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Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 15, pp. 10361 - 10373
Journal Article
Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 358 - 361
Transforming growth factor—β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit... 
Transcriptional regulatory elements | Echocardiography | Aortic diseases | Root growth | REPORTS | Placebos | Aneurysms | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | CELLS | ACTIVATION | VALSALVA | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | MOUSE MODEL | NOONANS-SYNDROME | RECEPTOR | MUTATIONS | INHIBITOR | Diphenylamine - pharmacology | Aortic Aneurysm - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Anthracenes - therapeutic use | MAP Kinase Signaling System | Diphenylamine - analogs & derivatives | Marfan Syndrome - drug therapy | Smad4 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Transforming Growth Factor beta - immunology | Diphenylamine - therapeutic use | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Aortic Aneurysm - physiopathology | Losartan - pharmacology | Smad2 Protein - metabolism | Sulfonamides - pharmacology | Anthracenes - pharmacology | Disease Progression | Aorta - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Protein Kinase Inhibitors - pharmacology | Smad4 Protein - deficiency | Enzyme Activation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Therapy | Progressions | Pathways | Strategy | Activation | Inhibition | Kinases
Journal Article
Science, ISSN 0036-8075, 1/2013, Volume 339, Issue 6116, pp. 218 - 222
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 4, pp. 1311 - 1321
Background & Aims: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure. C-jun N-terminal kinase (JNK) is thought to play a... 
Gastroenterology and Hepatology | JNK ACTIVATION | APOPTOSIS | GAMMA-RADIATION | PROTEIN-KINASE | MAP KINASES | TNF-ALPHA | STRESS | GASTROENTEROLOGY & HEPATOLOGY | ISOLATED MOUSE HEPATOCYTES | CELL-DEATH | INDUCED HEPATOTOXICITY | Drug Overdose - metabolism | Hepatocytes - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Mitogen-Activated Protein Kinase 9 - genetics | Drug Overdose - pathology | Acetaminophen - poisoning | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinase 5 - metabolism | Chemical and Drug Induced Liver Injury - pathology | Disease Models, Animal | Drug Overdose - physiopathology | MAP Kinase Kinase Kinase 5 - genetics | Mitogen-Activated Protein Kinase 9 - metabolism | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 8 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Chemical and Drug Induced Liver Injury - physiopathology | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Signal Transduction - physiology | Mice | Analgesics, Non-Narcotic - poisoning | Hepatocytes - enzymology | Liver diseases | Protein kinases | Liver | Glutathione | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0124007 - e0124007
Cell invasion is a crucial mechanism of cancer metastasis and malignancy. Matrix metallo-proteinase-9 (MMP-9) is an important proteolytic enzyme involved in... 
MATRIX METALLOPROTEINASES | ANGIOGENESIS | NUCLEAR-FACTOR | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | INDUCED MATRIX-METALLOPROTEINASE-9 EXPRESSION | CYCLOOXYGENASE-2 EXPRESSION | PROLIFERATION | FOS | C-JUN | NF-KAPPA-B | Phosphorylation | Epithelial Cells - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Transcription Factor AP-1 - genetics | Epithelial Cells - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Gastric Mucosa - metabolism | Mitogen-Activated Protein Kinase 9 - genetics | Tetradecanoylphorbol Acetate - antagonists & inhibitors | Transcription Factor AP-1 - metabolism | Dose-Response Relationship, Drug | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Oligodeoxyribonucleotides - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Flavonoids - pharmacology | Stomach - drug effects | Oligodeoxyribonucleotides - metabolism | Stomach - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Proto-Oncogene Proteins c-fos - metabolism | Epithelial Cells - pathology | Antibodies - pharmacology | Cell Movement - drug effects | Transcription Factor AP-1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Antineoplastic Agents, Phytogenic - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Enzymes | Care and treatment | Oligodeoxynucleotides | Stomach cancer | Cancer cells | Cancer | Transcription factors | Oligonucleotides | Malignancy | Metastasis | Matrix metalloproteinase | Kinases | Cancer therapies | Medical schools | Western blotting | Metastases | Anticancer properties | Angiogenesis | Signal transduction | Pathways | Fos protein | Proteolysis | Metalloproteinase | c-Fos protein | Gastric cancer | Invasiveness | Extracellular signal-regulated kinase | c-Jun protein | Blocking | Breast cancer | Gene expression | Gelatinase B | Polymerase chain reaction | Signaling | Acetic acid | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 19, pp. 13165 - 13173
Journal Article
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. 968 - 981
Background & Aims c-Jun N-terminal kinase (JNK) 1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated... 
