X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (20182) 20182
Book Chapter (14) 14
Book / eBook (2) 2
Conference Proceeding (2) 2
Dissertation (2) 2
Publication (2) 2
Reference (2) 2
Newsletter (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (12502) 12502
humans (11101) 11101
phosphorylation (6072) 6072
mice (5874) 5874
mitogen-activated protein kinases - metabolism (5293) 5293
rats (4830) 4830
cells, cultured (4626) 4626
signal transduction (4517) 4517
male (4351) 4351
enzyme inhibitors - pharmacology (4335) 4335
mitogen-activated protein kinase 1 - metabolism (4255) 4255
cell biology (4223) 4223
biochemistry & molecular biology (4154) 4154
p38 mitogen-activated protein kinases - metabolism (3898) 3898
apoptosis (3705) 3705
signal transduction - drug effects (3526) 3526
expression (3459) 3459
activation (3402) 3402
mitogen-activated protein kinase 3 - metabolism (3378) 3378
cell line, tumor (2953) 2953
mitogen-activated protein kinases - antagonists & inhibitors (2844) 2844
cell line (2816) 2816
female (2799) 2799
phosphorylation - drug effects (2722) 2722
p38 mitogen-activated protein kinases - antagonists & inhibitors (2631) 2631
apoptosis - drug effects (2490) 2490
oncology (2395) 2395
map kinase (2368) 2368
protein kinase inhibitors - pharmacology (2326) 2326
kinases (2267) 2267
enzyme activation (2140) 2140
activated protein-kinase (2090) 2090
proteins (2089) 2089
enzyme activation - drug effects (2071) 2071
blotting, western (2023) 2023
pyridines - pharmacology (1996) 1996
jnk mitogen-activated protein kinases - metabolism (1986) 1986
imidazoles - pharmacology (1980) 1980
rats, sprague-dawley (1961) 1961
map kinase signaling system - drug effects (1940) 1940
neurosciences (1850) 1850
dose-response relationship, drug (1835) 1835
pharmacology & pharmacy (1815) 1815
flavonoids - pharmacology (1800) 1800
gene-expression (1744) 1744
mitogen-activated protein kinase 1 - antagonists & inhibitors (1686) 1686
cell proliferation - drug effects (1666) 1666
protein kinases (1648) 1648
inflammation (1582) 1582
mitogen-activated protein kinase 3 (1568) 1568
inhibition (1553) 1553
cells (1509) 1509
cancer (1499) 1499
physiology (1491) 1491
research (1486) 1486
time factors (1452) 1452
gene expression (1433) 1433
signal transduction - physiology (1427) 1427
nf-kappa b - metabolism (1417) 1417
immunology (1380) 1380
phosphatidylinositol 3-kinases - metabolism (1377) 1377
nf-kappa-b (1356) 1356
pathway (1328) 1328
mitogen-activated protein kinase 3 - antagonists & inhibitors (1324) 1324
oxidative stress (1320) 1320
p38 mitogen-activated protein kinases (1303) 1303
proto-oncogene proteins c-akt - metabolism (1297) 1297
mitogen-activated protein kinase kinases - metabolism (1281) 1281
in-vitro (1274) 1274
rna, messenger - metabolism (1270) 1270
jnk mitogen-activated protein kinases - antagonists & inhibitors (1236) 1236
cell survival - drug effects (1232) 1232
proliferation (1223) 1223
research article (1214) 1214
extracellular signal-regulated map kinases - metabolism (1209) 1209
transfection (1207) 1207
mitogen-activated protein kinase kinases - antagonists & inhibitors (1196) 1196
mice, inbred c57bl (1186) 1186
mitogen-activated protein kinase (1173) 1173
analysis (1140) 1140
physiological aspects (1101) 1101
kinase (1089) 1089
endocrinology & metabolism (1080) 1080
mitogen-activated protein kinases (1070) 1070
cell proliferation (1054) 1054
growth (1048) 1048
signal-transduction (1041) 1041
phosphatidylinositol 3-kinases - antagonists & inhibitors (1036) 1036
up-regulation (1031) 1031
multidisciplinary sciences (1025) 1025
protein-kinase (1021) 1021
extracellular signal-regulated kinase (995) 995
tumor cells, cultured (971) 971
disease models, animal (970) 970
mapk (969) 969
nitriles - pharmacology (968) 968
receptor (968) 968
map kinase signaling system - physiology (957) 957
reactive oxygen species - metabolism (947) 947
rodents (925) 925
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (20171) 20171
Japanese (150) 150
Chinese (74) 74
Russian (8) 8
Portuguese (4) 4
Korean (3) 3
Spanish (2) 2
Dutch (1) 1
French (1) 1
German (1) 1
Italian (1) 1
Norwegian (1) 1
Swedish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2004, Volume 64, Issue 19, pp. 7099 - 7109
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1897 - 17
.... We found that early after mitogenic stimulation, RUNX3 binds to its target loci, where it opens chromatin structure by sequential recruitment of Trithorax group proteins and cellcycle regulators... 
