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The Journal of cell biology, ISSN 1540-8140, 12/2010, Volume 191, Issue 7, pp. 1367 - 1380
.... Here we show that ubiquitination of mitofusins Mfn1 and Mfn2, large GTPases that mediate mitochondrial fusion, is induced by Parkin upon membrane depolarization and leads to their degradation... 
Depolarization | Mitochondria | Drosophila | Ubiquitins | Cell lines | HeLa cells | Antibodies | Parkinson disease | Opal | Standard deviation | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Humans | Autophagy - physiology | Mitochondrial Proteins - genetics | Membrane Potential, Mitochondrial - drug effects | Autophagy - drug effects | Mitochondrial Membrane Transport Proteins | Mitochondrial Proteins - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Ubiquitination - physiology | Nuclear Proteins - genetics | Membrane Fusion - drug effects | Fibroblasts - metabolism | Membrane Proteins - genetics | HCT116 Cells | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Dynamins | Nuclear Proteins - metabolism | Mitochondria - drug effects | Mice, Knockout | Leupeptins - pharmacology | Animals | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Models, Biological | Ubiquitin-Conjugating Enzymes - metabolism | Fibroblasts - drug effects | Cell Line, Tumor | Adenosine Triphosphatases - genetics | Mice | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Membrane Fusion - physiology | Mitochondria - physiology | Proteasome Inhibitors | Ubiquitin-Protein Ligases - genetics | Protein Binding - physiology | Proteins | Ligases | Research | Properties | Ubiquitin-proteasome system | Guanosine triphosphatase | Adenosine triphosphatase | Index Medicus
Journal Article
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 08/2011, Volume 118, Issue 4, pp. 636 - 645
Journal Article
Cell death and differentiation, ISSN 1350-9047, 09/2012, Volume 19, Issue 9, pp. 1459 - 1469
... of apoptosis by specifically increasing the degradation rate of the BH3-only protein Bik. This effect... 
Erk1/2 | proteasome | apoptosis | Bik | Src | Bim | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | NIH 3T3 Cells | Humans | Mitochondrial Proteins - genetics | raf Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | MAP Kinase Signaling System | MAP Kinase Kinase 1 - genetics | Neoplasms - genetics | Mitochondrial Proteins - metabolism | Proteolysis | Mitogen-Activated Protein Kinase 1 - genetics | src-Family Kinases - metabolism | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | raf Kinases - genetics | MAP Kinase Kinase 2 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Enzyme Activation - drug effects | Apoptosis Regulatory Proteins - metabolism | Drug Resistance, Neoplasm - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Thapsigargin - pharmacology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Enzyme Activation - genetics | Neoplasms - pathology | src-Family Kinases - genetics | Staurosporine - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Oncogene Protein p21(ras) - genetics | Index Medicus | Erk1 | Original Paper
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 01/2013, Volume 49, Issue 1, pp. 121 - 132
Journal Article
Journal Article