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Biomaterials, ISSN 0142-9612, 2011, Volume 33, Issue 7, pp. 2372 - 2387
Abstract In this study, the aminated gelatin was grafted with carboxylic end-capped poly( N -isopropylacrylamide) (PN) via a carbodiimide-mediated coupling... 
Advanced Basic Science | Dentistry | Intracameral delivery system | Pilocarpine | Biodegradable in situ forming gel | Gelatin- g-PNIPAAm | Glaucoma therapy | Gelatin-g-PNIPAAm | MATERIALS SCIENCE, BIOMATERIALS | POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS | ENGINEERING, BIOMEDICAL | HYALURONIC-ACID HYDROGELS | CONTROLLED-RELEASE | CELL SHEET | OCULAR DRUG-DELIVERY | LINKED GELATIN MEMBRANES | N-ISOPROPYLACRYLAMIDE | OPHTHALMIC DELIVERY | EPITHELIAL-CELLS | ARTIFICIAL EXTRACELLULAR-MATRIX | Biocompatible Materials - metabolism | Intraocular Pressure - drug effects | Miotics - therapeutic use | Biocompatible Materials - chemistry | Humans | Spectroscopy, Fourier Transform Infrared | Drug Carriers - chemistry | Miotics - pharmacology | Pilocarpine - pharmacokinetics | Biocompatible Materials - chemical synthesis | Pilocarpine - therapeutic use | Miotics - pharmacokinetics | Miotics - administration & dosage | Acrylamides - metabolism | Acrylic Resins | Molecular Structure | Pilocarpine - administration & dosage | Gelatin - chemistry | Rabbits | Drug Carriers - metabolism | Polymers - chemical synthesis | Ophthalmic Solutions - administration & dosage | Ophthalmic Solutions - therapeutic use | Glaucoma - drug therapy | Materials Testing | Drug Carriers - chemical synthesis | Acrylamides - chemistry | Animals | Gelatin - chemical synthesis | Pilocarpine - pharmacology | Polymers - chemistry | Gelatin - metabolism | Drug Delivery Systems - methods | Acrylamides - chemical synthesis | Polymers - metabolism | Glaucoma | Biological products | Ophthalmology | Universities and colleges | Analysis | Biomedical engineering | Drugs | Biodegradability | Delivery systems | Forming | Gelatins | Grafting | Density
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 10/2015, Volume 21, Issue 32, pp. 4673 - 4681
Journal Article
Biochemistry, ISSN 0006-2960, 08/2017, Volume 56, Issue 30, pp. 3877 - 3880
The second extracellular loop (ECL2) of the G protein-coupled receptor (GPCR) family is important for ligand interaction and drug discovery. ECL2 of the family... 
COMPLEX | ACTIVATION | GENE-RELATED PEPTIDE | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Protein Multimerization | Cercopithecus aethiops | Peptide Fragments - pharmacology | Receptor Activity-Modifying Protein 1 - chemistry | Calcitonin Gene-Related Peptide - chemistry | Receptors, Calcitonin Gene-Related Peptide - metabolism | Calcitonin Receptor-Like Protein - agonists | Miotics - pharmacology | Receptors, Calcitonin Gene-Related Peptide - chemistry | Miotics - metabolism | Receptors, Calcitonin Gene-Related Peptide - agonists | Protein Interaction Domains and Motifs | Calcitonin Gene-Related Peptide - metabolism | Binding Sites | Peptide Fragments - genetics | Binding, Competitive | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Calcitonin Gene-Related Peptide - pharmacology | Miotics - chemistry | Calcitonin Receptor-Like Protein - chemistry | Models, Molecular | Receptor Activity-Modifying Protein 1 - metabolism | Recombinant Proteins - chemistry | Calcitonin Gene-Related Peptide - genetics | Receptor Activity-Modifying Protein 1 - genetics | Recombinant Proteins - pharmacology | Calcitonin Receptor-Like Protein - metabolism | Protein Interaction Mapping | Point Mutation | Peptide Fragments - chemistry | Animals | Signal Transduction - drug effects | Calcitonin Receptor-Like Protein - genetics | Ligands | Protein Conformation | Receptors, Calcitonin Gene-Related Peptide - genetics | Structural Homology, Protein | Kinetics | COS Cells | Amino Acid Substitution | Usage | Research | Antibiosis | Antimetabolites | Calcitonin
Journal Article
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 2011, Volume 411, Issue 1, pp. 78 - 85
gelling systems are viscous polymer-based solutions that exhibit a sol-to-gel phase transition upon change in a physicochemical parameter such as ionic... 
Ocular irritancy | Anionic polysaccharides | Pharmacokinetic study | Ocular drug delivery | Gamma scintigraphy | In situ gelling systems | VITRO | DRAINAGE | MICROEMULSIONS | RESIDENCE | FORMULATIONS | IRRITATION | PHARMACOLOGY & PHARMACY | RABBIT | Viscosity | Excipients - pharmacokinetics | Humans | Carrageenan - chemistry | Ophthalmic Solutions - chemistry | Male | Ophthalmic Solutions - pharmacokinetics | Drug Delivery Systems | Pilocarpine - pharmacokinetics | Miotics - pharmacokinetics | Anions | Excipients - chemistry | Chemical Phenomena | Gels - pharmacokinetics | Miotics - administration & dosage | Gels - chemistry | Pilocarpine - administration & dosage | Polysaccharides, Bacterial - chemistry | Rabbits | Ophthalmic Solutions - administration & dosage | Eye - chemistry | Gels - administration & dosage | Miotics - chemistry | Carrageenan - pharmacokinetics | Cornea - chemistry | Polysaccharides, Bacterial - metabolism | Excipients - administration & dosage | Cornea - metabolism | Animals | Pilocarpine - chemistry | Polysaccharides, Bacterial - analysis | Carrageenan - administration & dosage | Drugs | Methylcellulose | Drug delivery systems | Polysaccharides | Surface active agents | Pilocarpine | Universities and colleges | Comparative analysis | Polyamines | Vehicles | Pharmacodynamics | carrageenans | Drains | Xanthan gum | Drug delivery | pH effects | Ionic strength | Temperature effects | Cations | gellan gum | Tears | Phase transition | Radioactivity
Journal Article
Journal Article
JAMA Ophthalmology, ISSN 2168-6165, 09/2016, Volume 134, Issue 9, pp. 976 - 981
IMPORTANCE: The in vivo effect of pilocarpine hydrochloride on the Schlemm canal may help explain its pharmacologic mechanism of action and better indicate its... 
Trabecular Meshwork - pathology | Intraocular Pressure - drug effects | Follow-Up Studies | Humans