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Journal of Biological Chemistry, ISSN 0021-9258, 08/2006, Volume 281, Issue 33, pp. 23658 - 23667
MAPK-activated protein kinase 2 (MAPKAP K2 or MK2) is one of several kinases directly regulated by p38 MAPK. A role for p38 MAPK in the pathology of Alzheimer... 
TUMOR-NECROSIS-FACTOR | IN-VITRO | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAPKAP KINASE-2 | CENTRAL-NERVOUS-SYSTEM | MICE | AMYLOID PRECURSOR PROTEIN | TNF-ALPHA | P38 KINASE | BRAIN | TAU-HYPERPHOSPHORYLATION | Protein Kinases - metabolism | Neurons - pathology | Phosphorylation | Protein Kinases - genetics | Coculture Techniques | Humans | Protein-Serine-Threonine Kinases | Astrocytes - pathology | Cerebral Cortex - pathology | Astrocytes - enzymology | Lipopolysaccharides - antagonists & inhibitors | Cerebral Cortex - cytology | Alzheimer Disease - pathology | Chemokines - antagonists & inhibitors | Inflammation Mediators - metabolism | Interferon-gamma - antagonists & inhibitors | Inflammation Mediators - antagonists & inhibitors | Protein Kinases - deficiency | p38 Mitogen-Activated Protein Kinases - metabolism | Protein Kinases - biosynthesis | Disease Models, Animal | Astrocytes - cytology | Cell Line | Cerebral Cortex - enzymology | Chemokines - secretion | Microglia - secretion | Mice, Inbred C57BL | Cytokines - secretion | Intracellular Signaling Peptides and Proteins | Microglia - enzymology | Rats | Mice, Transgenic | Alzheimer Disease - enzymology | Down-Regulation - genetics | Mice, Knockout | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Peptide Fragments - antagonists & inhibitors | Neurons - enzymology | Mice | Cytokines - antagonists & inhibitors | Alzheimer Disease - genetics
Journal Article
Oncogene, ISSN 0950-9232, 05/2007, Volume 26, Issue 22, pp. 3227 - 3239
The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein (MAP) kinase pathway plays a central role in cell proliferation... 
Signal transduction | MAP kinase | ERK1/2 | Cell cycle | G1 phase | SIGNAL-TRANSDUCTION PATHWAYS | signal transduction | cell cycle | EARLY GENE-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | INITIATION-FACTOR 4E | DNA-SYNTHESIS | CELL BIOLOGY | NIH 3T3 CELLS | DEPENDENT KINASE | ONCOLOGY | GENETICS & HEREDITY | SMOOTH-MUSCLE-CELLS | MESSENGER-RNA TRANSPORT | MAP Kinase Signaling System - physiology | Cell Proliferation | Mitogen-Activated Protein Kinase 1 - physiology | Mitogen-Activated Protein Kinase 3 - genetics | Humans | Mitogen-Activated Protein Kinase 1 - deficiency | G1 Phase - physiology | S Phase - genetics | Mitogen-Activated Protein Kinase 3 - physiology | Animals | MAP Kinase Signaling System - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | S Phase - physiology | Mitogen-Activated Protein Kinase 3 - deficiency | G1 Phase - genetics | Enzyme Activation - genetics | Enzyme Activation - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Control | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Protein kinases | Genetics | Kinases | Mammals | Cancer | Life Sciences | G1 Phase | S Phase | Biochemistry, Molecular Biology | Enzyme Activation | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | MAP Kinase Signaling System
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, ISSN 1079-5642, 05/2003, Volume 23, Issue 5, pp. 795 - 801
OBJECTIVE—We investigated the comparative roles of mitogen-activated protein (MAP) kinases, including c-Jun NH2-terminal kinase (JNK), extracellular... 
Vascular smooth muscle cell | Platelet-derived growth factor | Proliferation | Gene transfer | Gene expression | PATHWAYS | FACTOR-BETA | gene transfer | proliferation | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | platelet-derived growth factor | RAT MODEL | PDGF | DISEASE | PERIPHERAL VASCULAR DISEASE | vascular smooth muscle cell | ACTIVATED PROTEIN-KINASES | C-JUN | HEMATOLOGY | SIGNAL-REGULATED KINASE | gene expression | SMOOTH-MUSCLE CELLS | Mitogen-Activated Protein Kinase Kinases - genetics | Hyperplasia | Cyclins - genetics | Mitogen-Activated Protein Kinase Kinases - physiology | Recombinant Fusion Proteins - physiology | Mitogen-Activated Protein Kinase 1 - deficiency | Male | Transforming Growth Factor beta - biosynthesis | Cyclins - biosynthesis | MAP Kinase Kinase 4 | Mitogen-Activated Protein Kinase 1 - genetics | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | JNK Mitogen-Activated Protein Kinases | Plasminogen Activator Inhibitor 1 - genetics | p38 Mitogen-Activated Protein Kinases | Carotid Artery Injuries - pathology | Muscle, Smooth, Vascular - drug effects | Transforming Growth Factor beta1 | Transduction, Genetic | Mitogen-Activated Protein Kinase 1 - physiology | Cyclin-Dependent Kinase Inhibitor p21 | Proto-Oncogene Proteins c-sis | Rats | Chemokine CCL2 - genetics | Cell Cycle Proteins - biosynthesis | Mitogen-Activated Protein Kinase Kinases - deficiency | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Cell Division - drug effects | Cyclin-Dependent Kinase Inhibitor p27 | Gene Expression Regulation - drug effects | Mitogen-Activated Protein Kinases - deficiency | Cell Movement - drug effects | Plasminogen Activator Inhibitor 1 - biosynthesis | Animals | Transforming Growth Factor beta - genetics | Tunica Intima - pathology | Mitogen-Activated Protein Kinases - physiology | Chemokine CCL2 - biosynthesis | Mitogen-Activated Protein Kinases - genetics | Tumor Suppressor Proteins - biosynthesis | Muscle, Smooth, Vascular - enzymology | Mitogen-Activated Protein Kinase 3
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2013, Volume 23, Issue 8, pp. 994 - 1006
Journal Article
Plos one, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106300
Adipose tissue inflammation is considered an important contributor to insulin resistance. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is... 
