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European heart journal, ISSN 0195-668X, 2015, Volume 36, Issue 7, pp. 449 - 456
Journal Article
Circulation, ISSN 0009-7322, 02/2013, Volume 127, Issue 7, pp. 832 - 841
Journal Article
Journal Article
CARDIOVASCULAR RESEARCH, ISSN 0008-6363, 01/2017, Volume 113, Issue 1, pp. 40 - 51
Aims Myxomatous valve disease (MVD) is the most common aetiology of primary mitral regurgitation. Recent studies suggest that defects in heart valve... 
CARDIAC & CARDIOVASCULAR SYSTEMS | MOUSE | ECM remodelling | BETA-CATENIN | INTERSTITIAL-CELLS | Wnt/beta-catenin signalling | PATHOGENESIS | ORGANIZATION | Myxomatous valve disease | MARFAN-SYNDROME | Heart valve development | Axin2 | EXTRACELLULAR-MATRIX | DIFFERENTIATION | MITRAL-VALVE | UP-REGULATION | Axin Protein - deficiency | Cell Proliferation | Axin Protein - genetics | Aortic Valve - abnormalities | Extracellular Matrix - metabolism | Mitral Valve - metabolism | Mitral Valve - physiopathology | Mitral Valve Insufficiency - genetics | Morphogenesis | Heart Defects, Congenital - genetics | Bone Morphogenetic Proteins - metabolism | Gene Expression Regulation, Developmental | Fibrillin-1 - metabolism | Fibrillin-1 - genetics | Wnt Signaling Pathway | SOX9 Transcription Factor - metabolism | Aortic Valve Insufficiency - metabolism | Genetic Predisposition to Disease | Heart Defects, Congenital - pathology | Aortic Valve - physiopathology | Aortic Valve Insufficiency - physiopathology | Aortic Valve Insufficiency - pathology | Aggrecans - metabolism | Aortic Valve - metabolism | Marfan Syndrome - genetics | Mice, Knockout | Collagen - metabolism | Mitral Valve Insufficiency - pathology | Phenotype | Animals | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Heart Defects, Congenital - metabolism | Heart Defects, Congenital - physiopathology | Mutation | Extracellular Matrix - pathology | Mitral Valve Insufficiency - physiopathology | SOX9 Transcription Factor - genetics | Mitral Valve - abnormalities | Mitral Valve Insufficiency - metabolism | β-catenin signalling | Original | Axin2 • Heart valve development • Myxomatous valve disease • ECM remodelling • Wnt
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 01/2016, Volume 67, Issue 3, pp. 275 - 287
Abstract Background In patients with myocardial infarction (MI), leaflet tethering by displaced papillary muscles induces mitral regurgitation (MR), which... 
Cardiovascular | Internal Medicine | endothelial-to-mesenchymal transition | papillary muscle | inflammation | mitral regurgitation | echocardiography | CARDIAC & CARDIOVASCULAR SYSTEMS | TGF-BETA | HEART-FAILURE | INTERSTITIAL-CELLS | GROWTH-FACTOR-BETA | COLLAGEN-SYNTHESIS | LEAFLET ADAPTATION | 3-DIMENSIONAL ECHOCARDIOGRAPHY | EXTRACELLULAR-MATRIX | CARDIAC FIBROSIS | COMPENSATORY MECHANISM | Adaptation, Physiological | Epithelial-Mesenchymal Transition - physiology | Cell Proliferation - physiology | Myocardial Infarction - metabolism | Ventricular Remodeling - physiology | Mitral Valve - physiopathology | Mitral Valve Insufficiency - pathology | Myocardial Infarction - complications | Animals | Mitral Valve - diagnostic imaging | Myocardial Infarction - pathology | Sheep | Matrix Metalloproteinases - metabolism | Mitral Valve Insufficiency - etiology | Papillary Muscles - pathology | Mitral Valve Insufficiency - physiopathology | Transforming Growth Factor beta - metabolism | Echocardiography, Three-Dimensional - methods | Disease Models, Animal | Mitral Valve Insufficiency - metabolism | Heart valve diseases | Medical colleges | Cardiac patients | Mortality | Stem cells | Cardiology | Health aspects | Heart attack | Cardiovascular agents | Endothelium | Heart failure | Ostomy | Heart attacks | Histopathology | Adaptation | Euthanasia
Journal Article
Circulation, ISSN 0009-7322, 07/2006, Volume 114, Issue 1, pp. I492 - I498
Journal Article
Circulation, ISSN 0009-7322, 10/2016, Volume 134, Issue 17, pp. 1247 - 1256
Journal Article