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Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 10, pp. 1571 - 1587
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 45, pp. 31246 - 31255
The strength and duration of mitogen-activated protein kinase signaling is regulated through phosphorylation and dephosphorylation by dedicated... 
SIGNAL-REGULATED KINASE-2 | MOUSE DEVELOPMENT | ACTIVATED PROTEIN-KINASE | PHOSPHATASE 2A | GENETIC INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | IN-VIVO | P38 MAPK | MUSCLE CELL-PROLIFERATION | TRANSGENIC MICE | Dual Specificity Phosphatase 6 - genetics | Fibroblasts - enzymology | Cell Proliferation | Cell Survival - genetics | Apoptosis - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Cardiomyopathy, Hypertrophic - enzymology | Myocytes, Cardiac - enzymology | Phosphorylation - genetics | MAP Kinase Signaling System - genetics | Mice, Mutant Strains | Mitogen-Activated Protein Kinase 1 - genetics | Embryo, Mammalian - enzymology | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Embryo, Mammalian - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Disease Susceptibility - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Myocardium - pathology | Mitogen-Activated Protein Kinase 7 - genetics | Mitogen-Activated Protein Kinase 7 - metabolism | Fibroblasts - pathology | Dual Specificity Phosphatase 6 - metabolism | Myocytes, Cardiac - pathology | Myocardium - enzymology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | Cardiomyopathy, Hypertrophic - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Mechanisms of Signal Transduction
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5214 - 5224
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2014, Volume 33, Issue 16, pp. 1784 - 1801
Journal Article
Neuron, ISSN 0896-6273, 2011, Volume 69, Issue 1, pp. 91 - 105
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2015, Volume 112, Issue 46, pp. 14284 - 14289
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2017, Volume 31, Issue 7, pp. 2963 - 2972
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 05/2013, Volume 105, Issue 10, pp. 733 - 742
Journal Article
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2013, Volume 19, Issue 10, pp. 2677 - 2687
Purpose: To analyze the antimyeloma potential of TG02, an ERK5/CDK inhibitory drug. Experimental Design: Utilizing different multiple myeloma cell lines we... 
MULTIPLE-MYELOMA | CANCER-CELLS | ACTIVATION | ONCOLOGY | INDUCED APOPTOSIS | CYCLIN D1 | PHOSPHORYLATION | SENSITIVITY | TRANSDUCTION | DEPENDENT KINASE INHIBITOR | EXPRESSION | Cell Cycle - genetics | Gene Expression Regulation, Enzymologic - drug effects | Cyclin-Dependent Kinases - metabolism | Humans | Cell Survival - genetics | Thalidomide - pharmacology | Heterocyclic Compounds, 4 or More Rings - pharmacology | CDC2 Protein Kinase - metabolism | Dose-Response Relationship, Drug | Thalidomide - analogs & derivatives | Mitogen-Activated Protein Kinase 7 - antagonists & inhibitors | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Cyclin-Dependent Kinases - genetics | Multiple Myeloma - enzymology | Cell Survival - drug effects | Cyclin-Dependent Kinase 2 - metabolism | CDC2 Protein Kinase - genetics | Bortezomib | CDC2 Protein Kinase - antagonists & inhibitors | Cyclin-Dependent Kinase 9 - genetics | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 7 - genetics | Mitogen-Activated Protein Kinase 7 - metabolism | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Synergism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cyclin-Dependent Kinase 9 - metabolism | Protein Kinase Inhibitors - pharmacology | Multiple Myeloma - prevention & control | Cell Cycle - drug effects | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2011, Volume 104, Issue 4, pp. 664 - 672
BACKGROUND: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)-extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been... 
Prostate cancer; signalling; invasive phenotype | CELLS | TIMP-2 EXPRESSION | TRANSCRIPTION | PROLIFERATION | MATRIX METALLOPROTEINASES | prostate cancer | ONCOLOGY | PATHWAY | GENE-EXPRESSION | MATRIX-METALLOPROTEINASE-9 | invasive phenotype | INHIBITORS | MMP-9 | signalling | MAP Kinase Kinase 5 - physiology | Prostatic Neoplasms - metabolism | MAP Kinase Signaling System - physiology | Prostatic Hyperplasia - pathology | Humans | Male | Transplantation, Heterologous | Cell Movement - genetics | MAP Kinase Signaling System - genetics | Prostatic Neoplasms - genetics | Transfection | MAP Kinase Kinase 5 - metabolism | Benzamides - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Drug Evaluation, Preclinical | Mitogen-Activated Protein Kinase 7 - physiology | Gene Expression Regulation, Neoplastic - genetics | Prostatic Neoplasms - pathology | Neoplasm Invasiveness | RNA, Small Interfering - pharmacology | Cells, Cultured | Mitogen-Activated Protein Kinase 7 - genetics | MAP Kinase Kinase 5 - genetics | Mitogen-Activated Protein Kinase 7 - metabolism | Prostatic Hyperplasia - genetics | Prostatic Hyperplasia - metabolism | Cell Movement - drug effects | Phenotype | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus | Molecular Diagnostics
Journal Article