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Brain Behavior and Immunity, ISSN 0889-1591, 02/2018, Volume 68, pp. 132 - 145
Journal Article
Neurotoxicity Research, ISSN 1029-8428, 05/2017, Volume 31, Issue 4, pp. 505 - 520
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2013, Volume 33, Issue 10, pp. 4216 - 4233
Neurogenesis must be properly regulated to ensure that cell production does not exceed the requirements of the growing cerebral cortex, yet our understanding... 
HUMAN NEOCORTEX | BRAIN TRAUMA | RADIAL GLIAL-CELLS | HYPOXIA-ISCHEMIA | ADULT HIPPOCAMPAL NEUROGENESIS | SPINAL-CORD | ACTIVATED MICROGLIA | DENTATE GYRUS | NEUROSCIENCES | INTERMEDIATE PROGENITOR CELLS | PREFRONTAL CORTEX | Age Factors | Embryo, Mammalian | Minocycline - pharmacology | Cell Count | Male | Cerebral Cortex - cytology | Lipopolysaccharide Receptors - metabolism | Indoles - metabolism | Microglia - physiology | Cerebral Ventricles - growth & development | Female | Macaca | Microfilament Proteins - metabolism | Cerebral Ventricles - embryology | HLA-DR Antigens - metabolism | Animals, Newborn | Calcium-Binding Proteins - metabolism | Lipopolysaccharides - toxicity | Neural Stem Cells - drug effects | Phagocytosis - physiology | Neural Stem Cells - physiology | Rats | Cerebral Cortex - transplantation | T-Box Domain Proteins - metabolism | Nerve Tissue Proteins - metabolism | Pregnancy | Microscopy, Confocal | Animals | Analysis of Variance | Cerebral Cortex - embryology | Neurogenesis - physiology | Cerebral Cortex - growth & development | Luminescent Proteins - genetics | Cerebral Ventricles - cytology | Proliferating Cell Nuclear Antigen - metabolism | Prenatal Exposure Delayed Effects - chemically induced | Prenatal Exposure Delayed Effects - pathology | Luminescent Proteins - metabolism | Nitric Oxide Synthase Type II - metabolism
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2006, Volume 99, Issue 4, pp. 1263 - 1272
It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin‐1β... 
interleukin‐1β | interferon‐γ | long‐term potentiation | age | interleukin‐18 | microglial activation | Interleukin-18 | Interferon-γ | Interleukin-1β | Long-term potentiation | Age | Microglial activation | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | NEUROSCIENCES | PROTEIN-KINASES | CELL-DEATH | IN-VITRO | interleukin-1 beta | interleukin-18 | MOUSE MODEL | AGING HUMAN BRAIN | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | interferon-gamma | long-term potentiation | Memory Disorders - physiopathology | Microglia - metabolism | Interleukin-18 - immunology | Interleukin-1alpha - immunology | Rats, Wistar | Minocycline - pharmacology | Memory Disorders - metabolism | Interleukin-1alpha - metabolism | Male | Gliosis - physiopathology | Interferon-gamma - metabolism | Dentate Gyrus - physiopathology | CD40 Antigens - metabolism | Encephalitis - physiopathology | Microglia - immunology | Long-Term Potentiation - drug effects | Encephalitis - metabolism | Long-Term Potentiation - physiology | Gliosis - immunology | B7-2 Antigen - immunology | Cytokines - immunology | Biomarkers - metabolism | Dentate Gyrus - metabolism | Cytokines - metabolism | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Intercellular Adhesion Molecule-1 - immunology | Gliosis - metabolism | Rats | Encephalitis - immunology | Memory Disorders - immunology | B7-2 Antigen - metabolism | Hippocampus - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Aging - physiology | Interferon-gamma - immunology | Hippocampus - physiopathology | CD40 Antigens - immunology | Interleukin-18 - metabolism | Brain | Neurology | Cytokines | Long term | Rodents
Journal Article
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 10/2010, Volume 69, Issue 10, pp. 1017 - 1033
The complex manifestations of chronic multiple sclerosis (MS)are due in part to widespread axonal abnormalities that affect lesional and nonlesional areas in... 
