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The Journal of infectious diseases, ISSN 1537-6613, 2015, Volume 211, Issue 1, pp. 156 - 165
Background. A predominantly T-helper type 2 (Th2) immune response is critical in the prognosis of pulmonary Pseudomonas aeruginosa infection. But the mucosal... 
human-milk | cytokine production | butyrate | in-vitro | chain fatty-acids | galacto-oligosaccharides | t-cells | lactobacillus | virus-infection | cystic-fibrosis patients | intestinal microbiota | prebiotics | Th1 and M1 polarization | P. aeruginosa lung infection | INFECTIOUS DISEASES | VIRUS-INFECTION | GALACTO-OLIGOSACCHARIDES | MICROBIOLOGY | IMMUNOLOGY | CYTOKINE PRODUCTION | HUMAN-MILK | METABOLISM | CYSTIC-FIBROSIS PATIENTS | CHAIN FATTY-ACIDS | BUTYRATE | T-CELLS | LACTOBACILLUS | Intestines - drug effects | Lung Diseases - microbiology | GATA3 Transcription Factor - immunology | Pseudomonas aeruginosa - growth & development | Microbiota - drug effects | Male | T-Box Domain Proteins - immunology | Lung Diseases - drug therapy | Th1 Cells - immunology | Intestines - immunology | Leukocytes - immunology | Oligosaccharides - pharmacology | Leukocytes - microbiology | Tumor Necrosis Factor-alpha - immunology | Keratinocytes - microbiology | Macrophages - immunology | Macrophages - microbiology | Chemotactic Factors - immunology | Microbiota - immunology | Pseudomonas Infections - drug therapy | Pseudomonas aeruginosa - drug effects | Pseudomonas Infections - microbiology | Keratinocytes - immunology | Pectins - chemistry | Pseudomonas Infections - immunology | Lung Diseases - immunology | Interleukin-4 - immunology | Th1 Cells - microbiology | Animals | Intestines - microbiology | Interferon-gamma - immunology | Mice | Mice, Inbred BALB C | Interleukin-10 - immunology | Pseudomonas Infections/microbiology | Macrophages/microbiology | Oligosaccharides/pharmacology | Macrophages/immunology | Lung Diseases/immunology | Lung Diseases/microbiology | Interferon-gamma/immunology | Keratinocytes/microbiology | Microbiota/drug effects | Life Sciences | Leukocytes/microbiology | Pseudomonas Infections/immunology | Interleukin-10/immunology | Lung Diseases/drug therapy | T-Box Domain Proteins/immunology | Leukocytes/immunology | Pseudomonas aeruginosa/drug effects | Th1 Cells/microbiology | GATA3 Transcription Factor/immunology | Interleukin-4/immunology | Intestines/drug effects | Intestines/microbiology | Keratinocytes/immunology | Chemotactic Factors/immunology | Tumor Necrosis Factor-alpha/immunology | Microbiota/immunology | Pseudomonas aeruginosa/growth & development | Pectins/chemistry | Pseudomonas Infections/drug therapy | Th1 Cells/immunology | Intestines/immunology
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 130, Issue 2, pp. 523 - 530.e9
Background There is evidence that gene expression of innate immunity receptors is upregulated by farming-related exposures. Objective We sought to determine... 
Allergy and Immunology | nutrition | childhood | prenatal | farming | farm milk | Toll-like receptors | Innate immunity | CD14 | FARM MILK CONSUMPTION | TIME QUANTITATIVE PCR | POLYMORPHISM | IMMUNOLOGY | CHILDHOOD ASTHMA | CHILDREN | PROTECT | TOLL-LIKE RECEPTOR-2 | ALLERGY | HEALTH | ALLERGIC DISEASES | ATOPIC SENSITIZATION | RNA, Messenger - immunology | Prospective Studies | Humans | Immunity, Innate - genetics | Prenatal Exposure Delayed Effects - prevention & control | Infant | Male | Maternal Exposure | RNA, Messenger - biosynthesis | Rural Population | Fetal Blood - chemistry | Gene Expression - immunology | Hypersensitivity, Immediate - immunology | Adult | Female | Surveys and Questionnaires | Agriculture | Milk - immunology | Polymorphism, Single Nucleotide - immunology | Fetal Blood - immunology | Cats | Toll-Like Receptors - immunology | Hypersensitivity, Immediate - genetics | Lipopolysaccharide Receptors - immunology | Hypersensitivity, Immediate - prevention & control | Pregnancy | Prenatal Exposure Delayed Effects - genetics | Immunity, Innate - immunology | Animals | Prenatal Exposure Delayed Effects - immunology | Toll-Like Receptors - genetics | Lipopolysaccharide Receptors - genetics | Polymorphism, Single Nucleotide - genetics | Allergy | Medical colleges | Pregnant women | Analysis | Genes | Environmental health | Genetic research | Respiratory tract diseases | Gene expression | Allergic reaction | Biometry | Public health | Disease | Rural areas | Farm buildings | Allergies | Asthma | Hay fever | Womens health | Questionnaires | Age | Immune system | Farming | Neonates | Inventories | TLR7 protein | TLR5 protein | Hypersensitivity | Single-nucleotide polymorphism | Regression analysis | TLR4 protein | CD14 antigen | Gene polymorphism | Immunity | Rural environments | TLR9 protein | Cord blood | Farms | Pasture | Prenatal experience | Food | Milk | Prenatal Exposure Delayed Effects | Antigens, CD14 | Hypersensitivity, Immediate | Life Sciences | Toll-Like Receptors | Pulmonology and respiratory tract | Gene Expression | Immunity, Innate | Human health and pathology | Polymorphism, Single Nucleotide | RNA, Messenger | Fetal Blood
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 130, Issue 6, pp. 1260 - 1274
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2015, Volume 42, Issue 3, pp. 512 - 523
Oral immunotherapy has had limited success in establishing tolerance in food allergy, reflecting failure to elicit an effective regulatory T (Treg) cell... 
