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Cancer Research, ISSN 0008-5472, 08/2007, Volume 67, Issue 15, pp. 7406 - 7420
This study is the first to investigate the anticancer effect of isoobtusilactone A (IOA) in two human breast cancer cell lines, MCF-7 and MDA-MB-231. IOA... 
INHIBITS APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | REACTIVE OXYGEN | THERAPY | ONCOLOGY | THIOREDOXIN | ASK1 | REGULATING KINASE-1 | DEATH | FACTOR RECEPTOR | Immunoprecipitation | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Immunoblotting | JNK Mitogen-Activated Protein Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | Cyclin B1 | Lactones - pharmacology | Breast Neoplasms - metabolism | CDC2 Protein Kinase - metabolism | Caspases - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinase 5 - metabolism | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | MAP Kinase Kinase Kinase 5 - genetics | Cyclin A - metabolism | Cytochromes c - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Alkanes - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Antioxidants - pharmacology | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Breast Neoplasms - pathology | Mice, Nude | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Cyclin B - metabolism | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Cell Cycle - drug effects | Index Medicus
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1938 - 1938
Chloranthalactone B (CTB), a lindenane-type sesquiterpenoid, was obtained from the Chinese medicinal herb Sarcandra glabra, which is frequently used as a... 
Sesquiterpene | Sarcandra glabra | Chloranthalactone B | Inflammation | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | P38 MAPK | RAW 264.7 CELLS | INDUCED INFLAMMATION | IL-6 EXPRESSION | sesquiterpene | CHEMISTRY, MULTIDISCIPLINARY | AP-1 INACTIVATION | inflammation | SIGNALING PATHWAY | SESQUITERPENE LACTONE | SARCANDRA-GLABRA | NF-KAPPA-B | chloranthalactone B | Tumor Necrosis Factor-alpha - genetics | MAP Kinase Kinase 3 - genetics | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Lactones - pharmacology | MAP Kinase Kinase 6 - genetics | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Interleukin-6 - metabolism | Nitric Oxide - biosynthesis | Interleukin-6 - genetics | Macrophages - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | MAP Kinase Kinase 6 - antagonists & inhibitors | Models, Molecular | MAP Kinase Kinase 3 - metabolism | Macrophages - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 3 - chemistry | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Inflammation - prevention & control | Mice | Dinoprostone - antagonists & inhibitors | MAP Kinase Kinase 6 - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dinoprostone - biosynthesis | MAP Kinase Kinase 3 - antagonists & inhibitors | Transcription Factor AP-1 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Transcription Factor AP-1 - metabolism | MAP Kinase Kinase 6 - metabolism | Cell Line | Nitric Oxide - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Transcription Factor AP-1 - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Sesquiterpenes - pharmacology | Herbal medicine | Polymerase chain reaction | Kinases | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 01/2001, Volume 20, Issue 2, pp. 147 - 155
The anti-cancer agent paclitaxel (Taxol) stabilizes microtubules leading to G2/M cell cycle arrest and apoptotic cell death. In order to analyse the molecular... 
MAP kinase | Her-2 | Taxol | Cell cycle | Apoptosis | p53 | CARCINOMA-CELLS | ACTIVATED PROTEIN-KINASE | cell cycle | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | PHOSPHOINOSITIDE 3-KINASE | HEREGULIN | CELL BIOLOGY | BREAST-CANCER CELLS | BCL-2 | ONCOLOGY | GROWTH ARREST | GENETICS & HEREDITY | taxol | DIFFERENTIATION | HUMAN TUMOR-CELLS | Cyclin-Dependent Kinases - metabolism | Paclitaxel - pharmacology | Receptor, ErbB-2 - genetics | Apoptosis - drug effects | Humans | Receptor, ErbB-2 - metabolism | G2 Phase - drug effects | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Cyclin-Dependent Kinases - drug effects | Cyclin-Dependent Kinase 2 | Cyclins - metabolism | Cyclins - drug effects | Retinoblastoma Protein - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Flavonoids - pharmacology | Tumor Cells, Cultured | Carcinoma - pathology | Receptor, ErbB-2 - drug effects | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Carcinoma - drug therapy | CDC2-CDC28 Kinases | Cyclin-Dependent Kinase Inhibitor p21 | Retinoblastoma Protein - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Rats | Imidazoles - pharmacology | Breast Neoplasms - drug therapy | Tumor Suppressor Protein p53 - drug effects | Animals | MAP Kinase Signaling System - drug effects | Mitosis - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Breast Neoplasms - pathology | Protein-Serine-Threonine Kinases - drug effects | Pyridines - pharmacology | Carcinoma - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Mitogen-Activated Protein Kinases - drug effects | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 51, Issue 1, pp. 57 - 69
Highwire is an extremely large, evolutionarily conserved E3 ubiquitin ligase that negatively regulates synaptic growth at the NMJ. Highwire has been proposed... 
