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Molecular Pharmaceutics, ISSN 1543-8384, 11/2014, Volume 11, Issue 11, pp. 3965 - 3973
Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid clearance from nontumor tissues. Here, we demonstrate that... 
minibody | PSMA | Cys-diabody | huJ591 | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 12/2016, Volume 57, Issue 12, pp. 1858 - 1864
We conducted a phase I dose-escalation study with Zr-89-desferriox-amjne-IAB2M (Zr-89-IAB2M), an anti-prostate-specific membrane antigen minibody, in patients... 
minibody | MEMBRANE ANTIGEN | dosimetry | IMMUNO-PET | prostate cancer imaging | PILOT TRIAL | TUMORS | SOFTWARE | PSMA | FRAGMENTS | THERAPY | IN-VIVO | Zr-89-IAB2M | MONOCLONAL-ANTIBODIES | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 07/2005, Volume 65, Issue 13, pp. 5907 - 5916
We have recently described the in vivo properties of an iodinated anti-p185(HER2) engineered antibody fragment [minibody (scFv-C(H)3)2; 80 kDa], made from the... 
RECOMBINANT ANTIBODY | CELLS | HUMAN-BREAST-CANCER | ONCOLOGY | MINIBODY | DOTA | SINGLE-CHAIN FV | MONOCLONAL-ANTIBODIES | EXPRESSION | BINDING | XENOGRAFTS
Journal Article
MOLECULAR PHARMACEUTICS, ISSN 1543-8384, 11/2014, Volume 11, Issue 11, pp. 3965 - 3973
Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid clearance from nontumor tissues. Here, we demonstrate that... 
minibody | MEDICINE, RESEARCH & EXPERIMENTAL | RADIOIMMUNOTHERAPY | EXTRACELLULAR DOMAIN | Cys-diabody | MEMBRANE ANTIGEN PSMA | CANCER | RADIOLABELED MONOCLONAL-ANTIBODIES | PSMA | INTERNALIZATION | 16-BETA-F-18-FLUORO-5-ALPHA-DIHYDROTESTOSTERONE | PHARMACOLOGY & PHARMACY | huJ591 | CARCINOEMBRYONIC ANTIGEN | EXPRESSION | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 03/2014, Volume 55, Issue 3, pp. 452 - 459
Prostate stem cell antigen (PSCA) is expressed on the cell surface in 83%-100% of local prostate cancers and 87%-100% of prostate cancer bone metastases. In... 
minibody | partial volume correction | MEMBRANE ANTIGEN | METASTASES | CHALLENGES | antibody fragments | prostate cancer | immunoPET | POSITRON-EMISSION-TOMOGRAPHY | I-124 | LYMPH-NODE | IN-VIVO | prostate stem cell antigen (PSCA) | STEM-CELL ANTIGEN | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Zr-89 | GLEASON SCORE | PET
Journal Article
Journal Article
ANNALS OF NUCLEAR MEDICINE, ISSN 0914-7187, 02/2019, Volume 33, Issue 2, pp. 119 - 127
ObjectiveWe conducted the present phase I/IIa positron emission tomography (PET) imaging study with Zr-89 conjugated with desferroxamine-IAB2M... 
ANTIBODIES | Urological cancer | PHARMACOKINETICS | Zirconium-labeled tracer | Prostate-specific membrane antigen | POSITRON EMISSION TOMOGRAPHY | Clinical trial | Minibody | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e113442 - e113442
Cetuximab, a chimeric monoclonal antibody developed for targeting the Epidermal Growth Factor Receptor (EGFR), has been intensively used to treat cancer... 
GROWTH-FACTOR RECEPTOR | CETUXIMAB | INHIBITION | ANTIBODY FRAGMENT | STABILITY | CONSTRUCTS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | SINGLE-CHAIN FV | ANTAGONISTS | EXPRESSION | Antibody Specificity | Receptor, Epidermal Growth Factor - immunology | Humans | Head and Neck Neoplasms - drug therapy | Male | Molecular Targeted Therapy | Antibodies, Monoclonal, Humanized - genetics | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Signal Transduction - immunology | Head and Neck Neoplasms - immunology | Animals | Single-Chain Antibodies - genetics | Escherichia coli - genetics | Base Sequence | Protein Engineering | Single-Chain Antibodies - therapeutic use | Cell Line, Tumor | Mice | Cetuximab | Single-Chain Antibodies - immunology | Proteins | Analysis | Immunoglobulin G | Colorectal cancer | Monoclonal antibodies | Head and neck cancer | Health aspects | Phosphorylation | Xenotransplantation | Colorectal carcinoma | Amino acids | Biochemistry | Kinases | Cancer therapies | Metastases | Anticancer properties | Engineering | Receptors | Epidermal growth factor | E coli | Xenografts | Physiology | Life sciences | Neck | Growth factors | Deoxyribonucleic acid--DNA | Binding | Head | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Radioactive half-life | Medicine | Protein arrays | Medical prognosis | Ligands | Head & neck cancer | Solid tumors | Pharmaceuticals | Cancer | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 11/2008, Volume 14, Issue 22, pp. 7488 - 7496
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 02/2007, Volume 48, Issue 2, pp. 304 - 310
In this study, we investigated the F-18-labeled anti-carcinoembryonic antigen (CEA) T84.66 diabody, a genetically engineered noncovalent dimer of single-chain... 
BRAIN-TUMOR ANGIOGENESIS | colorectal cancer | CEA DIABODY | MICROPET | MINIBODY | T84.66 diabody | carcinoembryonic antigen (CEA) | F-18 | small-animal PET | ANTIBODY FRAGMENTS | BREAST-CANCER | RGD PEPTIDE | MONOCLONAL-ANTIBODIES | EXPRESSION | DOSIMETRY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2015, Volume 56, Issue 1, pp. 140 - 144
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2014, Volume 5, Issue 4, pp. 411 - 415
Minibodies show rapider blood clearance than IgGs due to smaller size that improves target-to-background ratio (TBR) in in vivo imaging. Additionally, the... 
minibody | Molecular imaging | near-infrared fluorescence | prostate cancer | indocyanine green | ANTIBODIES | CHEMISTRY, MEDICINAL | CANCER | TUMORS | ANTIGEN
Journal Article
Molecular Imaging and Biology, ISSN 1536-1632, 2019, pp. 1 - 10
A great challenge in the diagnosis and treatment of prostate cancer is distinguishing between indolent or local disease and aggressive or metastatic disease.... 
Prostate stem cell antigen (PSCA) | Zirconium-89 | Antibody fragment | Iodine-124 | Diabody | Minibody | Immuno-PET | Prostate cancer | Syngeneic grafts | Zirconium isotopes | Antibodies | Bladder | Blood | Lymph nodes | Metastases | Tomography | Diagnosis | Emitters | Iodine | Spleen | Urine | Iodine isotopes | Antigens | Stomach | Level (quantity) | Kidneys | Organs | Positron emission | Radioactive half-life | Zirconium | Stem cells | Mice | Positron emission tomography | Prostate | Tumors | Cancer
Journal Article
Molecular Therapy - Oncolytics, ISSN 2372-7705, 12/2018, Volume 11, pp. 20 - 38
We generated two humanized interleukin-13 receptor α2 (IL-13Rα2) chimeric antigen receptors (CARs), Hu07BBz and Hu08BBz, that recognized human IL-13Rα2, but... 
minibody | glioblastoma | IL-13Rα2 | CAR | chimeric antigen receptor | canine | CTLA-4 | TIM-3 | PD-1 | immune checkpoint blockade
Journal Article
Journal Article
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