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Plant Cell, ISSN 1040-4651, 01/2007, Volume 19, Issue 1, pp. 63 - 73
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 2, pp. 193 - 208
Journal Article
Circulation Research, ISSN 0009-7330, 01/2009, Volume 104, Issue 1, pp. 15 - 18
Ischemic postconditioning (IPoC) reduces infarct size following ischemia/reperfusion. Whether or not phosphorylation of RISK (reperfusion injury salvage... 
PERMEABILITY TRANSITION PORE | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | REPERFUSION | reperfusion injury | NECROSIS-FACTOR-ALPHA | ADENOSINE RECEPTORS | infarct size | INHIBITION | MYOCARDIAL INFARCT SIZE | cardioprotection | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | MOUSE HEARTS | SIGNAL TRANSDUCER | Glycogen Synthase Kinase 3 - physiology | MAP Kinase Kinase 2 - physiology | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Ribosomal Protein S6 Kinases, 70-kDa - physiology | MAP Kinase Kinase 1 - physiology | Myocardial Reperfusion Injury - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Protein Processing, Post-Translational - drug effects | Swine | Mitogen-Activated Protein Kinase 3 - biosynthesis | Myocardial Infarction - pathology | Swine, Miniature | Phosphorylation - drug effects | Myocardial Infarction - enzymology | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Glycogen Synthase Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 1 - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Coronary Occlusion - enzymology | Enzyme Induction | Proto-Oncogene Proteins c-akt - physiology | Enzyme Activation - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Androstadienes - pharmacology | Myocardial Reperfusion | MAP Kinase Kinase 2 - antagonists & inhibitors | Coronary Occlusion - pathology | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Myocardial Reperfusion Injury - prevention & control | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 11/2005, Volume 19, Issue 22, pp. 2668 - 2681
TGF-beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-kappa B and AP-1... 
NF-κB | TGF-β | TAB2 | TAB1 | TAK1 | JNK | KINASE-ALPHA | MAP KINASE | DEVELOPMENTAL BIOLOGY | DEFICIENT MICE | TRANSDUCTION PATHWAY | TGF-beta | TUMOR-NECROSIS-FACTOR | NF-kappa B | INNATE IMMUNE-RESPONSES | LIVER DEGENERATION | GENETICS & HEREDITY | EMBRYONIC LETHALITY | NF-KAPPA-B | TNF Receptor-Associated Factor 6 - physiology | Receptors, Immunologic - physiology | Humans | Cercopithecus aethiops | Interleukin-1 Receptor-Associated Kinases | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | TNF Receptor-Associated Factor 2 - physiology | I-kappa B Kinase - physiology | Toll-Like Receptors - physiology | GTPase-Activating Proteins - physiology | Cell Line | Interleukin-1 - metabolism | MAP Kinase Kinase Kinases - genetics | Myeloid Differentiation Factor 88 | Antigens, Differentiation - physiology | Adaptor Proteins, Signal Transducing - physiology | Animals | Protein Kinases - physiology | Transcription Factor AP-1 - physiology | Tumor Necrosis Factor-alpha - physiology | MAP Kinase Kinase Kinases - physiology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Mutation | Intracellular Signaling Peptides and Proteins - physiology | COS Cells | Cell Line, Transformed | Immune response | Research | Cytokines | Transforming growth factors | Index Medicus | Research Papers
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2457 - 2473
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2001, Volume 108, Issue 1, pp. 73 - 81
Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun... 
RHEUMATOID-ARTHRITIS | TRANSCRIPTION FACTORS | SIGNAL-TRANSDUCTION | PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | KAPPA-B REGULATION | P38 | COLLAGENASE | GENE-EXPRESSION | JNK2 | Rats, Inbred Lew | MAP Kinase Signaling System | Arthritis, Experimental - pathology | Protein-Tyrosine Kinases - physiology | RNA, Messenger - biosynthesis | Protein-Tyrosine Kinases - genetics | Transcription Factor AP-1 - deficiency | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Flavonoids - pharmacology | Interleukin-1 - antagonists & inhibitors | Phosphorylation - drug effects | p38 Mitogen-Activated Protein Kinases | Isoenzymes - physiology | Cells, Cultured - drug effects | Collagenases - genetics | Collagenases - biosynthesis | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Rats | Anthracenes - pharmacology | Cells, Cultured - enzymology | Interleukin-1 - pharmacology | Matrix Metalloproteinase 13 | Mice, Knockout | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinase 9 | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | Proto-Oncogene Proteins c-jun - metabolism | Activating Transcription Factor 2 | Transcription Factor AP-1 - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Arthritis, Experimental - enzymology | Isoenzymes - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinase 3 | Synovial Membrane - cytology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2004, Volume 24, Issue 45, pp. 10211 - 10222
To investigate whether activation of mitogen-activated protein kinase ( MAPK) in damaged and/or undamaged primary afferents participates in neuropathic pain... 
