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Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 33, pp. 28017 - 28026
Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials. A reduction of IFN-gamma-producing CD4(+) T cells is... 
TRANSCRIPTIONAL ACTIVATION | MULTIPLE-SCLEROSIS | PHOSPHORYLATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | GENE-EXPRESSION | INDUCTION | T-BET | P65 | INNATE IMMUNITY | Dendritic Cells - immunology | Th1 Cells - immunology | MAP Kinase Signaling System - immunology | Th1 Cells - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Th17 Cells - metabolism | Transcription Factor RelA - immunology | Th17 Cells - cytology | Phosphorylation - immunology | B7-1 Antigen - biosynthesis | Phosphorylation - drug effects | B7-2 Antigen - immunology | Dimethyl Fumarate | Immunosuppressive Agents - pharmacology | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Mitogen-Activated Protein Kinase 3 - immunology | B7-1 Antigen - immunology | Cells, Cultured | Histocompatibility Antigens Class II - biosynthesis | Interleukin-12 - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - immunology | Cell Differentiation - immunology | Animals | B7-2 Antigen - biosynthesis | Histocompatibility Antigens Class II - immunology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Transcription Factor RelA - metabolism | Cell Differentiation - drug effects | Fumarates - pharmacology | Interleukin-12 - immunology | Interleukin-6 - immunology | Th17 Cells - immunology | Dendritic Cells - cytology | Mice | Th1 Cells - cytology | Multiple Sclerosis | MAP Kinases (MAPKs) | Immunology | Dendritic Cells | Antigen Presentation | NF-Kappa B (NF-KB) | Cytokine
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 121, Issue 4, pp. 893 - 902.e2
Background Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown. Objectives We sought to study... 
Allergy and Immunology | mitogen-activated protein kinase | chemokines | epithelial function | bronchial biopsy | Asthma | LUNG | BRONCHIAL EPITHELIAL-CELLS | MAP KINASE | asthma | PROLIFERATION | IMMUNOLOGY | ALLERGY | GM-CSF | PATHWAY | INFLAMMATION | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | EXPRESSION | Phosphorylation | Bronchi - enzymology | Humans | Middle Aged | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Enzyme Induction - immunology | MAP Kinase Signaling System - immunology | Enzyme Activation - immunology | Respiratory Mucosa - pathology | Chemokines - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - biosynthesis | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Bronchi - pathology | Respiratory Mucosa - secretion | Chemokines - biosynthesis | Chemokines - secretion | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Asthma - enzymology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Respiratory Mucosa - enzymology | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Asthma - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Protein kinases | Proteins | Studies | Signal transduction | Cell culture | Rodents | Cloning | Smooth muscle | Kinases
Journal Article
The Journal of Physiology, ISSN 0022-3751, 04/2009, Volume 587, Issue 7, pp. 1535 - 1546
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2008, Volume 412, Issue 2, pp. 287 - 298
DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2... 
Fibroblast growth factor (FGF) | Transcription | Phosphatase | Mitogen-activated protein kinase phosphatase-3 (MKP-3) | Mitogen-activated protein kinase (MAPK) | Dual-specificity phosphatase 6 (DUSP6) | ACTIVATED PROTEIN-KINASE | transcription | MKP3 | MAP-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | mitogen-activated protein kinase phosphatase-3 (MKP-3) | FAMILY | EMBRYO | IN-VIVO | fibroblast growth factor (FGF) | phosphatase | dual-specificity phosphatase 6 (DUSP6) | EXPRESSION | DUAL-SPECIFICITY PHOSPHATASES | CATALYTIC ACTIVATION | VERTEBRATE LIMB | Dual Specificity Phosphatase 6 - genetics | Proto-Oncogene Proteins c-ets - genetics | Humans | Molecular Sequence Data | Phosphatidylinositol 3-Kinases - metabolism | Fibroblast Growth Factors - metabolism | Base Sequence | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins c-ets - metabolism | Transgenes | Binding Sites | Cell Line | Promoter Regions, Genetic | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - genetics | Dual Specificity Phosphatase 6 - metabolism | Sequence Alignment | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - physiology | Mice | Enzyme Activation | Feedback, Physiological - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | MEK, MAPK | SRF, serum-response factor | SRY, sex-determining region Y | PI3K, phosphoinositide 3-kinase | FGFR, FGF receptor | MKP, MAPK phosphatase | βGal, β-galactosidase | Ets, E twenty-six | JNK, c-Jun N-terminal kinase | ERK kinase | DUSP, dual-specificity phosphatase | ChIP, chromatin immunoprecipitation | HH10, Hamburger and Hamilton stage 10 | ERK, extracellular-signal-regulated kinase | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | mRFP, monomeric red fluorescent protein | TNFα, tumour necrosis factor α | IκBα, inhibitor of nuclear factor κB α | EGFP, enhanced green fluorescent protein | NF-κB, nuclear factor κB | PBX1, pre-B-cell leukaemia transcription factor 1 | Elk1, Ets-like kinase 1 | FBS, fetal bovine serum | FKHD, Forkhead mutant | FGF, fibroblast growth factor | RSV, rous sarcoma virus | MKK, MAPK kinase | HA, haemagglutinin | EMSA, electrophoretic mobility-shift assay | ER, oestrogen receptor | AER, apical ectodermal ridge | ConA, concanavalin A | MKKK, MAPK kinase kinase | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2012, Volume 32, Issue 26, pp. 8855 - 8864
Journal Article
Immunologic Research, ISSN 0257-277X, 10/2011, Volume 51, Issue 1, pp. 45 - 60
Complement system activation plays an important role in both innate and acquired immunity. Activation of the complement and the subsequent formation of C5b-9... 
