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Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 38, pp. 26481 - 26491
The B cell lymphoma-2 (BCL-2) family is the key mediator of cellular sensitivity to apoptosis during pharmacological interventions for numerous human... 
POTENT | OLIGOMERIZES BAK | CANCERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MITOCHONDRIAL-MEMBRANE | INHIBITORS | CYTOCHROME-C RELEASE | DISCOVERY | ADDICTION | MEMBRANE PERMEABILIZATION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Mitochondria, Liver - metabolism | Humans | Unilamellar Liposomes - chemistry | bcl-2-Associated X Protein - physiology | Piperazines - chemistry | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | Nitrophenols - chemistry | Benzopyrans - chemistry | bcl-X Protein - chemistry | Molecular Mimicry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Membrane Proteins - physiology | Sulfones - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Benzamides - pharmacology | Protein Interaction Domains and Motifs | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzamides - chemistry | Aniline Compounds - pharmacology | BH3 Interacting Domain Death Agonist Protein - physiology | Sulfonamides - chemistry | Apoptosis Regulatory Proteins - chemistry | Permeability | Sulfonamides - pharmacology | Piperazines - pharmacology | Mitochondrial Membranes - metabolism | Mitochondria, Liver - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - physiology | Pyrroles - pharmacology | Animals | Membrane Proteins - chemistry | bcl-X Protein - physiology | Nitriles - chemistry | Proto-Oncogene Proteins - physiology | Pyrroles - chemistry | Apoptosis Regulatory Proteins - physiology | Mice | Aniline Compounds - chemistry | HeLa Cells | Index Medicus | BH3 Mimetics | MOMP | Mitochondria | Bcl-2 Proteins | Bax | Anticancer Drug | Cell Biology | Apoptosis
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 11/2018, Volume 362, Issue 6416, pp. 829 - 834
Membrane proteins reside in lipid bilayers and are typically extracted from this environment for study, which often compromises their integrity. In this work,... 
OUTER-MEMBRANE | NMR | OXIDASE | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | LIPIDS | SUBUNIT | Molecular Chaperones - metabolism | Bacterial Proteins - chemistry | Porins - metabolism | Molecular Chaperones - chemistry | Proteome - chemistry | Adenine Nucleotide Translocator 1 - chemistry | Cattle | Mass Spectrometry | Mitochondrial Membranes - chemistry | Porins - chemistry | Membrane Proteins - metabolism | SEC Translocation Channels - chemistry | SEC Translocation Channels - metabolism | Bacterial Outer Membrane Proteins - chemistry | Escherichia coli Proteins - metabolism | Adenine Nucleotide Translocator 1 - metabolism | Mitochondrial Proton-Translocating ATPases - chemistry | Mitochondrial Proton-Translocating ATPases - metabolism | Mitochondrial Membranes - metabolism | Animals | Bacterial Outer Membrane Proteins - metabolism | Membrane Proteins - chemistry | Protein Conformation, beta-Strand | Bacterial Proteins - metabolism | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Escherichia coli Proteins - chemistry | Proteome - metabolism | Physiological aspects | Mass spectrometry | Methods | Membrane proteins | Escherichia coli | Muscle proteins | Fatty acids | Porins | Adenosine triphosphate | Adenosine triphosphatase | Stoichiometry | Membranes | Outer membranes | Lipids | Translocase | Chaperones | ADP | Lipid bilayers | Proteins | Mitochondria | E coli | Bacteria | Assemblies | Efflux | Inner membranes | Adenosine | Adenosine diphosphate | Membrane vesicles | Mass spectroscopy | Electron microscopy | Organic chemistry | Scientific imaging | Dimers | Disruption | ATP | Ejection | Index Medicus
Journal Article
Biochemistry, ISSN 0006-2960, 12/2014, Volume 53, Issue 49, pp. 7816 - 7823
Through a ligand-directed tosyl (LDT) chemistry strategy using the synthetic acetogenin ligand AL1, we succeeded in the pinpoint alkynylation (-C=CH) of Asp160... 
SITE | CYCLOADDITION | DOMAIN | SPACER | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARCHITECTURE | DYNAMIC FUNCTION | PROTEINS | INHIBITORY-ACTION | NADH-UBIQUINONE OXIDOREDUCTASE | ACETOGENINS | Catalytic Domain - drug effects | NADH Dehydrogenase - antagonists & inhibitors | Mitochondria, Heart - metabolism | Molecular Weight | Benzoates - chemistry | Furans - pharmacology | Mitochondria, Heart - drug effects | Acetogenins - metabolism | Electron Transport Complex I - metabolism | Acetogenins - chemistry | Protein Subunits - metabolism | Tosyl Compounds - pharmacology | Pyrazoles - chemistry | Cattle | Furans - chemistry | Enzyme Inhibitors - chemistry | Indicators and Reagents - pharmacology | Indicators and Reagents - chemistry | Quinazolines - chemistry | Tosyl Compounds - antagonists & inhibitors | Pyrazoles - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Click Chemistry | Enzyme Inhibitors - pharmacology | Mitochondria, Heart - enzymology | Models, Molecular | Tosyl Compounds - chemistry | NADH Dehydrogenase - chemistry | NADH Dehydrogenase - metabolism | Electron Transport Complex I - chemistry | Animals | Benzoates - pharmacology | Ligands | Protein Conformation | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Aspartic Acid - chemistry | Quinazolines - pharmacology | Chemical reactions | Analysis | Proteomics | Index Medicus
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 840 - 846
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2006, Volume 281, Issue 12, pp. 7834 - 7841
Journal Article