DEVBIO | MOLNEURO | SIGNALING | DROSOPHILA NEUROMUSCULAR-JUNCTION | ACTIVATED PROTEIN-KINASE | GENE | II RECEPTOR | ENDODERM INDUCTION | MOLECULAR-CLONING | C-ELEGANS | ZIPPER-BEARING KINASE | EXPRESSION | NEUROSCIENCES | MOUSE EMBRYO | Drosophila melanogaster - embryology | MAP Kinase Signaling System - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Drosophila Proteins - metabolism | Central Nervous System - embryology | Central Nervous System - growth & development | Cell Differentiation - genetics | Female | Growth Inhibitors - genetics | Hydrolases - metabolism | MAP Kinase Kinase Kinases - genetics | Drosophila melanogaster - cytology | Proto-Oncogene Proteins c-fos - metabolism | Ubiquitin-Protein Ligases - metabolism | Synapses - enzymology | Synapses - ultrastructure | Chromosome Mapping | MAP Kinase Kinase Kinases - metabolism | Nerve Tissue Proteins - genetics | Drosophila Proteins - isolation & purification | Growth Cones - enzymology | MAP Kinase Kinase Kinases - isolation & purification | Growth Inhibitors - metabolism | Nerve Tissue Proteins - metabolism | Animals | Central Nervous System - cytology | Growth Cones - ultrastructure | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Ubiquitin | Enzymes | Hydrolases | Gene expression | Growth | Ligases | Proteins | Mutation | Insects | Kinases | Neurons | Colleges & universities | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8531 - 8536
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and... 
Proteins | Phosphorylation | Cell growth | Receptors | Transcription factors | HEK293 cells | Cell lines | Amino acids | Physiological regulation | Ovarian cancer | Signal transduction | Cross-talk | PROTEIN-KINASE-A | PATHWAYS | RECRUITMENT | ACTIVATION | MECHANISM | signal transduction | cross-talk | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTOR RECEPTOR | PAK | RHO-GTPASES | CAMP | Phosphorylation - physiology | MAP Kinase Signaling System - physiology | Humans | Multienzyme Complexes - metabolism | Guanosine Triphosphate - metabolism | raf Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Female | Cyclic AMP - genetics | Receptors, Adrenergic, beta - metabolism | raf Kinases - genetics | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Multienzyme Complexes - genetics | Receptors, Adrenergic, beta - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | Guanosine Triphosphate - genetics | rac1 GTP-Binding Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | rac1 GTP-Binding Protein - genetics | Tyrosine | Physiological aspects | Cellular signal transduction | Research | G proteins | Guanosine triphosphatase | Health aspects | Phosphotransferases | Glycoproteins | Kinases | Cells | Index Medicus | Biological Sciences
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2009, Volume 100, Issue 2, pp. 370 - 375
LKB1/STK11 is a multitasking tumour suppressor kinase. Germline inactivating mutations of the gene are responsible for the Peutz-Jeghers hereditary cancer... 
MEK | KRAS | NSCLC | LKB1 | CI-1040 | ACTIVATION | GEFITINIB | MASTER | PEUTZ-JEGHERS-SYNDROME | LKB1 KINASE | BRAF | B-RAF KINASE | ONCOLOGY | RHEB | GROWTH | MUTATIONS | Protein Kinases - metabolism | Lung Neoplasms - drug therapy | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Antibiotics, Antineoplastic - pharmacology | Lung Neoplasms - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | ras Proteins - metabolism | Immunoblotting | Mitogen-Activated Protein Kinase Kinases - metabolism | Benzamides - pharmacology | Tumor Cells, Cultured | Protein-Serine-Threonine Kinases - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins - genetics | Mutation - genetics | Sirolimus - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Carcinoma, Non-Small-Cell Lung - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Genetics and Genomics
Journal Article
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2562 - 2562
Journal Article
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2014, Volume 15, Issue 10, pp. 965 - 972
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 106 - 110
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer(1). Normally, ROS levels are tightly controlled by an inducible antioxidant program... 
TRANSFORMATION | OXIDATIVE STRESS | ACTIVATION | INHIBITION | K-RAS | PATHWAY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | HEME OXYGENASE-1 | MUTATIONS | EXPRESSION | NIH 3T3 Cells | Cell Proliferation | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Antioxidants - metabolism | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Transformation, Neoplastic - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Proto-Oncogene Proteins B-raf - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Oncogenes - genetics | Oxidation-Reduction | Pancreatic Neoplasms - pathology | Cells, Cultured | Pancreatic Neoplasms - genetics | NF-E2-Related Factor 2 - deficiency | Cell Transformation, Neoplastic - metabolism | Animals | Proto-Oncogene Proteins B-raf - genetics | Genes, myc - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alleles | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Polymerase chain reaction | Usage | Reactive oxygen species | Physiological aspects | Research | Gene expression | Oncogenes | Studies | Mass spectrometry | Rodents | Evacuations & rescues | Cancer | Index Medicus
Journal Article