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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1782, Volume 289, Issue 21, pp. 14913 - 14924
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. To address this problem, we used a systems-based discovery... 
HYPERTROPHY | ALPHA-TOMATINE | ACTIVATION | MANAGEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOMATOES | SARCOPENIA | DEFICIENT MICE | EXPRESSION SIGNATURES | FAT MASS | PROTECTS | Gene Expression - drug effects | TOR Serine-Threonine Kinases - metabolism | Humans | Mitochondria, Muscle - metabolism | Drug Discovery - methods | Immunoblotting | Male | Multiprotein Complexes - genetics | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Tomatine - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Myoblasts, Skeletal - cytology | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | Muscular Atrophy - prevention & control | Mitochondria, Muscle - genetics | Myoblasts, Skeletal - metabolism | Cell Line | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Cells, Cultured | Muscular Atrophy - genetics | Tomatine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | Muscle Proteins - genetics | Animals | Signal Transduction - drug effects | Cell Line, Tumor | HL-60 Cells | Muscle Fibers, Skeletal - cytology | Mice | Mitochondria, Muscle - drug effects | Muscle, Skeletal - pathology | Myoblasts, Skeletal - drug effects | Skeletal Muscle | Skeletal Muscle Metabolism | Muscle Atrophy | Tomatidine | Metabolism | Systems Biology | mTOR complex (mTORC)
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 07/2010, Volume 19, Issue 20, pp. 3948 - 3958
Mitochondrial respiratory chain (RC) deficiency is among the most common causes of inherited metabolic disease, but its physiological consequences are poorly... 
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA | SKELETAL-MUSCLE | PPAR-ALPHA | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | MULTIPLE DELETIONS | GENE-EXPRESSION | FIBROBLAST GROWTH FACTOR-21 | MICE | MAMMALIAN-CELLS | MTDNA MAINTENANCE | Sequence Deletion | Mitochondrial Myopathies - metabolism | Mitochondria, Muscle - metabolism | Stress, Physiological | Fibroblast Growth Factors - genetics | Muscle, Skeletal - metabolism | Gene Expression Profiling | Mitochondrial Proteins - genetics | Starvation - metabolism | Amino Acids - metabolism | DNA, Mitochondrial - genetics | Base Sequence | Polymerase Chain Reaction | Lipid Metabolism - genetics | Electron Transport - physiology | Proto-Oncogene Proteins c-akt - metabolism | DNA Helicases - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Starvation - genetics | Mitochondria, Muscle - genetics | Gene Expression | Mitochondria, Muscle - enzymology | DNA, Mitochondrial - metabolism | Gene Expression Regulation | Mice, Transgenic | Adipocytes - pathology | Mitochondrial Myopathies - pathology | DNA Helicases - metabolism | Mitochondrial Myopathies - genetics | Animals | Mice | Basic Medicine | Other Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | signal transduction | hormones | liver | mitochondria | amino acids | proto-oncogene proteins c-akt | fasting | Mitochondrial myopathies | mice | mutation | stress response | dna | Medicinska och farmaceutiska grundvetenskaper | Annan medicinsk grundvetenskap | diet | mitochondrial | gene expression profiling | adipocytes | skeletal muscles
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 44, pp. 19090 - 19095
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, pp. 2705 - 2710
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2005, Volume 102, Issue 15, pp. 5618 - 5623
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2014, Volume 588, Issue 10, pp. 1935 - 1941
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial... 
Testosterone | Mitochondrial biogenesis | Skeletal muscle | Androgen receptor deficient mice | ANDROGEN RECEPTOR | ACTIVATED RECEPTOR-GAMMA | ADIPOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN SENSITIVITY | CELL BIOLOGY | OBESITY | BIOPHYSICS | MASS | MEN | LATE-ONSET | HYPOGONADISM | EXPRESSION | Myoglobin - metabolism | Troponin - genetics | Mitochondria, Muscle - metabolism | Myoglobin - genetics | Body Weight - drug effects | Male | Muscle, Skeletal - metabolism | Receptors, Androgen - deficiency | Cytochromes c - genetics | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Weight Loss - drug effects | Muscle, Skeletal - cytology | Testosterone - pharmacology | Nuclear Respiratory Factor 1 - genetics | Testosterone - metabolism | DNA, Mitochondrial - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Nuclear Respiratory Factor 1 - metabolism | Mitochondria, Muscle - genetics | Troponin - metabolism | Cell Line | DNA, Mitochondrial - metabolism | Cytochromes c - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Eating - drug effects | Animals | Receptors, Androgen - genetics | Androgens - pharmacology | Muscle Fibers, Skeletal - cytology | Mice | Androgens - metabolism | Blood Glucose - metabolism | Energy Metabolism - drug effects | Muscles | Biosynthesis | Body weight | Weight loss
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2446 - 12
Mitochondrial dysfunction is usually associated with various metabolic disorders and ageing. However, salutary effects in response to mild mitochondrial... 
OXIDATIVE STRESS | SUBSTRATE OXIDATION | TRANSCRIPTION FACTOR NRF2 | ENERGY-EXPENDITURE | MULTIDISCIPLINARY SCIENCES | GLUTATHIONE-PEROXIDASE | ANTIOXIDANT RESPONSE | DIET-INDUCED OBESITY | ROS PRODUCTION | INTEGRATED STRESS-RESPONSE | ONE-CARBON METABOLISM | Oxidative Stress | Glutathione Reductase - metabolism | Electron Transport - genetics | Mitochondria, Muscle - metabolism | Male | Muscle, Skeletal - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Glutathione Reductase - genetics | Organelle Biogenesis | Hormesis - genetics | Female | NF-E2-Related Factor 2 - genetics | Citrate (si)-Synthase - metabolism | Mitochondria, Muscle - genetics | Glutathione Peroxidase - metabolism | Uncoupling Protein 1 - genetics | Signal Transduction | Catalase - genetics | Mitochondria, Muscle - pathology | Uncoupling Protein 1 - metabolism | Gene Expression Regulation | Oxidative Phosphorylation | Mice, Transgenic | NF-E2-Related Factor 2 - deficiency | Glutathione Peroxidase - genetics | Catalase - metabolism | Animals | Citrate (si)-Synthase - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Muscle, Skeletal - pathology | Glutathione peroxidase | Oxidative stress | Phosphorylation | Serine | Quinone | Transgenic mice | Glycine | Skeletal muscle | NAD | Carbon cycle | Musculoskeletal system | Mitochondria | Oxidative phosphorylation | Catalase | Rodents | Metabolic disorders | Cellular stress response
Journal Article