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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Cell host & microbe, ISSN 1931-3128, 2007, Volume 1, Issue 1, pp. 77 - 83
Many bacteria pathogenic for plants or animals, including Shigella spp., which is responsible for shigellosis in humans, use a type III secretion apparatus to inject effector proteins into host cells... 
PROTEINS | MICROBIO | SHIGELLA-FLEXNERI | IMMUNITY | MUTANTS | TRANSCRIPTION | MICROBIOLOGY | DIVERSITY | SACCHAROMYCES-CEREVISIAE | G-PROTEIN | EXPRESSION | APPARATUS | CELL-DEATH | Protein Kinases - metabolism | Protein Kinases - genetics | Shigella flexneri - genetics | Saccharomyces cerevisiae - genetics | Shigella flexneri - metabolism | Humans | Shigella flexneri - pathogenicity | Ubiquitin - metabolism | Antigens, Bacterial - genetics | Saccharomyces cerevisiae - metabolism | Mitogen-Activated Protein Kinase Kinases | Protein Kinase C - metabolism | Genes, Reporter | Protein Structure, Tertiary | Bacterial Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Pheromones - metabolism | Saccharomyces cerevisiae Proteins - genetics | Animals | Saccharomyces cerevisiae Proteins - metabolism | Bacterial Proteins - metabolism | Signal Transduction - physiology | Biological Transport - physiology | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Antigens, Bacterial - metabolism | Mitogen-Activated Protein Kinases - metabolism | Ubiquitin | Ligases | Mitogen-Activated Protein Kinases | Signal Transduction | Biochemistry, Molecular Biology | Shigella flexneri | Antigens, Bacterial | Pheromones | Proteasome Endopeptidase Complex | Bacterial Proteins | Ubiquitin-Protein Ligases | Life Sciences | Protein Kinases | Biological Transport | Saccharomyces cerevisiae Proteins | Saccharomyces cerevisiae | Protein Kinase C
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2017, Volume 77, Issue 17, pp. 4602 - 4612
Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we... 
TUMOR-PROTEIN-53-INDUCED-NUCLEAR-PROTEIN-1 | NUCLEAR-PROTEIN 1 | ONCOLOGY | MAP KINASE | PROSTATE-CANCER | KINASE PHOSPHATASES MKPS | GENE-EXPRESSION | TUMOR-SUPPRESSOR | STRESS | P53-INDUCED NUCLEAR-PROTEIN-1 | CELL-DEATH | Prognosis | Humans | Lung Neoplasms - metabolism | Tumor Protein p73 - genetics | Gene Expression Profiling | Tumor Protein p73 - metabolism | Heat-Shock Proteins - genetics | Neoplasm Metastasis | Lung Neoplasms - secondary | Carcinoma, Hepatocellular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Dual-Specificity Phosphatases - genetics | Liver Neoplasms - pathology | Tumor Cells, Cultured | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Dual-Specificity Phosphatases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase Phosphatases - genetics | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Protein Array Analysis | Mice | Mice, Inbred BALB C | Carcinoma, Hepatocellular - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Liver | Extracellular signal-regulated kinase | Hepatocellular carcinoma | Metastasis | Metastases | Liver cancer | Signal transduction | Signaling | Stress response | Binding sites | Cellular stress response | Tumors | Apoptosis | Cancer | Liver Neoplasms | Lung Neoplasms | Life Sciences | Tumor Protein p73 | Heat-Shock Proteins | Mitogen-Activated Protein Kinase Phosphatases | Carcinoma, Hepatocellular | Dual-Specificity Phosphatases | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | Carrier Proteins
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2017, Volume 474, Issue 4, pp. 597 - 609
.... PDE4 long isoforms can be phosphorylated by mitogen-activated protein kinase-activated protein kinase 2 (MK2... 
CELLS | SIGNALING PATHWAYS | ACTIVATION | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-MEDIATED PHOSPHORYLATION | BETA-ARRESTIN | BINDING-SITES | ROLIPRAM INHIBITION | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Intracellular Signaling Peptides and Proteins - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - chemistry | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Recombinant Proteins - chemistry | Ubiquitin-Conjugating Enzymes - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Molecular Docking Simulation | Protein-Serine-Threonine Kinases - chemistry | src-Family Kinases - genetics | COS Cells | Mitogen-Activated Protein Kinase 1 - metabolism | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | beta-Arrestins - metabolism | Cercopithecus aethiops | Ubiquitin-Conjugating Enzymes - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | HEK293 Cells | src-Family Kinases - metabolism | Protein Interaction Domains and Motifs | Mitogen-Activated Protein Kinase 3 - chemistry | beta-Arrestins - chemistry | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Protein Structure, Secondary | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - genetics | Amino Acid Motifs | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | beta-Arrestins - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | src-Family Kinases - chemistry | protein–protein interactions | cAMP | cyclic nucleotide phosphodiesterases
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2010, Volume 120, Issue 7, pp. 2457 - 2473
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 468, Issue 7326, pp. 968 - 972
...(1). Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK... 
TRANSFORMATION | CELLS | ACTIVATION | TUMOR PROGRESSION | GENE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | BRAF | MUTATIONS | CANCER | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer
Journal Article
PLoS genetics, ISSN 1553-7404, 2012, Volume 8, Issue 7, p. e1002816
Journal Article
The Plant cell, ISSN 1532-298X, 2012, Volume 24, Issue 5, pp. 2225 - 2236
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
ACTIVATION | MEK INHIBITION | DETERMINANTS | RAF | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | DEFICIENCY | Signal transduction | Kinetics | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1897 - 17
.... We found that early after mitogenic stimulation, RUNX3 binds to its target loci, where it opens chromatin structure by sequential recruitment of Trithorax group proteins and cellcycle regulators... 
UBIQUITINATION | AML1-ETO | ACETYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PROTEINS | QUANTITATIVE-ANALYSIS | POLYCOMB | CANCER | KINASES | FAMILY | Chromatin - metabolism | RNA, Small Interfering - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Polycomb-Group Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Chromatin - chemistry | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Signal Transduction | Epithelial Cells - pathology | MAP Kinase Kinase 1 - metabolism | Imidazoles - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Cell Cycle Checkpoints - drug effects | Polycomb-Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA, Small Interfering - metabolism | ras Proteins - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Cyclin-Dependent Kinase 4 - genetics | Epithelial Cells - drug effects | ras Proteins - metabolism | Drosophila melanogaster - genetics | Chromatin Assembly and Disassembly - drug effects | Drosophila melanogaster - metabolism | MAP Kinase Kinase 1 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Chromatin - drug effects | Histone-Lysine N-Methyltransferase - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Sirolimus - pharmacology | Animals | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Core Binding Factor Alpha 3 Subunit - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Polycomb group proteins | Regulators | Molecular modelling | S phase | Genes | Cell cycle | Loci | Runx3 protein | Recruitment | Tumors | Chromatin remodeling
Journal Article