Brain-derived neurotrophic factor | p38 mitogen-activated protein kinase | TRPV1 | Extracellular signal-regulated protein kinase | C-Jun N-terminal kinase/stress-activated protein kinase | Neuropathic pain | c-Jun N-terminal kinase/stress-activated protein kinase | NEUROTROPHIC FACTOR | WALLERIAN DEGENERATION | DRG NEURONS | NECROSIS-FACTOR-ALPHA | DORSAL-ROOT GANGLION | NEUROSCIENCES | RAT MODEL | neuropathic pain | MESSENGER-RNA | SCIATIC-NERVE | brain-derived neurotrophic factor | PRIMARY SENSORY NEURONS | extracellular signal-regulated protein kinase | Brain-Derived Neurotrophic Factor - genetics | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ion Channels - genetics | Stress, Mechanical | Male | Ganglia, Spinal - cytology | Ion Channels - physiology | Ganglia, Spinal - enzymology | Ligation | Brain-Derived Neurotrophic Factor - physiology | Brain-Derived Neurotrophic Factor - biosynthesis | Spinal Nerves - injuries | Pyrazoles - pharmacology | Butadienes - pharmacology | Ion Channels - biosynthesis | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Hot Temperature - adverse effects | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | TRPV Cation Channels | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation - physiology | Rats | Imidazoles - pharmacology | Neurons, Afferent - physiology | Rats, Sprague-Dawley | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - physiology | Hyperalgesia - physiopathology | Animals | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - physiology | Hyperalgesia - etiology | Pyridines - pharmacology | Rhizotomy | Enzyme Activation | Lumbar Vertebrae | Physical Stimulation - adverse effects | Index Medicus | c-Jun N-terminal kinase | Cellular | stress-activated protein kinase | Molecular
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, ISSN 1079-5642, 05/2003, Volume 23, Issue 5, pp. 795 - 801
OBJECTIVE—We investigated the comparative roles of mitogen-activated protein (MAP) kinases, including c-Jun NH2-terminal kinase (JNK), extracellular... 
Vascular smooth muscle cell | Platelet-derived growth factor | Proliferation | Gene transfer | Gene expression | PATHWAYS | FACTOR-BETA | gene transfer | proliferation | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | platelet-derived growth factor | RAT MODEL | PDGF | DISEASE | PERIPHERAL VASCULAR DISEASE | vascular smooth muscle cell | ACTIVATED PROTEIN-KINASES | C-JUN | HEMATOLOGY | SIGNAL-REGULATED KINASE | gene expression | SMOOTH-MUSCLE CELLS | Mitogen-Activated Protein Kinase Kinases - genetics | Hyperplasia | Cyclins - genetics | Mitogen-Activated Protein Kinase Kinases - physiology | Recombinant Fusion Proteins - physiology | Mitogen-Activated Protein Kinase 1 - deficiency | Male | Transforming Growth Factor beta - biosynthesis | Cyclins - biosynthesis | MAP Kinase Kinase 4 | Mitogen-Activated Protein Kinase 1 - genetics | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | JNK Mitogen-Activated Protein Kinases | Plasminogen Activator Inhibitor 1 - genetics | p38 Mitogen-Activated Protein Kinases | Carotid Artery Injuries - pathology | Muscle, Smooth, Vascular - drug effects | Transforming Growth Factor beta1 | Transduction, Genetic | Mitogen-Activated Protein Kinase 1 - physiology | Cyclin-Dependent Kinase Inhibitor p21 | Proto-Oncogene Proteins c-sis | Rats | Chemokine CCL2 - genetics | Cell Cycle Proteins - biosynthesis | Mitogen-Activated Protein Kinase Kinases - deficiency | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Cell Division - drug effects | Cyclin-Dependent Kinase Inhibitor p27 | Gene Expression Regulation - drug effects | Mitogen-Activated Protein Kinases - deficiency | Cell Movement - drug effects | Plasminogen Activator Inhibitor 1 - biosynthesis | Animals | Transforming Growth Factor beta - genetics | Tunica Intima - pathology | Mitogen-Activated Protein Kinases - physiology | Chemokine CCL2 - biosynthesis | Mitogen-Activated Protein Kinases - genetics | Tumor Suppressor Proteins - biosynthesis | Muscle, Smooth, Vascular - enzymology | Mitogen-Activated Protein Kinase 3 | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2013, Volume 127, Issue 21, pp. 2097 - 2106
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/1998, Volume 17, Issue 15, pp. 4426 - 4441
We have identified a novel mitogen‐ and stress‐activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is... 
