X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (26068) 26068
Publication (3272) 3272
Book Review (1144) 1144
Book Chapter (69) 69
Conference Proceeding (68) 68
Dissertation (15) 15
Reference (5) 5
Book / eBook (2) 2
Magazine Article (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (24971) 24971
animals (16022) 16022
humans (14225) 14225
mice (7504) 7504
phosphorylation (7457) 7457
mitogen-activated protein kinases - metabolism (7317) 7317
rats (6235) 6235
enzyme inhibitors - pharmacology (5980) 5980
cells, cultured (5971) 5971
signal transduction (5415) 5415
male (5284) 5284
biochemistry & molecular biology (5263) 5263
p38 mitogen-activated protein kinases - metabolism (4853) 4853
cell biology (4837) 4837
mitogen-activated protein kinase 1 - metabolism (4456) 4456
signal transduction - drug effects (4370) 4370
apoptosis (4240) 4240
mitogen-activated protein kinases - antagonists & inhibitors (4207) 4207
expression (3912) 3912
activation (3770) 3770
cell line (3687) 3687
cell line, tumor (3501) 3501
female (3431) 3431
p38 mitogen-activated protein kinases - antagonists & inhibitors (3426) 3426
mitogen-activated protein kinase 3 - metabolism (3396) 3396
phosphorylation - drug effects (3334) 3334
apoptosis - drug effects (2977) 2977
map kinase (2905) 2905
oncology (2875) 2875
protein kinase inhibitors - pharmacology (2841) 2841
enzyme activation (2814) 2814
activated protein-kinase (2800) 2800
imidazoles - pharmacology (2717) 2717
enzyme activation - drug effects (2714) 2714
pyridines - pharmacology (2704) 2704
blotting, western (2542) 2542
pharmacology & pharmacy (2496) 2496
map kinase signaling system - drug effects (2466) 2466
jnk mitogen-activated protein kinases - metabolism (2446) 2446
rats, sprague-dawley (2418) 2418
dose-response relationship, drug (2378) 2378
flavonoids - pharmacology (2377) 2377
kinases (2343) 2343
proteins (2316) 2316
gene-expression (2212) 2212
neurosciences (2145) 2145
cells (2088) 2088
p38 mitogen-activated protein kinases (2049) 2049
nf-kappa b - metabolism (2026) 2026
protein kinases (1983) 1983
cell proliferation - drug effects (1946) 1946
immunology (1824) 1824
signal transduction - physiology (1809) 1809
time factors (1803) 1803
inflammation (1792) 1792
mitogen-activated protein kinase 1 - antagonists & inhibitors (1772) 1772
nf-kappa-b (1751) 1751
cancer (1736) 1736
phosphatidylinositol 3-kinases - metabolism (1724) 1724
mitogen-activated protein kinase kinases - metabolism (1700) 1700
article (1686) 1686
in-vitro (1672) 1672
physiology (1665) 1665
abridged index medicus (1648) 1648
gene expression (1648) 1648
inhibition (1647) 1647
rna, messenger - metabolism (1647) 1647
pathway (1625) 1625
research (1625) 1625
oxidative stress (1617) 1617
mitogen-activated protein kinase kinases - antagonists & inhibitors (1611) 1611
transfection (1577) 1577
mitogen-activated protein kinase (1574) 1574
mitogen-activated protein kinase 3 (1560) 1560
jnk mitogen-activated protein kinases - antagonists & inhibitors (1550) 1550
cell survival - drug effects (1498) 1498
extracellular signal-regulated map kinases - metabolism (1492) 1492
proto-oncogene proteins c-akt - metabolism (1472) 1472
mice, inbred c57bl (1424) 1424
signal-transduction (1417) 1417
mitogen-activated protein kinases (1390) 1390
proliferation (1382) 1382
phosphatidylinositol 3-kinases - antagonists & inhibitors (1369) 1369
analysis (1366) 1366
tumor cells, cultured (1349) 1349
protein-kinase (1346) 1346
in-vivo (1329) 1329
endocrinology & metabolism (1313) 1313
mitogen-activated protein kinase 3 - antagonists & inhibitors (1309) 1309
physiological aspects (1278) 1278
protein-serine-threonine kinases - metabolism (1241) 1241
up-regulation (1232) 1232
mapk (1221) 1221
map kinase signaling system - physiology (1215) 1215
reactive oxygen species - metabolism (1213) 1213
kinase (1210) 1210
nitriles - pharmacology (1203) 1203
cell proliferation (1199) 1199
disease models, animal (1168) 1168
research article (1151) 1151
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (25859) 25859
Chinese (157) 157
Japanese (30) 30
Russian (20) 20
French (10) 10
German (4) 4
Korean (4) 4
Polish (3) 3
Spanish (3) 3
Czech (2) 2
Swedish (2) 2
Danish (1) 1
Norwegian (1) 1
Portuguese (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1954 - 1965
Canonical neutrophil antimicrobial effector mechanisms, such as degranulation, production of reactive oxygen species, and release of neutrophil extracellular... 