Neurofascin | Node of Ranvier | Neuroinflammation | Multiple sclerosis | Sodium channel | Demyelination | CHANNEL EXPRESSION | MINOCYCLINE | SODIUM-CHANNELS | PATHOLOGY | NEUROSCIENCES | AUTOIMMUNE ENCEPHALOMYELITIS | CLINICAL NEUROLOGY | DEGENERATION | APPEARING WHITE-MATTER | JUNCTIONS | GLUTAMATE EXCITOTOXICITY | PARKINSONS-DISEASE | Peptide Fragments | Minocycline - pharmacology | Humans | Middle Aged | Encephalomyelitis, Autoimmune, Experimental - immunology | Caspase 1 - metabolism | Male | Ranvier's Nodes - metabolism | Brain - metabolism | DNA-Binding Proteins - metabolism | Anti-Bacterial Agents - therapeutic use | Microglia - immunology | Microglia - physiology | NAV1.6 Voltage-Gated Sodium Channel | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Minocycline - therapeutic use | Sodium Channels - metabolism | Microglia - pathology | Adult | Female | Indoles | HLA-DR Antigens - metabolism | Encephalomyelitis, Autoimmune, Experimental - pathology | Gene Expression Regulation - immunology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Myelin-Oligodendrocyte Glycoprotein | Glycoproteins | Ranvier's Nodes - drug effects | CD3 Complex - metabolism | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Microscopy, Confocal | Animals | Analysis of Variance | Kv1.2 Potassium Channel - metabolism | Axons - pathology | Brain - pathology | Multiple Sclerosis - pathology | Aged | Anti-Bacterial Agents - pharmacology | Mice | Ranvier's Nodes - pathology | Neurofilament Proteins - metabolism | Postmortem Changes | Nitric Oxide Synthase Type II - metabolism
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 7/2016, Volume 53, Issue 5, pp. 2761 - 2777
Accumulation of zinc (Zn) in dopaminergic neurons is implicated in Parkinson’s disease (PD), and microglial activation plays a critical role in toxin-induced... 
Neurology | Oxidative stress | Neurosciences | Biomedicine | Dopaminergic neurodegeneration | Neurobiology | Minocycline | Zinc | Parkinson’s disease | Cell Biology | Microglia | NADPH OXIDASE | Parkinson's disease | MICROGLIAL ACTIVATION | MOUSE | PARKINSONS-DISEASE PHENOTYPE | SUBSTANTIA-NIGRA | NEUROTOXICITY | NEUROSCIENCES | CELL-DEATH | MICE | HEME OXYGENASE-1 | Substantia Nigra - physiopathology | Microglia - metabolism | Tyrosine 3-Monooxygenase - metabolism | Heme Oxygenase-1 - metabolism | Rats, Wistar | Substantia Nigra - pathology | Antigens, Nuclear - metabolism | Dopaminergic Neurons - pathology | Minocycline - pharmacology | Caspase 3 - metabolism | NADPH Oxidases - metabolism | Nerve Degeneration - physiopathology | Male | Substantia Nigra - metabolism | Motor Activity | Nerve Degeneration - metabolism | Behavior, Animal | Membrane Transport Proteins - genetics | Minocycline - therapeutic use | Dopaminergic Neurons - metabolism | Lipid Peroxidation - drug effects | Dopaminergic Neurons - drug effects | Microglia - pathology | Membrane Transport Proteins - metabolism | Dopamine - metabolism | Microglia - drug effects | Cytochromes c - metabolism | Metabolome | Mitochondria - metabolism | Mitochondria - drug effects | Nerve Degeneration - pathology | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Rotarod Performance Test | Substantia Nigra - drug effects | Animals | CD11b Antigen - metabolism | Oxidative Stress - drug effects | Nerve Degeneration - drug therapy | Oxidases | Tyrosine | Cytochrome c | Phosphates | Niacinamide | Zinc compounds | Neurons | Heme | Mitochondrial DNA | Superoxide | Biochemistry | Dopamine | Molecular biology | Neurodegeneration | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2015, Volume 308, Issue 8, pp. E688 - E698
Neuroinflammation and neurodegeneration have been observed in the brain in type 1 diabetes (T1D). However, little is known about the mediators of these... 
