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Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2457 - 2473
Journal Article
Developmental Cell, ISSN 1534-5807, 11/2012, Volume 23, Issue 5, pp. 1020 - 1031
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2017, Volume 66, Issue 5, pp. 698 - 710.e5
TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes... 
cytokine | caspase-8 | complex-II | p38 | cell death | MK2 | IAPs | RIPK1 | TNF | necroptosis | KINASE-ACTIVITY | SPATA2 LINKS CYLD | ACTIVATION | UBIQUITIN | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-DEPENDENT APOPTOSIS | PROGRAMMED NECROSIS | NF-KAPPA-B | CANCER | SIGNALING COMPLEX | CELL BIOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Phosphorylation | Apoptosis - drug effects | Humans | Multiprotein Complexes | Caspase 8 - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Necrosis | Dose-Response Relationship, Drug | Transfection | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Mice, Inbred C57BL | Fas-Associated Death Domain Protein - metabolism | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Mice, Knockout | HT29 Cells | Tumor Necrosis Factor-alpha - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Signal Transduction - drug effects | Medical research | Green buildings | Green design | RNA | Tumor necrosis factor | Cell death | Medicine, Experimental | Biochemistry | Research institutes | Genetic transcription | Genetic translation | Sustainable development | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2014, Volume 20, Issue 10, pp. 1138 - 1146
In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs or molecularly targeted therapies. Here, we describe a system... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA | INTEGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | SENSITIVITY | KINASE INHIBITORS | MAP KINASES | JAK/STAT | STRATEGIES | CELL BIOLOGY | Niacinamide - analogs & derivatives | RNA, Small Interfering - genetics | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Male | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Carcinoma, Hepatocellular - genetics | Female | Antineoplastic Agents - pharmacology | Liver Neoplasms, Experimental - genetics | Liver Neoplasms - genetics | Signal Transduction | Mice, Inbred C57BL | Liver Neoplasms - drug therapy | Mitogen-Activated Protein Kinase 14 - genetics | Activating Transcription Factor 2 - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Liver Neoplasms, Experimental - drug therapy | Liver Neoplasms - metabolism | Mice | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Carcinoma, Hepatocellular - metabolism | Liver cancer | Research | Drug therapy | Drug resistance | Analysis | Biomarkers | Signal transduction | Protein expression | Pharmacology | Ribonucleic acid--RNA | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16161 - 16173
Journal Article
Circulation, ISSN 0009-7322, 08/2017, Volume 136, Issue 6, pp. 549 - 561
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2013, Volume 18, Issue 6, pp. 803 - 815
A hallmark of obesity is selective suppression of hepatic insulin signaling (“insulin resistance”), but critical gaps remain in our understanding of the... 
SKELETAL-MUSCLE | LIPID-METABOLISM | TRIBBLES HOMOLOG | PHOSPHORYLATION | LIVER | ENDOCRINOLOGY & METABOLISM | RESISTANCE | TRB3 EXPRESSION | MICE | ENDOPLASMIC-RETICULUM STRESS | GLUCOSE-PRODUCTION | CELL BIOLOGY | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Hepatocytes - cytology | Mitogen-Activated Protein Kinase 14 - metabolism | Palmitates - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Insulin - pharmacology | Endoplasmic Reticulum Stress - drug effects | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Mitogen-Activated Protein Kinase 14 - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Insulin - metabolism | Animals | Mice, Obese | Mice | Type 2 diabetes | Obesity | Insulin resistance | Protein kinases | Insulin | Cells | Index Medicus
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 3, pp. 255 - 264
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 443 - 456
Journal Article