MAMMALIAN TARGET | NADPH OXIDASE | NETTING NEUTROPHILS | SIGNALING PATHWAYS | RESPIRATORY BURST | SYNOVIAL-FLUID | SUPEROXIDE-PRODUCTION | IN-VIVO | IMMUNOLOGY | RECEPTOR-III | CELL-DEATH | Reactive Oxygen Species - metabolism | Nitriles - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - immunology | Macrophage-1 Antigen - immunology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, IgG - antagonists & inhibitors | Protein-Tyrosine Kinases - immunology | Lymphocyte Function-Associated Antigen-1 - immunology | Macrophage-1 Antigen - metabolism | Syk Kinase | CD11a Antigen - metabolism | Butadienes - pharmacology | Neutrophil Activation - immunology | GPI-Linked Proteins - immunology | Cell Degranulation | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Autoimmune Diseases - immunology | Cells, Cultured | Neutrophils - immunology | Imidazoles - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Pyrimidines - pharmacology | Receptors, IgG - immunology | src-Family Kinases - immunology | CD18 Antigens - metabolism | Mesalamine - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Aminopyrine - pharmacology | Ascorbic Acid - pharmacology | Pyridines - pharmacology | Antigen-Antibody Complex - immunology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2017, Volume 18, Issue 5, p. 1088
Recently, the interplay between autophagy and apoptosis has become an important factor in chemotherapy for cancer treatment. Inhibition of autophagy may be an... 
Prostate cancer cells | Reactive oxygen species | Salinomycin | Autophagy | Apoptosis | prostate cancer cells | ACTIVATION | autophagy | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | reactive oxygen species | ROS | KINASE | ACQUIRED-RESISTANCE | apoptosis | salinomycin | CHEMISTRY, MULTIDISCIPLINARY | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Imidazoles - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Signaling System - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Flavonoids - pharmacology | Pyridines - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Pyrans - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drugs | Acridine | Cysteine | Reversing | Acetylcysteine | Staining | AKT protein | Propidium iodide | Assaying | Kinases | Caspase-3 | Mitochondria | Control | Pathways | Membrane potential | Inhibition | Pretreatment | Retarding | Oxygen | Extracellular signal-regulated kinase | Caspase | MAP kinase | Rapamycin | Mammals | 1-Phosphatidylinositol 3-kinase | Acridine orange | Chemotherapy | Sensitivity | Inhibitors | Antitumor activity | N-Acetyl-L-cysteine | Annexin V | Viability | Prostate cancer | Prostate | Phagocytosis | Cancer | Index Medicus
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 01/2018, Volume 44, Issue 5, pp. 1842 - 1855
Background/Aims: GLP-1 and ghrelin are common appetite-regulating hormones. Both have multiple functions beyond metabolic regulation. However, the effects of... 
Original Paper | Senescence | Glp-1 | Ghrelin | Microvascular endothelial cells | Apoptosis | OXIDATIVE STRESS | PHYSIOLOGY | ANGIOGENESIS | RECEPTOR | CARDIOMYOCYTES | CELL BIOLOGY | ANALOG LIRAGLUTIDE PROTECTS | PI3K/AKT SIGNALING PATHWAY | TNF-ALPHA | DYSFUNCTION | EXPRESSION | PROMOTES | Reactive Oxygen Species - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Caspase 3 - metabolism | Cellular Senescence - drug effects | Lipids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Microvessels - cytology | Endothelial Cells - metabolism | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Glucagon-Like Peptide 1 - pharmacology | Ghrelin - pharmacology | Glucose - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Endothelial Cells - cytology | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Diabetic retinopathy | Neurosciences | Cardiomyocytes | Lipids | Metabolism | Kinases | Experiments | Angiogenesis | Cell growth | Nitric oxide | Rodents | Atherosclerosis | Diabetes | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e85116 - e85116
In the current study, we showed that the combination of mammalian target of rapamycin (mTOR) inhibitor RAD001 (everolimus) and Akt inhibitor MK-2206 exerted... 
