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Journal of Clinical Immunology, ISSN 0271-9142, 6/2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 06/2006, Volume 69, Issue 12, pp. 2212 - 2218
Angiotensin-converting enzyme 2 (ACE2) is a homolog of ACE, which is not blocked by ACE inhibitors. High amounts of ACE2 are present in the proximal tubule,... 
ACE2 | TGF-β1 | receptor | phosphorylation | renin–angiotensin system | Phosphorylation | Renin-angiotensin system | TGF- β | Receptor | ACTIVATED PROTEIN-KINASE | VASCULAR SMOOTH-MUSCLE | SIGNAL-TRANSDUCTION | TGF-beta | GROWTH-FACTOR-BETA | MESSENGER-RNA | CONVERTING ENZYME-2 | ENDOTHELIAL-CELLS | MESANGIAL CELLS | NITRIC-OXIDE | UROLOGY & NEPHROLOGY | HYPERTENSIVE-RATS | renin-angiotensin system | Mitogen-Activated Protein Kinase 3 - analysis | Receptors, G-Protein-Coupled - metabolism | RNA, Messenger - analysis | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Peptide Fragments - pharmacology | Peptidyl-Dipeptidase A - physiology | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Mitogen-Activated Protein Kinase Kinases - metabolism | Transforming Growth Factor beta - analysis | Angiotensin I - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Kidney Tubules, Proximal - enzymology | Phosphorylation - drug effects | Cyclic AMP - metabolism | Proto-Oncogene Proteins - metabolism | Kidney Tubules, Proximal - cytology | Proto-Oncogene Proteins - antagonists & inhibitors | Angiotensin II - pharmacology | Peptide Fragments - metabolism | Transforming Growth Factor beta1 | Mitogen-Activated Protein Kinase Kinases - analysis | Enzyme-Linked Immunosorbent Assay | Cells, Cultured | Rats | Proto-Oncogene Proteins - genetics | Peptidyl-Dipeptidase A - analysis | Angiotensin I - metabolism | JNK Mitogen-Activated Protein Kinases - analysis | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Kidney Tubules, Proximal - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Signal Transduction - physiology | Receptors, G-Protein-Coupled - genetics | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Affective Disorders, ISSN 0165-0327, 2009, Volume 124, Issue 1, pp. 164 - 169
Journal Article
Life Sciences, ISSN 0024-3205, 2006, Volume 79, Issue 20, pp. 1895 - 1905
The enhanced production of nitric oxide (NO) via inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of neuronal apoptosis after... 
Neuron | Rat | Inducible nitric oxide synthase | Mitogen-activated protein kinase | Spinal cord injury | Macrophages | Microglia | spinal cord injury | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | MICROGLIAL ACTIVATION | rat | BRAIN-INJURY | NITRIC-OXIDE SYNTHASE | neuron | NECROSIS-FACTOR-ALPHA | inducible nitric oxide synthase | PATHOPHYSIOLOGY | mitogen-activated protein kinase | EXCITOTOXICITY | macrophages | TRANSIENT FOREBRAIN ISCHEMIA | PHARMACOLOGY & PHARMACY | microglia | SIGNAL-REGULATED KINASE | EXPRESSION | Neurons - pathology | Up-Regulation | Phosphorylation | Mitogen-Activated Protein Kinase 3 - analysis | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | RNA, Messenger - analysis | Male | RNA, Messenger - metabolism | p38 Mitogen-Activated Protein Kinases - analysis | Spinal Cord Injuries - pathology | Nitric Oxide Synthase Type II - analysis | Microglia - immunology | Mitogen-Activated Protein Kinases - analysis | Spinal Cord Injuries - enzymology | p38 Mitogen-Activated Protein Kinases - metabolism | Macrophages - immunology | Nerve Degeneration - enzymology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Rats | Mitogen-Activated Protein Kinase 1 - analysis | Rats, Sprague-Dawley | Macrophage Activation | Macrophages - enzymology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Nitric Oxide Synthase Type II - genetics | Neurons - enzymology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide Synthase Type II - metabolism | Immunohistochemistry | Neurosciences | Messenger RNA | Earthquakes | Neurons | Nitric oxide | Physiological aspects | Spinal cord injuries | Protein kinases | Index Medicus
Journal Article
Journal of Periodontology, ISSN 0022-3492, 12/2014, Volume 85, Issue 12, pp. 1806 - 1813
Background: Fluid shear stress (FSS) is a major type of mechanical stress that is loaded on human periodontal ligament cells (hPDLCs) during mastication and... 
p38 mitogen‐activated protein kinases | periodontal ligament | Cell differentiation | stress, mechanical | Periodontal ligament | P38 mitogen-activated protein kinases | Stress | Mechanical | OSTEOBLAST DIFFERENTIATION | INVOLVEMENT | p38 mitogen-activated protein kinases | MESENCHYMAL STEM-CELLS | ALKALINE-PHOSPHATASE ACTIVITY | GINGIVAL FIBROBLASTS | FORCE | BONE-FORMATION | MECHANICAL-STRESS | DENTISTRY, ORAL SURGERY & MEDICINE | MINERALIZATION | MAPK PATHWAY | MAP Kinase Signaling System - physiology | Osteogenesis - physiology | Mitogen-Activated Protein Kinase 3 - analysis | Nitriles - pharmacology | Calcium - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Stress, Mechanical | Male | p38 Mitogen-Activated Protein Kinases - analysis | Young Adult | Periodontal Ligament - cytology | Periodontal Ligament - enzymology | Cell Shape | Alkaline Phosphatase - analysis | Adult | Female | Cell Differentiation - physiology | Child | Cell Survival - physiology | Osteogenesis - genetics | Butadienes - pharmacology | Calcification, Physiologic - drug effects | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | Calcification, Physiologic - physiology | Hydrodynamics | Imidazoles - pharmacology | Mitogen-Activated Protein Kinase 1 - analysis | Alkaline Phosphatase - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Biomechanical Phenomena | Adolescent | Collagen Type I - analysis | Pyridines - pharmacology | Actin Cytoskeleton - ultrastructure | Index Medicus | Dentistry
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132105 - e0132105
Profiling cellular proteome is critical to understanding signal integration during cell fate determination. In this study, the capability of capillary... 
