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Cancer research (Chicago, Ill.), ISSN 1538-7445, 09/2017, Volume 77, Issue 17, pp. 4602 - 4612
Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Prognosis | Humans | Lung Neoplasms - metabolism | Tumor Protein p73 - genetics | Gene Expression Profiling | Tumor Protein p73 - metabolism | Heat-Shock Proteins - genetics | Neoplasm Metastasis | Lung Neoplasms - secondary | Carcinoma, Hepatocellular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Dual-Specificity Phosphatases - genetics | Liver Neoplasms - pathology | Tumor Cells, Cultured | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Dual-Specificity Phosphatases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase Phosphatases - genetics | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Protein Array Analysis | Mice | Mice, Inbred BALB C | Carcinoma, Hepatocellular - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Liver | Extracellular signal-regulated kinase | Hepatocellular carcinoma | Metastasis | Metastases | Liver cancer | Signal transduction | Signaling | Stress response | Binding sites | Cellular stress response | Tumors | Apoptosis | Cancer | Index Medicus | Liver Neoplasms | Lung Neoplasms | Life Sciences | Tumor Protein p73 | Heat-Shock Proteins | Mitogen-Activated Protein Kinase Phosphatases | Carcinoma, Hepatocellular | Dual-Specificity Phosphatases | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | Carrier Proteins
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Cell death & disease, ISSN 2041-4889, 03/2019, Volume 10, Issue 3, pp. 213 - 213
... neurons, leading to changes in expression and phosphorylation of specific proteins to modulate their functions... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neurons - pathology | Phosphorylation | tau Proteins - metabolism | Neurons - cytology | Casein Kinase II - genetics | Proto-Oncogene Proteins c-akt - genetics | tau Proteins - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Tandem Mass Spectrometry | Nerve Tissue Proteins - chemistry | tau Proteins - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cell Death | Chromatography, Liquid | Neurons - metabolism | Mitogen-Activated Protein Kinase 3 - chemistry | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Cell Survival | Cells, Cultured | Computational Biology | Signal Transduction - genetics | Glycogen Synthase Kinase 3 - metabolism | Nerve Tissue Proteins - metabolism | Casein Kinase II - chemistry | Animals | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Receptor, trkA - metabolism | Signal Transduction - drug effects | Proteomics | Receptor, trkA - genetics | Glutamic Acid - metabolism | Mice | Software | Glutamic Acid - toxicity | Casein Kinase II - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Transcription factors | Cell survival | Glucocorticoids | Glutamic acid receptors (ionotropic) | Glycogen | Extracellular signal-regulated kinase | Glycogen synthase kinase 3 | c-Jun protein | MAP kinase | AKT protein | Kinases | Casein kinase II | Cyclin-dependent kinase 5 | MAP kinase kinase | Calcium influx | Neurological diseases | Proteins | Signal transduction | Casein | Tau protein | Cell death | Excitotoxicity | Apoptosis | Index Medicus
Journal Article
Diabetes (New York, N.Y.), ISSN 0012-1797, 2006, Volume 55, Issue 8, pp. 2220 - 2230
.... We observed that 10 mmol/1 glucose-induced CREB phosphorylation was totally inhibited by the protein kinase A (PKA) inhibitor H89 (2 mu mol/1) and reduced by 50... 
Protein kinase A | DMEM | Glucagon-like peptide-1 | CREB | GLP-1 | cAMP-responsive element-binding protein | PKA | Extracellular signal-regulated kinase | Dulbecco's modified Eagle's medium | ERK | siRNA, small interfering RNA | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | RNA, Small Interfering - genetics | Phosphorylation | Rats, Wistar | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | RNA, Messenger - analysis | Male | CREB-Binding Protein - metabolism | Isoquinolines - pharmacology | Transfection | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins c-bcl-2 - analysis | Flavonoids - pharmacology | Islets of Langerhans - ultrastructure | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cell Line | Microscopy, Electron, Transmission | Gene Expression | Islets of Langerhans - physiology | Mitogen-Activated Protein Kinase 1 - physiology | Mitogen-Activated Protein Kinase 3 - genetics | Cell Survival | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Rats | Glucose - pharmacology | Sulfonamides - pharmacology | Genes, bcl-2 - genetics | Mitogen-Activated Protein Kinase 3 - physiology | Cyclic AMP-Dependent Protein Kinases - physiology | Animals | CREB-Binding Protein - analysis | Protein Kinase Inhibitors - pharmacology | Apoptosis | Index Medicus | Abridged Index Medicus | Isoquinolines | Glucose | Life Sciences | Endocrinology and metabolism | Cyclic AMP-Dependent Protein Kinases | CREB-Binding Protein | Genes, bcl-2 | Human health and pathology | Protein Kinase Inhibitors | Flavonoids | Sulfonamides | RNA, Small Interfering | Islets of Langerhans | Proto-Oncogene Proteins c-bcl-2 | Mitogen-Activated Protein Kinase 1 | RNA, Messenger | Mitogen-Activated Protein Kinase 3
Journal Article
PloS one, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167071 - e0167071
...) in podocytes, cDNAs and cell lysate of cultured human podocytes were used for the expression of nAChR mRNAs and proteins, respectively... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Apoptosis - genetics | Male | Nicotinic Antagonists - pharmacology | Spin Labels | Reactive Oxygen Species - agonists | Nicotine - pharmacology | MAP Kinase Kinase 4 - metabolism | Cyclic N-Oxides - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Female | MAP Kinase Kinase 4 - antagonists & inhibitors | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Receptors, Nicotinic - metabolism | Podocytes - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Tissue Culture Techniques | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Nicotine - antagonists & inhibitors | Podocytes - cytology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Podocytes - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oxidative Stress - drug effects | Receptors, Nicotinic - genetics | Cell Line, Transformed | Mitogen-Activated Protein Kinase 1 - metabolism | Oxidative stress | Physiological aspects | Research | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking | Apoptosis | Cell proliferation | Reactive oxygen species | Phosphorylation | Laboratories | Syngeneic grafts | Downstream effects | Tempol | Acetylcysteine | Superoxide dismutase | mRNA | Medical schools | Antioxidants | Proteins | Receptors | Rodents | Mesangial cells | Localization | Medical research | Oxygen | Extracellular signal-regulated kinase | JNK protein | Permeability | Gene expression | Cigarette smoking | Signaling | Molecular modelling | Inhibitors | Acetylcholine receptors (nicotinic) | In vivo methods and tests | Kidney diseases | Diabetes | Kidney transplantation | Index Medicus
Journal Article
Journal Article