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The FEBS Journal, ISSN 1742-464X, 02/2018, Volume 285, Issue 3, pp. 416 - 431
Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and... 
BCL‐2 family | mitochondria | apoptosis | BAX | mitochondrial outer membrane permeabilization | BAK | DRP1 | BCL-2 family | OUTER-MEMBRANE | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PORE FORMATION | BH3 DOMAINS | CELL-DEATH | PROSURVIVAL BCL-2 PROTEINS | CYTOCHROME-C | CONFORMATIONAL-CHANGES | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | Mitochondrial Dynamics | Mitochondria - enzymology | bcl-2-Associated X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - agonists | Humans | Protein Multimerization | bcl-2-Associated X Protein - agonists | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondrial Membranes - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Mitochondrial Membranes - enzymology | Protein Interaction Domains and Motifs | Mitochondria - chemistry | Dimerization | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Lipid Mobilization | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Models, Biological | Apoptosis Regulatory Proteins - agonists | Protein Conformation | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Porosity | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | bcl-2 Homologous Antagonist-Killer Protein - agonists | Mitochondria | Regulators | Oligomerization | Bax protein | Bcl-2 protein | Spatial discrimination | Organelles
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2002, Volume 8, Issue 8, pp. 808 - 815
A major concern in cancer therapy is resistance of tumors such as glioblastoma to current treatment protocols. Here, we report that transfer of the gene... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CD95 APO-1/FAS | SMAC/DIABLO | DEATH RECEPTOR | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CELL-DEATH | CELL BIOLOGY | INHIBITION | TRAIL-INDUCED APOPTOSIS | TUMORICIDAL ACTIVITY | Neoplasm Transplantation | Apoptosis - drug effects | Humans | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Mitochondrial Proteins - genetics | Mitochondrial Proteins - agonists | Antineoplastic Agents - metabolism | Brain - metabolism | Carrier Proteins - agonists | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Flow Cytometry | Peptides - metabolism | TNF-Related Apoptosis-Inducing Ligand | Mitochondrial Proteins - metabolism | Glioma - pathology | X-Linked Inhibitor of Apoptosis Protein | Tumor Cells, Cultured | Brain - cytology | Enzyme Inhibitors - metabolism | Brain - physiopathology | Intracellular Signaling Peptides and Proteins | Mitochondria - metabolism | Remission Induction | Peptides - pharmacology | Carrier Proteins - genetics | Tumor Necrosis Factor-alpha - therapeutic use | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Membrane Glycoproteins - therapeutic use | Proteins - metabolism | Mice, Nude | Brain - pathology | Ligands | Mice | Apoptosis - physiology | Glioma - physiopathology | Glioma - drug therapy | Research | Gliomas | Analysis | Apoptosis
Journal Article
Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2014, Volume 16, Issue 8, pp. 711 - 718
Aims This work explored the effects of irisin on metabolism, gene expression and mitochondrial content in cultured myocytes. Methods C2C12 myocytes were... 
myokine | fibronectin type III domain containing protein 5 (FNDC5) | mitochondrial uncoupling protein 3 (UCP3) | peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α) | Myokine | Fibronectin type III domain containing protein 5 (FNDC5) | Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) | Mitochondrial uncoupling protein 3 (UCP3) | peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) | CELLS | COACTIVATOR | MITOCHONDRIAL BIOGENESIS | TISSUE | NUCLEAR RESPIRATORY FACTORS | OBESITY | NRF-1 | ENDOCRINOLOGY & METABOLISM | PGC-1 | FAT | Humans | Mitochondria, Muscle - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Glycolysis - drug effects | Nuclear Respiratory Factor 1 - genetics | DNA-Binding Proteins - metabolism | Oxidative Phosphorylation - drug effects | DNA-Binding Proteins - agonists | Nuclear Respiratory Factor 1 - agonists | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | High Mobility Group Proteins - agonists | Muscle Proteins - metabolism | Nuclear Respiratory Factor 1 - metabolism | Fibronectins - agonists | Cell Line | Cell Survival - drug effects | Fibronectins - pharmacology | High Mobility Group Proteins - metabolism | Recombinant Proteins - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Fibronectins - metabolism | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Transcription Factors - metabolism | Muscle Proteins - agonists | Mitochondrial Turnover - drug effects | Animals | Muscle Fibers, Skeletal - cytology | Cell Proliferation - drug effects | Fibronectins - genetics | Mice | Mitochondria, Muscle - drug effects | Kinetics | Transcription Factors - agonists | High Mobility Group Proteins - genetics | Fibronectins | Glucose metabolism | Muscles | Biosynthesis | Chemical properties | Glucose | Gene expression | Dextrose | Protein binding | Medical research | Metabolism | Rodents
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 9, pp. 4523 - 4536
Inhibiting class I histone deacetylases (HDACs) increases energy expenditure, reduces adiposity, and improves insulin sensitivity in obese mice. However, the... 
