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Apoptosis (London), ISSN 1360-8185, 3/2008, Volume 13, Issue 3, pp. 343 - 353
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 06/2016, Volume 36, Issue 6, pp. 1122 - 1131
OBJECTIVE—The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling... 
atherosclerosis | apoptosis | macrophages | MAP kinase signaling system | endoplasmic reticulum stress | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Bone Marrow Cells - enzymology | Atherosclerosis - genetics | Mitogen-Activated Protein Kinase 9 - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Atherosclerosis - enzymology | Hypercholesterolemia - enzymology | Diet, High-Fat | Bone Marrow Transplantation | Receptors, LDL - deficiency | bcl-Associated Death Protein - metabolism | Bone Marrow Cells - drug effects | Mitogen-Activated Protein Kinase 8 - genetics | Aortic Diseases - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Macrophages - pathology | Signal Transduction | Cell Survival | Aorta - drug effects | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Cells, Cultured | PTEN Phosphohydrolase - metabolism | Plaque, Atherosclerotic | Mitogen-Activated Protein Kinase 9 - deficiency | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Mitogen-Activated Protein Kinase 8 - deficiency | Aortic Diseases - genetics | Phenotype | Animals | Endoplasmic Reticulum Stress | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Macrophages - drug effects | Protein Kinase Inhibitors - pharmacology | Hypercholesterolemia - genetics | Index Medicus
Journal Article
Applied biochemistry and biotechnology, ISSN 0273-2289, 1/2015, Volume 175, Issue 2, pp. 657 - 665
.... These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2... 
Biochemistry, general | Biotechnology | Chemistry | Inflammation | Extract from Grateloupia lanceolata | Macrophage | MAPK signaling | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Plant Extracts - chemistry | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Plant Extracts - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Mitogen-Activated Protein Kinase 9 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Line | Nitric Oxide - biosynthesis | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Mitogen-Activated Protein Kinase 9 - metabolism | Nitric Oxide - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Gene Expression Regulation | Rhodophyta - chemistry | p38 Mitogen-Activated Protein Kinases - genetics | Macrophages - cytology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. 968 - 981
Background & Aims c-Jun N-terminal kinase (JNK) 1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions... 
Gastroenterology and Hepatology | APAP | Gene Regulation | Pharmacologic Treatment | Mouse Model | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Cell Proliferation | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Oxidative Stress | Carbon Tetrachloride | Humans | Middle Aged | Liver Failure, Acute - enzymology | Hepatocytes - pathology | Male | Gene Expression Profiling | Mitogen-Activated Protein Kinase 9 - genetics | Case-Control Studies | Young Adult | Time Factors | Liver Failure, Acute - genetics | Cell Death | Female | Mitogen-Activated Protein Kinase 8 - genetics | Liver Failure, Acute - prevention & control | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - enzymology | Hepatocytes - drug effects | Disease Models, Animal | Chemical and Drug Induced Liver Injury - prevention & control | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Liver Failure, Acute - chemically induced | Chemical and Drug Induced Liver Injury - genetics | Mitogen-Activated Protein Kinase 9 - deficiency | Mice, Knockout | Mitogen-Activated Protein Kinase 8 - deficiency | Animals | Acetaminophen | Liver Failure, Acute - pathology | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Hepatocytes - enzymology | Proteins | Medical colleges | Liver diseases | Liver | Carbon tetrachloride | Physiological aspects | Index Medicus | Abridged Index Medicus | pharmacological treatment | mouse model | gene regulation
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 10/2010, Volume 30, Issue 40, pp. 13348 - 13361
In the adult mouse, signaling through c-Jun N-terminal kinases (JNKs) links exposure to acute stress to various physiological responses... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | CA1 Region, Hippocampal - cytology | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Molecular Sequence Data | Male | Amnesia - chemically induced | Mitogen-Activated Protein Kinase 9 - physiology | Female | Hippocampus - enzymology | Mitogen-Activated Protein Kinase 8 - physiology | Isoenzymes - physiology | Amino Acid Sequence | CA1 Region, Hippocampal - enzymology | Amnesia - enzymology | Amnesia - prevention & control | CA3 Region, Hippocampal - cytology | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 10 - physiology | CA3 Region, Hippocampal - enzymology | Avoidance Learning - physiology | Isoenzymes - deficiency | Hippocampus - cytology | Association Learning - physiology | Down-Regulation - genetics | Mitogen-Activated Protein Kinase 9 - deficiency | Mice, Knockout | Down-Regulation - physiology | Mitogen-Activated Protein Kinase 8 - deficiency | Stress, Psychological - genetics | Animals | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Neurons - enzymology | Anisomycin - pharmacology | Mice | Mitogen-Activated Protein Kinase 10 - deficiency | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 10 - antagonists & inhibitors | Stress, Psychological - enzymology | Isoenzymes - antagonists & inhibitors | Stress, Psychological - physiopathology | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e43383 - e43383
...]. Bone morphogenetic proteins (BMPs), members of transforming growth factors beta (TGF[beta]) superfamily, are known to play important roles in stem cell biology... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Growth Differentiation Factor 2 - pharmacology | Growth Differentiation Factor 2 - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Growth Differentiation Factor 2 - genetics | Core Binding Factor Alpha 1 Subunit - metabolism | Stem Cell Transplantation | Cell Differentiation - genetics | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Skull - drug effects | Organ Culture Techniques | Osteogenesis - genetics | Cell Line | Mesenchymal Stromal Cells - drug effects | Skull - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | HCT116 Cells | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Osteogenesis - drug effects | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Enzyme Activation - drug effects | Blotting, Western | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Mice, Nude | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice | Pyridines - pharmacology | Core Binding Factor Alpha 1 Subunit - genetics | Skull - growth & development | Culture Media, Conditioned - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphatases | Cell differentiation | Adenoviruses | Stem cells | Cell culture | Alkaline phosphatase | Surgical implants | Phosphorylation | Transcription factors | Mesenchyme | Laboratories | Activation | Kinases | Blockage | Proteins | Signal transduction | Bone growth | Biomedical materials | Mineralization | Education | Biocompatibility | Inhibition | Cbfa-1 protein | Osteocalcin | Extracellular signal-regulated kinase | Implantation | siRNA | Gene expression | Progenitor cells | Medicine | Studies | Signaling | Inhibitors | Cells (biology) | Organ culture | Differentiation | Bone morphogenetic protein 9 | Osteogenesis | Apoptosis | Index Medicus
Journal Article