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Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6090, pp. 96 - 100
Pyruvate constitutes a critical branch point in cellular carbon metabolism. We have identified two proteins, Mpc1 and Mpc2, as essential for mitochondrial... 
Yeasts | Mitochondria | Diet | Plasmids | Drosophila | REPORTS | Amino acids | Oxidation | Respiration | Sugars | Medical schools | RAT-LIVER | TRANSPORT | COMPLEX | MECHANISM | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | Metabolomics | Humans | Molecular Sequence Data | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Drosophila melanogaster - metabolism | Saccharomyces cerevisiae - metabolism | Amino Acids - metabolism | Biological Transport | Mitochondrial Proteins - metabolism | Pyruvic Acid - metabolism | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Carbohydrate Metabolism | Mitochondria - metabolism | Drosophila Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Citric Acid Cycle | Mitochondrial Membranes - metabolism | Point Mutation | Animals | Drosophila melanogaster - chemistry | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Drosophila Proteins - genetics | Anion Transport Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Cell metabolism | Pyruvates | Chemical properties | Research | Molecular biology | Proteins | Yeast | Metabolism | Index Medicus | Carriers | Human | Bacteria | Transport | Transporter
Journal Article
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6090, pp. 93 - 96
The transport of pyruvate, the end product of glycolysis, into mitochondria is an essential process that provides the organelle with a major oxidative fuel.... 
Essential amino acids | Yeasts | Lactates | Cell growth | Mitochondria | Dehydrogenases | REPORTS | Mitochondrial membranes | Amino acids | Keto acids | Implementation maturity model | CATABOLISM | TRANSPORT | SPECIFICITY | LIPOIC ACID | MEMBRANE | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | LACTOCOCCUS-LACTIS | DEHYDROGENASE | Proprotein Convertase 2 | Proprotein Convertase 1 - genetics | Saccharomyces cerevisiae - genetics | Thioctic Acid - biosynthesis | Molecular Sequence Data | Lactococcus lactis - metabolism | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Thioctic Acid - metabolism | Saccharomyces cerevisiae - metabolism | Biological Transport | Culture Media | Pyruvic Acid - metabolism | Proprotein Convertase 1 - chemistry | Lactococcus lactis - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Leucine - metabolism | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Proprotein Convertase 1 - metabolism | Biosynthetic Pathways | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Valine - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Mice | Anion Transport Proteins - genetics | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | Plant mitochondria | Genetic aspects | Research | Plant molecular biology | Proteins | Glycoproteins | Yeast | Mutagenesis | Index Medicus
Journal Article
Journal Article
by Zhang, Bing and Zhang, Bing and Wang, Jing and Wang, Jing and Wang, Xiaojing and Wang, Xiaojing and Zhu, Jing and Zhu, Jing and Liu, Q and Liu, Qi and Shi, Zhiao and Shi, Zhiao and Chambers, Matthew C and Chambers, Matthew C and Zimmerman, Lisa J and Zimmerman, Lisa J and Shaddox, Kent F and Shaddox, Kent F and Kim, Sangtae and Kim, Sangtae and Davies, Sherri R and Davies, Sherri R and Wang, Sean and Wang, Sean and Wang, Pei and Wang, Pei and Kinsinger, Christopher R and Kinsinger, Christopher R and Rivers, Robert C and Rivers, Robert C and Rodriguez, Henry and Rodriguez, Henry and Townsend, R. Reid and Townsend, R Reid and Ellis, Matthew J. C and Ellis, Matthew J C and Carr, Steven A and Carr, Steven A and Tabb, David L and Tabb, David L and Coffey, Robert J and Coffey, Robert J and Slebos, Robbert J C and Slebos, Robbert J. C and Liebler, Daniel C and Liebler, Daniel C and NCI CPTAC, CPTAC and Gillette, Michael A and Klauser, Karl R and Kuhn, Eric and Mani, D.R and Mertins, Philipp and Ketchum, Karen A and Paulovich, Amanda G and Whiteaker, Jeffrey R and Edwards, Nathan J and McGarvey, Peter B and Madhavan, Subha and Chan, Daniel and Pandey, Akhilesh and Shih, Ie-Ming and Zhang, Hui and Zhang, Zhen and Zhu, Heng and Whiteley, Gordon A and Skates, Steven J and White, Forest M and Levine, Douglas A and Boja, Emily S and Hiltke, Tara and Mesri, Mehdi and Shaw, Kenna M and Stein, Stephen E and Fenyo, David and Liu, Tao and McDermott, Jason E and Payne, Samuel H and Rodland, Karin D and Smith, Richard D and Rudnick, Paul and Snyder, Michael and Zhao, Yingming and Chen, Xian and Ransohoff, David F and Hoofnagle, Andrew N and Sanders, Melinda E and Wang, Yue and Ding, Li and NCI CPTAC and the NCI CPTAC
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 382 - 387
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e55785 - e55785
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis... 
