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Cell Metabolism, ISSN 1550-4131, 11/2011, Volume 14, Issue 5, pp. 612 - 622
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal... 
LIFE-SPAN | MITOCHONDRIAL-FUNCTION | ENDOCRINOLOGY & METABOLISM | MUSCLE | FAT | MICE | INSULIN SENSITIVITY | SIRT1 ACTIVATION | EXERCISE | BETA-CELL FUNCTION | PROTECTS | CELL BIOLOGY | Blood Pressure | Stilbenes - administration & dosage | Obesity - drug therapy | Stilbenes - therapeutic use | Humans | Middle Aged | Mitochondria, Muscle - metabolism | Heat-Shock Proteins - biosynthesis | Male | Muscle, Skeletal - metabolism | Adipose Tissue - metabolism | Netherlands | Liver - drug effects | Muscle, Skeletal - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Protein Kinases - biosynthesis | Fatty Acids - metabolism | Citrate (si)-Synthase - biosynthesis | Blood Glucose - analysis | Double-Blind Method | Liver - metabolism | Sirtuin 1 - biosynthesis | Transcription Factors - biosynthesis | Alanine Transaminase - analysis | Caloric Restriction - methods | Switzerland | Obesity - metabolism | Cross-Over Studies | Triglycerides - blood | Glycerol - blood | Mitochondria, Muscle - drug effects | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Glycerin | Analysis | Resveratrol | Physiological aspects | Glycerol | Triglycerides | Glucose | Fatty acids | Dextrose | skeletal-muscle | insulin sensitivity | lipid-metabolism | beta-cell function | mitochondrial-function | life-span | sirt1 activation | saccharomyces-cerevisiae | fat oxidation | exercise
Journal Article
Diabetes, ISSN 0012-1797, 07/2009, Volume 58, Issue 7, pp. 1509 - 1517
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 769 - 780
Background Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress... 
Allergy and Immunology | airway hyperresponsiveness | antioxidant | proliferation | MitoQ | inflammation | mitochondria | airway smooth muscle | Ozone | oxidative stress | chronic obstructive pulmonary disease | ASTHMA FEATURES | MECHANISMS | IMMUNOLOGY | FRAGMENTATION | HYPERRESPONSIVENESS | BETA | RESPONSES | ALLERGY | ENERGY-METABOLISM | EXPRESSION | COPD | Respiratory System - pathology | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | Bronchial Hyperreactivity - genetics | Ubiquinone - pharmacology | Muscle, Smooth - drug effects | Smoking - physiopathology | Organophosphorus Compounds - pharmacology | Myocytes, Smooth Muscle - drug effects | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Bronchial Hyperreactivity - chemically induced | Signal Transduction | Mitochondria - pathology | Smoking - metabolism | Bronchial Hyperreactivity - pathology | Reactive Oxygen Species - antagonists & inhibitors | Electron Transport Chain Complex Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - chemically induced | Respiratory System - drug effects | Airway Remodeling - genetics | Mice | Oxidative Stress - drug effects | Bronchial Hyperreactivity - drug therapy | Myocytes, Smooth Muscle - pathology | Pneumonia - pathology | Membrane Potential, Mitochondrial - drug effects | Pneumonia - chemically induced | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Myocytes, Smooth Muscle - metabolism | Ubiquinone - analogs & derivatives | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Muscle, Smooth - metabolism | Animals | Pneumonia - drug therapy | Respiratory System - metabolism | Aged | Muscle, Smooth - pathology | Oxidative stress | Care and treatment | Lung diseases, Obstructive | Inflammation | Pharmaceutical industry | Biomedical research | Disease | Laboratories | Mortality | Colleges & universities | Smooth muscle | Mitochondrial DNA | Metabolism | Defects | Antioxidants | Mitochondria | Hospitals | Biopsy | Chronic obstructive pulmonary disease | Apoptosis | Smoking | NO, Nitric oxide | ΔΨm, Mitochondrial membrane potential | ASM, Airway smooth muscle | NAC, N-acetylcysteine | RL, Lung resistance | BAL, Bronchoalveolar lavage | OCR, Oxygen consumption rate | dTPP, Decyltriphenylphosphonium bromide | AHR, Airway hyperresponsiveness | logPC100, Concentration of acetylcholine that increased lung resistance by 100 | GOLD, Global Initiative for Chronic Obstructive Lung Disease | ATP, Adenosine triphosphate | KC, Keratinocyte-derived cytokine | JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | COPD, Chronic obstructive pulmonary disease | ROS, Reactive oxygen species | Mechanisms of Allergy and Clinical Immunology
Journal Article
Critical Care Medicine, ISSN 0090-3493, 07/2011, Volume 39, Issue 7, pp. 1749 - 1759
BACKGROUND:Mechanical ventilation is a life-saving intervention used to provide adequate pulmonary ventilation in patients suffering from respiratory failure.... 
