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PLoS genetics, ISSN 1553-7404, 2012, Volume 8, Issue 1, p. e1002456
..., apoptosis, oxidative stress and accumulation of protein inclusions have been implicated in the etiology of the disease, mitochondrial dysfunction appears to play... 
LIFE-SPAN | OXIDATIVE STRESS | DROSOPHILA-PARKIN MUTANTS | ALTERNATIVE OXIDASE | QUINONE OXIDOREDUCTASE | NDI1 GENE | HUMAN-CELLS | INCREASED SENSITIVITY | GENETICS & HEREDITY | MITOCHONDRIAL-DYSFUNCTION | RESERVE POOL | Electron Transport Complex III - genetics | Electron Transport Complex III - metabolism | Cytoskeletal Proteins - genetics | Saccharomyces cerevisiae - genetics | Humans | Male | Drosophila Proteins - metabolism | Ciona intestinalis - genetics | Drosophila melanogaster - genetics | Electron Transport Complex I - metabolism | GTP-Binding Proteins - genetics | Electron Transport Complex IV - metabolism | Drosophila melanogaster - metabolism | Mitochondria - genetics | Electron Transport Complex I - genetics | Mitochondrial Proteins - metabolism | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Plant Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Oxidoreductases - metabolism | Membrane Proteins - genetics | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Electron Transport Complex IV - genetics | Parkinson Disease - genetics | Saccharomyces cerevisiae Proteins - genetics | Animals, Genetically Modified - metabolism | Animals | Animals, Genetically Modified - genetics | Saccharomyces cerevisiae Proteins - metabolism | Drosophila Proteins - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | GTP-Binding Proteins - metabolism | Parkinson's disease | Physiological aspects | NADH dehydrogenase | Genetic aspects | Mitochondrial DNA | Research | Electron transport | Risk factors | Enzymes | Mitochondria | Yeast | Insects | Parkinsons disease | Genetic engineering | Grants | Experiments | Evacuations & rescues | Deoxyribonucleic acid--DNA | Defects | Deoxyribonucleic acid | DNA
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2012, Volume 75, Issue 4, pp. 618 - 632
.... We have previously demonstrated that stabilization of actin by tau is critical for neurotoxicity of the protein... 
ALZHEIMERS-DISEASE BRAIN | DOMINANT OPTIC ATROPHY | MITOCHONDRIAL-FUNCTION | MOUSE MODEL | LIGHT-CHAIN | FRONTOTEMPORAL DEMENTIA | AXONAL-TRANSPORT | NEUROSCIENCES | DYNAMIN-RELATED PROTEIN | PHOSPHORYLATION SITES | TRANSGENIC MICE | Neurons - pathology | Microtubule-Associated Proteins - genetics | Tauopathies - genetics | Cytoskeletal Proteins - genetics | Gelsolin - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Tauopathies - pathology | Cytoplasm - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | GTP-Binding Proteins - genetics | Nerve Degeneration - metabolism | Neurons - ultrastructure | tau Proteins - genetics | Cell Death - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | ATP Synthetase Complexes - metabolism | Cell Cycle Proteins - genetics | Tauopathies - complications | Cytoskeletal Proteins - metabolism | Myosins - metabolism | Cytoplasm - genetics | RNA Interference - physiology | Disease Models, Animal | In Situ Nick-End Labeling | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | Cell Cycle Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Analysis of Variance | GTP Phosphohydrolases - genetics | Gelsolin - genetics | Mice | Drosophila Proteins - genetics | Nerve Degeneration - etiology | Voltage-Dependent Anion Channels - metabolism | GTP-Binding Proteins - metabolism | Nervous system diseases | Actin | Neurons | Utrophin | Myosin | Mitochondrial DNA | Alzheimer's disease | Proteins | Phosphorylation | Mitochondria | Neurotoxicity | Insects | Microscopy | Neurodegeneration | Pathogenesis | Morphology | Mutation | Defects | Neurodegenerative diseases | Tau protein | Cell death | Elongation
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 31, pp. 12754 - 12763
..., and the antiviral response. Genetic and cell biological studies over almost 2 decades have revealed some 30 proteins involved in the synthesis of cellular [2Fe-2S] and [4Fe-4S... 