EGG ALLERGY | PROTEIN | GENE | IMMUNOTHERAPY | AUTOIMMUNITY | INFLAMMATION | IL-4 | REG-CELLS | IMMUNOLOGY | ANAPHYLAXIS | COWS MILK ALLERGY | Humans | Immunity, Mucosal | Child, Preschool | Interleukin-13 - immunology | Gastric Mucosa - pathology | Infant | Male | STAT6 Transcription Factor - genetics | Th2 Cells - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Interleukin-13 - genetics | Food Hypersensitivity - immunology | Allergens - immunology | Female | Interleukin-4 - genetics | Child | Th2 Cells - pathology | Food Hypersensitivity - genetics | Transforming Growth Factor beta - immunology | Mast Cells - immunology | Genetic Predisposition to Disease | Signal Transduction | Interleukin-13 - deficiency | Gene Expression Regulation | Immune Tolerance | Interleukin-4 - deficiency | Mice, Transgenic | STAT6 Transcription Factor - immunology | Receptors, Cell Surface - immunology | Cellular Reprogramming - immunology | Food Hypersensitivity - pathology | Gastric Mucosa - immunology | Interleukin-4 - immunology | Animals | Transforming Growth Factor beta - genetics | Mast Cells - pathology | Adolescent | Mice | Receptors, Cell Surface - genetics | Food allergy | Allergens | T cells | Immunotherapy | Disease prevention | Food allergies | Immunology | Pathogenesis | Lymphocytes | Rodents | Population | Allergies | Evacuations & rescues | Children & youth | Food
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 136, Issue 2, pp. 312 - 322.e7
Background The mechanism underlying severe asthma with fungal sensitization (SAFS) is unknown. IL-33 is important in fungus-induced asthma exacerbations, but... 
Allergy and Immunology | steroid resistance | Severe asthma | innate immunity | IL-33 | fungal sensitization | pediatric | VORICONAZOLE | IMMUNITY | ALLERGENS | INNATE | ITRACONAZOLE | IMMUNOLOGY | CHILDREN | ALLERGY | EXACERBATIONS | MOLDS | LUNG INFLAMMATION | EXPOSURE | Interleukin-1 Receptor-Like 1 Protein | Anti-Asthmatic Agents - therapeutic use | Humans | Receptors, Interleukin - deficiency | Interleukin-13 - immunology | Omalizumab | Male | Th2 Cells - immunology | Interleukins - genetics | Interleukin-13 - genetics | Immunoglobulin E - immunology | Immunoglobulin E - genetics | Interleukins - immunology | Asthma - immunology | Female | Antibodies, Anti-Idiotypic - therapeutic use | Child | Th2 Cells - pathology | Disease Models, Animal | Animals, Newborn | Severity of Illness Index | Pyroglyphidae - chemistry | Antibodies, Monoclonal, Humanized - therapeutic use | Skin Tests | Receptors, Interleukin - immunology | Interleukin-33 | Asthma - drug therapy | Receptors, Interleukin - genetics | Alternaria - immunology | Cladosporium - immunology | Animals | Asthma - complications | Aspergillus fumigatus - immunology | Budesonide - therapeutic use | Mycoses - pathology | Adolescent | Mycoses - drug therapy | Mice | Mycoses - complications | Asthma - pathology | Mycoses - immunology | Pyroglyphidae - immunology | Pediatrics | Asthma in children | Fungi | Cytokines | Mortality | Smooth muscle | Inflammation | Allergies | Morbidity | Asthma | Milk | ABPA, Allergic bronchopulmonary aspergillosis | ICOS, Inducible costimulator | SPT, Skin prick test | sIgE, Specific IgE | BAL, Bronchoalveolar lavage | HDM, House dust mite | SAFS, Severe asthma with fungal sensitization | MMP-9, Matrix metalloproteinase 9 | Asthma and Lower Airway Disease | STRA, Severe therapy-resistant asthma | ILC, Innate lymphoid cell | AHR, Airway hyperresponsiveness
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 43, pp. 17444 - 17449
Breast milk oligosaccharides shape the intestinal environment by affecting mucosal immunity and bacterial colonization. To clarify the role of milk... 