UBIQUITINATION | AML1-ETO | ACETYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PROTEINS | QUANTITATIVE-ANALYSIS | POLYCOMB | CANCER | KINASES | FAMILY | Chromatin - metabolism | RNA, Small Interfering - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Polycomb-Group Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Chromatin - chemistry | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Signal Transduction | Epithelial Cells - pathology | MAP Kinase Kinase 1 - metabolism | Imidazoles - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Cell Cycle Checkpoints - drug effects | Polycomb-Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA, Small Interfering - metabolism | ras Proteins - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Cyclin-Dependent Kinase 4 - genetics | Epithelial Cells - drug effects | ras Proteins - metabolism | Drosophila melanogaster - genetics | Chromatin Assembly and Disassembly - drug effects | Drosophila melanogaster - metabolism | MAP Kinase Kinase 1 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Chromatin - drug effects | Histone-Lysine N-Methyltransferase - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Sirolimus - pharmacology | Animals | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Core Binding Factor Alpha 3 Subunit - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Polycomb group proteins | Regulators | Molecular modelling | S phase | Genes | Cell cycle | Loci | Runx3 protein | Recruitment | Tumors | Chromatin remodeling
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
ACTIVATION | MEK INHIBITION | DETERMINANTS | RAF | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | DEFICIENCY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1938 - 1938
... Medical College and Huaian Second Peoples Hospital, Huaian 223300, China; sj30918@163.com 3 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091... 
Sesquiterpene | Sarcandra glabra | Chloranthalactone B | Inflammation | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | P38 MAPK | RAW 264.7 CELLS | INDUCED INFLAMMATION | IL-6 EXPRESSION | sesquiterpene | CHEMISTRY, MULTIDISCIPLINARY | AP-1 INACTIVATION | inflammation | SIGNALING PATHWAY | SESQUITERPENE LACTONE | SARCANDRA-GLABRA | NF-KAPPA-B | chloranthalactone B | Tumor Necrosis Factor-alpha - genetics | MAP Kinase Kinase 3 - genetics | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Lactones - pharmacology | MAP Kinase Kinase 6 - genetics | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Interleukin-6 - metabolism | Nitric Oxide - biosynthesis | Interleukin-6 - genetics | Macrophages - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | MAP Kinase Kinase 6 - antagonists & inhibitors | Models, Molecular | MAP Kinase Kinase 3 - metabolism | Macrophages - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 3 - chemistry | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Inflammation - prevention & control | Mice | Dinoprostone - antagonists & inhibitors | MAP Kinase Kinase 6 - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dinoprostone - biosynthesis | MAP Kinase Kinase 3 - antagonists & inhibitors | Transcription Factor AP-1 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Transcription Factor AP-1 - metabolism | MAP Kinase Kinase 6 - metabolism | Cell Line | Nitric Oxide - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Transcription Factor AP-1 - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Sesquiterpenes - pharmacology | Herbal medicine | Polymerase chain reaction | Kinases
Journal Article
PloS one, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167071
...) in podocytes, cDNAs and cell lysate of cultured human podocytes were used for the expression of nAChR mRNAs and proteins, respectively... 
