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Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 97 - 122
A healthy proteome is essential for cell survival. Protein misfolding is linked to a rapidly expanding list of human diseases, ranging from neurodegenerative... 
neurodegenerative diseases | aging | molecular chaperones | proteostasis | protein aggregation | misfolded protein clearance | Aging | Protein aggregation | Misfolded protein clearance | Proteostasis | Molecular chaperones | Neurodegenerative diseases | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AGGREGATED PROTEINS | ER-ASSOCIATED DEGRADATION | HEAT-SHOCK | ALPHA-SYNUCLEIN | DAMAGED PROTEINS | EUKARYOTIC STRESS GRANULES | ASYMMETRIC INHERITANCE | MISFOLDED PROTEINS | Proteostasis Deficiencies - metabolism | Protein Biosynthesis | Molecular Chaperones - metabolism | Humans | Amyloidogenic Proteins - chemistry | Prion Proteins - metabolism | Cell Compartmentation | Aging - genetics | Protein Aggregation, Pathological - pathology | Proteolysis | Prion Proteins - chemistry | Prion Proteins - genetics | Protein Aggregation, Pathological - genetics | Amyloidogenic Proteins - genetics | Neurodegenerative Diseases - pathology | Gene Expression Regulation | Molecular Chaperones - genetics | Protein Refolding | Proteostasis Deficiencies - pathology | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Protein Folding | Aging - pathology | Proteostasis Deficiencies - genetics | Amyloidogenic Proteins - metabolism | Protein Conformation | Protein Aggregation, Pathological - metabolism | Aging - metabolism | Physiological aspects | Research | Protein folding | Proteomics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2016, Volume 291, Issue 23, pp. 12245 - 12253
Protein homeostasis is maintained by quality control mechanisms that detect and eliminate deficient translation products. Cytosolic defective proteins can... 
YEAST | MESSENGER-RNA SURVEILLANCE | DISSOCIATION | QUALITY-CONTROL COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEASOME | DEGRADATION | MISFOLDED PROTEINS | TRANSLATION | TRANSCRIPTION FACTOR | RIBOSOME | Protein Aggregates | RNA-Binding Proteins - genetics | Threonine - chemistry | Saccharomyces cerevisiae - genetics | Valosin Containing Protein | Alanine - chemistry | Threonine - metabolism | Cell Cycle Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Ubiquitination | Ribosome Subunits, Large, Eukaryotic - metabolism | Alanine - genetics | Proteolysis | Threonine - genetics | Cell Cycle Proteins - genetics | Protein Biosynthesis - genetics | Proteomics - methods | Ribosome Subunits, Large, Eukaryotic - genetics | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Alanine - metabolism | Saccharomyces cerevisiae Proteins - genetics | Ubiquitin-Protein Ligases - chemistry | Blotting, Western | Saccharomyces cerevisiae Proteins - metabolism | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | RNA-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | translation control | Saccharomyces cerevisiae | protein aggregation | protein degradation | ubiquitin | Protein Synthesis and Degradation
Journal Article
PLoS Genetics, ISSN 1553-7390, 12/2016, Volume 12, Issue 12, p. e1006531
Safeguarding the proteome is central to the health of the cell. In multi-cellular organisms, the composition of the proteome, and by extension, protein-folding... 
MYOD HOMOLOG HLH-1 | PROTEIN-QUALITY CONTROL | BODY-WALL MUSCLE | GENETICS & HEREDITY | MOLECULAR CHAPERONE | MUSCULAR-DYSTROPHY | C-ELEGANS | MISFOLDED PROTEINS | UNC-45 CHAPERONE | J-DOMAIN PROTEIN | FUNCTIONAL SPECIFICITY | Molecular Chaperones - metabolism | Caenorhabditis elegans Proteins - metabolism | Heat-Shock Proteins - biosynthesis | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Heat-Shock Proteins - genetics | Gene Expression Regulation, Developmental | HSP90 Heat-Shock Proteins - genetics | Binding Sites | Molecular Chaperones - biosynthesis | Promoter Regions, Genetic | HSP40 Heat-Shock Proteins - metabolism | Caenorhabditis elegans - growth & development | HSP40 Heat-Shock Proteins - genetics | Myogenic Regulatory Factors - genetics | Caenorhabditis elegans - genetics | Embryonic Development - genetics | Molecular Chaperones - genetics | Muscle Cells - metabolism | Myogenic Regulatory Factors - metabolism | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | HSP90 Heat-Shock Proteins - metabolism | Muscle Development - genetics | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans Proteins - biosynthesis | Biotechnology | Immunoglobulins | Transcription factors | Young adults | Funding | Genes | Colleges & universities | Experiments | Embryos | Proteins | Life sciences | Bioinformatics | Age
Journal Article