LUNG-CANCER | I-ALPHA | STEM-CELLS | CYCLIC-GMP | CANCER CELLS | PROTEIN-KINASE-G | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | ADIPOCYTE DIFFERENTIATION | POSTTRANSLATIONAL MODIFICATIONS | SIGNAL INTEGRATION | Microscopy - methods | Cell Line | Phosphorylation | Mitogen-Activated Protein Kinase 3 - analysis | Signal Transduction | Humans | Cells, Cultured | Cyclic GMP-Dependent Protein Kinase Type I - biosynthesis | Adipocytes - cytology | Adipocytes - enzymology | Protein Isoforms - analysis | Mitogen-Activated Protein Kinase 1 - analysis | Blotting, Western | Omentum - cytology | HeLa Cells - chemistry | Cyclic GMP-Dependent Protein Kinase Type I - analysis | Proto-Oncogene Proteins c-akt - analysis | Isoelectric Focusing - methods | Spectrum Analysis, Raman | Protein Processing, Post-Translational | Proteomics - methods | Electrophoresis, Capillary - methods | Adipogenesis | Cell differentiation | Phosphotransferases | Nitric oxide | Proteomics | Health sciences | Immunoassay | Profiling | Disease | Laboratories | Protein kinase G | Differentiation (biology) | AKT protein | Adipocytes | Kinases | Proteins | Signal transduction | Cell fate | Cyclic GMP | Post-translation | Isoelectric focusing | Obesity | Immunoglobulins | Integration | Extracellular signal-regulated kinase | Preadipocytes | MAP kinase | Insulin | Medicine | Signaling | Sensitivity | Biopsy | Isoforms | Diabetes | Immunoassays | Methods | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 09/2009, Volume 297, Issue 3, pp. 749 - 758
Acute contractile activity increases the activation of protein kinases involved in signal transduction. We hypothesized that the contractile activity-induced... 
Adenosine | 5′-monophosphate-activated protein kinase | p38 mitogen-activated protein kinase | Exercise signaling | Fiber type | ACTIVATION | PHYSIOLOGY | HUMAN SKELETAL-MUSCLE | CONTRACTILE ACTIVITY | exercise signaling | fiber type | CHRONIC ELECTRICAL-STIMULATION | BIOGENESIS | PATHWAY | ENDURANCE EXERCISE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | AMP KINASE | adenosine 5 '-monophosphate-activated protein kinase | PGC-1-ALPHA TRANSCRIPTION | Protein Kinases - metabolism | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Mitogen-Activated Protein Kinase 3 - analysis | Mitochondria, Muscle - metabolism | AMP-Activated Protein Kinases - analysis | Male | Muscle, Skeletal - metabolism | Physical Endurance - physiology | p38 Mitogen-Activated Protein Kinases - analysis | Muscle, Skeletal - chemistry | Mitochondria, Muscle - physiology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Muscle, Skeletal - ultrastructure | Rats | Mitogen-Activated Protein Kinase 1 - analysis | Rats, Sprague-Dawley | Down-Regulation - physiology | Algorithms | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Muscle Contraction - physiology | Proto-Oncogene Proteins c-akt - analysis | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Musculoskeletal system | Enzymes | Kinases | Comparative analysis | Index Medicus
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 04/2008, Volume 10, Issue 2, pp. R43 - R43
Introduction Cannabis-based medicines have a number of therapeutic indications, including anti- inflammatory and analgesic effects. The endocannabinoid... 
C-REACTIVE PROTEIN | CB2 RECEPTORS | NEUROPATHIC PAIN | ACTIVATION | RAT | ACID AMIDE HYDROLASE | INFLAMMATORY PAIN | RHEUMATOLOGY | MECHANICALLY EVOKED-RESPONSES | BONE MASS | DORSAL-HORN | Mitogen-Activated Protein Kinase 3 - analysis | Cytokines - analysis | Humans | Middle Aged | Synovial Fluid - metabolism | RNA, Messenger - analysis | Male | Synovial Fluid - chemistry | Arthritis, Rheumatoid - metabolism | Arachidonic Acids - analysis | Arachidonic Acids - metabolism | Piperidines - pharmacology | Glycerides - analysis | Mass Spectrometry | Chromatography, Liquid | Female | Phosphorylation - drug effects | Amidohydrolases - analysis | Endocannabinoids | Fibroblasts - metabolism | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Knee Joint - metabolism | Cytokines - metabolism | Cells, Cultured | Osteoarthritis - metabolism | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Mitogen-Activated Protein Kinase 1 - analysis | Polyunsaturated Alkamides - analysis | Synovial Membrane - metabolism | Blotting, Western | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Aged | Mitogen-Activated Protein Kinase 1 - metabolism | Synovial fluid | Cannabinoids | Dosage and administration | Research | Drug therapy | Osteoarthritis | Health aspects | Index Medicus
Journal Article