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Genes and Cancer, ISSN 1947-6019, 2015, Volume 6, Issue 3-4, pp. 144 - 152
Malignant mesothelioma is a devastating disease with a poor prognosis for which there is a clear need for more successful therapeutic approaches. Triptolide, a... 
Mesothelioma | Hsp70 | Minnelide | Triptolide | Research Paper | minnelide | mesothelioma
Journal Article
Journal of Surgical Oncology, ISSN 0022-4790, 07/2017, Volume 116, Issue 1, pp. 114 - 122
The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen... 
pancreatic cancer | calcium | HSP70 | minnelide | triptolide | lysosomes | pancreatitis
Journal Article
Plant Science, ISSN 0168-9452, 08/2019, Volume 285, pp. 184 - 192
is known to contain various types of bioactive diterpenoids that exhibit many remarkable activities. Many studies have recently been targeted toward the... 
Subunit interactions | Engineering bacteria | Tripterygium wilfordii | Geranylgeranyl diphosphate synthase | Geranyl diphosphate synthase small subunit | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CANCER | CHAIN-LENGTH SPECIFICITY | PLANT SCIENCES | CLONING | SMALL-SUBUNIT | GENE FAMILY | MINNELIDE | EXPRESSION | TRIPTOLIDE
Journal Article
by Zhang, C and He, XJ and Li, L and Lu, C and Lu, AP
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 08/2017, Volume 8, pp. 490 - 490
Objective : Triptolide (TL), a natural product isolated from Tripterygium wilfordii Hook F (TwHF), shows potent anticancer effects in vitro and in vivo. We... 
TRIPTERYGIUM-WILFORDII | APOPTOSIS | HEAT-SHOCK-PROTEIN-70 | triptolide | PROLIFERATION | systematic review | COMBINATION | LINES | CELL-DEATH | pancreatic cancer | biochemical mechanisms | PHARMACOLOGY & PHARMACY | MINNELIDE | EXPRESSION
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 47, pp. 33927 - 33938
Pancreatic cancer, the fourth most prevalent cancer-related cause of death in the United States, is a disease with a dismal survival rate of 5% 5 years after... 
PATHWAYS | APOPTOSIS | ACTIVATION | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | Pancreatic Cancer | KAPPA-B | O-GlcNAc | N-ACETYLGLUCOSAMINE TRANSFERASE | Heat Shock Protein | Minnelide | IN-VITRO | INHIBITION | Sp1 | Triptolide | Pancreas | TUMOR-GROWTH | EXPRESSION | Pancreatic Neoplasms - metabolism | Humans | Cell Survival - genetics | N-Acetylglucosaminyltransferases - genetics | Antineoplastic Agents, Alkylating - pharmacology | NF-kappa B - metabolism | Sp1 Transcription Factor - metabolism | Glycosylation - drug effects | Neoplasm Proteins - metabolism | Acetylglucosamine - metabolism | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Cell Nucleus - metabolism | Epoxy Compounds - pharmacology | Cell Death - genetics | Cell Nucleus - pathology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Active Transport, Cell Nucleus - genetics | Gene Expression Regulation, Neoplastic - genetics | HSP70 Heat-Shock Proteins - biosynthesis | Diterpenes - pharmacology | Cell Survival - drug effects | Pancreatic Neoplasms - pathology | HSP70 Heat-Shock Proteins - genetics | Pancreatic Neoplasms - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Acetylglucosamine - genetics | DNA-Binding Proteins - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | N-Acetylglucosaminyltransferases - metabolism | Transcription Factors - metabolism | Phenanthrenes - pharmacology | Cell Nucleus - genetics | NF-kappa B - genetics | Signal Transduction - drug effects | Sp1 Transcription Factor - genetics | Active Transport, Cell Nucleus - drug effects | Cell Line, Tumor | N-Acetylglucosaminyltransferases - antagonists & inhibitors | Index Medicus | Molecular Bases of Disease
Journal Article
Cancer Research, ISSN 0008-5472, 03/2018, Volume 78, Issue 5, pp. 1321 - 1333
Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) that stimulate... 
GROWTH-FACTOR-BETA | THERAPY | STROMAL BIOLOGY | ONCOLOGY | DUCTAL ADENOCARCINOMA | RNA-SEQ | TRANSCRIPTION FACTOR SP1 | STELLATE CELLS | MINNELIDE | EXPRESSION | TRIPTOLIDE | Cell Proliferation | Epithelial Cells - metabolism | Cancer-Associated Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Epithelial Cells - drug effects | Humans | Cancer-Associated Fibroblasts - drug effects | Gene Expression Profiling | Carcinogenesis | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Disease Models, Animal | Signal Transduction | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Organophosphates - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Phenanthrenes - pharmacology | Cancer-Associated Fibroblasts - pathology | Animals | Mice | Mutation | Transforming Growth Factor beta - metabolism | Apoptosis | Deregulation | Deactivation | Epithelial cells | p53 Protein | Crosstalk | Stroma | Regression | Sp1 protein | Inactivation | Signal transduction | Signaling | Pancreatic cancer | Fibroblasts | Conditioning | Tumors | Cancer | Index Medicus | pancreatic stellate cells | TGFβ | Minnelide | pancreatic cancer | Cancer associated fibroblasts
Journal Article
Current Opinion in Gastroenterology, ISSN 0267-1379, 07/2016, Volume 32, Issue 5, pp. 401 - 407
PURPOSE OF REVIEWPancreatic cancer is the most devastating of all cancers with an extremely poor prognosis. In US alone, over 50 000 new cases of pancreatic... 