PROTEIN | ESSENTIAL COMPONENT | RNAI THERAPEUTICS | METABOLISM | RESPIRATION | MULTIDISCIPLINARY SCIENCES | RAT KIDNEY MITOCHONDRIA | CA2+ UPTAKE | OSCILLATIONS | MCU | DELIVERY | Multigene Family | Calcium Channels - metabolism | Calcium - metabolism | Humans | Mitochondrial Membrane Transport Proteins - genetics | Multiprotein Complexes - metabolism | Cell Respiration - genetics | Mitochondria - genetics | RNA Interference | Cation Transport Proteins - metabolism | HEK293 Cells | Membrane Potential, Mitochondrial - genetics | Cation Transport Proteins - genetics | Protein Stability | Calcium Channels - genetics | Calcium Signaling | Calcium-Binding Proteins - metabolism | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - metabolism | Liver - metabolism | Mitochondria - metabolism | Protein Transport | Sequence Alignment | Animals | Calcium Channels - chemistry | Protein Binding | Mice | HeLa Cells | Calcium-Binding Proteins - genetics | Proteins | Genomes | Cell death | Genes | Genomics | Calcium | Liver | Science | Tissues | Calcium influx | Medical schools | Calcium signalling | Mitochondria | Membrane potential | Bioinformatics | Medical research | Departments | RNA-mediated interference | Metabolism | Gene expression | Calcium (mitochondrial) | Medicine | Silence | Hospitals | Gene duplication | Molecular biology | Electron transport | Pore formation | Pharmaceuticals | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2013, Volume 32, Issue 6, pp. 886 - 898
The mitochondrial presequence translocase interacts with presequence‐containing precursors at the intermembrane space (IMS) side of the inner membrane to... 
import | mitochondria | presequence | TIM23 complex | CONTACT SITES | MATRIX | INNER MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | PREPROTEIN TRANSLOCASES | MITOCHONDRIAL TIM23 COMPLEX | CELL BIOLOGY | TIM50 | STRUCTURAL BASIS | MOLECULAR MACHINES | MOTOR | Protein Sorting Signals - physiology | Protein Interaction Domains and Motifs - physiology | Saccharomyces cerevisiae - genetics | Substrate Specificity | Membrane Transport Proteins - physiology | Mitochondrial Membrane Transport Proteins - genetics | Saccharomyces cerevisiae - metabolism | Mitochondrial Membrane Transport Proteins - physiology | Membrane Transport Proteins - genetics | Protein Interaction Domains and Motifs - genetics | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Binding Sites | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Protein Structure, Secondary | Membrane Proteins - genetics | Models, Molecular | Saccharomyces cerevisiae Proteins - genetics | Protein Transport - genetics | Membrane Transport Proteins - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Membrane Proteins - chemistry | Protein Sorting Signals - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae Proteins - physiology | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Signal transduction | Membranes | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2013, Volume 17, Issue 6, pp. 976 - 987
Journal Article
Nature Genetics, ISSN 1061-4036, 02/2014, Volume 46, Issue 2, pp. 188 - 193
Mitochondrial Ca2+ uptake has key roles in cell life and death. Physiological Ca2+ signaling regulates aerobic metabolism, whereas pathological Ca2+ overload... 
UNIPORTER | DISEASE | GENETICS & HEREDITY | MUSCULAR-DYSTROPHY | CA2+ UPTAKE | CELL-SURVIVAL | PROTEINS | MCU | Immunohistochemistry | Calcium Channels - metabolism | Calcium Signaling - physiology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Mitochondrial Membrane Transport Proteins - genetics | Histological Techniques | Cation Transport Proteins - metabolism | Base Sequence | Membrane Potential, Mitochondrial - genetics | Cation Transport Proteins - genetics | Quadriceps Muscle - pathology | Real-Time Polymerase Chain Reaction | Calcium-Binding Proteins - metabolism | Mitochondrial Membrane Transport Proteins - metabolism | Mitochondria - metabolism | Sequence Analysis, DNA | Exome - genetics | Phenotype | Analysis of Variance | Pedigree | Extrapyramidal Tracts - pathology | Fluorescent Antibody Technique | Polymorphism, Single Nucleotide - genetics | Learning Disorders - genetics | Movement Disorders - genetics | Muscular Diseases - genetics | Calcium Signaling - genetics | Calcium-Binding Proteins - genetics | Gene mutations | Cellular signal transduction | Muscle diseases | Genetic aspects | Research | Health aspects | Risk factors | Proteins | Medical research | Cell culture | Mitochondria | Genealogy | Biomedical research | Nuclear magnetic resonance--NMR | Mutation | Kinases | Muscular dystrophy | Index Medicus
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2136 - 2148
Journal Article