MSK1 | p38 MAP kinase | MAP kinase | CREB | signal transduction | Signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | CELLULAR STRESSES | IDENTIFICATION | PHOSPHORYLATION SITES | CELL BIOLOGY | INSULIN | SAP KINASES | SUBSTRATE-SPECIFICITY | PATHWAY | SEQUENCE | S6 KINASE | Tetradecanoylphorbol Acetate - pharmacology | Epidermal Growth Factor - physiology | Ribosomal Protein S6 Kinases - metabolism | Humans | Molecular Sequence Data | PC12 Cells | Kidney | Ribosomal Protein S6 Kinases - immunology | Ultraviolet Rays | Base Sequence | Ribosomal Protein S6 Kinases - chemistry | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Mitogen-Activated Protein Kinases | Amino Acid Sequence | Cell Line | Transcription Factors - radiation effects | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Protein-Serine-Threonine Kinases - isolation & purification | Intracellular Signaling Peptides and Proteins | Rats | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Precipitin Tests | Cyclic AMP Response Element-Binding Protein - radiation effects | Transcription Factors - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - isolation & purification | Phosphorylation - radiation effects | Animals | Activating Transcription Factor 1 | Cyclic AMP Response Element-Binding Protein - metabolism | Tumor Necrosis Factor-alpha - physiology | Signal Transduction - physiology | Mice | HeLa Cells | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa | Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 121, Issue 4, pp. 893 - 902.e2
Background Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown. Objectives We sought to study... 
Allergy and Immunology | mitogen-activated protein kinase | chemokines | epithelial function | bronchial biopsy | Asthma | LUNG | BRONCHIAL EPITHELIAL-CELLS | MAP KINASE | asthma | PROLIFERATION | IMMUNOLOGY | ALLERGY | GM-CSF | PATHWAY | INFLAMMATION | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | EXPRESSION | Phosphorylation | Bronchi - enzymology | Humans | Middle Aged | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Enzyme Induction - immunology | MAP Kinase Signaling System - immunology | Enzyme Activation - immunology | Respiratory Mucosa - pathology | Chemokines - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - biosynthesis | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Bronchi - pathology | Respiratory Mucosa - secretion | Chemokines - biosynthesis | Chemokines - secretion | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Asthma - enzymology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Respiratory Mucosa - enzymology | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Asthma - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Protein kinases | Proteins | Studies | Signal transduction | Cell culture | Rodents | Cloning | Smooth muscle | Kinases | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2009, Volume 94, Issue 7, pp. 2507 - 2515
Context: Adipose tissue in obesity is thought to be exposed to various stresses, predominantly in intraabdominal depots. We recently reported that p38MAPK and... 
OXIDATIVE STRESS | METABOLIC SYNDROME | OBESITY | IMPACT | DISEASE | ENDOCRINOLOGY & METABOLISM | ENDOPLASMIC-RETICULUM | REGULATING KINASE-1 | FAMILY PROTEINS | SUBCUTANEOUS FAT | ADIPOSE-TISSUE | MAP Kinase Kinase 4 - physiology | Obesity - immunology | Humans | Middle Aged | JNK Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinase 5 - physiology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Case-Control Studies | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Insulin Resistance - physiology | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Chemotaxis - immunology | MAP Kinase Kinase Kinase 5 - metabolism | Extracellular Signal-Regulated MAP Kinases - physiology | Macrophages - immunology | Intra-Abdominal Fat - immunology | Macrophages - physiology | Stress, Physiological - physiology | MAP Kinase Kinase Kinase 5 - genetics | p38 Mitogen-Activated Protein Kinases - physiology | Inflammation - immunology | Omentum - metabolism | Intra-Abdominal Fat - metabolism | Obesity - metabolism | Obesity - pathology | Macrophages - metabolism | JNK Mitogen-Activated Protein Kinases - physiology | Omentum - pathology | Signal Transduction - physiology | Aged | Intra-Abdominal Fat - enzymology | Intra-Abdominal Fat - pathology | Enzyme Activation - physiology | Index Medicus | Abridged Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 04/2014, Volume 59, Issue 4, pp. 1543 - 1554
This study examines the role of protein kinase C (PKC) and AMP‐activated kinase (AMPK) in acetaminophen (APAP) hepatotoxicity. Treatment of primary mouse... 
OXIDATIVE STRESS | ACTIVATION | INHIBITION | RAT HEPATOCYTES | PHORBOL 12-MYRISTATE 13-ACETATE | AUTOPHAGY | GASTROENTEROLOGY & HEPATOLOGY | ISOENZYMES | INDUCED LIVER-INJURY | EXTENDED FAMILY | CELL-DEATH | Acetaminophen - adverse effects | Mitochondria, Liver - metabolism | Maleimides - pharmacology | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Necrosis - pathology | AMP-Activated Protein Kinases - drug effects | Indoles - pharmacology | Chemical and Drug Induced Liver Injury - pathology | Hepatocytes - drug effects | Disease Models, Animal | JNK Mitogen-Activated Protein Kinases - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase C - physiology | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | Protein Kinase C - drug effects | Cells, Cultured | Necrosis - metabolism | Protein Kinase C - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - physiopathology | Mitochondria, Liver - drug effects | AMP-Activated Protein Kinases - physiology | Animals | Chemical and Drug Induced Liver Injury - metabolism | JNK Mitogen-Activated Protein Kinases - physiology | Signal Transduction - physiology | Mice | Protein Kinase Inhibitors - pharmacology | In Vitro Techniques | Cytotoxicity | Mitochondria | Kinases | Autophagy | Liver | Hepatology | Index Medicus
Journal Article