Allergology | Signal transduction | Immunology | Medicine & Public Health | Cell cycle | Internal Medicine | Membrane attack complex | C5b-9 terminal complement complex | Transcriptional regulation | Medicine/Public Health, general | Apoptosis | ACTIVATED PROTEIN-KINASE | SYSTEMIC LUPUS-ERYTHEMATOSUS | GUILLAIN-BARRE-SYNDROME | ULCERATIVE-COLITIS | GLOMERULAR EPITHELIAL-CELLS | C5B-9 COMPLEX | IMMUNOLOGY | S-PROTEIN | MANNAN-BINDING LECTIN | ACUTE MYOCARDIAL-INFARCTION | SMOOTH-MUSCLE-CELLS | Forkhead Transcription Factors - immunology | CDC2 Protein Kinase | Complement Membrane Attack Complex - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Caspase 8 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Complement Membrane Attack Complex - immunology | MAP Kinase Signaling System - immunology | Phosphatidylinositol 3-Kinases - immunology | Cell Cycle Proteins - immunology | Cyclin B - immunology | Forkhead Transcription Factors - metabolism | Muscle Proteins - metabolism | bcl-Associated Death Protein - metabolism | Cell Membrane - metabolism | Phosphorylation - immunology | Cyclin-Dependent Kinases | Proto-Oncogene Proteins c-akt - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Mitogen-Activated Protein Kinase 3 - immunology | Muscle Proteins - immunology | G1 Phase - immunology | S Phase - immunology | Nerve Tissue Proteins - immunology | Cell Cycle Proteins - metabolism | bcl-Associated Death Protein - immunology | Cyclin-Dependent Kinase 4 - metabolism | Nerve Tissue Proteins - metabolism | Caspase 8 - immunology | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-akt - immunology | Mitogen-Activated Protein Kinase 3 - metabolism | BH3 Interacting Domain Death Agonist Protein - immunology | Cyclin B - metabolism | Cell Membrane - immunology | Forkhead Box Protein O1 | Cyclin-Dependent Kinase 2 - immunology | Medical colleges | Membranes | Immune system | apoptosis | membrane attack complex | cell cycle | signal transduction | transcriptional regulation
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 04/2009, Volume 8, Issue 4, pp. 834 - 843
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 9932 - 9943
G protein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor 1 (GPER1), is thought to play important roles in breast cancer and... 
ACTIVATION | COMPLEX | 30 GPR30 | CANCER CELLS | KINASE-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCINEURIN | SCAFFOLDS | ENDOCYTOSIS | PLASMA-MEMBRANE | ANCHORING PROTEIN | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Receptors, G-Protein-Coupled - agonists | Recombinant Fusion Proteins - metabolism | GTP-Binding Protein alpha Subunits, Gi-Go - chemistry | Quinolines - pharmacology | Mitogen-Activated Protein Kinase 1 - chemistry | A Kinase Anchor Proteins - genetics | Protein Processing, Post-Translational - drug effects | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Phosphorylation - drug effects | Radioligand Assay | Mitogen-Activated Protein Kinase 3 - chemistry | Phosphatidylinositol 3-Kinase - metabolism | A Kinase Anchor Proteins - metabolism | A Kinase Anchor Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Cyclopentanes - pharmacology | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Phosphatidylinositol 3-Kinase - chemistry | Up-Regulation - drug effects | MAP Kinase Signaling System - drug effects | Receptors, Estrogen - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Phosphatidylinositol 3-Kinase - genetics | PDZ Domains | Receptors, G-Protein-Coupled - genetics | Mutation | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Mitogen-Activated Protein Kinase 1 - metabolism | Signal Transduction | GPER1 | A-kinase-anchoring protein (AKAP) | G protein-coupled receptor (GPCR) | GPR30 | PDZ domain | calcineurin | extracellular signal-regulated kinase (ERK) | G protein
Journal Article
Journal Article
Virology, ISSN 0042-6822, 2016, Volume 492, pp. 145 - 154
Abstract Asian-American (AA) HPV-16 variants are associated with higher risk of cancer. Abnormal activation of intracellular signaling play a critical role in... 
Infectious Disease | HPV-16 | Transformation | Molecular variants | Intracellular signaling | Migration | PROTEIN | 16 E6 VARIANTS | KINASE | RISK | CERVICAL-CANCER | SUFFICIENT | VIROLOGY | GENE | UP-REGULATION | IMMORTALIZATION | RNA, Small Interfering - genetics | Cell Proliferation | Keratinocytes - virology | Humans | Glycogen Synthase Kinase 3 beta | Male | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Papillomavirus E7 Proteins - genetics | MAP Kinase Kinase 1 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Oncogene Proteins, Viral - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Transduction, Genetic | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Gene Expression Regulation | Repressor Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Genotype | MAP Kinase Kinase 1 - metabolism | Glycogen Synthase Kinase 3 - metabolism | Human papillomavirus 16 - metabolism | Host-Pathogen Interactions | Phosphatidylinositol 3-Kinases - genetics | Keratinocytes - pathology | Papillomavirus E7 Proteins - metabolism | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Keratinocytes - metabolism | Primary Cell Culture | Human papillomavirus 16 - genetics | Cell Movement | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Proteins | Medical colleges | Development and progression | Papillomavirus infections | Analysis | Stem cells | Tyrosine | Evaluation | Glycogen | Heat shock proteins | Papillomaviruses | Synthesis | Exhibitions | Mitogens | Health aspects | Protein kinases | Protein binding | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2008, Volume 283, Issue 27, pp. 18478 - 18482
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2009, Volume 284, Issue 43, pp. 29817 - 29827
Journal Article