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Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6090, pp. 96 - 100
Pyruvate constitutes a critical branch point in cellular carbon metabolism. We have identified two proteins, Mpc1 and Mpc2, as essential for mitochondrial... 
Yeasts | Mitochondria | Diet | Plasmids | Drosophila | REPORTS | Amino acids | Oxidation | Respiration | Sugars | Medical schools | RAT-LIVER | TRANSPORT | COMPLEX | MECHANISM | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | Metabolomics | Humans | Molecular Sequence Data | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Drosophila melanogaster - metabolism | Saccharomyces cerevisiae - metabolism | Amino Acids - metabolism | Biological Transport | Mitochondrial Proteins - metabolism | Pyruvic Acid - metabolism | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Carbohydrate Metabolism | Mitochondria - metabolism | Drosophila Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Citric Acid Cycle | Mitochondrial Membranes - metabolism | Point Mutation | Animals | Drosophila melanogaster - chemistry | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Drosophila Proteins - genetics | Anion Transport Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Cell metabolism | Pyruvates | Chemical properties | Research | Molecular biology | Proteins | Yeast | Metabolism | Index Medicus | Carriers | Human | Bacteria | Transport | Transporter
Journal Article
Neuron, ISSN 0896-6273, 08/2012, Volume 75, Issue 4, pp. 618 - 632
Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between... 
ALZHEIMERS-DISEASE BRAIN | DOMINANT OPTIC ATROPHY | MITOCHONDRIAL-FUNCTION | MOUSE MODEL | LIGHT-CHAIN | FRONTOTEMPORAL DEMENTIA | AXONAL-TRANSPORT | NEUROSCIENCES | DYNAMIN-RELATED PROTEIN | PHOSPHORYLATION SITES | TRANSGENIC MICE | Neurons - pathology | Microtubule-Associated Proteins - genetics | Tauopathies - genetics | Cytoskeletal Proteins - genetics | Gelsolin - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Tauopathies - pathology | Cytoplasm - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | GTP-Binding Proteins - genetics | Nerve Degeneration - metabolism | Neurons - ultrastructure | tau Proteins - genetics | Cell Death - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | ATP Synthetase Complexes - metabolism | Cell Cycle Proteins - genetics | Tauopathies - complications | Cytoskeletal Proteins - metabolism | Myosins - metabolism | Cytoplasm - genetics | RNA Interference - physiology | Disease Models, Animal | In Situ Nick-End Labeling | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | Cell Cycle Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Analysis of Variance | GTP Phosphohydrolases - genetics | Gelsolin - genetics | Mice | Drosophila Proteins - genetics | Nerve Degeneration - etiology | Voltage-Dependent Anion Channels - metabolism | GTP-Binding Proteins - metabolism | Nervous system diseases | Actin | Neurons | Utrophin | Myosin | Mitochondrial DNA | Alzheimer's disease | Proteins | Phosphorylation | Mitochondria | Neurotoxicity | Insects | Microscopy | Neurodegeneration | Pathogenesis | Morphology | Mutation | Defects | Index Medicus | Neurodegenerative diseases | Tau protein | Cell death | Elongation
Journal Article
EMBO reports, ISSN 1469-221X, 01/2010, Volume 11, Issue 1, pp. 45 - 51
Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for degradation in the lysosome. Recent evidence indicates that autophagy... 
mitophagy | Nix | LC3 | GABARAP | selective autophagy | Selective autophagy | Mitophagy | APOPTOSIS | PROTEIN | RETICULOCYTE MATURATION | UBIQUITIN | BNIP3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-DEATH | CELL BIOLOGY | STRUCTURAL BASIS | DEGRADATION | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cercopithecus aethiops | Molecular Sequence Data | Substrate Specificity | Autophagy - physiology | Mitochondrial Proteins - genetics | Proto-Oncogene Proteins - chemistry | Mitochondrial Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Binding Sites | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | Amino Acid Motifs | Autophagy-Related Protein 8 Family | Animals | Membrane Proteins - chemistry | Reticulocytes - cytology | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Mice | Receptors, GABA-A - metabolism | COS Cells | Proteins | Mitochondria | Cellular biology | Cytoplasm | Index Medicus | Scientific Report
Journal Article
Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods | Index Medicus
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6090, pp. 93 - 96
The transport of pyruvate, the end product of glycolysis, into mitochondria is an essential process that provides the organelle with a major oxidative fuel.... 
