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MOLECULAR AND CELLULAR NEUROSCIENCE, ISSN 1044-7431, 11/2014, Volume 63, pp. 13 - 23
Mitochondria( dysfunction and oxidative stress are implicated in many neurodegenerative diseases. Mitochondria-targeted drugs that effectively decrease... 
OXIDATIVE STRESS | DEPRIVED SYMPATHETIC NEURONS | Caspase | NEUROSCIENCES | NERVE GROWTH-FACTOR | CELL-DEATH | PERMEABILITY TRANSITION | Cytochrome c | INHIBITS APOPTOSIS | Mitochondria | TARGETED ANTIOXIDANT MITOQ | MitoQ | ROS | IN-VIVO | DEGENERATIVE DISEASES | CYTOCHROME-C RELEASE | Apoptosis
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2019, Volume 370, pp. 78 - 92
Mitochondrial dysfunctions induced by oxidative stress could play a pivotal role in the development of testicular damage and degeneration, leading to impaired... 
Blood-Testis Barrier | MitoQ | Oxidative Stress | Nrf2/Keap1 | Pharmacokinetics | Mitochondrial Targeting | SPERMATOGENESIS | BARRIER | MALE-INFERTILITY | TARGETED ANTIOXIDANT MITOQ | REACTIVE OXYGEN | SIGNALING PATHWAY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DYSFUNCTION | STRESS | TRIPTOLIDE | MOLECULAR-MECHANISMS | Proteins | Antioxidants | Testosterone | Analysis | Genes
Journal Article
British Journal of Nutrition, ISSN 0007-1145, 02/2016, Volume 115, Issue 7, pp. 1155 - 1166
Journal Article
ISSN 0925-4439, 2018
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra compacta (SNc). Although mitochondrial... 
Mitochondrial fusion | Mfn2 | PGC-1α | Parkinson's disease | MitoQ
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 11/2010, Volume 432, Issue 1, pp. 9 - 19
Journal Article
Redox Biology, ISSN 2213-2317, 2013, Volume 1, Issue 1, pp. 86 - 93
Mitochondria are recognized as critical sites of localized injury in a number of chronic pathologies which has led to the development of organelle directed... 
Extracellular flux | Mitochondria | TPP+ derivatives | MitoQ | Redox | Respiration | Mitochondrial targeted compounds | BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 02/2018, Volume 341, pp. 1 - 7
Exposure to iron ion Fe radiation (IR) during space missions poses a significant risk to the central nervous system and radiation exposure is intimately linked... 
56Fe ion radiation | Oxidative stress | Mitochondria | MitoQ | Fe ion radiation | Index Medicus
Journal Article
Nature Reviews Neuroscience, ISSN 1471-003X, 02/2018, Volume 19, Issue 2, pp. 63 - 80
Synapses enable neurons to communicate with each other and are therefore a prerequisite for normal brain function. Presynaptically, this communication requires... 
MOTOR-NERVE TERMINALS | PRIMARY CORTICAL-NEURONS | SYSTEM IN-VIVO | AMYLOID BETA-PEPTIDE | TARGETED ANTIOXIDANT MITOQ | SYNAPTIC VESICLE ENDOCYTOSIS | FAST AXONAL-TRANSPORT | DYNAMIN-RELATED PROTEIN-1 | AMYOTROPHIC-LATERAL-SCLEROSIS | ACTIVITY-DEPENDENT REGULATION | NEUROSCIENCES | Presynapse | Homeostasis | Calcium buffering | Mitochondria
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9170 - 9179
Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to... 
ANTIOXIDANT MITOQ | IN-VITRO | CHEMISTRY, MEDICINAL | TRIPHENYLPHOSPHONIUM CATIONS | DELIVERY-SYSTEMS | NITROGEN-MUSTARD | CHRONIC LYMPHOCYTIC-LEUKEMIA | DNA-REPAIR | CELL-LINES | IMAGING AGENTS | STRAND BREAKS
Journal Article
BMC Medicine, ISSN 1741-7015, 08/2013, Volume 11, Issue 1, pp. 178 - 178
Background: MitoQ is a mitochondria-targeted derivative of the antioxidant ubiquinone, with antioxidant and anti-apoptotic functions. Reactive oxygen species... 
MitoQ;NLRP-3 inflammasome | Reactive oxygen species | Interleukin-18 | Dextran sulfate sodium | Interleukin-1 beta | OXIDATIVE STRESS | NADPH-OXIDASE | CROHNS-DISEASE | INTERLEUKIN-1 RECEPTOR ANTAGONIST | ULCERATIVE-COLITIS | MitoQ:NLRP-3 inflammasome | BOWEL-DISEASE | INTESTINAL INFLAMMATION | MEDICINE, GENERAL & INTERNAL | T-CELL-ACTIVATION | ANIMAL-MODELS | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Colitis - pathology | Male | Inflammasomes - antagonists & inhibitors | Ubiquinone - therapeutic use | Female | Colitis - drug therapy | Inflammation Mediators - antagonists & inhibitors | Inflammation Mediators - physiology | Disease Models, Animal | Carrier Proteins - physiology | Ubiquinone - administration & dosage | Ubiquinone - analogs & derivatives | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Organophosphorus Compounds - therapeutic use | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Mitochondria - pathology | Inflammasomes - physiology | Antioxidants - therapeutic use | Animals | Colitis - metabolism | Mice | Mice, Inbred BALB C | Organophosphorus Compounds - administration & dosage | Drug Delivery Systems - methods | Antioxidants | Medical research | Inflammatory bowel diseases | Interleukins | Cytokines | Medicine, Experimental | Ubiquinones | Inflammation | Colitis | Apoptosis | Inflammatory bowel disease | Proteins | Medicine | Studies | Mitochondria | Womens health | Pathogenesis | Lymphocytes | Rodents | Clinical trials | Animal models
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2015, Volume 29, Issue 12, pp. 4766 - 4771
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 09/2018, Volume 1864, Issue 9, pp. 2859 - 2870
Journal Article