4FE-4S CLUSTERS | acyl carrier protein (ACP) | cysteine desulfurase | fatty acid metabolism | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOTHIOL GLUTAREDOXINS FUNCTION | FUNCTIONAL-CHARACTERIZATION | glutaredoxin | mitochondrial disease | frataxin | ACYL CARRIER PROTEIN | ferredoxin | metal biology | chaperone | INTERACTING PROTEIN | ASSEMBLY MACHINERY | AZOTOBACTER-VINELANDII (NIF)ISCA | FE-S PROTEINS | SCAFFOLD PROTEIN | lipoic acid | Mitochondria - enzymology | Adrenodoxin - genetics | Species Specificity | Humans | Protein Multimerization | Adrenodoxin - metabolism | Iron-Sulfur Proteins - genetics | Iron-Binding Proteins - chemistry | Mitochondrial Proteins - genetics | Iron-Sulfur Proteins - chemistry | Iron-Binding Proteins - metabolism | Mitochondrial Proteins - metabolism | Apoenzymes - metabolism | Sulfurtransferases - chemistry | Acyl Carrier Protein - metabolism | Models, Molecular | Sulfurtransferases - genetics | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | Protein Transport | Gene Expression Regulation, Enzymologic | Acyl Carrier Protein - chemistry | Animals | Models, Biological | Acyl Carrier Protein - genetics | Apoenzymes - genetics | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Apoenzymes - chemistry | Adrenodoxin - chemistry | Iron-Binding Proteins - genetics | Protein Conformation | Iron-Sulfur Proteins - metabolism | Sulfurtransferases - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Minireviews
Journal Article
Neuron, ISSN 0896-6273, 04/2013, Volume 78, Issue 1, pp. 57 - 64
Valosin-containing protein (VCP) is a highly expressed member of the type II AAA+ ATPase family. VCP mutations are the cause of inclusion body myopathy... 
LIPID-PEROXIDATION | SPINAL-CORD PATHOLOGY | MOUSE MODEL | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | DYSFUNCTION | BONE | NEUROSCIENCES | PAGET-DISEASE | TRANSGENIC MICE | REVEALS | RNA, Small Interfering - genetics | Humans | Middle Aged | Male | Frontotemporal Dementia - metabolism | Neurons - ultrastructure | Muscular Dystrophies, Limb-Girdle - genetics | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial - genetics | Muscular Dystrophies, Limb-Girdle - pathology | NAD - metabolism | Fibroblasts - metabolism | Animals, Newborn | Frontotemporal Dementia - genetics | Magnesium - metabolism | Mitochondria - pathology | Fibroblasts - pathology | Mutation - genetics | Myositis, Inclusion Body - genetics | Osteitis Deformans - pathology | Muscular Dystrophies, Limb-Girdle - metabolism | Analysis of Variance | Luminescent Proteins - genetics | Adenosine Triphosphatases - genetics | Mice | Lipid Peroxidation - genetics | RNA, Small Interfering - metabolism | Valosin Containing Protein | Osteitis Deformans - metabolism | Family Health | Cerebral Cortex - cytology | Case-Control Studies | Osteitis Deformans - genetics | Transfection | Mitochondria - genetics | Cell Cycle Proteins - genetics | Myositis, Inclusion Body - pathology | Adult | Female | Neuroblastoma - pathology | Frontotemporal Dementia - pathology | Adenosine Triphosphatases - deficiency | Mice, Inbred C57BL | Cells, Cultured | Cell Cycle Proteins - deficiency | Mitochondria - metabolism | Animals | Oxygen Consumption - genetics | Myositis, Inclusion Body - metabolism | Aged | Nervous system diseases | Neurosciences | Genes | Amyotrophic lateral sclerosis | Genetic aspects | Adenosine triphosphatase | Dementia | Proteins | Medical research | Phosphorylation | Biomedical research | Disease | Rodents | Respiration | Experiments | Patients | Report
Journal Article
Neuron, ISSN 0896-6273, 04/2013, Volume 78, Issue 1, pp. 65 - 80
...  Introduction Mutations in valosin-containing protein (VCP) cause a dominantly inherited, multisystem degenerative disease that affects muscle, bone... 
