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1. Letting post-marketing bridge the evidence gap: The case of orphan drugs
by Joppi, Roberta and Gerardi, Chiara and Bertele, Vittorio and Garattini, Silvio
BMJ (Online), ISSN 0959-8146, 2016, Volume 353, p. i2978
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Thrombocythemia, Essential - drug therapy | Ibuprofen - therapeutic use | Ductus Arteriosus, Patent - drug therapy | Humans | Antineoplastic Agents - therapeutic use | Mitotane - therapeutic use | Adrenal Cortex Neoplasms - drug therapy | Adrenocortical Carcinoma - drug therapy | Orphan Drug Production | Zinc Acetate - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Barrett Esophagus - drug therapy | Quinazolines - therapeutic use | Antineoplastic Agents, Hormonal - therapeutic use | Cladribine - therapeutic use | Leukemia, Hairy Cell - drug therapy | Product Surveillance, Postmarketing | Dihematoporphyrin Ether - therapeutic use | Hepatolenticular Degeneration - drug therapy | Platelet Aggregation Inhibitors - therapeutic use
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2. Full Text Review of therapeutic drug monitoring of anticancer drugs part 1 – Cytotoxics
by Paci, Angelo and Veal, Gareth and Bardin, Christophe and Levêque, Dominique and Widmer, Nicolas and Beijnen, Jos and Astier, Alain and Chatelut, Etienne
European journal of cancer (1990), ISSN 0959-8049, 2014, Volume 50, Issue 12, pp. 2010 - 2019
Hematology, Oncology and Palliative Medicine | Therapeutic drug monitoring | Chemotherapy | 5-Fluorouracil | Mitotane | Paediatric oncology | Oncology | Busulfan | Pharmacokinetics | Methotrexate | Cytotoxics | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Pharmacology. Drug treatments | Tumors | Dose-Response Relationship, Drug | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Clinical Trials as Topic | Drug Monitoring - methods | Cytotoxins - pharmacokinetics | Antineoplastic Agents - toxicity | Antineoplastic Combined Chemotherapy Protocols - toxicity | Neoplasms - drug therapy | Antimitotic agents | Antineoplastic agents | Health aspects | Analysis | Cancer | Index Medicus
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3. Medical Management of Cushing Disease
by Tritos, Nicholas A and Biller, Beverly M. K
Neurosurgery clinics of North America, ISSN 1042-3680, 10/2019, Volume 30, Issue 4, p. 499
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Temozolomide - therapeutic use | Cabergoline - therapeutic use | Ketoconazole - therapeutic use | Somatostatin - analogs & derivatives | Pituitary ACTH Hypersecretion - complications | Humans | Treatment Outcome | Somatostatin - therapeutic use | Metyrapone - therapeutic use | Mitotane - therapeutic use | Pituitary ACTH Hypersecretion - drug therapy | Etomidate - therapeutic use
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4. Full Text Adrenocortical cancer: A molecularly complex disease where surgery matters
by Payabyab, Eden C and Balasubramaniam, Sanjeeve and Edgerly, Maureen and Velarde, Margarita and Merino, Maria J and Venkatesan, Aradhana M and Leuva, Harshraj and Litman, Thomas and Bates, Susan E and Fojo, Tito
Clinical cancer research, ISSN 1078-0432, 10/2016, Volume 22, Issue 20, pp. 4989 - 5000
Life Sciences & Biomedicine | Oncology | Science & Technology | Doxorubicin - therapeutic use | Laparoscopy - mortality | Adrenocortical Carcinoma - genetics | Humans | Etoposide - therapeutic use | Combined Modality Therapy | Adrenocortical Carcinoma - therapy | Mitotane - therapeutic use | Adrenal Cortex Neoplasms - genetics | Adrenal Cortex Neoplasms - therapy | Cisplatin - therapeutic use | Laparoscopy - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Antineoplastic Agents, Hormonal - therapeutic use | Retrospective Studies | Peritoneal Neoplasms - secondary | Index Medicus
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5. Full Text Medical Treatment of Cushing's Disease
by Feelders, Richard A and Hofland, Leo J
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 02/2013, Volume 98, Issue 2, pp. 425 - 438
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Feeding. Feeding behavior | Adrenals. Adrenal axis. Renin-angiotensin system (diseases) | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Vertebrates: anatomy and physiology, studies on body, several organs or systems | Vertebrates: endocrinology | Biological and medical sciences | Endocrinopathies | Medical sciences | Receptors, Glucocorticoid - antagonists & inhibitors | Somatostatin - analogs & derivatives | Antineoplastic Agents, Hormonal - therapeutic use | Humans | Dopamine Agonists - therapeutic use | Somatostatin - therapeutic use | Octreotide - therapeutic use | Mitotane - therapeutic use | Pituitary ACTH Hypersecretion - drug therapy | Index Medicus | Abridged Index Medicus
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6. Full Text Mitotane, Metyrapone, and Ketoconazole Combination Therapy as an Alternative to Rescue Adrenalectomy for Severe ACTH-Dependent Cushing's Syndrome
by Kamenický, Peter and Droumaguet, Céline and Salenave, Sylvie and Blanchard, Anne and Jublanc, Christel and Gautier, Jean-François and Brailly-Tabard, Sylvie and Leboulleux, Sophie and Schlumberger, Martin and Baudin, Eric and Chanson, Philippe and Young, Jacques