WHITE FAT | PROTEIN | GENE | BEIGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | EPIGENETIC REGULATION | UPSTREAM ENHANCER | INSULIN SENSITIVITY | EXPRESSION | ADIPOSE-TISSUE | Polycomb Repressive Complex 2 - antagonists & inhibitors | Polycomb Repressive Complex 2 - agonists | Polycomb Repressive Complex 2 - genetics | Adipocytes, Brown - metabolism | Polycomb Repressive Complex 1 - metabolism | Humans | Ion Channels - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Mitochondrial Proteins - genetics | Mitochondrial Proteins - agonists | Adrenergic beta-3 Receptor Agonists - pharmacology | Promoter Regions, Genetic - drug effects | Polycomb Repressive Complex 1 - genetics | Adipocytes, Brown - enzymology | Protein Processing, Post-Translational - drug effects | RNA Interference | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Polycomb Repressive Complex 1 - antagonists & inhibitors | Histone Deacetylase 1 - antagonists & inhibitors | Lysine - metabolism | Histone Deacetylase 1 - genetics | Recombinant Proteins - metabolism | Adipocytes, Brown - drug effects | Mitochondrial Proteins - antagonists & inhibitors | Ubiquitin-Protein Ligases - metabolism | Recombinant Proteins - chemistry | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, Inbred Strains | Enhancer of Zeste Homolog 2 Protein | Ion Channels - antagonists & inhibitors | Gene Expression Regulation - drug effects | Polycomb Repressive Complex 1 - agonists | Transcription Factors - metabolism | Acetylation - drug effects | Animals | Ion Channels - metabolism | Methylation - drug effects | Ion Channels - agonists | Histones - metabolism | Thermogenesis - drug effects | Transcription Factors - agonists | Uncoupling Protein 1 | Polycomb Repressive Complex 2 - metabolism | Ubiquitin-Protein Ligases - genetics | Cell Line, Transformed | Histone Deacetylase 1 - metabolism | histone methylation | thermogenesis | brown adipocytes | UCP1 | histone deacetylation | H3K27 | Metabolism | epigenetics | obesity | histone deacetylase 1 (HDAC1) | uncoupling protein
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 02/2010, Volume 17, Issue 2, pp. 159 - 164
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 2017, Volume 31, Issue 11, pp. 4866 - 4878
The stimulator of IFN genes (STING)-mediated DNA-sensing pathway plays an important role in the innate immune response to pathogen infection, autoimmunity, and... 
Mitochondria fission | IFN-β pathway | Inflammasome | INFLAMMASOME ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | CELLULAR ANTIVIRAL RESPONSE | IFN-beta pathway | SIGNALING PROTEIN | I INTERFERON | NALP3 INFLAMMASOME | 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID | CELL BIOLOGY | ADAPTIVE IMMUNITY | inflammasome | mitochondria fission | BIOLOGY | CYCLIC DI-GMP | INTERLEUKIN-1-BETA RELEASE | Mitochondrial Dynamics - genetics | Membrane Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | GTPase-Activating Proteins - metabolism | Transcription Factors - genetics | Mice, Knockout | NLR Family, Pyrin Domain-Containing 3 Protein - agonists | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Transcription Factors - metabolism | Animals | GTP Phosphohydrolases - metabolism | Mitochondrial Dynamics - drug effects | Interferon-beta - metabolism | Signal Transduction - drug effects | GTP Phosphohydrolases - genetics | Interferon-beta - genetics | Membrane Proteins - metabolism | Mice | Nigericin - pharmacology | GTPase-Activating Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Efflux | Regulators | Immune response | Downstream effects | Genes | Activation | Kinases | Fission | Nigericin | Signal transduction | Signaling | Mitochondria | Interferon regulatory factor 3 | Regulatory mechanisms (biology) | Dynamin | Interferon | Detection | Potassium | Deoxyribonucleic acid--DNA | Cancer | Immune system
Journal Article
Science, ISSN 0036-8075, 9/2008, Volume 321, Issue 5895, pp. 1493 - 1495
Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10306 - 10315
Journal Article
by Park, S and Lim, W and Bazer, FW and Song, G
MOLECULAR HUMAN REPRODUCTION, ISSN 1360-9947, 12/2017, Volume 23, Issue 12, pp. 842 - 854
STUDY QUESTION: Does the flavonoid naringenin inhibit proliferation of human endometriosis cells? SUMMARY ANSWER: Naringenin suppresses proliferation and... 
AROMATASE-ACTIVITY | DIAGNOSIS | ACTIVATION | MANAGEMENT | PROTEIN | endometriosis | ER stress | DOWN-REGULATION | apoptosis | DEVELOPMENTAL BIOLOGY | PATHOPHYSIOLOGY | OBSTETRICS & GYNECOLOGY | naringenin | WOMEN | REPRODUCTIVE BIOLOGY | ROS | PROSTATE-CANCER CELLS | THERAPIES | Transcription Factor CHOP - agonists | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Stromal Cells - pathology | Humans | bcl-2-Associated X Protein - agonists | bcl-2 Homologous Antagonist-Killer Protein - genetics | Annexin A5 - genetics | Estrogen Antagonists - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Eukaryotic Initiation Factor-2 - agonists | Reactive Oxygen Species - agonists | Dose-Response Relationship, Drug | Heat-Shock Proteins - genetics | Stromal Cells - drug effects | Eukaryotic Initiation Factor-2 - metabolism | Female | Protein-Serine-Threonine Kinases - metabolism | bcl-2-Associated X Protein - genetics | Endometrium - metabolism | Cell Line | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Signal Transduction | Flavanones - pharmacology | Heat-Shock Proteins - metabolism | Stromal Cells - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | bcl-2-Associated X Protein - metabolism | Endometriosis - pathology | Mitochondria - metabolism | Mitochondria - drug effects | Phosphatidylinositol 3-Kinases - genetics | Heat-Shock Proteins - agonists | Annexin A5 - metabolism | Eukaryotic Initiation Factor-2 - genetics | Endometriosis - metabolism | Mitogen-Activated Protein Kinases - genetics | Endometrium - pathology | Transcription Factor CHOP - metabolism | Mitogen-Activated Protein Kinases - metabolism | bcl-2 Homologous Antagonist-Killer Protein - agonists
Journal Article