PATHOGENESIS | PARKIN | VALOSIN-CONTAINING-PROTEIN | INCLUSION-BODY MYOPATHY | DROSOPHILA MODEL | FRONTOTEMPORAL DEMENTIA | PAGETS-DISEASE | BONE | NEUROSCIENCES | P97 | DEGENERATION | Embryo, Mammalian | Humans | Ganglia, Spinal - cytology | Drosophila Proteins - metabolism | HSP72 Heat-Shock Proteins - genetics | Protein Tyrosine Phosphatases - genetics | Neurons - ultrastructure | Time Factors | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Neuromuscular Junction - genetics | Neurons - metabolism | Protein-Serine-Threonine Kinases - metabolism | Mitochondrial Membrane Transport Proteins - metabolism | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Mutation - genetics | Leupeptins - pharmacology | GTP Phosphohydrolases - metabolism | Luminescent Proteins - genetics | Adenosine Triphosphatases - genetics | Ubiquitin-Protein Ligases - genetics | RNA, Small Interfering - metabolism | Immunoprecipitation | Neuromuscular Junction - metabolism | Valosin Containing Protein | Mitochondria - ultrastructure | Transfection | Mitochondria - genetics | Proton Ionophores - pharmacology | Cell Cycle Proteins - genetics | Microscopy, Electron, Transmission | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Proteins - metabolism | Drosophila Proteins - genetics | In Vitro Techniques | Ubiquitination - genetics | Luminescent Proteins - metabolism | Ubiquitin | Analysis | Genomics | Quality control | Amyotrophic lateral sclerosis | Genetic aspects | Mitochondrial DNA | Dementia | Neurons | Parkinsons disease | Biosynthesis | Digital cameras | Kinases | DNA repair | Proteins | Mitochondria | Brain research | Insects | Microscopy | Morphology | Mutation
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 513, Issue 7518, pp. 382 - 387
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2010, Volume 285, Issue 35, pp. 27487 - 27498
The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study... 
WILD-TYPE P53 | UV-RADIATION | CANCER-CELLS | P53-MEDIATED APOPTOSIS | P53-INDUCED APOPTOSIS | CARCINOMA-CELLS | MDM2 GENE | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | PIFITHRIN-ALPHA | RNA, Small Interfering - genetics | Caspase 9 - genetics | Caspase 9 - metabolism | Inhibitor of Apoptosis Proteins - genetics | Membrane Potential, Mitochondrial - radiation effects | Humans | Caspase 3 - metabolism | Cell Survival - genetics | Multiprotein Complexes - genetics | Nerve Growth Factors - metabolism | fas Receptor - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Multiprotein Complexes - metabolism | RNA, Messenger - biosynthesis | Phosphorylation - genetics | S100 Proteins - genetics | Ultraviolet Rays | Caspase 3 - genetics | fas Receptor - genetics | Biomarkers, Tumor - metabolism | Membrane Potential, Mitochondrial - genetics | Inhibitor of Apoptosis Proteins - metabolism | S100 Calcium Binding Protein beta Subunit | Down-Regulation | S100 Proteins - metabolism | Melanoma - pathology | Enzyme Activation - radiation effects | Phosphorylation - radiation effects | RNA, Neoplasm - biosynthesis | Nerve Growth Factors - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Mutation | Transcription, Genetic - genetics | Enzyme Activation - genetics | Caspase 8 - metabolism | Gene Expression Regulation, Neoplastic | Transcription, Genetic - radiation effects | Cytochromes c - genetics | Tumor Suppressor Protein p53 - genetics | Caspase 8 - genetics | Melanoma - genetics | Melanoma - metabolism | Cytochromes c - metabolism | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Cell Survival - radiation effects | Carrier Proteins - genetics | Carrier Proteins - metabolism | Apoptosis | Molecular Bases of Disease | S100 Proteins | Calcium-binding Proteins | S100B | Cell Biology | p53 | Protein-Protein Interactions | Tumor Suppressor
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85212
.... In the budding yeast Saccharomyces cerevisiae the RNA binding protein Ssd1 helps control cell wall remodeling by repressing translation of proteins involved in wall expansion... 
LOCALIZATION | GREEN FLUORESCENT PROTEIN | WALL | MESSENGER-RNA | SACCHAROMYCES-CEREVISIAE W303-1A | MULTIDISCIPLINARY SCIENCES | KINASE | MITOTIC EXIT | YEAST CBK1 | GENETIC INTERACTIONS | RNA-BINDING PROTEIN | Protein Biosynthesis | Saccharomyces cerevisiae - genetics | 3' Untranslated Regions - genetics | 5' Untranslated Regions - genetics | Chitinases - metabolism | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Chitinases - genetics | Saccharomyces cerevisiae - metabolism | Heat-Shock Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Gene Expression Regulation, Fungal | Green Fluorescent Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Morphogenesis - genetics | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Cell Wall - genetics | Repressor Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Cell Wall - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Proteins | Messenger RNA | Protein kinases | Protein binding | Repressing | Translation | Protein kinase C | Baking yeast | Yeast | Immunoprecipitation | Transcription | Cell walls | RNA polymerase | Remodeling | Kinases | Gene expression | Ribonucleic acid--RNA | Morphogenesis | RNA-binding protein | Cell growth | Protein kinase | Genetics | Viability | RNA | Ribonucleic acid
Journal Article