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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19403 - 19422
All coronaviruses, including the recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV) from the beta-CoV subgroup, require the proteolytic... 
DIMER INTERFACE | DESIGN | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL EVALUATION | MAIN PROTEASE | DIFFRACTION DATA | INHIBITORS | CATALYTIC-ACTIVITY | 3C-LIKE PROTEASE | SARS-CORONAVIRUS | Cysteine Endopeptidases - chemistry | Peptidomimetics - chemical synthesis | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Viral Proteins - metabolism | Cysteine Endopeptidases - metabolism | Antiviral Agents - chemistry | Escherichia coli - metabolism | Middle East Respiratory Syndrome Coronavirus - enzymology | Recombinant Proteins - metabolism | Amino Acid Sequence | Antiviral Agents - pharmacology | Gene Expression | Peptidomimetics - pharmacology | Viral Proteins - chemistry | Middle East Respiratory Syndrome Coronavirus - drug effects | Recombinant Proteins - chemistry | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | Peptidomimetics - chemistry | Recombinant Proteins - genetics | Sequence Alignment | Escherichia coli - genetics | Middle East Respiratory Syndrome Coronavirus - genetics | Cysteine Endopeptidases - genetics | Antiviral Agents - chemical synthesis | Hydrophobic and Hydrophilic Interactions | Ligands | Molecular Docking Simulation | Kinetics | Protein Multimerization - drug effects | viral protease | X-ray crystallography | Protein Structure and Folding | analytical ultracentrifugation | monomer-dimer equilibrium | enzyme inhibitor | ligand-induced dimerization | β-CoV | enzyme inactivation | MERS-CoV 3CLpro | enzyme kinetics
Journal Article
Journal Article
Journal Article