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 09/2011, Volume 96, Issue 9, pp. 2796 - 2804
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Feeding. Feeding behavior | Adrenals. Adrenal axis. Renin-angiotensin system (diseases) | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Vertebrates: anatomy and physiology, studies on body, several organs or systems | Vertebrates: endocrinology | Biological and medical sciences | Endocrinopathies | Medical sciences | Humans | Middle Aged | Hydrocortisone - urine | Male | Treatment Outcome | Antineoplastic Agents - therapeutic use | Antimetabolites - therapeutic use | Mitotane - therapeutic use | Ketoconazole - therapeutic use | Cushing Syndrome - urine | Adolescent | Adult | Female | Aged | Drug Therapy, Combination | Metyrapone - therapeutic use | Cushing Syndrome - drug therapy | Index Medicus | Abridged Index Medicus
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7. Full Text A simplified method for therapeutic drug monitoring of mitotane by gas chromatography‐electron ionization‐mass spectrometry
by Ando, Motozumi and Hirabatake, Masaki and Yasui, Hisateru and Fukushima, Shoji and Sugioka, Nobuyuki and Hashida, Tohru
Biomedical chromatography, ISSN 0269-3879, 03/2020, Volume 34, Issue 3, pp. e4776 - n/a
adrenal cortical carcinoma, electron ionization, gas chromatography, mitotane, therapeutic drug monitoring | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Pharmacology & Pharmacy | Chemistry, Analytical | Science & Technology | Gas Chromatography-Mass Spectrometry - methods | Limit of Detection | Reproducibility of Results | Humans | Linear Models | Mitotane - chemistry | Drug Monitoring - methods | Mitotane - therapeutic use | Mitotane - pharmacokinetics | Antineoplastic Agents, Hormonal - blood | Adrenal Cortex Neoplasms - drug therapy | Antineoplastic Agents, Hormonal - pharmacokinetics | Mitotane - blood | Adrenocortical Carcinoma - drug therapy | Antineoplastic Agents, Hormonal - therapeutic use | Antineoplastic Agents, Hormonal - chemistry | Index Medicus | Short Communication
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8. Full Text Therapeutic Concentrations of Mitotane (o,p′-DDD) Inhibit Thyrotroph Cell Viability and TSH Expression and Secretion in a Mouse Cell Line Model
by Zatelli, Maria Chiara and Gentilin, Erica and Daffara, Fulvia and Tagliati, Federico and Reimondo, Giuseppe and Carandina, Gianni and Ambrosio, Maria Rosaria and Terzolo, Massimo and degli Uberti, Ettore C
Endocrinology (Philadelphia), ISSN 0013-7227, 06/2010, Volume 151, Issue 6, pp. 2453 - 2461
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: endocrinology | Biological and medical sciences | Cell Survival - drug effects | Thyrotropin - genetics | Antineoplastic Agents, Hormonal - pharmacology | Enzyme-Linked Immunosorbent Assay | Thyrotrophs - metabolism | Humans | Thyrotropin-Releasing Hormone - pharmacology | Mitotane - adverse effects | Thyroxine - blood | Reverse Transcriptase Polymerase Chain Reaction | Thyrotropin - metabolism | Mitotane - therapeutic use | Mitotane - pharmacology | Triiodothyronine - blood | Antineoplastic Agents, Hormonal - adverse effects | Animals | Thyrotrophs - cytology | Antineoplastic Agents, Hormonal - therapeutic use | Thyrotrophs - drug effects | Mice | Index Medicus | Abridged Index Medicus
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9. Advances in medical therapies for Cushing's syndrome
by Tritos, Nicholas A and Biller, Beverly M K
Discovery medicine, ISSN 1539-6509, 2012, Volume 13, Issue 69, pp. 171 - 179
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Somatostatin - analogs & derivatives | Humans | Tetrahydronaphthalenes - therapeutic use | Cushing Syndrome - metabolism | Mitotane - therapeutic use | Etomidate - therapeutic use | Ketoconazole - therapeutic use | Animals | Quinazolines - therapeutic use | Somatostatin - therapeutic use | Metyrapone - therapeutic use | Cushing Syndrome - drug therapy | Mifepristone - therapeutic use
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10. Full Text Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane
by Sbiera, Silviu and Kendl, Sabine and Weigand, Isabel and Sbiera, Iuliu and Fassnacht, Martin and Kroiss, Matthias
Molecular and cellular endocrinology, ISSN 0303-7207, 01/2019, Volume 480, pp. 36 - 41
Treatment | Cell line | In vitro | Heat shock protein | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Pyrazoles - therapeutic use | Adenine - analogs & derivatives | Adrenocortical Carcinoma - genetics | Humans | RNA, Messenger - genetics | Adenine - pharmacology | RNA, Messenger - metabolism | Mitotane - therapeutic use | Mitotane - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Drug Synergism | Adrenocortical Carcinoma - pathology | Adrenocortical Carcinoma - drug therapy | Adenine - therapeutic use | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - therapeutic use | Computer Simulation | HSP90 Heat-Shock Proteins - metabolism | HSP90 Heat-Shock Proteins - genetics | Pyridines - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pyrazoles - pharmacology | Pyridines - therapeutic use | Proteins | Antimitotic agents | Carcinoma | Analysis | Heat shock proteins | Antineoplastic agents | Gene expression | Drug therapy | Cancer | Index Medicus
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