atrophy | antioxidant | redox signaling | respiratory muscles | oxidative stress | weaning | REQUIREMENTS | ACTIVATION | ARRANGEMENT | CONTRACTILE DYSFUNCTION | REPERFUSION INJURY | HYDROPEROXIDE | RAT DIAPHRAGM | SKELETAL-MUSCLE MITOCHONDRIA | CRITICAL CARE MEDICINE | Calpain - metabolism | Diaphragm - drug effects | Mitochondria, Muscle - metabolism | Oxidative Stress - physiology | Actins - metabolism | Caspase 3 - metabolism | Diaphragm - ultrastructure | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Muscular Atrophy - physiopathology | Respiration, Artificial - adverse effects | Muscle Fibers, Skeletal - ultrastructure | Muscle Proteins - metabolism | Mitochondria, Muscle - physiology | Female | Muscular Atrophy - prevention & control | Diaphragm - metabolism | Muscle Weakness - prevention & control | Muscular Atrophy - etiology | Muscle Fibers, Skeletal - physiology | Diaphragm - physiopathology | Muscle Weakness - etiology | Ubiquitin-Protein Ligases - metabolism | Rats | SKP Cullin F-Box Protein Ligases - metabolism | Rats, Sprague-Dawley | Hydrogen Peroxide - metabolism | Animals | Muscle Contraction - drug effects | Muscle Contraction - physiology | Mitochondria, Muscle - drug effects | Muscle Weakness - physiopathology | Oxidative Stress - drug effects | Oligopeptides - pharmacology
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 10, pp. 6968 - 6979
The purpose of this study was to evaluate the role of sirtuin 1 (SirT1) in exercise-and resveratrol (RSV)-induced skeletal muscle mitochondrial biogenesis.... 
SKELETAL-MUSCLE | GLUCOSE-HOMEOSTASIS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | NAD(+) SALVAGE PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | METABOLIC ADAPTATION | CALORIC RESTRICTION | CHRONIC CONTRACTILE ACTIVITY | AUTOREGULATORY LOOP | ENERGY-METABOLISM | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Mitochondria, Muscle - metabolism | Immunoblotting | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Stilbenes - pharmacology | Sirtuin 1 - genetics | Cell Nucleus - metabolism | Muscle, Skeletal - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Muscle Fibers, Skeletal - physiology | Cell Line | Vasodilator Agents - pharmacology | Mice, Transgenic | Muscle, Skeletal - physiology | Physical Conditioning, Animal - physiology | Mice, Knockout | Animals | Muscle Contraction - drug effects | Active Transport, Cell Nucleus - drug effects | Trans-Activators - metabolism | Mice | Mitochondria, Muscle - drug effects | Transcription Factors | Cell Nucleus - drug effects | Microscopy, Fluorescence | Exercise | Reactive Oxygen Species (ROS) | Skeletal Muscle | Cytochrome c Oxidase Activity | Nampt | Resveratrol | Sirt1 | PGC-1α | Metabolism | Mitochondrial Biogenesis | Mitochondrial Respiration
Journal Article
Circulation Research, ISSN 0009-7330, 05/2012, Volume 110, Issue 11, pp. 1484 - 1497
RATIONALE:Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by pulmonary vascular obstruction caused, in part, by pulmonary artery... 
mitotic checkpoint | cyclin B1/cyclin-dependent kinase 1 | mitochondrial fission | hypoxia-inducible factor-1 | mitochondrial division inhibitor-1 | CARDIAC & CARDIOVASCULAR SYSTEMS | ENTRY | INDUCIBLE FACTOR 1-ALPHA | HYPOXIA | DRP1 | PATHWAY | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | GENE-EXPRESSION | GERMLINE MUTATIONS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | K+ CHANNELS | Antihypertensive Agents - pharmacology | Humans | Monocrotaline | Male | Cyclin B1 - metabolism | Cobalt | Hypertension, Pulmonary - therapy | CDC2 Protein Kinase - metabolism | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Myocytes, Smooth Muscle - drug effects | Hypertension, Pulmonary - enzymology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Myocytes, Smooth Muscle - enzymology | Dynamins - genetics | Rats | Familial Primary Pulmonary Hypertension | Hypoxia - complications | Rats, Sprague-Dawley | Pulmonary Artery - enzymology | Cell Cycle Checkpoints | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Mitochondria, Muscle - drug effects | Enzyme Activation | Hypertension, Pulmonary - etiology | Muscle, Smooth, Vascular - enzymology | Dynamins - metabolism | Phosphorylation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Serine | Myocytes, Smooth Muscle - pathology | Mitochondrial Proteins - genetics | Case-Control Studies | Transfection | Quinazolinones - pharmacology | Mitochondria, Muscle - enzymology | Mitochondria, Muscle - pathology | Cells, Cultured | Muscle, Smooth, Vascular - pathology | Animals | Mitosis - drug effects | Glycolysis | Cell Proliferation - drug effects | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Genetic Therapy - methods | Hypoxia-inducible factor 1 | CDK1-cyclin B1 | Mitochondrial division inhibitor-1 (Mdivi-1) | Mitochondrial fission | Mitotic check point
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1782, Volume 289, Issue 21, pp. 14913 - 14924
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. To address this problem, we used a systems-based discovery... 
HYPERTROPHY | ALPHA-TOMATINE | ACTIVATION | MANAGEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOMATOES | SARCOPENIA | DEFICIENT MICE | EXPRESSION SIGNATURES | FAT MASS | PROTECTS | Gene Expression - drug effects | TOR Serine-Threonine Kinases - metabolism | Humans | Mitochondria, Muscle - metabolism | Drug Discovery - methods | Immunoblotting | Male | Multiprotein Complexes - genetics | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Tomatine - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Myoblasts, Skeletal - cytology | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | Muscular Atrophy - prevention & control | Mitochondria, Muscle - genetics | Myoblasts, Skeletal - metabolism | Cell Line | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Cells, Cultured | Muscular Atrophy - genetics | Tomatine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | Muscle Proteins - genetics | Animals | Signal Transduction - drug effects | Cell Line, Tumor | HL-60 Cells | Muscle Fibers, Skeletal - cytology | Mice | Mitochondria, Muscle - drug effects | Muscle, Skeletal - pathology | Myoblasts, Skeletal - drug effects | Skeletal Muscle | Skeletal Muscle Metabolism | Muscle Atrophy | Tomatidine | Metabolism | Systems Biology | mTOR complex (mTORC)
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2015, Volume 172, Issue 11, pp. 2782 - 2798
Journal Article