Brain | Inflammation | Diabetes | Sympathetic nervous system | OXIDATIVE STRESS | PHYSIOLOGY | MICROGLIAL ACTIVATION | sympathetic nervous system | INDOLEAMINE 2,3-DIOXYGENASE | RAT HYPOTHALAMUS | brain | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | MATRIX METALLOPROTEINASES | inflammation | DOUBLE-EDGED-SWORD | ENDOCRINOLOGY & METABOLISM | RETINOPATHY | CENTRAL-NERVOUS-SYSTEM | diabetes | GROWTH-FACTOR-I | Encephalitis - prevention & control | Microglia - metabolism | Astrocytes - pathology | Male | Sympathetic Nervous System - immunology | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Minocycline - therapeutic use | Microglia - pathology | Diabetic Neuropathies - immunology | Neurons - metabolism | Sympathetic Nervous System - pathology | Hypothalamus - drug effects | Diabetic Neuropathies - prevention & control | Macrophages - pathology | Encephalitis - immunology | Hypothalamus - pathology | Disease Progression | Macrophages - metabolism | Hypothalamus - metabolism | Diabetic Neuropathies - metabolism | Insulin-Like Growth Factor I - metabolism | Astrocytes - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Neurons - pathology | Sympathetic Nervous System - drug effects | Diabetes Mellitus, Type 1 - complications | Sympathetic Nervous System - metabolism | Microglia - immunology | Astrocytes - immunology | Encephalitis - metabolism | Inflammation Mediators - metabolism | Encephalitis - complications | Inflammation Mediators - antagonists & inhibitors | Neurons - drug effects | Macrophages - immunology | Hypothalamus - immunology | Astrocytes - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Microglia - drug effects | Diabetes Mellitus, Type 1 - physiopathology | Mice, Inbred C57BL | Neurons - immunology | Down-Regulation - drug effects | Diabetes Mellitus, Type 1 - drug therapy | Nerve Tissue Proteins - metabolism | Up-Regulation - drug effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Diabetic Neuropathies - pathology | Macrophages - drug effects | Complications and side effects | Type 1 diabetes | Physiological aspects | Nervous system | Degeneration | Risk factors
Journal Article
Inflammation Research, ISSN 1023-3830, 2/2017, Volume 66, Issue 2, pp. 157 - 166
Chronic low-grade inflammation occurs in diabetic retinopathy (DR), but the underlying mechanism(s) remains (remain) unclear. NLRP3 inflammasome activation is... 
Allergology | Neurology | Diabetic retinopathy | Biomedicine | Immunology | Dermatology | Rheumatology | Minocycline | Pharmacology/Toxicology | NLRP3 inflammasome | PATHOGENESIS | OXIDATIVE STRESS | ENDOTHELIAL-CELLS | IMMUNOLOGY | EXPRESSION | CELL BIOLOGY | Diabetic Retinopathy - drug therapy | RNA, Small Interfering - genetics | Diabetes Mellitus, Experimental - drug therapy | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Minocycline - pharmacology | Humans | Caspase 3 - metabolism | Capillary Permeability - drug effects | Caspase 1 - metabolism | Male | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Interleukin-1beta - metabolism | Minocycline - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Diabetes Mellitus, Experimental - metabolism | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Cells, Cultured | Glucose - pharmacology | Inflammation | Rats, Sprague-Dawley | Diabetic Retinopathy - metabolism | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Interleukin-18 - metabolism | Endothelial Cells - drug effects | Antioxidants | Interleukins | Analysis | Permeability | Glucose | Ophthalmology | Dextrose
Journal Article
Journal Article
Brain, ISSN 0006-8950, 11/2009, Volume 132, Issue 11, pp. 3152 - 3164
Journal Article
Experimental Physiology, ISSN 0958-0670, 06/2018, Volume 103, Issue 6, pp. 884 - 895
New Findings What is the central question of this study? Microglia are presumed to be the source of inflammatory mediators that contribute to hypoxia‐induced... 
C1 region | inflammation | microglia | hypothalamic paraventricular nucleus | acute hypoxia | PROJECTING CATECHOLAMINERGIC NEURONS | ACTIVATION | PHYSIOLOGY | MECHANISMS | INTERLEUKIN-6 | PARAVENTRICULAR NUCLEUS | ROSTRAL VENTROLATERAL MEDULLA | GENE-EXPRESSION | NF-KAPPA-B | HYPOTHALAMUS | Biomarkers - metabolism | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | Tyrosine 3-Monooxygenase - metabolism | Microglia - drug effects | Rats, Wistar | Autonomic Nervous System - drug effects | Medulla Oblongata - drug effects | Minocycline - pharmacology | Medulla Oblongata - metabolism | Rats | Male | RNA, Messenger - metabolism | Hypoxia - metabolism | Inflammation - metabolism | Matrix Metalloproteinase 9 - metabolism | Paraventricular Hypothalamic Nucleus - drug effects | Animals | Paraventricular Hypothalamic Nucleus - metabolism | Autonomic Nervous System - metabolism | Neurons - metabolism | Neurons - drug effects | Brain | Genetic research | Physiological aspects | Minocycline | Inflammation | Diagnosis | Gene expression | Tyrosine | Immune response | Neurons | Hydroxylase | Central nervous system | Hypothalamus | Matrix metalloproteinase | Tumor necrosis factor-α | Paraventricular nucleus | IL-1β | Tyrosine 3-monooxygenase | Gelatinase B | Autonomic nervous system | Rodents | Ventilation | Hypoxia | Metalloproteinase | Medulla oblongata | Tumors
Journal Article