craniotomy | Female | Decompression, Surgical - utilization | France | Research Design
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10. Full Text MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia
by Hamzei Taj, Somayyeh and Kho, Widuri and Riou, Adrien and Wiedermann, Dirk and Hoehn, Mathias
Biomaterials, ISSN 0142-9612, 2016, Volume 91, pp. 151 - 165
Abstract microRNA-124 (miR-124), the most abundant miRNA of the CNS, was recently shown to modulate the polarization of activated microglia and infiltrating... 
Advanced Basic Science | Dentistry | Neuroprotection | microRNA-124 | Immune cell modulation/polarization | Ischemic stroke | Arginase-1 | Functional improvement | MicroRNA-124 | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | GLIAL SCAR | MACROPHAGES | CNS | STROKE | MICROGLIA | REACTIVE ASTROCYTES | CENTRAL-NERVOUS-SYSTEM | MICRORNA-124 PROTECTS | BRAIN | MicroRNAs - therapeutic use | Arginase - analysis | Neurons - pathology | Animals | Macrophages - pathology | Mice, Inbred C57BL | Brain - pathology | Microglia - pathology | Male | Infarction, Middle Cerebral Artery - pathology | Infarction, Middle Cerebral Artery - therapy | Stroke (Disease) | Mice | MicroRNA | Ischemia | Macrophages | Neurons | Polarization | Strokes | Lesions | Arteries
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11. Full Text Plaque distribution of stenotic middle cerebral artery and its clinical relevance
by Xu, Wei-Hai and Li, Ming-Li and Gao, Shan and Ni, Jun and Zhou, Li-Xin and Yao, Ming and Peng, Bin and Feng, Feng and Jin, Zheng-Yu and Cui, Li-Ying
Stroke, ISSN 0039-2499, 10/2011, Volume 42, Issue 10, pp. 2957 - 2959
Background and Purpose-Microanatomy studies reveal that most penetrating branches of middle cerebral artery (MCA) arise from the dorsal-superior surface of the... 
MRI | plaque | middle cerebral artery | PERIPHERAL VASCULAR DISEASE | CORONARY-ARTERY | CLINICAL NEUROLOGY | Intracranial Arteriosclerosis - pathology | Magnetic Resonance Imaging | Atherosclerosis - pathology | Humans | Middle Cerebral Artery - pathology | Retrospective Studies | Plaque, Atherosclerotic - pathology
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12. Full Text CT and MRI early vessel signs reflect clot composition in acute stroke
by Liebeskind, David S and Sanossian, Nerses and Yong, William H and Starkman, Sidney and Tsang, Michael P and Moya, Antonio L and Zheng, David D and Abolian, Anna M and Kim, Doojin and Ali, Latisha K and Shah, Samir H and Towfighi, Amytis and Ovbiagele, Bruce and Kidwell, Chelsea S and Tateshima, Satoshi and Jahan, Reza and Duckwiler, Gary R and Viñuela, Fernando and Salamon, Noriko and Villablanca, J. Pablo and Vinters, Harry V and Marder, Victor J and Saver, Jeffrey L
Stroke, ISSN 0039-2499, 05/2011, Volume 42, Issue 5, pp. 1237 - 1243
Background and Purpose-The purpose of this study was to provide the first correlative study of the hyperdense middle cerebral artery sign (HMCAS) and... 
thrombus | MRI | stroke | cerebral ischemia | MIDDLE CEREBRAL-ARTERY | MERCI TRIAL | INTRAARTERIAL | TISSUE-PLASMINOGEN ACTIVATOR | THROMBECTOMY | PROGNOSTIC VALUE | COMPUTED-TOMOGRAPHY | CLINICAL NEUROLOGY | ACUTE ISCHEMIC-STROKE | THROMBOLYSIS | PERIPHERAL VASCULAR DISEASE | MECHANICAL EMBOLUS REMOVAL | Blood Platelets - pathology | Leukocytes - pathology | Stroke - diagnostic imaging | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Infarction, Middle Cerebral Artery - pathology | Leukocytes - diagnostic imaging | Thrombosis - diagnostic imaging | Fibrin - ultrastructure | Stroke - pathology | Artifacts | Magnetic Resonance Imaging | Thrombosis - pathology | Thrombectomy | Aged, 80 and over | Erythrocytes - pathology | Female | Aged | Blood Platelets - diagnostic imaging | Retrospective Studies | Erythrocytes - diagnostic imaging | Infarction, Middle Cerebral Artery - diagnostic imaging | Stroke
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