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Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16161 - 16173
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 443 - 456
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 32, pp. 23322 - 23330
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e66226
Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo... 
POTENT | ACTIVATION | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | BEHAVIORAL DEFICITS | MOUSE MODEL | P38-ALPHA MAPK | CYTOKINE UP-REGULATION | INHIBITORS | BINDING | DISCOVERY | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Peptide Fragments - toxicity | Pyridines - chemistry | Humans | Brain - enzymology | Male | Pyridazines - pharmacology | Pyridazines - chemical synthesis | Brain - metabolism | Protein Kinase Inhibitors - chemistry | Long-Term Potentiation - drug effects | Drug Design | Mitogen-Activated Protein Kinase 14 - chemistry | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Catalytic Domain | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Pyridines - chemical synthesis | Models, Molecular | Pyridazines - chemistry | Brain - drug effects | Animals | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Development and progression | Nervous system diseases | Cognition disorders | Protein kinases | Analysis | G protein-coupled receptors | Target recognition | Disease | Serine | Central nervous system | Cognitive ability | Activation | Biology | Selectivity | Catalytic activity | Kinases | Crystallography | Neuronal-glial interactions | Proteins | Cascades | Modulation | Aging | Catalysis | Probes | Alzheimer's disease | Cytokines | Threonine | Neurodegenerative diseases | Pharmacology | Mammals | Screens | Studies | Pathology | Signaling | Chemistry | Inhibitors | Protein kinase | β-Amyloid | In vivo methods and tests
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0167379 - e0167379
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 278 - 293
Journal Article
Acta Crystallographica Section D, ISSN 1399-0047, 02/2014, Volume 70, Issue 2, pp. 392 - 404
The small kinase inhibitor SKF86002 lacks intrinsic fluorescence but becomes fluorescent upon binding to the ATP‐binding sites of p38 mitogen‐activated protein... 
SKF86002 | co‐crystallization | kinase | fluorescence | inhibitor screening | co-crystallization | HCK | DESIGN | POTENT | BIOPHYSICS | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOOP | BIOCHEMICAL RESEARCH METHODS | CRYSTALLOGRAPHY | COCKTAIL CRYSTALLOGRAPHY | DISCOVERY | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Imidazoles - chemistry | Crystallography, X-Ray | Protein Kinase Inhibitors - chemistry | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Escherichia coli - metabolism | Proto-Oncogene Proteins c-hck - chemistry | Proto-Oncogene Proteins c-hck - antagonists & inhibitors | Mitogen-Activated Protein Kinase 14 - chemistry | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | Binding, Competitive | Fluorescent Dyes - chemistry | Proto-Oncogene Proteins c-pim-1 - chemistry | MAP Kinase Kinase Kinase 5 - genetics | MAP Kinase Kinase Kinase 5 - chemistry | AMP-Activated Protein Kinases - antagonists & inhibitors | Crystallization | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Mitogen-Activated Protein Kinase 14 - genetics | AMP-Activated Protein Kinases - chemistry | Molecular Probes - chemistry | High-Throughput Screening Assays | Escherichia coli - genetics | Protein Binding | Proto-Oncogene Proteins c-pim-1 - genetics | Ligands | Proto-Oncogene Proteins c-hck - genetics | Thiazoles - chemistry | Adenosine Triphosphate - chemistry | AMP-Activated Protein Kinases - genetics | Fluorescence | Medical screening | Phosphotransferases | Mitogens | Kinases | Binding sites | Crystals
Journal Article
Journal Article