5-fluorouracil | Minnelide | pancreatic cancer | gemcitabine | HSP70 | chemotherapy | PLUS GEMCITABINE | SURVIVAL | HEAT-SHOCK-PROTEIN-70 | DUCTAL ADENOCARCINOMA | SECRETING TUMOR VACCINE | RANDOMIZED-TRIAL | PHASE-II | CELL-DEATH | IMMUNE ACTIVATION | GASTROENTEROLOGY & HEPATOLOGY | TRIPTOLIDE | Chemotherapy | Pancreatic Cancer | Gemcitabine
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2014, Volume 20, Issue 9, pp. 2388 - 2399
Purpose: Pancreatic adenocarcinoma is the fourth leading cause for cancer-related mortality with a survival rate of less than 5%. Late diagnosis and lack of... 
PROGENITOR CELLS | CHOLANGIOCARCINOMA | STEM-CELLS | ONCOLOGY | DUCTAL ADENOCARCINOMA | MARKER | C-MET | SELF-RENEWAL | EXPRESSION | TRIPTOLIDE | HEMATOPOIETIC STEM | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Glycoproteins - metabolism | Peptides - genetics | Cell Survival - genetics | Apoptosis - genetics | NF-kappa B - metabolism | Antineoplastic Agents - administration & dosage | Antigens, CD - genetics | Cell Movement - genetics | Antigens, CD - metabolism | Pancreatic Neoplasms - drug therapy | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Antigens, Surface - metabolism | Antineoplastic Agents - pharmacology | Disease Models, Animal | Glycoproteins - genetics | Organophosphates - administration & dosage | Cell Survival - drug effects | Gene Expression | Pancreatic Neoplasms - pathology | Phenanthrenes - administration & dosage | Immunophenotyping | Mice, Transgenic | Pancreatic Neoplasms - genetics | AC133 Antigen | Cell Transformation, Neoplastic - metabolism | Organophosphates - pharmacology | Phenanthrenes - pharmacology | Phenotype | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Index Medicus | Minnelide | Triptolide | pancreatic tumor initiating cells | NF-kB | CD133
Journal Article
Cancer Letters, ISSN 0304-3835, 2013, Volume 335, Issue 2, pp. 412 - 420
Journal Article
The Prostate, ISSN 0270-4137, 05/2017, Volume 77, Issue 6, pp. 584 - 596
Journal Article
Journal Article
Journal of Gastrointestinal Surgery, ISSN 1091-255X, 1/2016, Volume 20, Issue 1, pp. 13 - 24
Oxaliplatin is part of pancreatic cancer therapy in the FOLFIRINOX or GEMOX/XELOX regimen. DNA damage repair is one of the factors responsible for oxaliplatin... 
Minnelide | Oxaliplatin | Medicine & Public Health | DNA damage pancreatic cancer | Surgery | Triptolide | Gastroenterology | NER | SURGERY | BLADDER-CANCER | GEMCITABINE | NUCLEOTIDE EXCISION-REPAIR | CELL-DEATH | IN-VITRO | CISPLATIN | ERCC1 | GASTROENTEROLOGY & HEPATOLOGY | UP-REGULATION | EXPRESSION | Apoptosis - drug effects | Humans | Organophosphates - therapeutic use | Antineoplastic Agents - therapeutic use | Organoplatinum Compounds - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Epoxy Compounds - pharmacology | Female | Antineoplastic Agents - pharmacology | DNA Damage - drug effects | Diterpenes - pharmacology | Cell Survival - drug effects | Epoxy Compounds - therapeutic use | DNA Repair - drug effects | Diterpenes - therapeutic use | Phenanthrenes - therapeutic use | Pancreatic Neoplasms - pathology | Random Allocation | Down-Regulation - drug effects | Organophosphates - pharmacology | Phenanthrenes - pharmacology | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Mice | Organoplatinum Compounds - therapeutic use | Cell death | DNA damage | Analysis | Pancreatic cancer | DNA | Genetic research | Development and progression | Genetic aspects | Health aspects | DNA repair | Cancer | Index Medicus | triptolide
Journal Article