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Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2017, Volume 474, Issue 4, pp. 597 - 609
Cyclic AMP (cAMP)-specific phosphodiesterase-4 (PDE4) enzymes underpin compartmentalised cAMP signalling by localising to distinct signalling complexes. PDE4... 
CELLS | SIGNALING PATHWAYS | ACTIVATION | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-MEDIATED PHOSPHORYLATION | BETA-ARRESTIN | BINDING-SITES | ROLIPRAM INHIBITION | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Intracellular Signaling Peptides and Proteins - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - chemistry | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Recombinant Proteins - chemistry | Ubiquitin-Conjugating Enzymes - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Molecular Docking Simulation | Protein-Serine-Threonine Kinases - chemistry | src-Family Kinases - genetics | COS Cells | Mitogen-Activated Protein Kinase 1 - metabolism | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | beta-Arrestins - metabolism | Cercopithecus aethiops | Ubiquitin-Conjugating Enzymes - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | HEK293 Cells | src-Family Kinases - metabolism | Protein Interaction Domains and Motifs | Mitogen-Activated Protein Kinase 3 - chemistry | beta-Arrestins - chemistry | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Protein Structure, Secondary | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - genetics | Amino Acid Motifs | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | beta-Arrestins - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | src-Family Kinases - chemistry | Index Medicus | protein–protein interactions | cAMP | cyclic nucleotide phosphodiesterases
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 9932 - 9943
G protein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor 1 (GPER1), is thought to play important roles in breast cancer and... 
ACTIVATION | COMPLEX | 30 GPR30 | CANCER CELLS | KINASE-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCINEURIN | SCAFFOLDS | ENDOCYTOSIS | PLASMA-MEMBRANE | ANCHORING PROTEIN | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Receptors, G-Protein-Coupled - agonists | Recombinant Fusion Proteins - metabolism | GTP-Binding Protein alpha Subunits, Gi-Go - chemistry | Quinolines - pharmacology | Mitogen-Activated Protein Kinase 1 - chemistry | A Kinase Anchor Proteins - genetics | Protein Processing, Post-Translational - drug effects | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Phosphorylation - drug effects | Radioligand Assay | Mitogen-Activated Protein Kinase 3 - chemistry | Phosphatidylinositol 3-Kinase - metabolism | A Kinase Anchor Proteins - metabolism | A Kinase Anchor Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Cyclopentanes - pharmacology | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Phosphatidylinositol 3-Kinase - chemistry | Up-Regulation - drug effects | MAP Kinase Signaling System - drug effects | Receptors, Estrogen - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Phosphatidylinositol 3-Kinase - genetics | PDZ Domains | Receptors, G-Protein-Coupled - genetics | Mutation | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Signal Transduction | GPER1 | A-kinase-anchoring protein (AKAP) | G protein-coupled receptor (GPCR) | GPR30 | PDZ domain | calcineurin | extracellular signal-regulated kinase (ERK) | G protein
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2015, Volume 28, Issue 2, pp. 170 - 182
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 44, pp. 26661 - 26674
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2018, Volume 61, Issue 11, pp. 4978 - 4992
Journal Article
BMC Biology, ISSN 1741-7007, 04/2016, Volume 14, Issue 1, pp. 31 - 31
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2004, Volume 90, Issue 2, pp. 352 - 358
Microtubule-associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative... 
c-Jun N-terminal kinase | Stress-activated protein kinase | Tau protein | Tauopathy | NEUROFIBRILLARY TANGLES | NERVOUS-SYSTEM | tauopathy | ALZHEIMERS-DISEASE BRAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTOTEMPORAL DEMENTIA | DEPENDENT MONOCLONAL-ANTIBODY | NEUROSCIENCES | GLYCOGEN-SYNTHASE KINASE-3-BETA | FTDP-17 MUTATIONS | stress-activated protein kinase | PAIRED HELICAL FILAMENTS | SITES | tau protein | NANOELECTROSPRAY MASS-SPECTROMETRY | Phosphorylation | Epitopes - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Immunoblotting | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | tau Proteins - chemistry | Mitogen-Activated Protein Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Protein-Tyrosine Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | tau Proteins - genetics | Isoenzymes - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Protein-Tyrosine Kinases - chemistry | JNK Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycogen Synthase Kinase 3 - chemistry | Isoenzymes - genetics | Protein-Serine-Threonine Kinases - genetics | Recombinant Fusion Proteins - chemistry | Epitopes - genetics | Glycogen Synthase Kinase 3 - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 9 | Recombinant Fusion Proteins - genetics | Mitogen-Activated Protein Kinases - genetics | Mice | Protein-Serine-Threonine Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 6, pp. 3642 - 3658
The glucagon-like peptide-1 receptor (GLP-1R) is a therapeutically important family B G protein-coupled receptor (GPCR) that is pleiotropically coupled to... 
PARATHYROID-HORMONE-RECEPTOR | CORTICOTROPIN-RELEASING-FACTOR | LIGAND-BINDING | CRITICAL DETERMINANTS | CRYSTAL-STRUCTURE | MOLECULAR RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL DOMAIN | DETERMINE SPECIFICITY | PROTEIN-COUPLED-RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTORS | MAP Kinase Signaling System - physiology | Receptors, Glucagon - antagonists & inhibitors | Cricetulus | Humans | Mutation, Missense | Glucagon-Like Peptide 1 - genetics | Mitogen-Activated Protein Kinase 1 - chemistry | Cyclic AMP - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Cyclic AMP - genetics | Mitogen-Activated Protein Kinase 3 - chemistry | Cyclic AMP - metabolism | CHO Cells | Protein Structure, Tertiary | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Cricetinae | Glucagon-Like Peptide 1 - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Peptides - chemistry | Protein Structure, Secondary | Glucagon-Like Peptide 1 - pharmacology | Receptors, Glucagon - metabolism | Glucagon-Like Peptide 1 - chemistry | Peptides - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Glucagon-Like Peptide-1 Receptor | Mitogen-Activated Protein Kinase 3 - metabolism | Receptors, Glucagon - chemistry | Protein Binding | Amino Acid Substitution | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | G Protein-coupled Receptors (GPCR) | Peptide Hormones | Receptor Structure-Function | Signal Transduction | Cell Signaling | Ligand-directed Signal Bias | Glucagon-like Peptide-1 Receptor
Journal Article