MAMMALIAN TARGET | BREAST-CANCER | INHIBITION | THERAPY | SIGNALING PATHWAY | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | AKT | PI3K/AKT/MTOR PATHWAY | MTOR | Cyclin D1 - metabolism | Microtubule-Associated Proteins - genetics | Nitriles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Gastric Mucosa - pathology | Gastric Mucosa - metabolism | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | PTEN Phosphohydrolase - antagonists & inhibitors | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Gastric Mucosa - drug effects | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Everolimus | Beclin-1 | PTEN Phosphohydrolase - genetics | Butadienes - pharmacology | Sirolimus - analogs & derivatives | Adenine - analogs & derivatives | Signal Transduction | Membrane Proteins - genetics | PTEN Phosphohydrolase - metabolism | Adenine - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Sirolimus - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Cyclin D1 - genetics | Membrane Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Biochemistry | Phosphatases | Stomach cancer | Cancer cells | Cancer | TOR protein | Toxicity | Chloroquine | Cytotoxicity | Oncology | Homology | AKT protein | Cyclin D1 | Kinases | Cancer therapies | Autophagy | Proteins | Cell growth | Cell cycle | Inhibition | Growth factors | Gastric cancer | Tensin | Mortality | Extracellular signal-regulated kinase | MAP kinase | Rapamycin | Inhibitors | Cell death | PTEN protein | Phagocytosis | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/1999, Volume 286, Issue 5443, pp. 1358 - 1362
A mechanism by which the Ras-mitogen-activated protein kinase (MAPK) signaling pathway mediates growth factor-dependent cell survival was characterized. The... 
Phosphorylation | Cell growth | Neuroscience | Neurons | Plasmids | Cell death | Genes | Antibodies | Immunoblotting | Reports | Apoptosis | CEREBELLAR GRANULE NEURONS | APOPTOSIS | CREB | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PROTEIN-KINASE AKT | GENE-EXPRESSION | DEATH | BINDING PROTEIN | BCL-2 FAMILY | CAMP | Insulin-Like Growth Factor I - pharmacology | Ribosomal Protein S6 Kinases - metabolism | Protein-Serine-Threonine Kinases | Rats, Long-Evans | ras Proteins - metabolism | Neurons - cytology | Recombinant Fusion Proteins - metabolism | MAP Kinase Kinase 1 | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Brain-Derived Neurotrophic Factor - pharmacology | Transfection | Transcription, Genetic | Flavonoids - pharmacology | Neurons - metabolism | Cell Survival | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Rats | Phosphoserine - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cerebellum - cytology | Cyclic AMP Response Element-Binding Protein - metabolism | Enzyme Activation | Mutation | Ribosomal Protein S6 Kinases - genetics | bcl-Associated Death Protein | Mitogen-Activated Protein Kinases - metabolism | Protein kinases | Research | Proteins | Cellular biology | Cells | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/1999, Volume 274, Issue 37, pp. 26563 - 26571
Journal Article
Science, ISSN 0036-8075, 5/1998, Volume 280, Issue 5364, pp. 734 - 737
Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of death in animals infected with anthrax. One component of this toxin,... 