ACETYLCHOLINE-RECEPTORS | CIGARETTE-SMOKING | NMDA RECEPTORS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | RENAL-FUNCTION | INJURY | DIABETIC-NEPHROPATHY | CHRONIC KIDNEY-DISEASE | CARDIOVASCULAR MORBIDITY | ROS PRODUCTION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Apoptosis - genetics | Male | Nicotinic Antagonists - pharmacology | Spin Labels | Reactive Oxygen Species - agonists | Nicotine - pharmacology | MAP Kinase Kinase 4 - metabolism | Cyclic N-Oxides - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Female | MAP Kinase Kinase 4 - antagonists & inhibitors | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Receptors, Nicotinic - metabolism | Podocytes - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Tissue Culture Techniques | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Nicotine - antagonists & inhibitors | Podocytes - cytology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Podocytes - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oxidative Stress - drug effects | Receptors, Nicotinic - genetics | Cell Line, Transformed | Mitogen-Activated Protein Kinase 1 - metabolism | Oxidative stress | Physiological aspects | Research | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking | Apoptosis | Cell proliferation | Reactive oxygen species | Phosphorylation | Laboratories | Syngeneic grafts | Downstream effects | Tempol | Acetylcysteine | Superoxide dismutase | mRNA | Medical schools | Antioxidants | Proteins | Receptors | Rodents | Mesangial cells | Localization | Medical research | Oxygen | Extracellular signal-regulated kinase | JNK protein | Permeability | Gene expression | Cigarette smoking | Signaling | Molecular modelling | Inhibitors | Acetylcholine receptors (nicotinic) | In vivo methods and tests | Kidney diseases | Diabetes | Kidney transplantation
Journal Article
PloS one, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0124007
... comprising of proliferation, migration, invasion, and the subsequent adhesion and angiogenesis in other organs or tissues [3]. Since invasion is one of the fundamental... 
MATRIX METALLOPROTEINASES | ANGIOGENESIS | NUCLEAR-FACTOR | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | INDUCED MATRIX-METALLOPROTEINASE-9 EXPRESSION | CYCLOOXYGENASE-2 EXPRESSION | PROLIFERATION | FOS | C-JUN | NF-KAPPA-B | Phosphorylation | Epithelial Cells - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Transcription Factor AP-1 - genetics | Epithelial Cells - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Gastric Mucosa - metabolism | Mitogen-Activated Protein Kinase 9 - genetics | Tetradecanoylphorbol Acetate - antagonists & inhibitors | Transcription Factor AP-1 - metabolism | Dose-Response Relationship, Drug | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Oligodeoxyribonucleotides - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Flavonoids - pharmacology | Stomach - drug effects | Oligodeoxyribonucleotides - metabolism | Stomach - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Proto-Oncogene Proteins c-fos - metabolism | Epithelial Cells - pathology | Antibodies - pharmacology | Cell Movement - drug effects | Transcription Factor AP-1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Antineoplastic Agents, Phytogenic - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Enzymes | Care and treatment | Oligodeoxynucleotides | Stomach cancer | Cancer cells | Cancer | Transcription factors | Oligonucleotides | Malignancy | Metastasis | Matrix metalloproteinase | Kinases | Cancer therapies | Medical schools | Western blotting | Metastases | Anticancer properties | Angiogenesis | Signal transduction | Pathways | Fos protein | Proteolysis | Metalloproteinase | c-Fos protein | Gastric cancer | Invasiveness | Extracellular signal-regulated kinase | c-Jun protein | Blocking | Breast cancer | Gene expression | Gelatinase B | Polymerase chain reaction | Signaling | Acetic acid
Journal Article
Journal of cell science, ISSN 0021-9533, 2013, Volume 126, Issue 17, pp. 3990 - 3999
.... Here, we use MCF10A cells, which fail to form tight junctions and express very little endogenous Crumbs3, to show that inducing expression of the polarity protein Scribble is sufficient to promote... 
