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Apoptosis (London), ISSN 1360-8185, 3/2008, Volume 13, Issue 3, pp. 343 - 353
Journal Article
Nature chemical biology, ISSN 1552-4469, 09/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 06/2016, Volume 36, Issue 6, pp. 1122 - 1131
OBJECTIVE—The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling... 
atherosclerosis | apoptosis | macrophages | MAP kinase signaling system | endoplasmic reticulum stress | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Bone Marrow Cells - enzymology | Atherosclerosis - genetics | Mitogen-Activated Protein Kinase 9 - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Atherosclerosis - enzymology | Hypercholesterolemia - enzymology | Diet, High-Fat | Bone Marrow Transplantation | Receptors, LDL - deficiency | bcl-Associated Death Protein - metabolism | Bone Marrow Cells - drug effects | Mitogen-Activated Protein Kinase 8 - genetics | Aortic Diseases - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Macrophages - pathology | Signal Transduction | Cell Survival | Aorta - drug effects | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Cells, Cultured | PTEN Phosphohydrolase - metabolism | Plaque, Atherosclerotic | Mitogen-Activated Protein Kinase 9 - deficiency | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Mitogen-Activated Protein Kinase 8 - deficiency | Aortic Diseases - genetics | Phenotype | Animals | Endoplasmic Reticulum Stress | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Macrophages - drug effects | Protein Kinase Inhibitors - pharmacology | Hypercholesterolemia - genetics | Index Medicus
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 05/2016, Volume 20, Issue 5, pp. 962 - 972
.... We founded that HBMMSCs notably secrete interleukin‐8 (IL‐8) protein. Administration of IL... 
mesenchymal stem cell | gastric cancer | Src | 17β‐estradiol | IL‐8 | cell invasion motility | Mesenchymal stem cell | 17β-estradiol | IL-8 | Gastric cancer | Cell invasion motility | Paxillin - metabolism | Interleukin-8 - genetics | Paxillin - genetics | Epithelial Cells - metabolism | Coculture Techniques | Epithelial Cells - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Crk-Associated Substrate Protein - metabolism | Gastric Mucosa - metabolism | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Kinase 4 - metabolism | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | Bone Marrow Cells - drug effects | Female | MAP Kinase Kinase 4 - antagonists & inhibitors | Interleukin-8 - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Mesenchymal Stem Cells - metabolism | Estradiol - pharmacology | Stomach - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Bone Marrow Cells - cytology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Epithelial Cells - pathology | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Interleukin-8 - antagonists & inhibitors | Paxillin - antagonists & inhibitors | Crk-Associated Substrate Protein - genetics | Cell Movement - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Crk-Associated Substrate Protein - antagonists & inhibitors | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Bone Marrow Cells - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Motility | Mesenchyme | Estrogens | Interleukin | Antibodies | Paracrine signalling | 17β-Estradiol | Metastasis | Kinases | Epidemiology | Stomach cancer | Estradiol | Incidence | Cell adhesion & migration | Proteins | Angiogenesis | Signal transduction | Cell activation | Bone marrow | Growth factors | Interleukin 8 | Cytokines | Invasiveness | Neutrophils | Health risks | Extracellular signal-regulated kinase | Cell division | Src protein | Gelatinase B | Signaling | Sex hormones | Medical prognosis | Stem cells | Hormone replacement therapy | Paxillin | Cancer | Index Medicus | Original
Journal Article
Applied biochemistry and biotechnology, ISSN 0273-2289, 1/2015, Volume 175, Issue 2, pp. 657 - 665
.... These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2... 
Biochemistry, general | Biotechnology | Chemistry | Inflammation | Extract from Grateloupia lanceolata | Macrophage | MAPK signaling | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Plant Extracts - chemistry | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Plant Extracts - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Mitogen-Activated Protein Kinase 9 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Line | Nitric Oxide - biosynthesis | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Mitogen-Activated Protein Kinase 9 - metabolism | Nitric Oxide - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Gene Expression Regulation | Rhodophyta - chemistry | p38 Mitogen-Activated Protein Kinases - genetics | Macrophages - cytology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 03/2012, Volume 16, Issue 3, pp. 496 - 506
...‐8 and phosphorylation of p38 mitogen‐activated protein kinase (MAPK), ERK1/2 and Akt in MHCC... 
MAPK pathway | Hepatocellular carcinoma | Interleukin‐8 | PI3K/Akt pathway | NF‐κB | CCR3 | NF-κB | Interleukin-8 | Phosphorylation | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Transcription Factor RelA - genetics | Proto-Oncogene Proteins c-akt - genetics | Carcinoma, Hepatocellular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Carcinoma, Hepatocellular - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor Cross-Talk | Liver Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Interleukin-8 - biosynthesis | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Liver Neoplasms - immunology | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Tumor Necrosis Factor-alpha - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Liver Neoplasms - metabolism | Cell Line, Tumor | Interleukin-8 - immunology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Carcinoma, Hepatocellular - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Interleukin | AKT protein | Kinases | Proteins | Liver cancer | Signal transduction | Receptors | Cell growth | Tumor necrosis factor-TNF | Synaptotagmin | Protein transport | Enzyme-linked immunosorbent assay | Translocation | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Nuclear transport | 1-Phosphatidylinositol 3-kinase | Molecular modelling | Inhibitors | Protein kinase | Tumor necrosis factor | Wortmannin | Regulatory mechanisms (biology) | Immunofluorescence | Tumors | Index Medicus | PI3K | Akt pathway | Original
Journal Article