Signal transduction | Antigens | Phosphorylation | Anthrax | Antibodies | Amino acids | Immunoblotting | Reports | Toxins | Oocytes | Cyclins | TRANSFORMATION | PROTEIN | TOXIN | INVITRO | MULTIDISCIPLINARY SCIENCES | COMPONENTS | BACILLUS-ANTHRACIS | INHIBITORS | ADENYLATE-CYCLASE | MAMMALIAN-CELLS | PROTECTIVE ANTIGEN | Sequence Deletion | Protein-Tyrosine Kinases - metabolism | Humans | Bacterial Toxins - toxicity | Metalloendopeptidases - metabolism | Bacillus anthracis - enzymology | MAP Kinase Kinase 2 | Recombinant Fusion Proteins - metabolism | MAP Kinase Kinase 1 | Protein-Tyrosine Kinases - genetics | Mitogen-Activated Protein Kinase Kinases | Enzyme Inhibitors - toxicity | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Myelin Basic Protein - metabolism | Signal Transduction | Xenopus laevis | Protein-Serine-Threonine Kinases - genetics | Antigens, Bacterial | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Metalloendopeptidases - toxicity | Bacterial Toxins - metabolism | Animals | Oocytes - physiology | Mice | Protein-Serine-Threonine Kinases - chemistry | Enzyme Activation | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Cell Line, Transformed | Protein-Tyrosine Kinases - antagonists & inhibitors | Research | Protein kinases | Bacteria, Pathogenic | Proteins | Bacteria | Disease | Cellular biology | Index Medicus
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 04/2008, Volume 294, Issue 4, pp. G1060 - G1069
Probiotics promote intestinal epithelial integrity and reduce infection and diarrhea. We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble... 
Protein kinase C | Zonula occludens-1 | Intestine | Lactobacillus rhamnosus GG | Mucosal protection | Occludin | zonula occludens-1 | mucosal protection | OXIDATIVE STRESS | PHYSIOLOGY | intestine | DIARRHEA | PERMEABILITY | CYTOSKELETON | CACO-2 CELL MONOLAYER | LACTOBACILLUS GG | TIGHT JUNCTIONS | occludin | IN-VIVO | GROWTH | INTESTINAL BARRIER | GASTROENTEROLOGY & HEPATOLOGY | protein kinase C | Protein Kinase C beta | Intestinal Mucosa - metabolism | Cadherins - metabolism | Nitriles - pharmacology | Humans | Tight Junctions - enzymology | Phosphoproteins - metabolism | Intestinal Mucosa - drug effects | Dose-Response Relationship, Drug | Lactobacillus rhamnosus - chemistry | Time Factors | Protein Kinase C - metabolism | Intestinal Mucosa - enzymology | Indoles - pharmacology | Membrane Proteins - metabolism | Tight Junctions - drug effects | Caco-2 Cells | Hydrogen Peroxide - toxicity | Tight Junctions - metabolism | Butadienes - pharmacology | Protein Kinase C - antagonists & inhibitors | Electric Impedance | Permeability | Probiotics - pharmacology | beta Catenin - metabolism | Probiotics - isolation & purification | Protein Transport | HT29 Cells | Bacterial Proteins - pharmacology | Pyrroles - pharmacology | Zonula Occludens-1 Protein | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase C-epsilon - metabolism | Inulin - metabolism | Protein Kinase Inhibitors - pharmacology | Bacterial Proteins - isolation & purification | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Studies | Bacteria | Kinases | Bacterial proteins | Digestive system | Cells | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2001, Volume 133, Issue 1, pp. 200 - 206
Recent data indicate that interleukin (IL)‐17 may contribute to neutrophilic airway inflammation by inducing the release of neutrophil‐mobilizing cytokines... 
