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PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e81747
Purpose: It is generally accepted that inflammation has a role in the progression of many central nervous system (CNS) diseases, although the mechanisms... 
NEURONAL APOPTOSIS | IN-VITRO | TRAUMATIC BRAIN-INJURY | MICROGLIA | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | MSK1 | LIPOPOLYSACCHARIDE | CENTRAL-NERVOUS-SYSTEM | MAPK | NF-KAPPA-B | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Glial Fibrillary Acidic Protein - genetics | Inflammation - pathology | RNA, Small Interfering - genetics | Phosphorylation | Tumor Necrosis Factor-alpha - genetics | Astrocytes - pathology | Cerebral Cortex - pathology | Injections, Intraventricular | Male | Brain Injuries - metabolism | Glial Fibrillary Acidic Protein - metabolism | Cerebral Cortex - metabolism | Lipopolysaccharides | Inflammation - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Interleukin-6 - metabolism | Interleukin-6 - genetics | Signal Transduction | Brain Injuries - chemically induced | Gene Expression Regulation | Rats | Brain Injuries - genetics | Rats, Sprague-Dawley | Animals | Nitric Oxide Synthase Type II - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Inflammation - genetics | Primary Cell Culture | Brain Injuries - pathology | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | RNA, Small Interfering - metabolism | Medical research | Enzymes | Brain | Cytokines | Inflammation | Gene expression | Analysis | Medicine, Experimental | Intermediate filament proteins | Mitogens | Protein kinases | Enzyme-linked immunosorbent assay | Injuries | Cerebral cortex | Traumatic brain injury | Disease | Laboratories | Central nervous system | Nervous system | Neurosurgery | Kinases | Interleukin 6 | Proteins | Head injuries | Synthesis | Neurodegeneration | Rodents | Bacteria | Ventricle (lateral) | Astrocytes | Glial fibrillary acidic protein | Cortex | MAP kinase | siRNA | Tumor necrosis factor-α | Nitric-oxide synthase | Signaling | Hospitals | Immunofluorescence | Brain injury | Apoptosis
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/1998, Volume 17, Issue 15, pp. 4426 - 4441
We have identified a novel mitogen‐ and stress‐activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is... 
MSK1 | p38 MAP kinase | MAP kinase | CREB | signal transduction | Signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | CELLULAR STRESSES | IDENTIFICATION | PHOSPHORYLATION SITES | CELL BIOLOGY | INSULIN | SAP KINASES | SUBSTRATE-SPECIFICITY | PATHWAY | SEQUENCE | S6 KINASE | Tetradecanoylphorbol Acetate - pharmacology | Epidermal Growth Factor - physiology | Ribosomal Protein S6 Kinases - metabolism | Humans | Molecular Sequence Data | PC12 Cells | Kidney | Ribosomal Protein S6 Kinases - immunology | Ultraviolet Rays | Base Sequence | Ribosomal Protein S6 Kinases - chemistry | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Mitogen-Activated Protein Kinases | Amino Acid Sequence | Cell Line | Transcription Factors - radiation effects | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Protein-Serine-Threonine Kinases - isolation & purification | Intracellular Signaling Peptides and Proteins | Rats | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Precipitin Tests | Cyclic AMP Response Element-Binding Protein - radiation effects | Transcription Factors - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - isolation & purification | Phosphorylation - radiation effects | Animals | Activating Transcription Factor 1 | Cyclic AMP Response Element-Binding Protein - metabolism | Tumor Necrosis Factor-alpha - physiology | Signal Transduction - physiology | Mice | HeLa Cells | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2003, Volume 305, Issue 3, pp. 455 - 461
Journal Article
Biological Psychiatry, ISSN 0006-3223, 12/2017, Volume 82, Issue 11, pp. 806 - 818
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 05/2010, Volume 298, Issue 5, pp. 1197 - 1204
Journal Article
The Journal of biological chemistry, 02/2011, Volume 286, Issue 7, p. 5003
Transforming growth factor-β (TGFβ) binding to its receptor leads to intracellular phosphorylation of Smad2 and Smad3, which oligomerize with Smad4. These... 
Cell Survival - genetics | Proto-Oncogene Proteins - biosynthesis | Gene Knockdown Techniques | Neoplasms - therapy | Phosphorylation - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Bcl-2-Like Protein 11 | Cell Death - genetics | Neoplasms - genetics | Smad4 Protein - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | bcl-Associated Death Protein - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cell Death - drug effects | Phosphorylation - drug effects | Nuclear Proteins - genetics | Apoptosis Regulatory Proteins - biosynthesis | bcl-Associated Death Protein - genetics | Cell Line | Cell Survival - drug effects | Gene Expression Regulation - genetics | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Neoplasms - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Smad4 Protein - metabolism | Gene Expression Regulation - drug effects | Transforming Growth Factor beta - pharmacology | Membrane Proteins - biosynthesis | Animals | Transforming Growth Factor beta - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | Enzyme Activation - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Transforming Growth Factor beta - metabolism
Journal Article
BBA - General Subjects, ISSN 0304-4165, 03/2014, Volume 1840, Issue 3, pp. 1014 - 1027
Given that lung cancer is the second leading cause of cancer-related deaths with low survival rates, the project was aimed to formulate an efficient drug with... 
Lung cancer cell | Mitochondrial dysfunction | MAPK | ATM/ATR | Malabaricone C | DNA strand break | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | P38 MAPK | JUN NH2-TERMINAL KINASE | S-PHASE CHECKPOINT | BIOPHYSICS | PATHWAY | CERVICAL-CANCER CELLS | IONIZING-RADIATION | STRESS | BCL-2 FAMILY | ATAXIA-TELANGIECTASIA | Cell death | Lung cancer | DNA damage | DNA | Biochemistry | Mitogens | Protein kinases | Index Medicus
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 08/2002, Volume 365, Issue 3, pp. 757 - 763
G-protein-coupled receptor agonists are powerful stimulators of mitogen-activated protein kinase (MAPK) cascades in cardiac myocytes. However, little is known... 
HEART | PATHWAYS | adrenergic agonist | HYPERTROPHY | STIMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENYLEPHRINE | MSK1 | CASCADE | VENTRICULAR MYOCYTES | endothelin-1 | ALPHA-ADRENERGIC RECEPTOR
Journal Article
Annals of Neurology, ISSN 0364-5134, 12/2008, Volume 64, Issue 6, pp. 644 - 653
Objective Although axons within neuromas have been shown to produce inappropriate spontaneous ectopic discharges, the molecular basis for pain in patients with... 
SPINAL SENSORY NEURONS | NEUROPATHIC PAIN | ECTOPIC IMPULSE GENERATION | PERIPHERAL-NERVES | PRIMARY AFFERENT NEURONS | DRG NEURONS | CLOSED-STATE INACTIVATION |