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Genes and Development, ISSN 0890-9369, 11/2005, Volume 19, Issue 22, pp. 2668 - 2681
TGF-beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-kappa B and AP-1... 
NF-κB | TGF-β | TAB2 | TAB1 | TAK1 | JNK | KINASE-ALPHA | MAP KINASE | DEVELOPMENTAL BIOLOGY | DEFICIENT MICE | TRANSDUCTION PATHWAY | TGF-beta | TUMOR-NECROSIS-FACTOR | NF-kappa B | INNATE IMMUNE-RESPONSES | LIVER DEGENERATION | GENETICS & HEREDITY | EMBRYONIC LETHALITY | NF-KAPPA-B | TNF Receptor-Associated Factor 6 - physiology | Receptors, Immunologic - physiology | Humans | Cercopithecus aethiops | Interleukin-1 Receptor-Associated Kinases | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | TNF Receptor-Associated Factor 2 - physiology | I-kappa B Kinase - physiology | Toll-Like Receptors - physiology | GTPase-Activating Proteins - physiology | Cell Line | Interleukin-1 - metabolism | MAP Kinase Kinase Kinases - genetics | Myeloid Differentiation Factor 88 | Antigens, Differentiation - physiology | Adaptor Proteins, Signal Transducing - physiology | Animals | Protein Kinases - physiology | Transcription Factor AP-1 - physiology | Tumor Necrosis Factor-alpha - physiology | MAP Kinase Kinase Kinases - physiology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Mutation | Intracellular Signaling Peptides and Proteins - physiology | COS Cells | Cell Line, Transformed | Immune response | Research | Cytokines | Transforming growth factors | Index Medicus | Research Papers
Journal Article
Plant Cell, ISSN 1040-4651, 01/2007, Volume 19, Issue 1, pp. 63 - 73
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 2, pp. 193 - 208
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2012, Volume 32, Issue 49, pp. 17714 - 17724
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2015, Volume 21, Issue 9, pp. 1038 - 1047
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2001, Volume 108, Issue 1, pp. 73 - 81
Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun... 
RHEUMATOID-ARTHRITIS | TRANSCRIPTION FACTORS | SIGNAL-TRANSDUCTION | PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | KAPPA-B REGULATION | P38 | COLLAGENASE | GENE-EXPRESSION | JNK2 | Rats, Inbred Lew | MAP Kinase Signaling System | Arthritis, Experimental - pathology | Protein-Tyrosine Kinases - physiology | RNA, Messenger - biosynthesis | Protein-Tyrosine Kinases - genetics | Transcription Factor AP-1 - deficiency | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Flavonoids - pharmacology | Interleukin-1 - antagonists & inhibitors | Phosphorylation - drug effects | p38 Mitogen-Activated Protein Kinases | Isoenzymes - physiology | Cells, Cultured - drug effects | Collagenases - genetics | Collagenases - biosynthesis | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Rats | Anthracenes - pharmacology | Cells, Cultured - enzymology | Interleukin-1 - pharmacology | Matrix Metalloproteinase 13 | Mice, Knockout | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinase 9 | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | Proto-Oncogene Proteins c-jun - metabolism | Activating Transcription Factor 2 | Transcription Factor AP-1 - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Arthritis, Experimental - enzymology | Isoenzymes - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinase 3 | Synovial Membrane - cytology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 2004, Volume 43, Issue 4, pp. 563 - 574
The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. We describe a Ca -sensitive protein complex... 
CAMKII | DOMAIN-CONTAINING PROTEINS | SYNGAP | RAS-GTPASE | PDZ DOMAINS | GTPASE-ACTIVATING PROTEIN | MOLECULAR-BASIS | NEUROSCIENCES | CULTURED HIPPOCAMPAL-NEURONS | CEREBRAL-CORTEX | PLASTICITY | Synaptic Transmission - physiology | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Molecular Sequence Data | Synapses - genetics | Receptors, N-Methyl-D-Aspartate - genetics | Transfection | Hippocampus - enzymology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | p38 Mitogen-Activated Protein Kinases | GTPase-Activating Proteins - physiology | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Carrier Proteins - physiology | Amino Acid Sequence | Cell Line | Nerve Tissue Proteins - physiology | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Synapses - physiology | ras GTPase-Activating Proteins | Rats | Synapses - enzymology | Receptors, N-Methyl-D-Aspartate - physiology | Carrier Proteins - genetics | Hippocampus - metabolism | Animals | Mitogen-Activated Protein Kinases - genetics | GTPase-Activating Proteins - genetics | Hippocampus - physiology | Mitogen-Activated Protein Kinases - metabolism | Proteins | Software | Kinases | Rodents | Index Medicus | Mitogen-Activated Protein Kinases | GTPase-Activating Proteins | Receptors, N-Methyl-D-Aspartate | Nerve Tissue Proteins | Calcium-Calmodulin-Dependent Protein Kinases | Cellular Biology | Synaptic Transmission | Life Sciences | Synapses | Hippocampus | Carrier Proteins
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1208 - 1216
The ataxia telangiectasia mutated (ATM) kinase, a master regulator of the DNA damage response (DDR), acts as a barrier to cellular senescence and... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | OXYGEN-INDUCED RETINOPATHY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | HISTONE H2AX | MECHANISMS | TUMOR ANGIOGENESIS | CELL BIOLOGY | MOUSE MODEL | NEOVASCULARIZATION | ATAXIA-TELANGIECTASIA | Protein-Serine-Threonine Kinases - deficiency | Reactive Oxygen Species - metabolism | Humans | Male | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Retinal Vessels - pathology | Tumor Suppressor Proteins - deficiency | Lipid Peroxidation - drug effects | Neovascularization, Pathologic - physiopathology | Ischemia - pathology | Hydrogen Peroxide - toxicity | Cells, Cultured - drug effects | DNA-Binding Proteins - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Retinal Vessels - drug effects | Ataxia Telangiectasia Mutated Proteins | Mice, Knockout | Tumor Suppressor Proteins - physiology | Signal Transduction - drug effects | Cells, Cultured - metabolism | Eye Proteins - physiology | Mice | Enzyme Activation | Retinal Neovascularization - physiopathology | Cell Cycle Proteins - physiology | Hydrogen Peroxide - antagonists & inhibitors | Vascular Endothelial Growth Factor A - physiology | Retinal Neovascularization - pathology | Oxidative Stress - physiology | Pyrones - pharmacology | DNA-Binding Proteins - deficiency | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Retinal Neovascularization - prevention & control | Female | Neovascularization, Pathologic - prevention & control | Acetylcysteine - therapeutic use | Melanoma, Experimental - blood supply | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | Cell Cycle Proteins - deficiency | Antioxidants - pharmacology | Ischemia - physiopathology | DNA-Binding Proteins - genetics | Antioxidants - therapeutic use | Animals | Ischemia - drug therapy | DNA Repair | Acetylcysteine - pharmacology | Apoptosis | Physiological aspects | Oxidative stress | Research | Neovascularization | Biological control systems | Endothelium | Angiogenesis | Signal transduction | Cellular biology | Kinases | DNA damage | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2013, Volume 127, Issue 21, pp. 2097 - 2106
Journal Article