bronchial epithelial cell | MAP kinase | neutrophil | Interleukin‐17 | Bronchial epithelial cell | Interleukin-17 | Neutrophil | PATHWAYS | PHOSPHATIDYLINOSITOL 3-KINASE | MAST-CELLS | NEUTROPHIL RECRUITMENT | INTERLEUKIN-8 | SIGNAL-TRANSDUCTION | interleukin-17 | IN-VITRO | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS | NF-KAPPA-B | Bronchi - enzymology | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Interleukin-17 - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Kinase 1 | Bronchi - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Protein Kinase C - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Bronchi - metabolism | Interleukin-8 - secretion | Interleukin-8 - metabolism | Epithelial Cells - cytology | Bronchi - cytology | Interleukin-6 - metabolism | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cytokines - metabolism | Cytokines - secretion | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Protein Kinase C - antagonists & inhibitors | Interleukin-6 - secretion | Cell Division - drug effects | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Epithelial Cells - enzymology | Cell Line, Transformed | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Papers | Cell Line | Interleukin-8/metabolism/secretion | Cytokines/metabolism/secretion | Epithelial Cells/cytology/drug effects/enzymology/metabolism | Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism | Bronchi/cytology/drug effects/enzymology/metabolism | Cell Division/drug effects | Enzyme Inhibitors/pharmacology | MAP Kinase Signaling System/drug effects | Transformed | Interleukin-17/pharmacology | inhibitors/metabolism | Interleukin-6/metabolism/secretion | Mitogen-Activated Protein Kinase Kinases/antagonists | Protein Kinase C/antagonists & inhibitors/metabolism | Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism | Lungmedicin och allergi | Respiratory Medicine and Allergy | 1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors/metabolism
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2011, Volume 164, Issue 1, pp. 170 - 180
BACKGROUND AND PURPOSE Up‐regulation of thioredoxin interacting protein (TXNIP), an endogenous inhibitor of thioredoxin (Trx), compromises cellular antioxidant... 
peroxynitrite | retina | neuroprotection | verapamil | NMDA | neurodegeneration | TXNIP | apoptosis | retinal ganglion cells | Thioredoxin | DIABETIC-RETINOPATHY | OXIDATIVE STRESS | RAT RETINA | FACTOR-KAPPA-B | CALCIUM-CHANNEL BLOCKERS | NERVE GROWTH-FACTOR | OPEN-ANGLE GLAUCOMA | IN-VIVO | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | UP-REGULATED PROTEIN-1 | Retina - drug effects | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Retina - metabolism | Apoptosis - drug effects | Caspase 3 - metabolism | Male | NF-kappa B - metabolism | Retinal Ganglion Cells - metabolism | Tyrosine - analogs & derivatives | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | MAP Kinase Kinase 4 - antagonists & inhibitors | Thioredoxins - metabolism | Thioredoxins - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinase 5 - metabolism | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | Eye Diseases - pathology | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - antagonists & inhibitors | Carrier Proteins - biosynthesis | Carrier Proteins - antagonists & inhibitors | Rats | Eye Diseases - metabolism | Up-Regulation - genetics | Caspase Inhibitors | Poly(ADP-ribose) Polymerase Inhibitors | Rats, Sprague-Dawley | Verapamil - pharmacology | Carrier Proteins - genetics | Poly(ADP-ribose) Polymerases - metabolism | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Eye Diseases - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Inflammation - genetics | Neuroglia - metabolism | Oxidative Stress - drug effects | Retinal Ganglion Cells - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | Research Papers
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2013, Volume 19, Issue 10, pp. 2677 - 2687
Purpose: To analyze the antimyeloma potential of TG02, an ERK5/CDK inhibitory drug. Experimental Design: Utilizing different multiple myeloma cell lines we... 
MULTIPLE-MYELOMA | CANCER-CELLS | ACTIVATION | ONCOLOGY | INDUCED APOPTOSIS | CYCLIN D1 | PHOSPHORYLATION | SENSITIVITY | TRANSDUCTION | DEPENDENT KINASE INHIBITOR | EXPRESSION | Cell Cycle - genetics | Gene Expression Regulation, Enzymologic - drug effects | Cyclin-Dependent Kinases - metabolism | Humans | Cell Survival - genetics | Thalidomide - pharmacology | Heterocyclic Compounds, 4 or More Rings - pharmacology | CDC2 Protein Kinase - metabolism | Dose-Response Relationship, Drug | Thalidomide - analogs & derivatives | Mitogen-Activated Protein Kinase 7 - antagonists & inhibitors | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Cyclin-Dependent Kinases - genetics | Multiple Myeloma - enzymology | Cell Survival - drug effects | Cyclin-Dependent Kinase 2 - metabolism | CDC2 Protein Kinase - genetics | Bortezomib | CDC2 Protein Kinase - antagonists & inhibitors | Cyclin-Dependent Kinase 9 - genetics | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 7 - genetics | Mitogen-Activated Protein Kinase 7 - metabolism | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Synergism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cyclin-Dependent Kinase 9 - metabolism | Protein Kinase Inhibitors - pharmacology | Multiple Myeloma - prevention & control | Cell Cycle - drug effects | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus
Journal Article