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Nature (London), ISSN 1476-4687, 03/2016, Volume 531, Issue 7593, pp. 253 - 257
Journal Article
Nature communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 83 - 83
.... Here, we report that TOP1MT is overexpressed in cancer tissues and demonstrate that TOP1MT deficiency attenuates tumor growth in human and mouse models of colon and liver cancer... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Carcinoma, Hepatocellular - mortality | Liver - pathology | Protein Biosynthesis | Cell Proliferation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms, Experimental - chemically induced | Male | Gene Expression Profiling | Liver Neoplasms - mortality | Carcinogens - toxicity | DNA, Mitochondrial - isolation & purification | Liver Neoplasms, Experimental - metabolism | Cell Nucleus - metabolism | DNA, Mitochondrial - genetics | Carcinoma, Hepatocellular - genetics | Fibroblasts | Female | Liver Neoplasms - pathology | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Datasets as Topic | DNA Topoisomerases, Type I - metabolism | Liver Neoplasms - genetics | HCT116 Cells | Liver - metabolism | DNA Topoisomerases, Type I - genetics | Mitochondria - metabolism | Mitochondria - pathology | Mice, Knockout | Carcinogenesis - pathology | Xenograft Model Antitumor Assays | Animals | Energy Metabolism | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Survival Analysis | Glycolysis | Liver - cytology | Mice | Carcinoma, Hepatocellular - metabolism | Cell proliferation | Phosphorylation | Animal models | Translation | Transcription | Liver | Hepatocellular carcinoma | Mitochondrial DNA | Drug development | Carcinogenesis | Liver cancer | Mitochondria | Carcinogens | Colon cancer | Oxidative phosphorylation | Colon | Cancer | Tumors | Index Medicus | Life Sciences | Human health and pathology
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 05/2014, Volume 146, Issue 5, pp. 1231 - 1239.e6
Journal Article
Journal of hepatology, ISSN 0168-8278, 04/2011, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article