DIABETES-MELLITUS | OVEREXPRESSION | OBESITY | DISEASES | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RESISTANCE | NF-KAPPA-B | MACROPHAGE POLARIZATION | ADIPOSE-TISSUE | INFILTRATION | Tumor Necrosis Factor-alpha - metabolism | Dyslipidemias - genetics | Protein-Serine-Threonine Kinases - deficiency | Cholesterol - blood | Liver | Intracellular Signaling Peptides and Proteins - deficiency | RNA, Messenger - biosynthesis | Diet, High-Fat | Chemokine CCL2 - metabolism | Interleukin-6 - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Glucose Tolerance Test | Glucose Transporter Type 4 - genetics | Mice, Inbred C57BL | Adipose Tissue - pathology | Protein-Serine-Threonine Kinases - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Inflammation - immunology | Abdominal Fat | Mice, Knockout | Animals | Glucose Transporter Type 4 - biosynthesis | Insulin Resistance - genetics | Triglycerides - blood | Mice | Adipose tissues | RNA | Body weight | Inflammation | Glucose | Insulin | Dextrose | Diet | Analysis | Insulin resistance | Health aspects | Mitogens | Protein kinases | Diabetes therapy | Pediatrics | Animal models | Adipose tissue | Arthritis | mRNA | Kinases | Macrophages | Experiments | Medical schools | Inflammatory diseases | High fat diet | Interleukin 6 | Proteins | Genotype & phenotype | Rodents | Cardiology | Glucose transporter | Obesity | Medical treatment | MAP kinase | Protein deficiency | Gene expression | Cholesterol | Glucose tolerance | Weight control | Protein kinase | Stem cells | Infiltration | Diabetes | Transporter | Monocyte chemoattractant protein 1 | Metabolic disorders
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2008, Volume 9, Issue 9, pp. 1028 - 1036
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2016, Volume 36, Issue 6, pp. 1122 - 1131
OBJECTIVE—The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling.... 
atherosclerosis | apoptosis | macrophages | MAP kinase signaling system | endoplasmic reticulum stress | SURVIVAL | ACTIVATION | PHOSPHORYLATION | BAD | SIGNAL-TRANSDUCTION | OBESITY | NH2-TERMINAL KINASE (JNK)1 | INSULIN-RESISTANCE | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | REQUIREMENT | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Bone Marrow Cells - enzymology | Atherosclerosis - genetics | Mitogen-Activated Protein Kinase 9 - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Atherosclerosis - enzymology | Hypercholesterolemia - enzymology | Diet, High-Fat | Bone Marrow Transplantation | Receptors, LDL - deficiency | bcl-Associated Death Protein - metabolism | Bone Marrow Cells - drug effects | Mitogen-Activated Protein Kinase 8 - genetics | Aortic Diseases - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Macrophages - pathology | Signal Transduction | Cell Survival | Aorta - drug effects | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Cells, Cultured | PTEN Phosphohydrolase - metabolism | Plaque, Atherosclerotic | Mitogen-Activated Protein Kinase 9 - deficiency | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Mitogen-Activated Protein Kinase 8 - deficiency | Aortic Diseases - genetics | Phenotype | Animals | Endoplasmic Reticulum Stress | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Macrophages - drug effects | Protein Kinase Inhibitors - pharmacology | Hypercholesterolemia - genetics
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 5, pp. 652 - 663
We have investigated the role of individual members of the Raf/Mek/Erk cascade in the onset of oncogene-driven non-small cell lung carcinoma (NSCLC). Ablation... 
C-RAF-1 GENE | APOPTOSIS | TUMOR PROGRESSION | ONCOLOGY | MAP KINASE | GROWTH | ORAL MEK INHIBITOR | PHASE-II | MICE | BRAF | CANCER | CELL BIOLOGY | Fibroblasts - enzymology | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Mitogen-Activated Protein Kinase 1 - deficiency | Lung Neoplasms - pathology | MAP Kinase Kinase 1 - genetics | Transfection | RNA Interference | Time Factors | Cellular Senescence | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 2 - genetics | Proto-Oncogene Proteins B-raf - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins B-raf - deficiency | Lung Neoplasms - enzymology | MAP Kinase Kinase 2 - deficiency | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Tumor Burden | Proto-Oncogene Proteins c-raf - metabolism | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Line, Tumor | Mice | Mitogen-Activated Protein Kinase 3 - deficiency | Carcinoma, Non-Small-Cell Lung - enzymology | Genes, ras | Apoptosis | MAP Kinase Kinase 1 - deficiency | Development and progression | Carcinoma | Lung cancer, Non-small cell | Phosphotransferases | Cancer
Journal Article
Developmental Cell, ISSN 1534-5807, 11/2012, Volume 23, Issue 5, pp. 1020 - 1031
Journal Article