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The Journal of biological chemistry, ISSN 1083-351X, 05/2016, Volume 291, Issue 21, pp. 11083 - 11093
The AlkB repair enzymes, including Escherichia coli AlkB and two human homologues, ALKBH2 and ALKBH3, are iron(II)- and 2-oxoglutarate-dependent dioxygenases... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | DNA Repair Enzymes - genetics | Crystallography, X-Ray | Mixed Function Oxygenases - metabolism | DNA Methylation | RNA Interference | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | DNA Repair Enzymes - metabolism | DNA Repair Enzymes - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Line | Catalytic Domain | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Mixed Function Oxygenases - antagonists & inhibitors | Recombinant Proteins - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | Escherichia coli Proteins - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | Anthraquinones - pharmacology | DNA Damage | Anthraquinones - chemistry | Mixed Function Oxygenases - genetics | Methyl Methanesulfonate - pharmacology | Index Medicus | cancer therapy | DNA and Chromosomes | bacteria | chemical biology | enzyme inhibitor | DNA-protein interaction | DNA repair | enzyme structure
Journal Article
Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2099 - 13
Effective therapy of acute myeloid leukemia (AML) remains an unmet need. DNA methyl-cytosine dioxygenase Ten-eleven translocation 1 (TET1) is a critical... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Leukemia, Myeloid, Acute - metabolism | Mixed Function Oxygenases - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Enzyme Inhibitors - administration & dosage | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | RNA Interference | STAT5 Transcription Factor - antagonists & inhibitors | Leukemia, Myeloid, Acute - drug therapy | Daunorubicin - administration & dosage | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Leukemia, Experimental - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Leukemia, Experimental - drug therapy | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Kaplan-Meier Estimate | THP-1 Cells | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins - genetics | Mixed Function Oxygenases - antagonists & inhibitors | Animals | Cell Line, Tumor | Mixed Function Oxygenases - genetics | STAT3 Transcription Factor - antagonists & inhibitors | Leukemia, Experimental - metabolism | Leukemia, Myeloid, Acute - genetics | Translocation | Dioxygenase | Data analysis | Transcription factors | Transcription | Myeloid leukemia | Leukemia | Stat3 protein | Data processing | Drug screening | Synergistic effects | Chemotherapy | Acute myeloid leukemia | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 10/2014, Volume 60, Issue 4, pp. 1302 - 1313
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 7, pp. 3546 - 3552
...) dependent oxygenases (2OG oxygenases for simplicity) that enable the repair of cytotoxic methylation damage in nucleic acids and