X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (59940) 59940
Publication (4845) 4845
Newspaper Article (659) 659
Book Chapter (509) 509
Book Review (385) 385
Conference Proceeding (102) 102
Book / eBook (100) 100
Dissertation (80) 80
Magazine Article (43) 43
Newsletter (38) 38
Data Set (14) 14
Web Resource (14) 14
Reference (12) 12
Trade Publication Article (9) 9
Government Document (7) 7
Paper (2) 2
Report (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (40515) 40515
rats (26402) 26402
mitochondria (24596) 24596
male (17453) 17453
humans (15419) 15419
index medicus (15138) 15138
mitochondria, liver - metabolism (12991) 12991
biochemistry & molecular biology (11751) 11751
mitochondria - metabolism (10703) 10703
mice (8420) 8420
liver (8097) 8097
mitochondria, liver - drug effects (7770) 7770
mitochondria, liver - enzymology (7717) 7717
oxidative stress (7478) 7478
apoptosis (7397) 7397
female (6946) 6946
liver - metabolism (6539) 6539
cell biology (6427) 6427
metabolism (5840) 5840
kinetics (5556) 5556
proteins (5182) 5182
in vitro techniques (4873) 4873
mitochondria - drug effects (4764) 4764
oxidation-reduction (4319) 4319
research (4134) 4134
mitochondrial dna (4114) 4114
liver - enzymology (3916) 3916
research article (3629) 3629
mitochondria - enzymology (3573) 3573
rats, wistar (3497) 3497
liver - drug effects (3454) 3454
physiological aspects (3404) 3404
multidisciplinary sciences (3282) 3282
rodents (3237) 3237
biophysics (3154) 3154
rats, inbred strains (3121) 3121
reactive oxygen species - metabolism (3044) 3044
enzymes (3007) 3007
oxidative phosphorylation (2980) 2980
medicine (2965) 2965
pharmacology & pharmacy (2952) 2952
liver - cytology (2951) 2951
physiology (2946) 2946
rat-liver mitochondria (2840) 2840
phosphorylation (2769) 2769
time factors (2769) 2769
gene expression (2692) 2692
article (2669) 2669
oxygen consumption (2665) 2665
microscopy, electron (2632) 2632
oxygen consumption - drug effects (2611) 2611
cells (2601) 2601
calcium - metabolism (2563) 2563
apoptosis - drug effects (2533) 2533
cancer (2514) 2514
expression (2509) 2509
biology (2493) 2493
rats, sprague-dawley (2474) 2474
reactive oxygen species (2449) 2449
biochemistry (2431) 2431
toxicology (2417) 2417
adenosine triphosphate - metabolism (2361) 2361
analysis (2343) 2343
cells, cultured (2339) 2339
science (2267) 2267
inhibition (2231) 2231
activation (2175) 2175
liver - pathology (2046) 2046
cattle (1996) 1996
hydrogen-ion concentration (1996) 1996
endocrinology & metabolism (1993) 1993
oncology (1932) 1932
antioxidants (1930) 1930
energy metabolism (1926) 1926
signal transduction (1911) 1911
electron transport (1872) 1872
cell line, tumor (1861) 1861
rat-liver (1851) 1851
health aspects (1833) 1833
toxicity (1833) 1833
medicine, research & experimental (1805) 1805
lipids (1798) 1798
mice, inbred c57bl (1793) 1793
molecular sequence data (1789) 1789
calcium (1763) 1763
permeability (1763) 1763
cell line (1747) 1747
dose-response relationship, drug (1746) 1746
kinases (1743) 1743
fatty acids (1725) 1725
adult (1715) 1715
hepatocytes (1695) 1695
oxidation (1646) 1646
amino acid sequence (1645) 1645
mutation (1630) 1630
cell-death (1621) 1621
oxidative phosphorylation - drug effects (1620) 1620
mitochondria, liver - ultrastructure (1614) 1614
cell death (1574) 1574
fatty acids - metabolism (1567) 1567
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (42) 42
Earth Sciences (Noranda) - Stacks (15) 15
UofT at Mississauga - Stacks (11) 11
Online Resources - Online (5) 5
UofT at Scarborough - Stacks (4) 4
UTL at Downsview - May be requested (3) 3
University Archives - Archives (3) 3
UofT at Scarborough - May be requested in 6-10 wks (3) 3
Collection Dvlpm't (Acquisitions) - Closed Orders (2) 2
Gerstein Science - Theses (2) 2
Chemistry (A D Allen) - Stacks (1) 1
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
Earth Sciences (Noranda) - Circulation Desk (1) 1
Earth Sciences (Noranda) - Oversize (1) 1
Gerstein Science - Circulation Desk (1) 1
Gerstein Science - Missing (1) 1
Gerstein Science - Reserve desk (1) 1
St. Michael's College (John M. Kelly) - 2nd Floor (1) 1
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
Thomas Fisher Rare Book - Rare Book (1) 1
Trinity College (John W Graham) - Stacks (1) 1
UofT at Mississauga - Circulation Desk (1) 1
Victoria University E.J. Pratt - Circulation Desk (1) 1
Victoria University E.J. Pratt - Oversize (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (56247) 56247
Russian (2308) 2308
German (735) 735
French (482) 482
Japanese (399) 399
Italian (309) 309
Chinese (191) 191
Ukrainian (129) 129
Polish (111) 111
Spanish (104) 104
Portuguese (41) 41
Czech (22) 22
Hungarian (21) 21
Slovak (20) 20
Romanian (19) 19
Korean (18) 18
Bulgarian (17) 17
Dutch (8) 8
Lithuanian (5) 5
Swedish (4) 4
Croatian (3) 3
Norwegian (3) 3
Serbian (3) 3
Hebrew (2) 2
Danish (1) 1
Finnish (1) 1
Hindi (1) 1
Persian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Drug Metabolism Reviews, ISSN 0360-2532, 2/2012, Volume 44, Issue 1, pp. 34 - 87
A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive metabolites that trigger hepatitis through direct toxicity or immune... 
