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2010, 2nd ed., Methods in molecular biology, ISBN 9781607617945, Volume 661., xiv, 529
Book
Diabetes, ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 514 - 525
The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation. In some conditions, certain white adipose... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2009, Volume 420, Issue 3, pp. 345 - 361
RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and different liation. In addition, RTKs reveal oncogenic potential when their... 
Extracellular-signal-regulated kinase (ERK) | Pleiotrophin | Anaplastic large cell lymphoma (ALCL) | Neuroblastoma | Non-small cell lung cancer (NSLCL) | Midkine | Anaplastic lymphoma kinase (ALK) | Inflammatory myofibroblastic tumour (IMT) | ALK PROTEIN EXPRESSION | inflammatory myofibroblastic tumour (IMT) | NPM-ALK | HEPARIN-BINDING | GROWTH-FACTOR PLEIOTROPHIN | non-small cell lung cancer (NSLCL) | BIOCHEMISTRY & MOLECULAR BIOLOGY | anaplastic lymphoma kinase (ALK) | EML4-ALK FUSION GENE | neuroblastoma | LARGE-CELL LYMPHOMA | extracellular-signal-regulated kinase (ERK) | pleiotrophin | NEUROTROPHIC FACTOR HBNF | INFLAMMATORY MYOFIBROBLASTIC TUMOR | NON-HODGKINS-LYMPHOMA | midkine | anaplastic large cell lymphoma (ALCL) | RECEPTOR TYROSINE KINASE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Oncogene Proteins, Fusion - metabolism | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Neuroblastoma - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Nuclear Proteins - metabolism | Receptor Protein-Tyrosine Kinases | Protein-Tyrosine Kinases - genetics | Models, Biological | Oncogene Proteins, Fusion - genetics | Lymphoma, Large-Cell, Anaplastic - pathology | Neuroblastoma - metabolism | Nuclear Proteins - genetics | Lymphoma, Large-Cell, Anaplastic - metabolism | Neuroblastoma - pathology | Lymphoma, Large-Cell, Anaplastic - genetics | ALK, anaplastic lymphoma kinase | LTK, leucocyte tyrosine kinase | MUC-1, mucin-1 | IRS-1, IR substrate-1 | PTN, pleiotrophin | TGFβ, transforming growth factor β | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | Shc, Src homology and collagen homology | TPM, tropomyosin | IMP cyclohydrolase | MK, midkine | MYH9, non-muscle myosin heavy chain | MAM, meprin, A5 protein and receptor protein tyrosine phosphatase mu | NPM, nucleophosmin | mTOR, mammalian target of rapamycin | NIPA, nuclear interacting partner of ALK | RPTP, receptor protein tyrosine phosphatase | DLBCL, diffuse large B-cell lymphoma | FOXO3a, forkhead box O 3a | NF-κB, nuclear factor κB | Shp1, SH2 domain-containing phosphatase 1 | RANBP2, Ran-binding protein 2 | ALCL, anaplastic large cell lymphoma | Dpp, decapentaplegic | FRS2, fibroblast growth factor receptor substrate 2 | LDLa, low-density lipoprotein class A | EGFR, epidermal growth factor receptor | SEC31L1, SEC31 homologue A | GIST, gastrointestinal stromal tumour | RTK, receptor tyrosine kinase | SH2, Src homology 2 | TFG, TRK-fused gene | ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | CLTC, clathrin heavy chain | MAPK, mitogen-activated protein kinase | Hen-1, hesitation-1 | MEK, MAPK | PI3K, phosphoinositide 3-kinase | HEK, human embryonic kidney | SCD-2, suppressor of constitutive dauer 2 | Review | EBPβ, CCAAT | CARS, cysteinyl-tRNA synthetase | JNK, c-Jun N-terminal kinase | ERK kinase | Grb2, growthfactor-receptor-bound protein 2 | SCC, squamous cell carcinoma | EML4, echinoderm microtubule-associated protein like 4 | SHH, sonic hedghog | BCR-Abl, breakpoint cluster region-Abl | IR, insulin receptor | ALO17, ALK lymphoma oligomerization partner on chromosome 17 | enhancer-binding protein β | PLCγ, phospholipase Cγ | NSCLC, non-small cell lung cancer | UCN-01, unco-ordinated 1 | Cdc42, cell division cycle 42 | STAT, signal transducer and activator of transcription | DRG, dorsal root ganglia | MSN, moesin | dALK, Drosophila ALK | IL-3, interleukin-3 | CNS, central nervous system | JAK, Janus kinase | CML, chronic myeloid leukaemia | Jeb, jelly belly | IMT, inflammatory myofibroblastic tumour | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
Journal Article
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 17, pp. 4602 - 4612
Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we... 