Gastroenterology and Hepatology | APAP | Gene Regulation | Pharmacologic Treatment | Mouse Model | APOPTOSIS | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | OXIDATIVE STRESS | ACTIVATION | MOUSE HEPATOCYTES | TERMINAL KINASE | SIGNAL-TRANSDUCTION | MITOCHONDRIAL PERMEABILITY TRANSITION | NECROSIS | INHIBITION | GASTROENTEROLOGY & HEPATOLOGY | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Cell Proliferation | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Oxidative Stress | Carbon Tetrachloride | Humans | Middle Aged | Liver Failure, Acute - enzymology | Hepatocytes - pathology | Male | Gene Expression Profiling | Mitogen-Activated Protein Kinase 9 - genetics | Case-Control Studies | Young Adult | Time Factors | Liver Failure, Acute - genetics | Cell Death | Female | Mitogen-Activated Protein Kinase 8 - genetics | Liver Failure, Acute - prevention & control | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - enzymology | Hepatocytes - drug effects | Disease Models, Animal | Chemical and Drug Induced Liver Injury - prevention & control | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Liver Failure, Acute - chemically induced | Chemical and Drug Induced Liver Injury - genetics | Mitogen-Activated Protein Kinase 9 - deficiency | Mice, Knockout | Mitogen-Activated Protein Kinase 8 - deficiency | Animals | Acetaminophen | Liver Failure, Acute - pathology | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Hepatocytes - enzymology | Proteins | Medical colleges | Liver diseases | Liver | Carbon tetrachloride | Physiological aspects | Index Medicus | Abridged Index Medicus | pharmacological treatment | mouse model | gene regulation
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2011, Volume 17, Issue 10, pp. 1251 - 1260
Here we show that p38 mitogen-activated protein kinase (p38 MAPK) phosphorylates the spliced form of X-box binding protein 1 (Xbp1s) on its Thr48 and Ser61... 
MEDICINE, RESEARCH & EXPERIMENTAL | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | INSULIN-RESISTANCE | GENE-EXPRESSION | PHOSPHOLIPID BIOSYNTHESIS | TRANSCRIPTION FACTOR | SIGNAL-TRANSDUCTION PATHWAY | TRANSMEMBRANE PROTEIN | Blood Glucose - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Phosphorylation | Active Transport, Cell Nucleus - physiology | Humans | MAP Kinase Kinase 3 - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | MAP Kinase Kinase 6 - metabolism | Tandem Mass Spectrometry | MAP Kinase Kinase 6 - genetics | Chromatography, Liquid | Fibroblasts | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Liver - metabolism | Cells, Cultured | Obesity - physiopathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Gene Knockout Techniques | Mutation - genetics | Regulatory Factor X Transcription Factors | Obesity - metabolism | Transcription Factors - metabolism | Animals | Analysis of Variance | Homeostasis - physiology | Mice | Homeostasis | Physiological aspects | Glucose metabolism | Genetic aspects | Research | Mitogen-activated protein kinases | Proteins | Diabetes | Kinases | Binding sites | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2001, Volume 108, Issue 1, pp. 73 - 81
Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun... 
RHEUMATOID-ARTHRITIS | TRANSCRIPTION FACTORS | SIGNAL-TRANSDUCTION | PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | KAPPA-B REGULATION | P38 | COLLAGENASE | GENE-EXPRESSION | JNK2 | Rats, Inbred Lew | MAP Kinase Signaling System | Arthritis, Experimental - pathology | Protein-Tyrosine Kinases - physiology | RNA, Messenger - biosynthesis | Protein-Tyrosine Kinases - genetics | Transcription Factor AP-1 - deficiency | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Flavonoids - pharmacology | Interleukin-1 - antagonists & inhibitors | Phosphorylation - drug effects | p38 Mitogen-Activated Protein Kinases | Isoenzymes - physiology | Cells, Cultured - drug effects | Collagenases - genetics | Collagenases - biosynthesis | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Rats | Anthracenes - pharmacology | Cells, Cultured - enzymology | Interleukin-1 - pharmacology | Matrix Metalloproteinase 13 | Mice, Knockout | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinase 9 | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | Proto-Oncogene Proteins c-jun - metabolism | Activating Transcription Factor 2 | Transcription Factor AP-1 - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Arthritis, Experimental - enzymology | Isoenzymes - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinase 3 | Synovial Membrane - cytology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2017, Volume 23, Issue 4, pp. 439 - 449
Journal Article
Journal Article