Scribble | Polarity | Tight junctions | Mammary epithelium | EMT | ERK | CELL-CELL JUNCTIONS | PROTEIN-KINASE-C | BARRIER FUNCTION | E-CADHERIN | MAMMALIAN EPITHELIAL-CELLS | BETA-CATENIN | MESENCHYMAL TRANSITION | TIGHT JUNCTION | CELL BIOLOGY | MALIGNANT PROGRESSION | TUMOR-SUPPRESSOR SCRIBBLE | MAP Kinase Signaling System - physiology | Phosphorylation | Epithelial-Mesenchymal Transition - physiology | Homeodomain Proteins - metabolism | Humans | Membrane Glycoproteins - biosynthesis | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transcriptional Activation | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Transcription, Genetic | Flavonoids - pharmacology | Membrane Proteins - metabolism | Chromones - pharmacology | Tight Junctions - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Homeodomain Proteins - biosynthesis | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Down-Regulation | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Anthracenes - pharmacology | Transcription Factors - metabolism | Membrane Proteins - biosynthesis | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Homeodomain Proteins - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Tumor Suppressor Proteins - biosynthesis | Mitogen-Activated Protein Kinase 1 - metabolism | Zinc Finger E-box-Binding Homeobox 1
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 1522-1539, 2005, Volume 288, Issue 2, pp. H971 - H976
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects the heart against ischemia-reperfusion injury... 
Myocardial infarction | Phosphatidylinositol 3-kinase-Akt | Reperfusion injury | Mitogen-activated protein kinases | MITOCHONDRIAL PERMEABILITY TRANSITION | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | phosphatidylinositol 3-kinase-Akt | mitogen-activated protein kinases | myocardial infarction | PORE | INJURY | PERIPHERAL VASCULAR DISEASE | reperfusion injury | Phosphorylation | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - pathology | Myocardial Infarction - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Myocardium - pathology | MAP Kinase Kinase 2 - metabolism | Myocardial Infarction - metabolism | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-akt | Myocardial Reperfusion Injury - metabolism | Myocardium - enzymology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Ischemic Preconditioning, Myocardial | MAP Kinase Kinase 2 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1480 - 11
.... In normal retinas, intravitreal injection of BaCl2 significantly increased GFAP expression in Muller cells, which was eliminated by co-injecting mitogen-activated protein kinase (MAPK) inhibitor U0126... 
ACTIVATED PROTEIN-KINASE | MESSENGER-RNA | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | GANGLION-CELLS | MEMBRANE CONDUCTANCE | INTRAOCULAR-PRESSURE | OCULAR HYPERTENSION MODEL | GLIAL-CELLS | EXPERIMENTAL GLAUCOMA | NUCLEUS-ACCUMBENS | Retina - drug effects | Glial Fibrillary Acidic Protein - genetics | Retina - metabolism | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ependymoglial Cells - metabolism | Gliosis - chemically induced | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Ocular Hypertension - metabolism | Glial Fibrillary Acidic Protein - metabolism | Ocular Hypertension - drug therapy | Gliosis - pathology | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Ependymoglial Cells - pathology | Disease Models, Animal | Barium Compounds - administration & dosage | Butadienes - pharmacology | Gliosis - genetics | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Ocular Hypertension - pathology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Potassium Channels, Inwardly Rectifying - genetics | Ependymoglial Cells - drug effects | Rats, Sprague-Dawley | Ocular Hypertension - genetics | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Chlorides - administration & dosage | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Proto-Oncogene Proteins c-fos - genetics | Gliosis - drug therapy | Protein Kinase Inhibitors - pharmacology | Chronic Disease | Potassium Channels, Inwardly Rectifying - metabolism | Retina - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Transcription factors | Potassium channels (inwardly-rectifying) | P elements | Glial fibrillary acidic protein | c-Jun protein | Extracellular signal-regulated kinase | MAP kinase | Retina | Injection | Cyclic AMP response element-binding protein | Kinases | Proteins | Signal transduction | Gliosis | Protein kinase | Rodents | c-Fos protein | Glutamic acid receptors (metabotropic)
Journal Article