Essential amino acids | Yeasts | Lactates | Cell growth | Mitochondria | Dehydrogenases | REPORTS | Mitochondrial membranes | Amino acids | Keto acids | Implementation maturity model | CATABOLISM | TRANSPORT | SPECIFICITY | LIPOIC ACID | MEMBRANE | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | LACTOCOCCUS-LACTIS | DEHYDROGENASE | Proprotein Convertase 2 | Proprotein Convertase 1 - genetics | Saccharomyces cerevisiae - genetics | Thioctic Acid - biosynthesis | Molecular Sequence Data | Lactococcus lactis - metabolism | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Thioctic Acid - metabolism | Saccharomyces cerevisiae - metabolism | Biological Transport | Culture Media | Pyruvic Acid - metabolism | Proprotein Convertase 1 - chemistry | Lactococcus lactis - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Leucine - metabolism | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Proprotein Convertase 1 - metabolism | Biosynthetic Pathways | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Valine - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Mice | Anion Transport Proteins - genetics | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | Plant mitochondria | Genetic aspects | Research | Plant molecular biology | Proteins | Glycoproteins | Yeast | Mutagenesis | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β... 
STERILE INFLAMMATORY RESPONSE | PROGRAMMED NECROSIS | CASPASE-8 | IL-1-BETA | NLRP3 INFLAMMASOME | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CIAP1 | NALP3 INFLAMMASOME | CELL-DEATH | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | X-Linked Inhibitor of Apoptosis Protein - deficiency | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Inhibitor of Apoptosis Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - agonists | Carrier Proteins - agonists | Inhibitor of Apoptosis Proteins - deficiency | Molecular Mimicry | Interleukin-1beta - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - metabolism | Macrophages - immunology | Macrophages - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Ubiquitin-Protein Ligases | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | Apoptosis | Proteins | Interleukins | Genes | Membranes | Mammals | Immune system | Caspase-8 | DIABLO protein | Cell activation | IAP protein | Reactive oxygen species | Interleukin 1 | Toll-like receptors | XIAP protein | Inflammation | Macrophages | Caspase-1 | Index Medicus
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2015, Volume 21, Issue 1, pp. 95 - 108
Mitochondria play essential roles in many aspects of biology, and their dysfunction has been linked to diverse diseases. Central to mitochondrial function is... 
YEAST | MAINTENANCE | NANOS TRANSLATION | PHOSPHORYLATION | DISEASE | MACHINERY | ENDOCRINOLOGY & METABOLISM | DOPAMINERGIC-NEURONS | MUTATIONS | DROSOPHILA | CELL BIOLOGY | RNA-Binding Proteins - genetics | Protein Biosynthesis | Humans | Drosophila Proteins - metabolism | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Ubiquitination | Guanine Nucleotide Exchange Factors - metabolism | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Nuclear Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Guanine Nucleotide Exchange Factors - genetics | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Rats | Nuclear Proteins - metabolism | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | DNA-Binding Proteins - genetics | Rats, Sprague-Dawley | Mitochondrial Membranes - metabolism | Heterogeneous-Nuclear Ribonucleoprotein Group F-H - metabolism | Animals | Electron Transport Chain Complex Proteins - metabolism | Drosophila Proteins - genetics | Lipid Peroxidation | Ubiquitin-Protein Ligases - genetics | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Biosynthesis | Mitochondrial DNA | Messenger RNA | Genetic translation | Genomics | Index Medicus
Journal Article