drug-induced liver injury | susceptibility | idiosyncrasy | liver | hepatotoxicity | mitochondria | mitochondrial DNA | mitochondrial permeability transition | mitochondrial dysfunction | Adverse drug reactions | hepatitis | steatosis | adverse drug reactions | PERMEABILITY TRANSITION PORE | COA DEHYDROGENASE-DEFICIENCY | ENDOPLASMIC-RETICULUM STRESS | HUMAN-IMMUNODEFICIENCY-VIRUS | ISOLATED RAT HEPATOCYTES | REVERSE-TRANSCRIPTASE INHIBITORS | HEPATITIS-C VIRUS | HEPATOCYTE PLASMA-MEMBRANE | FATTY-ACID OXIDATION | MANGANESE SUPEROXIDE-DISMUTASE | PHARMACOLOGY & PHARMACY | Liver - pathology | Fatty Liver - metabolism | Mitochondria, Liver - pathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | DNA, Mitochondrial - drug effects | Fatty Liver - pathology | Mitochondria, Liver - metabolism | Humans | Liver - metabolism | Mitochondrial Proteins - biosynthesis | Mitochondria, Liver - drug effects | Mitochondrial Proteins - drug effects | Pharmaceutical Preparations - metabolism | Chemical and Drug Induced Liver Injury - metabolism | Immune System - metabolism | Drug-Related Side Effects and Adverse Reactions | Mitochondria, Liver - ultrastructure | Cell Respiration - drug effects | Chemical and Drug Induced Liver Injury - pathology | DNA, Mitochondrial - biosynthesis | Fatty Liver - etiology | Index Medicus | Hépatology and Gastroenterology | Reactive Oxygen Species | Liver | DNA, Mitochondrial | Drug-Induced Liver Injury | Mitochondrial Proteins | Fatty Liver | Mitochondria, Liver | Life Sciences | Human health and pathology | Cell Respiration | Immune System | Pharmaceutical Preparations
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article
Journal Article
世界胃肠病学杂志:英文版(电子版), ISSN 1007-9327, 2015, Volume 21, Issue 18, pp. 5473 - 5481
AIM: To assess the effects of dihydromyricetin(DHM) as a hepatoprotective candidate in reducing hepatic injury and accelerating hepatocyte proliferation after... 
Dihydromyricetin | Tumor | factor-α | regeneration | necrosis | Liver | Liver regeneration | Tumor necrosis factor-α | PATHWAYS | APOPTOSIS | ACTIVATION | REGENERATION | IKK-BETA | PROLIFERATION | Tumor necrosis factor-alpha | CHEMICAL HEPATOCARCINOGENESIS | TNF-ALPHA | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | Caspase Inhibitors - pharmacology | Liver - pathology | Liver - enzymology | Carbon Tetrachloride | Tumor Necrosis Factor-alpha - blood | Liver Failure, Acute - enzymology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Liver - drug effects | Time Factors | Liver Failure, Acute - drug therapy | Chemical and Drug Induced Liver Injury - blood | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - enzymology | Disease Models, Animal | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitochondria, Liver - pathology | Anti-Inflammatory Agents - pharmacology | Cytochromes c - metabolism | Mice, Inbred C57BL | Inflammation Mediators - blood | Liver Failure, Acute - chemically induced | Biomarkers - blood | Mitochondria, Liver - enzymology | Mitochondria, Liver - drug effects | Animals | Signal Transduction - drug effects | Liver Failure, Acute - pathology | Chemical and Drug Induced Liver Injury - drug therapy | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Flavonols - pharmacology | Liver Failure, Acute - blood | Liver Regeneration - drug effects | Basic Study
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 5, pp. 1231 - 1239.e6
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 2015, Volume 308, Issue 6, pp. G540 - G549
The progression in nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis is a serious health concern, but the underlying mechanisms remain... 
