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PLoS Computational Biology, ISSN 1553-734X, 2014, Volume 10, Issue 2, pp. e1003470 - e1003470
Interleukin-1 (IL-1) is a large cytokine family closely related to innate immunity and inflammation. IL-1 proteins are key players in signaling pathways such... 
DATA-BANK | KINASE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | INTERFACES | PROTEIN-PROTEIN INTERACTIONS | RECEPTOR | SCALE | MOLECULAR DOCKING | EXPRESSION | SOMATIC MUTATIONS | BRAIN-TUMORS | Interleukin-1 Receptor Accessory Protein - genetics | MAP Kinase Kinase 7 - genetics | Neoplasms - metabolism | Interleukin-1 - genetics | Interleukin-1 Receptor Accessory Protein - chemistry | Humans | MAP Kinase Kinase 7 - chemistry | Mitogen-Activated Protein Kinase 9 - genetics | Mitogen-Activated Protein Kinase 10 - genetics | MAP Kinase Kinase 7 - metabolism | Interleukin-1 Receptor Accessory Protein - metabolism | Receptors, Interleukin-1 Type I - metabolism | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Neoplasms - genetics | Computer Simulation | Receptors, Interleukin-1 Type I - chemistry | Interleukin-1 - chemistry | Oncogenes | Mitogen-Activated Protein Kinase 9 - chemistry | Interleukin-1 - metabolism | Protein Interaction Maps - immunology | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Computational Biology | Models, Molecular | Inflammation - immunology | Mitogen-Activated Protein Kinase 10 - metabolism | Mitogen-Activated Protein Kinase 10 - chemistry | Mutagenesis | Protein Interaction Maps - genetics | Models, Biological | Neoplasms - immunology | Receptors, Interleukin-1 Type I - genetics | Inflammation - genetics | MAP Kinase Kinase 4 - chemistry | MAP Kinase Kinase 4 - genetics | Polymorphism, Single Nucleotide | Mutation | Complications and side effects | Interleukin-1 | Patient outcomes | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | Risk factors | Genetic polymorphisms | Apoptosis | Index Medicus | Proteins | Cytokines | Disease | Kinases | Cancer
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2001, Volume 108, Issue 1, pp. 73 - 81
Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun... 
RHEUMATOID-ARTHRITIS | TRANSCRIPTION FACTORS | SIGNAL-TRANSDUCTION | PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | KAPPA-B REGULATION | P38 | COLLAGENASE | GENE-EXPRESSION | JNK2 | Rats, Inbred Lew | MAP Kinase Signaling System | Arthritis, Experimental - pathology | Protein-Tyrosine Kinases - physiology | RNA, Messenger - biosynthesis | Protein-Tyrosine Kinases - genetics | Transcription Factor AP-1 - deficiency | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Flavonoids - pharmacology | Interleukin-1 - antagonists & inhibitors | Phosphorylation - drug effects | p38 Mitogen-Activated Protein Kinases | Isoenzymes - physiology | Cells, Cultured - drug effects | Collagenases - genetics | Collagenases - biosynthesis | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Rats | Anthracenes - pharmacology | Cells, Cultured - enzymology | Interleukin-1 - pharmacology | Matrix Metalloproteinase 13 | Mice, Knockout | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinase 9 | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | Proto-Oncogene Proteins c-jun - metabolism | Activating Transcription Factor 2 | Transcription Factor AP-1 - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Arthritis, Experimental - enzymology | Isoenzymes - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinase 3 | Synovial Membrane - cytology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 443 - 456
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2019, Volume 116, Issue 3, pp. 810 - 815
Journal Article
Science, ISSN 0036-8075, 11/2000, Volume 290, Issue 5496, pp. 1574 - 1577
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 26, pp. 20358 - 20368
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2004, Volume 90, Issue 2, pp. 352 - 358
Microtubule-associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative... 
c-Jun N-terminal kinase | Stress-activated protein kinase | Tau protein | Tauopathy | NEUROFIBRILLARY TANGLES | NERVOUS-SYSTEM | tauopathy | ALZHEIMERS-DISEASE BRAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTOTEMPORAL DEMENTIA | DEPENDENT MONOCLONAL-ANTIBODY | NEUROSCIENCES | GLYCOGEN-SYNTHASE KINASE-3-BETA | FTDP-17 MUTATIONS | stress-activated protein kinase | PAIRED HELICAL FILAMENTS | SITES | tau protein | NANOELECTROSPRAY MASS-SPECTROMETRY | Phosphorylation | Epitopes - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Immunoblotting | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | tau Proteins - chemistry | Mitogen-Activated Protein Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Protein-Tyrosine Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | tau Proteins - genetics | Isoenzymes - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Protein-Tyrosine Kinases - chemistry | JNK Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycogen Synthase Kinase 3 - chemistry | Isoenzymes - genetics | Protein-Serine-Threonine Kinases - genetics | Recombinant Fusion Proteins - chemistry | Epitopes - genetics | Glycogen Synthase Kinase 3 - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 9 | Recombinant Fusion Proteins - genetics | Mitogen-Activated Protein Kinases - genetics | Mice | Protein-Serine-Threonine Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 07/2009, Volume 12, Issue 7, pp. 864 - 871
Journal Article