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The EMBO Journal, ISSN 0261-4189, 02/2014, Volume 33, Issue 4, pp. 282 - 295
Journal Article
EMBO reports, ISSN 1469-221X, 02/2009, Volume 10, Issue 2, pp. 173 - 179
Ubiquilins (UBQLNs) are adaptor proteins thought to deliver ubiquitinated substrates to proteasomes. Here, we show a role for UBQLN in autophagy: enforced... 
ubiquitin‐like | PLIC | autophagy | ubiquilin | autophagosomes | APOPTOSIS | ubiquitin-like | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | MITOPHAGY | DEATH | MATURATION | HUNTINGTIN | INCLUSION-BODY FORMATION | CELL BIOLOGY | PROTEASOME | DEGRADATION | PROMOTES | Ubiquitin-Activating Enzymes - physiology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Ubiquitins - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | Recombinant Fusion Proteins - physiology | Autophagy - physiology | Autophagy - drug effects | Microscopy, Immunoelectron | Cell Cycle Proteins - antagonists & inhibitors | Recombinant Fusion Proteins - antagonists & inhibitors | RNA Interference | Cell Cycle Proteins - genetics | Carrier Proteins - physiology | Protein Structure, Tertiary | Ubiquitin-Activating Enzymes - genetics | Adaptor Proteins, Vesicular Transport - physiology | Adaptor Proteins, Vesicular Transport - antagonists & inhibitors | Phagosomes - metabolism | Carrier Proteins - antagonists & inhibitors | RNA, Small Interfering - physiology | Microtubule-Associated Proteins - antagonists & inhibitors | Ubiquitins - physiology | HeLa Cells - drug effects | Microtubule-Associated Proteins - physiology | Protein Interaction Mapping | Carrier Proteins - genetics | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Culture Media - pharmacology | Mice | HeLa Cells - cytology | Cell Cycle Proteins - physiology | Ubiquitins - antagonists & inhibitors | Proteins | Genetics | Nutrients | Molecular biology | Substrates | Scientific Report
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2017, Volume 40, Issue 6, pp. 583 - 594.e6
Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease... 
succinate | bioenergetics | mitochondria | fission | neuron | reverse electron transfer | respiration | superoxide | brain | fragmentation | ISCHEMIA-REPERFUSION INJURY | BRAIN MITOCHONDRIA | LIFE-SPAN | CELLS | ROS | DYNAMIN-RELATED PROTEIN-1 | DEVELOPMENTAL BIOLOGY | RAT-BRAIN | FISSION | DIVISION | DAMAGE | CELL BIOLOGY | Dynamins - metabolism | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cercopithecus aethiops | Saccharomyces cerevisiae - drug effects | GTP Phosphohydrolases - antagonists & inhibitors | Electron Transport Complex I - metabolism | Fibroblasts - ultrastructure | Saccharomyces cerevisiae - metabolism | Mitochondrial Proteins - metabolism | Cell Respiration - drug effects | Oxidation-Reduction - drug effects | Neurons - metabolism | NAD - metabolism | Quinazolinones - pharmacology | Fibroblasts - metabolism | Dynamins - antagonists & inhibitors | Electron Transport Complex I - antagonists & inhibitors | Mitochondrial Proteins - antagonists & inhibitors | Mitochondria - metabolism | Microtubule-Associated Proteins - antagonists & inhibitors | Mitochondria - drug effects | Rats, Sprague-Dawley | Mice, Knockout | Animals | GTP Phosphohydrolases - metabolism | Oxygen Consumption - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Mice | COS Cells | Brain | Medical colleges | Nervous system diseases | Heart diseases | Injuries | Biomedical engineering | Neurons | Superoxide
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 494 - 507
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the... 
ANTAGONISTS INDUCE | APOPTOSIS | ACTIVATION | ONCOLOGY | CODING GENOME | CARD11 MUTATIONS | CHAIN ASSEMBLY COMPLEX | IKK COMPLEX | NF-KAPPA-B | SOMATIC MUTATIONS | SIGNALING COMPLEX | CELL BIOLOGY | Inhibitor of Apoptosis Proteins - genetics | Humans | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Antigen, B-Cell - metabolism | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Triazoles - therapeutic use | NF-kappa B - antagonists & inhibitors | Dipeptides - therapeutic use | Lymphoma, Large B-Cell, Diffuse - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Indoles - therapeutic use | Mice, Inbred NOD | Mice | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Neoplasm Proteins - physiology | Ubiquitin-Protein Ligases - antagonists & inhibitors | Baculoviral IAP Repeat-Containing 3 Protein | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | Caspases - metabolism | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Dipeptides - pharmacology | Guanylate Cyclase - metabolism | Gene Dosage | Mice, SCID | Triazoles - pharmacology | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Animals | Intracellular Signaling Peptides and Proteins - chemistry | B-Cell CLL-Lymphoma 10 Protein | Lymphoma, Large B-Cell, Diffuse - classification | CRISPR-Cas Systems | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Care and treatment | Lymphomas | Ligases
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 8, pp. 911 - 918
Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in... 
MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | CELL BIOLOGY | THERMOGENESIS | GLUCOSE-HOMEOSTASIS | 3T3-L1 PREADIPOCYTES | BEIGE ADIPOCYTES | FAT | PPAR-GAMMA | DIFFERENTIATION | EXPRESSION | Adipocytes, Brown - metabolism | Adipose Tissue, White - metabolism | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | Dibenzazepines - pharmacology | RNA, Messenger - biosynthesis | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Female | Transcription, Genetic | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | DNA-Binding Proteins - antagonists & inhibitors | Ion Channels - biosynthesis | Immunoglobulin J Recombination Signal Sequence-Binding Protein - antagonists & inhibitors | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Blood Glucose | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Mitochondrial Proteins - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Obesity - metabolism | Animals | Energy Metabolism | Obesity - therapy | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Uncoupling Protein 1 | Receptor, Notch1 - genetics | DNA-Binding Proteins - biosynthesis | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Obesity | Glucose metabolism | Blood sugar | Risk factors | Signal transduction | Tissue | Glucose | Diabetes | Rodents
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 2, p. djt440
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2013, Volume 32, Issue 9, pp. 1280 - 1292
Dynamin 1‐like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and dysfunction of DNM1L has been implicated in several neurological... 
protein structure | dynamin superfamily GTPases | dynamin 1‐like protein | membrane remodelling | mitochondrial fission | dynamin 1-like protein | STALK REGION | FUSION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEROXISOMAL FISSION | DIVISION | DRP1 | CELL BIOLOGY | S-NITROSYLATION | CONFORMATIONAL-CHANGES | NUCLEOTIDE-FREE | GTPASE | Microtubule-Associated Proteins - chemistry | Mitochondrial Size - drug effects | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cercopithecus aethiops | Crystallography, X-Ray | Mitochondrial Proteins - genetics | GTP Phosphohydrolases - antagonists & inhibitors | Mitochondrial Size - genetics | GTP Phosphohydrolases - chemistry | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Protein Structure, Quaternary - physiology | Protein Structure, Secondary | Mitochondrial Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Models, Molecular | Mitochondria - metabolism | Microtubule-Associated Proteins - antagonists & inhibitors | Mitochondria - drug effects | Protein Folding | Mutation, Missense - physiology | Animals | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Models, Biological | Mitochondrial Proteins - chemistry | Mitochondria - physiology | COS Cells | Proteins | Mitochondria | Mutation | Neurological disorders | Crystal structure
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2004, Volume 47, Issue 18, pp. 4417 - 4426
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2016, Volume 126, Issue 5, pp. 1834 - 1856
Targeting multiple components of the MAPK pathway can prolong the survival of patients with BRAF(V600E) melanoma. This approach is not curative, as some... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE-PHOSPHORYLATION | CELLS | ONCOGENE | MELANOMA | MEK INHIBITION | PGC1-ALPHA | IMPROVED SURVIVAL | BRAF | STRESS | VEMURAFENIB | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Guanidines - pharmacology | Male | Neoplasm Proteins - antagonists & inhibitors | Mitochondrial Proteins - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Neoplasm Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Melanoma - genetics | Mitochondrial Proteins - metabolism | Female | HSP90 Heat-Shock Proteins - genetics | Neoplasm Proteins - genetics | Melanoma - metabolism | Mitochondria - metabolism | Melanoma - pathology | Mitochondria - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Lactams, Macrocyclic - pharmacology | Transcription Factors - metabolism | Animals | Mitochondrial Dynamics - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Melanoma - drug therapy | HSP90 Heat-Shock Proteins - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Mitochondrial biogenesis | Research | Drug resistance | Analysis | Extracellular signal-regulated kinases | Phosphorylation | Melanoma | Mitochondrial DNA | Biosynthesis | Genomes | Kinases | Metabolism | Gene expression | Studies | Protein folding | Tumors | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 9, pp. 4523 - 4536
Inhibiting class I histone deacetylases (HDACs) increases energy expenditure, reduces adiposity, and improves insulin sensitivity in obese mice. However, the... 
WHITE FAT | PROTEIN | GENE | BEIGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | EPIGENETIC REGULATION | UPSTREAM ENHANCER | INSULIN SENSITIVITY | EXPRESSION | ADIPOSE-TISSUE | Polycomb Repressive Complex 2 - antagonists & inhibitors | Polycomb Repressive Complex 2 - agonists | Polycomb Repressive Complex 2 - genetics | Adipocytes, Brown - metabolism | Polycomb Repressive Complex 1 - metabolism | Humans | Ion Channels - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Mitochondrial Proteins - genetics | Mitochondrial Proteins - agonists | Adrenergic beta-3 Receptor Agonists - pharmacology | Promoter Regions, Genetic - drug effects | Polycomb Repressive Complex 1 - genetics | Adipocytes, Brown - enzymology | Protein Processing, Post-Translational - drug effects | RNA Interference | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Polycomb Repressive Complex 1 - antagonists & inhibitors | Histone Deacetylase 1 - antagonists & inhibitors | Lysine - metabolism | Histone Deacetylase 1 - genetics | Recombinant Proteins - metabolism | Adipocytes, Brown - drug effects | Mitochondrial Proteins - antagonists & inhibitors | Ubiquitin-Protein Ligases - metabolism | Recombinant Proteins - chemistry | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, Inbred Strains | Enhancer of Zeste Homolog 2 Protein | Ion Channels - antagonists & inhibitors | Gene Expression Regulation - drug effects | Polycomb Repressive Complex 1 - agonists | Transcription Factors - metabolism | Acetylation - drug effects | Animals | Ion Channels - metabolism | Methylation - drug effects | Ion Channels - agonists | Histones - metabolism | Thermogenesis - drug effects | Transcription Factors - agonists | Uncoupling Protein 1 | Polycomb Repressive Complex 2 - metabolism | Ubiquitin-Protein Ligases - genetics | Cell Line, Transformed | Histone Deacetylase 1 - metabolism | histone methylation | thermogenesis | brown adipocytes | UCP1 | histone deacetylation | H3K27 | Metabolism | epigenetics | obesity | histone deacetylase 1 (HDAC1) | uncoupling protein
Journal Article