T lymphocytes | Inflammatory bowel diseases | Dendritic cells | Cytokines | Mice | Inflammation | Oligosaccharides | Colitis | Leukocytes | Neutrophil infiltration | Carbohydrate | Mouse innate immunity | Glycan | Prebiotics | CAMPYLOBACTER-JEJUNI | mouse innate immunity | TGF-BETA | DENDRITIC CELLS | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | SIALIC-ACID | carbohydrate | ENTEROCOLITIS | glycan | INFLAMMATORY-BOWEL-DISEASE | prebiotics | DIFFERENTIATION | POLARIZATION | T-CELLS | Immunity, Mucosal - immunology | Milk - chemistry | Lactose - immunology | Colitis - genetics | Dendritic Cells - immunology | Lactose - analogs & derivatives | Sialyltransferases - immunology | Male | Intestines - metabolism | CD11c Antigen - immunology | Gastrointestinal Tract - pathology | Intestines - immunology | CD11c Antigen - metabolism | Gastrointestinal Tract - immunology | Bacteria - immunology | Flow Cytometry | Lactose - metabolism | Gene Expression - immunology | Bacteria - classification | Female | Milk - immunology | Colitis - immunology | Sialic Acids - immunology | Cytokines - genetics | Immunity, Mucosal - genetics | Dendritic Cells - metabolism | Cytokines - immunology | Animals, Newborn | Lactation - immunology | Interleukin-10 - deficiency | Cytokines - metabolism | Mice, Inbred C57BL | Sialyltransferases - deficiency | Cells, Cultured | Sialic Acids - metabolism | Sialyltransferases - genetics | Gastrointestinal Tract - microbiology | Toll-Like Receptor 4 - immunology | Reverse Transcriptase Polymerase Chain Reaction | Bacteria - genetics | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Animals | Interleukin-10 - genetics | Colitis - metabolism | Interleukin-10 - immunology | Intestines - cytology | Biological Sciences
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2011, Volume 121, Issue 6, pp. 2221 - 2241
Journal Article
Journal of medical microbiology, ISSN 0022-2615, 12/2013, Volume 62, Issue 12, pp. 1815 - 1822
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 6, pp. 1546 - 1557.e4
Background Allergy to cow's milk increases the risk of sensitization to other foods in young children. Objectives We sought to evaluate the effect of early... 
Allergy and Immunology | Allergy | treatment | milk | epicutaneous immunotherapy | peanut | food allergy | prevention | INTACT SKIN | INHALED ALLERGEN | IMMUNOLOGY | NATURAL-HISTORY | CHILDREN | DELIVERY-SYSTEM | REGULATORY T-CELLS | ASTHMA | MILK-SPECIFIC IGE | SUBLINGUAL IMMUNOTHERAPY | Arachis - chemistry | Bronchial Hyperreactivity - immunology | Eosinophils - drug effects | Humans | Bronchial Hyperreactivity - genetics | Eosinophils - immunology | Milk Hypersensitivity - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Milk Proteins - administration & dosage | Allergens - administration & dosage | Allergens - immunology | Eosinophils - pathology | Child | Cytokines - genetics | Th1-Th2 Balance - drug effects | Disease Models, Animal | Pyroglyphidae - chemistry | T-Lymphocytes, Regulatory - drug effects | Milk Hypersensitivity - therapy | Peanut Hypersensitivity - physiopathology | Mice | Mice, Inbred BALB C | T-Lymphocytes, Regulatory - transplantation | Milk Hypersensitivity - physiopathology | Desensitization, Immunologic - methods | GATA3 Transcription Factor - genetics | Milk Proteins - isolation & purification | Peanut Hypersensitivity - genetics | GATA3 Transcription Factor - immunology | Cross Protection | Adoptive Transfer | Peanut Hypersensitivity - prevention & control | DNA Methylation | Milk Proteins - immunology | Bronchial Hyperreactivity - physiopathology | Female | Allergens - isolation & purification | Skin - pathology | Cytokines - immunology | Skin - immunology | Promoter Regions, Genetic | Bronchial Hyperreactivity - prevention & control | Milk Hypersensitivity - genetics | Peanut Hypersensitivity - immunology | Gene Expression Regulation - drug effects | Animals | Arachis - immunology | Plethysmography | Skin - drug effects | Pyroglyphidae - immunology | Prevention | Allergens | Allergic reaction | Immunotherapy | Proteins | Spleen | Food allergies | DNA methylation | Epigenetics | Experiments | Allergies | Milk | Food
Journal Article