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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
2008, Topics in current genetics, ISBN 9783540755685, Volume 20
Web Resource
2008, Topics in current genetics, ISBN 9783540755685, Volume 20
Web Resource
2008, Topics in current genetics, ISBN 9783540755685, Volume 20
Web Resource
Diabetes, ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 514 - 525
The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation. In some conditions, certain white adipose... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins | Proteins | Homeostasis | Diabetes | Kinases | Genes | Cells | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Trends in Plant Science, ISSN 1360-1385, 2002, Volume 7, Issue 7, pp. 301 - 308
Journal Article
The Plant Cell, ISSN 1040-4651, 5/2012, Volume 24, Issue 5, pp. 2225 - 2236
Journal Article
Plant Cell, ISSN 1040-4651, 01/2007, Volume 19, Issue 1, pp. 63 - 73
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2457 - 2473
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2004, Volume 24, Issue 13, pp. 3370 - 3378
The mechanisms of action of human synthetic and naturally secreted cell-derived amyloid beta-peptide (Abeta)(1-42) on the induction of long-term potentiation... 
Metabotropic glutamate receptors | Cdk5 | JNK | LTP | Amyloid β-protein | Alzheimer's disease | p38 MAPK | Hippocampus | NEURONAL APOPTOSIS | hippocampus | ALZHEIMERS-DISEASE | MAP KINASE | metabotropic glutamate receptors | amyloid beta-protein | SYNAPTIC PLASTICITY | FREQUENCY STIMULATION | AREA CA1 | NEUROSCIENCES | IN-VITRO | PATHWAY | MICE | PRECURSOR PROTEIN | Receptors, Metabotropic Glutamate - drug effects | Cyclin-Dependent Kinases - metabolism | Amyloid beta-Peptides - pharmacology | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Ovary - cytology | Excitatory Postsynaptic Potentials - drug effects | Cyclin-Dependent Kinases - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - genetics | JNK Mitogen-Activated Protein Kinases | Long-Term Potentiation - physiology | Receptor, Metabotropic Glutamate 5 | Female | Electric Stimulation - methods | Peptide Fragments - genetics | p38 Mitogen-Activated Protein Kinases | CHO Cells | Ovary - metabolism | Cricetinae | Enzyme Inhibitors - pharmacology | Peptide Fragments - secretion | Rats | Excitatory Amino Acid Antagonists - pharmacology | Cyclin-Dependent Kinase 5 | Animals | Ovary - secretion | Hippocampus - physiology | In Vitro Techniques | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 2, pp. 559 - 567
ATF3 (activating transcription factor 3) gene encodes a member of the ATF/CREB (cAMP-response-element-binding protein) family of transcription factors. Its... 
Mitogen activated protein kinase (MAPK) | Activating transcription factor 3 (ATF3) | p38 | Stress response | Stress kinase | MAPK kinase (MKK) | APOPTOSIS | activating transcription factor 3 (ATF3) | stress kinase | PHOSPHORYLATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR-3 | mitogen activated protein kinase (MAPK) | JUN NH2-TERMINAL KINASE | INDUCTION | stress response | VASCULAR ENDOTHELIAL-CELLS | C-JUN | STRESS | INHIBITOR | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Gene Expression Regulation | Activating Transcription Factor 3 - biosynthesis | Cercopithecus aethiops | JNK Mitogen-Activated Protein Kinases - metabolism | Imidazoles - pharmacology | MAP Kinase Kinase 7 - metabolism | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Anisomycin - pharmacology | Flavonoids - pharmacology | Pyridines - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | HeLa Cells | COS Cells | Activating Transcription Factor 3 - genetics | Index Medicus | IL-1β, interleukin 1β | JNK, c-Jun N-terminal kinase | DTT, dithiothreitol | shRNA, small-hairpin RNA | ERK, extracellular-signal-regulated kinase | SAPK, stress-activated protein kinase | DMEM, Dulbecco's modified Eagle's medium | ERK kinase 1 | CREB, CRE-binding protein | RT, reverse transcriptase | gadd153, growth-arrest and DNA-damage-inducible protein 153 | TNFα, tumour necrosis factor α | enhancer-binding protein | EBP-homologous protein 10 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | CRE, cAMP-response element | GST, glutathione S-transferase | HEK-293 cells, human embryonic kidney 293 cells | tetO, tet operator | NF-κB, nuclear factor κB | EBP, CCAAT | DN, dominant negative | FBS, fetal bovine serum | β-Gal, β-galactosidase | MKK, MAPK kinase | HA, haemagglutinin | CA, constitutively active | IP–kinase, immunoprecipitation coupled with kinase | MEK1, MAPK | ATF, activating transcription factor | Chop10, C | TGF-β, transforming growth factor-β | MEF, mouse embryonic fibroblast | MAPK, mitogen-activated protein kinase
Journal Article