TUMOR-PROTEIN-53-INDUCED-NUCLEAR-PROTEIN-1 | NUCLEAR-PROTEIN 1 | ONCOLOGY | MAP KINASE | PROSTATE-CANCER | KINASE PHOSPHATASES MKPS | GENE-EXPRESSION | TUMOR-SUPPRESSOR | STRESS | P53-INDUCED NUCLEAR-PROTEIN-1 | CELL-DEATH | Prognosis | Humans | Lung Neoplasms - metabolism | Tumor Protein p73 - genetics | Gene Expression Profiling | Tumor Protein p73 - metabolism | Heat-Shock Proteins - genetics | Neoplasm Metastasis | Lung Neoplasms - secondary | Carcinoma, Hepatocellular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Dual-Specificity Phosphatases - genetics | Liver Neoplasms - pathology | Tumor Cells, Cultured | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Dual-Specificity Phosphatases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase Phosphatases - genetics | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Protein Array Analysis | Mice | Mice, Inbred BALB C | Carcinoma, Hepatocellular - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Liver | Extracellular signal-regulated kinase | Hepatocellular carcinoma | Metastasis | Metastases | Liver cancer | Signal transduction | Signaling | Stress response | Binding sites | Cellular stress response | Tumors | Apoptosis | Cancer | Liver Neoplasms | Lung Neoplasms | Life Sciences | Tumor Protein p73 | Heat-Shock Proteins | Mitogen-Activated Protein Kinase Phosphatases | Carcinoma, Hepatocellular | Dual-Specificity Phosphatases | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | Carrier Proteins
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in... 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article
Oncogene, ISSN 0950-9232, 05/2007, Volume 26, Issue 22, pp. 3227 - 3239
The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein (MAP) kinase pathway plays a central role in cell proliferation... 
Signal transduction | MAP kinase | ERK1/2 | Cell cycle | G1 phase | SIGNAL-TRANSDUCTION PATHWAYS | signal transduction | cell cycle | EARLY GENE-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | INITIATION-FACTOR 4E | DNA-SYNTHESIS | CELL BIOLOGY | NIH 3T3 CELLS | DEPENDENT KINASE | ONCOLOGY | GENETICS & HEREDITY | SMOOTH-MUSCLE-CELLS | MESSENGER-RNA TRANSPORT | MAP Kinase Signaling System - physiology | Cell Proliferation | Mitogen-Activated Protein Kinase 1 - physiology | Mitogen-Activated Protein Kinase 3 - genetics | Humans | Mitogen-Activated Protein Kinase 1 - deficiency | G1 Phase - physiology | S Phase - genetics | Mitogen-Activated Protein Kinase 3 - physiology | Animals | MAP Kinase Signaling System - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | S Phase - physiology | Mitogen-Activated Protein Kinase 3 - deficiency | G1 Phase - genetics | Enzyme Activation - genetics | Enzyme Activation - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Control | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Protein kinases | Genetics | Kinases | Mammals | Cancer | Life Sciences | G1 Phase | S Phase | Biochemistry, Molecular Biology | Enzyme Activation | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | MAP Kinase Signaling System
Journal Article