Obese Otsuka Long-Evans Tokushima fatty rat | N ω -nitro-L-arginine methyl ester | Liver | Nitric oxide | nitric oxide | PHYSIOLOGY | liver | PHOSPHORYLATION | FATTY LIVER-DISEASE | PROTEIN-KINASE | obese Otsuka Long-Evans Tokushima fatty rat | N-omega-nitro-L-arginine methyl ester | ACID OXIDATION | MITOCHONDRIAL RESPIRATION | SINUSOIDAL ENDOTHELIAL-CELLS | NITRIC-OXIDE INHIBITION | INSULIN-RESISTANCE | DAILY EXERCISE | CALORIC RESTRICTION | GASTROENTEROLOGY & HEPATOLOGY | Adaptation, Physiological | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Liver - enzymology | Mitochondria, Liver - metabolism | Liver Cirrhosis, Experimental - etiology | Nitric Oxide Synthase - antagonists & inhibitors | Non-alcoholic Fatty Liver Disease - etiology | Liver - physiopathology | Obesity - blood | Non-alcoholic Fatty Liver Disease - blood | Liver Cirrhosis, Experimental - enzymology | Liver - drug effects | Time Factors | Enzyme Inhibitors - toxicity | Lipids - blood | Inflammation Mediators - metabolism | Non-alcoholic Fatty Liver Disease - enzymology | Chemical and Drug Induced Liver Injury - enzymology | Chemical and Drug Induced Liver Injury - etiology | Eating | Nitric Oxide - blood | Obesity - complications | Insulin Resistance | Obesity - physiopathology | Non-alcoholic Fatty Liver Disease - physiopathology | Disease Progression | Mitochondria, Liver - drug effects | Rats, Inbred OLETF | Macrophages - metabolism | Animals | Macrophages - drug effects | Nitric Oxide Synthase - metabolism | Obesity - enzymology | NG-Nitroarginine Methyl Ester - toxicity | Obesity | Liver diseases | Rattus | Rats | Physiological aspects | Research | Health aspects | Nω-nitro-l-arginine methyl ester | Liver and Biliary Tract
Journal Article
Journal of Gastroenterology and Hepatology (Australia), ISSN 0815-9319, 2009, Volume 24, Issue 3, pp. 443 - 452
We examined extrinsic and intrinsic (endogenous) mitochondrial apoptosis pathways in experimental non-alcoholic steatohepatitis (NASH). To assess extrinsic... 
Cell death pathways | TRAIL-R killer/DR5 | Methionine and choline deficiency | Mitochondria | Insulin-like growth factor-1 | TNF receptors | P53 | HEPATOCYTE APOPTOSIS | ACIDS | DR5 | mitochondria | FATTY LIVER-DISEASE | insulin-like growth factor-1 | NONALCOHOLIC STEATOHEPATITIS | cell death pathways | p53 | PATHOGENESIS | HEPATIC INFLAMMATION | NECROSIS | methionine and choline deficiency | MICE | TNF-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | TRAIL-R killer | NF-KAPPA-B | Liver - pathology | Liver - enzymology | Fatty Liver - pathology | Mitochondria, Liver - metabolism | Caspase 3 - metabolism | Choline Deficiency - complications | Male | Alanine Transaminase - blood | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | RNA, Messenger - metabolism | fas Receptor - metabolism | Tumor Suppressor Protein p53 - genetics | Time Factors | Receptors, Tumor Necrosis Factor, Type II - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Nutritional Status | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | Disease Models, Animal | Methionine - deficiency | Receptors, Tumor Necrosis Factor - metabolism | Fatty Liver - metabolism | Mitochondria, Liver - pathology | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Mitochondria, Liver - enzymology | Animals | Mice | bcl-X Protein - metabolism | Insulin-Like Growth Factor I - metabolism | Apoptosis | Fatty Liver - etiology | BH3 Interacting Domain Death Agonist Protein, metabolism | Receptors, Tumor Necrosis Factor, Type II, metabolism | Fatty Liver, pathology | Mitochondria, Liver, metabolism | Receptors, Tumor Necrosis Factor, metabolism | Cyclin-Dependent Kinase Inhibitor p21, metabolism | Insulin-Like Growth Factor I, metabolism | Caspase 3, metabolism | Antigens, CD95, metabolism | RNA, Messenger, metabolism | Tumor Suppressor Protein p53, metabolism | Methionine, deficiency | Choline Deficiency, complications | Tumor Suppressor Protein p53, genetics | bcl-X Protein, metabolism | Mitochondria, Liver, pathology | Liver, pathology | Alanine Transaminase, blood | Liver, metabolism | Fatty Liver, metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand, metabolism | Liver, enzymology | Fatty Liver, etiology | Mitochondria, Liver, enzymology | Receptors, Tumor Necrosis Factor, Type I, metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand, genetics | Messenger RNA | Choline | Methionine | Mitochondrial DNA | Tumor proteins | Peptide hormones | Growth factors
Journal Article
Journal Article